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Yi Heng Seow,Ru Xin Wong,John Heng Chi Lim,Weixiang Lian,Yoon Sim Yap,Fuh Yong Wong 한국유방암학회 2019 Journal of breast cancer Vol.22 No.2
Purpose: The American Joint Committee on Cancer 8th edition (AJCC8) prognostic stage (PS) was implemented January 1, 2018, but it is complex due to multiple permutations. A North American group proposed a simpler system using the anatomic stage with a risk score system (RSS) of 1 point each for grade 3 tumor and human epithelial growth factor receptor 2 (HER2) and estrogen receptor (ER) negativity. Here we aimed to evaluate this risk score system with our database of Asian breast cancer patients and compare it against the AJCC8 PS. Methods: Patients diagnosed with breast cancer stage I–IV in 2006–2012 were identified in the SingHealth Joint Breast Cancer Registry. Five-year breast cancer-specific survival (CSS) and overall survival (OS) were calculated for each anatomic stage according to the risk score and compared with the AJCC8 PS. Results: A total of 6,656 patients were analyzed. The median follow-up was 61 (interquartile range, 37–90) months. There was a high receipt of endocrine therapy (84.6% of ER+ patients), chemotherapy (84.3% of node-positive patients), and trastuzumab (86.0% of HER2+ patients). Within each anatomic stage, there were significant differences in survival in all sub-stages except IIIB. On multivariate analysis, the hazard ratio for negative ER was 1.74 (1.48–2.06), for negative HER2 was 1.49 (1.26–1.74), and for grade 3 was 1.84 (1.55–2.19). On multivariate analysis controlled for age, ethnicity, and receipt of chemotherapy, the RSS (Akaike information criterion [AIC] = 10,649.45; Harrell's Concordance Index [C] = 0.85) was not inferior to the AJCC8 PS (AIC = 10,726.65; C = 0.84) for CSS, nor was the RSS (AIC = 14,714.4; C = 0.82) inferior to the AJCC8 PS (AIC = 14,784.69; C = 0.81) for OS. Conclusion: The RSS is comparable to the AJCC8 PS for a patient population receiving chemotherapy as well as endocrine- and HER2-targeted therapy and further stratifies stage IV patients.
Zhao, Lian-Heng,Cao, Jingyuan,Zhang, Yingbin,Luo, Qiang Techno-Press 2015 Geomechanics & engineering Vol.8 No.3
In this paper, stabilities of a plane slide rock slope under different hydraulic distributions were studied based on the nonlinear Barton-Bandis (B-B) failure criterion. The influence of various parameters on the stability of rock slopes was analyzed. Parametric analysis indicated that studying the factor of safety (FS) of planar slide rock slopes using the B-B failure criterion is both simple and effective and that the effects of the basic friction angle of the joint (${\varphi}_b$), the joint roughness coefficient (JRC), and the joint compressive strength (JCS) on the FS of a planar slide rock slope are significant. Qualitatively, the influence of the JCS on the FS of a slope is small, whereas the influences of the ${\varphi}_b$ and the JRC are significant. The FS of the rock slope decreases as the water in a tension crack becomes deeper. This trend is more significant when the flow outlet is blocked, a situation that is particularly prevalent in regions with permafrost or seasonal frozen soil. Finally, the work is extended to study the reliability of the slope against plane failure according to the uncertainty from physical and mechanics parameters.
Liu, Lian-Ke,Wu, Heng-Fang,Guo, Zhi-Rui,Chen, Xiang-Jian,Yang, Di,Shu, Yong-Qian,Zhang, Ji-Nan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6
Objective: Lung cancer is one of the malignant tumors with greatest morbidity and mortality around the world. The keys to targeted therapy are discovery of lung cancer biomarkers to facilitate improvement of survival and quality of life for the patients with lung cancer. Translationally controlled tumor protein (TCTP) is one of the most overexpressed proteins in human lung cancer cells by comparison to the normal cells, suggesting that it might be a good biomarker for lung cancer. Materials and Methods: In the present study, the targeted efficacy of dihydroartemisinin (DHA) on TCTP expression in the A549 lung cancer cell model was explored. Results and Conclusions: DHA could inhibit A549 lung cancer cell proliferation, and simultaneously up-regulate the expression of TCTP mRNA, but down-regulate its protein expression in A549 cells. In addition, it promoted TCTP protein secretion. Therefore, TCTP might be used as a potential biomarker and therapeutic target for non-small cell lung cancers.
Effect of surface bolt on the collapse mechanism of a shallow rectangular cavity
Huang, Fu,Zhao, Lian-heng,Zhang, Sheng Techno-Press 2017 Geomechanics & engineering Vol.13 No.3
Based on the collapse characteristics of a shallow rectangular cavity, a three-dimensional failure mechanism which can be used to study the collapsing region of the rock mass above a shallow cavity roof is constructed. Considering the effects of surcharge pressure and surface bolt on the collapsing block, the external rate of works produced by surcharge pressure and surface bolt are included in the energy dissipation calculation. Using variational approach, an analytic expression of surface equation for the collapsing block, which can be used to study the collapsing region of the rock mass above a shallow cavity roof, is derived in the framework of upper bound theorem. Based on the analytic expression of surface equation, the shape of the collapsing block for shallow cavity is drawn. Moreover, the changing law of the collapsing region for different parameters indicates that the collapsing region of rock mass decreases with the increase of the density of surface bolt. This conclusion can provide reference for practicing geotechnical engineers to achieve an optimal design of supporting structure for a shallow cavity.
Hui-Xian Yan,Hai-Lian Hong,Lian-Hui Zheng,Heng-Di Su 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.73 No.7
Due to ionic migration and adsorption, an electrical double layer with a thickness scaled by the Debye length is formed at the hydrogel-solution interface. For a thin temperature-pH dual sensitive hydrogel whose chickness is comparable to the Debye length, its mechanical behavior may be affected by the electrical double layer. In this paper, by incorporating electromagnetic field theory into thermodynamic theory, we develop a coupled field theory for a temperature-pH dual sensitive hydrogel, and we take into account the electrical double layer. The proposed model can be used to analyze the in uences of the size effect, ionic concentration, ambient temperature and solution pH value on the swelling of a thin layer of the temperature-pH sensitive hydrogel.
Synthesis of N-Azaaryl Anilines: An Efficient Protocol via Smiles Rearrangement
Xia, Shuai,Wang, Li-Ying,Sun, Heng-Zhi,Yue, Huan,Wang, Xiu-Hua,Tan, Jia-Lian,Wang, Yin,Hou, Di,He, Xiao-Yan,Mun, Ki-Cheol,Kumar, B. Prem,Zuo, Hua,Shin, Dong-Soo Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.2
An efficient process for the synthesis of N-azaaryl anilines via Smiles rearrangement as a tool. A variety of N-azaaryl anilines were generated by the reaction of substituted phenols, substituted anilines, aminopyridines and chloroacetyl chloride or pyridols, under base condition in good to excellent yields.
Li-Ying Wang,Xiu-Hua Wang,Jia-Lian Tan,Shuai Xia,Heng-Zhi Sun,Jin-Wen Shi,Ming-Dong Jiang,Liang Fang,Hua Zuo,Gautam Dupati,장기완,신동수 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.11
A number of novel small molecules, safrole oxide derivatives 4a-c, 6a-c, 9a-h, were synthesized by the reaction of safrole oxide with anilines 3 and 5, or its alkyl allyl ether derivative 7 with alkyl bromide 8 in moderate yields. The antiproliferative effects of all the target molecules on A549 cell growth were investigated and it was found that the 14 novel compounds could suppress A549 lung cancer cell growth. Among them, compound 6b was the most effective compound in inhibiting the proliferation of A549 cells.
Synthesis of N-Azaaryl Anilines: An Efficient Protocol via Smiles Rearrangement
Shuai Xia,Li-Ying Wang,Heng-Zhi Sun,Huan Yue,Xiu-Hua Wang,Jia-Lian Tan,Yin Wang,Di Hou,Xiao-Yan He,Ki-Cheol Mun,B. Prem kumar,Hua Zuo,신동수 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.2
An efficient process for the synthesis of N-azaaryl anilines via Smiles rearrangement as a tool. A variety of Nazaaryl anilines were generated by the reaction of substituted phenols, substituted anilines, aminopyridines and chloroacetyl chloride or pyridols, under base condition in good to excellent yields.
Empirical likelihood for the class of single index hazard regression models
Jianbo Li,Minglong Guo,Changxin Du,Riquan Zhang,Heng Lian 한국통계학회 2015 Journal of the Korean Statistical Society Vol.44 No.4
Based on the B spline approximation technique and right censored data, we consider the empirical likelihood inference for the index parameters and its partial components in a class of single index hazard regression models. Under some regular conditions, we show that our proposed empirical likelihood ratio statistics follow the standard χ2 distribution. Some numerical studies are given to illustrate our proposed methodology.
Zou Jin-feng,Li Shuai-shuai,Xu Yuan,Dan Han-cheng,Zhao Lian-heng 대한토목학회 2016 KSCE JOURNAL OF CIVIL ENGINEERING Vol.20 No.2
Seepage force is simplified as seepage volumetric force in the stress field along the radial direction. Out-of-plane stress and seepage force are incorporated, and the theoretical solutions for stress, displacement, and plastic radius of a circular opening for the elastic-brittle-plastic and elastic-plastic rock mass are proposed based on the Mohr–Coulomb (MC) and generalized Hoek-Brown (HB) failure criteria. The presented solution and Wang’s solution (2012) are compared, and the corrected version of the proposed method is validated. Numerical examples of the proposed method based on the MC and generalized HB failure criteria reveal that the distributions of stress and displacement in the surrounding rock of the tunnel are significantly influenced by seepage force and out-ofplane stress. Displacement and plastic radius when seepage force and out-of-plane stress are considered are larger than those when the seepage force is not considered; the regulations of stress, however, run opposite. The results of displacement and plastic radius based on the generalized HB failure criterion are larger than those based on the MC failure criterion.