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Zhao Linjie,Yang Mao,Xiao Chengjian,Gong Yu,Ran Guangming,Chen Xiaojun,Li Jiamao,Yue Lei,Chen Chao,Hou Jingwei,Wang Heyi,Long Xinggui,Peng Shuming 한국원자력학회 2024 Nuclear Engineering and Technology Vol.56 No.1
Understanding the tritium release and retention behavior of candidate tritium breeder materials is crucial for breeder blanket design. Recently, a melt spraying process was developed to prepare Li4SiO4 pebbles, which were subsequently subjected to the in-pile tritium production and extraction platform in China Mianyang Research Reactor (CMRR) to investigate their in-situ tritium release behavior and irradiation performance. The results demonstrate that HT is the main tritium release form, and adding hydrogen to the purge gas reduces tritium retention while increasing the HT percent in the purge gas. Post-irradiation experiments reveal that the irradiated pebbles darken in color and their grains swell, but the mechanical properties remain largely unchanged. It is concluded that the tritium residence time of Li4SiO4 made by melt spraying method at 467 ◦C is approximately 23.34 h. High-density Li4SiO4 pebbles exhibit tritium release at relatively low temperatures (<600 ◦C) that is mainly controlled by bulk diffusion. The diffusion coefficient at 525 ◦C and 550 ◦C is 1.19 × 10 11 cm2/s and 5.34 × 10 11 cm2/s, respectively, with corresponding tritium residence times of 21.3 hours and 4.7 hours.
Fang Gong,Tong Zhang,Jun Sheng,Jing Li,Xianghong Wang,Zhenming Chi 한국생물공학회 2008 Biotechnology and Bioprocess Engineering Vol.13 No.5
The extracellular inulinase of the marine yeast Pichia guilliermondii strain 1 was purified to homogeneity resulting in a 7.2-fold increase in specific inulinase activity. The molecular mass of the purified enzyme was estimated to be 50.0 kDa. The op-timal pH and temperature for the purified enzyme were 6.0 and 60C, respectively. The enzyme was activated by Mn²+, Ca²+, K+, Li+, Na+, Fe³+, Fe²+, Cu²+, and Co²+, but Mg²+, Hg²+, and Ag+ inhibited activity. The enzyme was strongly inhibited by phenylmethanesulphonyl fluoride (PMSF), iodoacetic acid, EDTA, and 1, 10-phenanthroline. The Km and Vmax values of the purified inulinase for inulin were 21.1 mg/mL and 0.08 mg/min, respectively. A large number of monosaccharides were de-tected after the hydrolysis of inulin. The deduced protein sequence from the cloned P. guilliermondii strain 1 inulinase gene contained the consensus motifs R-D-P-K-V-F-W-H and W-M-N-D-P-N-G, which are conserved among the inulinases from other microorganisms.
Qin, Xiu-Yuan,Lee, Jinhyuk,Zheng, Li,Yang, Jun-Mo,Gong, Yan,Park, Yong-Doo Elsevier 2018 Process biochemistry Vol.65 No.-
<P><B>Abstract</B></P> <P>The phenomenon of α-glucosidase inhibition has attracted the attention of researchers due to its association with type 2 diabetes treatment in humans. In this study, we found that 2-thiobarbituric acid (TBA) induces complex inhibition of α-glucosidase using kinetics tests and molecular dynamics (MD) simulations. Computational MD and docking simulations demonstrate that TBA interacts with three residues on active sites of α-glucosidase such as Met69, Arg212, and His348. These biochemical tests indicate that TBA reversibly inhibits α-glucosidase in a parabolic noncompetitive manner (<I>IC</I> <SUB>50</SUB> =17.13±1.14mM; <I>K</I> <SUB>i</SUB> =13.25±0.56mM) and that this inhibition is accompanied by a biphasic kinetic process. The tertiary conformational changes were not synchronized with TBA inhibition but we observed hydrophobic disruption after inactivation at higher concentrations of TBA. Our results provide insight into the functional roles of residues located at the active sites of α-glucosidase, and we suggest that compounds similar to TBA (heterocyclic compounds) targeting the key residues of active sites are potential α-glucosidase inhibitors.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 2-Thiobarbituric acid (TBA) induces complex inhibition of α-glucosidase. </LI> <LI> Computational MD simulations demonstrate that TBA interacts with Met69, Arg212, and His348. </LI> <LI> TBA reversibly inhibits α-glucosidase in a parabolic noncompetitive manner (<I>IC</I> <SUB>50</SUB> =17.13±1.14mM; <I>K</I> <SUB>i</SUB> =13.25±0.56mM). </LI> <LI> The high dose of TBA induces hydrophobic disruption after inactivation. </LI> <LI> Heterocyclic compounds targeting the key residues of active sites are potential α-glucosidase inhibitors. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Pyrophosphate-triggered nanoaggregates with aggregation-induced emission
Li, Chun-Tao,Xu, You-Liang,Yang, Jian-Gong,Chen, Yong,Kim, Hyeong Seok,Cao, Qian-Yong,Kim, Jong Seung Elsevier Sequoia 2017 Sensors and actuators. B Chemical Vol.251 No.-
<P><B>Abstract</B></P> <P>A novel tetraphenylethene-based probe bearing bis-imidazolium anion donors is herein reported for pyrophosphate anion recognition. This probe can self-assemble finite, small sphere nanoaggregates with very weak emission in aqueous solution, and changes into large rod-like nanoaggregates with strong aggregation-induced emission upon binding with the pyrophosphate anion.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A bis-imidazolium functionalized tetraphenylethene probe was prepared. </LI> <LI> This probe self-assemble finite small sphere nanoaggregates in aqueous solution. </LI> <LI> The probe can recognize pyrophosphate anion with strong aggregation-induced emission. </LI> <LI> The probe/pyrophosphate assembly can fluorescence assay alkaline phosphatase. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>A novel nanoaggregates for recognition of pyrophosphate anion with aggregation-induced emission in pure aqueous solution is introduced.</P> <P>[DISPLAY OMISSION]</P>
Life Prediction of Hydraulic Concrete Based on Grey Residual Markov Model
Li Gong,Xuelei Gong,Ying Liang,Bingzong Zhang,Yiqun Yang 한국정보처리학회 2022 Journal of information processing systems Vol.18 No.4
Hydraulic concrete buildings in the northwest of China are often subject to the combined effects of lowtemperaturefrost damage, during drying and wetting cycles, and salt erosion, so the study of concretedeterioration prediction is of major importance. The prediction model of the relative dynamic elastic modulus(RDEM) of four different kinds of modified concrete under the special environment in the northwest of Chinawas established using Grey residual Markov theory. Based on the available test data, modified values of thedynamic elastic modulus were obtained based on the Grey GM(1,1) model and the residual GM(1,1) model,combined with the Markov sign correction, and the dynamic elastic modulus of concrete was predicted. Thecomputational analysis showed that the maximum relative error of the corrected dynamic elastic modulus wassignificantly reduced, from 1.599% to 0.270% for the BS2 group. The analysis error showed that the modelwas more adjusted to the concrete mixed with fly ash and mineral powder, and its calculation error wassignificantly lower than that of the rest of the groups. The analysis of the data for each group proved that themodel could predict the loss of dynamic elastic modulus of the deterioration of the concrete effectively, as wellas the number of cycles when the concrete reached the damaged state.
The study of GIS Model Base System
Gong, Hui Li,Ma, Jia,Xiao, Jun Feng 대한원격탐사학회 2000 International Symposium on Remote Sensing Vol.16 No.1
Theoretically GIS has great advantages in spatial analysis, but for the deficiency in spatial analysis and model function, there are great limits in GIS practical application. So in this case the development of Models and Model Base System has become the key to GIS applications. Model Base System can classify, sustain models and produce, save, query, run, analysis the applications of Models, which should be independent of detailed application fields. At first the article describes the conception, functions, research contents of Model Base System and Model Dictionary in detail and then compares them systematically. The design method and overall frame of Model Base System are subsequently presented. At last, take the water resources and environment decision support system for example, the article describes the detailed application of Model Base System.
Six new dammarane-type triterpene saponins from Panax ginseng flower buds and their cytotoxicity
Li, Ke-Ke,Li, Sha-Sha,Xu, Fei,Gong, Xiao-Jie The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.2
Background: Panax ginseng has been used for a variety of medical purposes in eastern countries for more than two thousand years. From the extensive experiences accumulated in its long medication use history and the substantial strong evidence in modern research studies, we know that ginseng has various pharmacological activities, such as antitumor, antidiabetic, antioxidant, and cardiovascular system-protective effects. The active chemical constituents of ginseng, ginsenosides, are rich in structural diversity and exhibit a wide range of biological activities. Methods: Ginsenoside constituents from P. ginseng flower buds were isolated and purified by various chromatographic methods, and their structures were identified by spectroscopic analysis and comparison with the reported data. The 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H- tetrazolium bromide method was used to test their cytotoxic effects on three human cancer cell lines. Results: Six ginsenosides, namely 6'-malonyl formyl ginsenoside F<sub>1</sub> (1), 3β-acetoxyl ginsenoside F<sub>1</sub> (2), ginsenoside Rh<sub>24</sub> (6), ginsenoside Rh<sub>25</sub> (7), 7β-hydroxyl ginsenoside Rd (8) and ginsenoside Rh<sub>26</sub> (10) were isolated and elucidated as new compounds, together with four known compounds (3-5 and 9). In addition, the cytotoxicity of these isolated compounds was shown as half inhibitory concentration values, a tentative structure-activity relationship was also discussed based on the results of our bioassay. Conclusion: The study of chemical constituents was useful for the quality control of P. ginseng flower buds. The study on antitumor activities showed that new Compound 1 exhibited moderate cytotoxic activities against HL-60, MGC80-3 and Hep-G2 with half inhibitory concentration values of 16.74, 29.51 and 20.48 μM, respectively.
Damage Mechanism of Drift Ice Impact
Li Gong,Zhonghui Wang,Yaxian Li,Chunling Jin,Jing Wang 한국정보처리학회 2019 Journal of information processing systems Vol.15 No.6
The ice damage occurs frequently in cold and dry region of western China in winter ice period and spring thawperiod. In the drift ice condition, it is easy to form different extrusion force or impact force to damage tunnellining, causing project failure. The failure project could not arrive the original planning and construction goal,giving rise to the water allocation pressure which influences diversion irrigation and farming production inspring. This study conducts the theoretical study on contact-impact algorithm of drift ices crashing diversiontunnel based on the symmetric penalty function in finite element theory. ANSYS/LS-DYNA is adopted as theplatform to establish tunnel model and drift ice model. LS-DYNA SOLVER is used as the solver and LSPREPOSTis used to do post-processing, analyzing the damage degrees of drift ices on tunnel. Constructingphysical model in the experiment to verify and reveal the impact damage mechanism of drift ices on diversiontunnel. The software simulation results and the experiment results show that tunnel lining surface will formvarying degree deformation and failure when drift ices crash tunnel lining on different velocity, different plansize and different thickness of drift ice. The researches also show that there are damages of drift ice impact forceon tunnel lining in the thawing period in cold and dry region. By long time water scouring, the tunnel liningsurfaces are broken and falling off which breaks the strength and stability of the structure.
Li, Hong-Yang,Zhou, Shi-Ji,Li, Min,Xiong, Ding,Singh, Akanand,Guo, Qing-Xi,Liu, Chang-An,Gong, Jian-Ping Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2
Background: The management of hepatolithiasis combined with intrahepatic cholangicarcinoma (IHHCC) remains a challenge due to poor prognosis. The aim of this study was to summarize our diagnosis and cure experience of IHHCC over the recent 10 years. Methods: From January 1996 to January 2006, 66 patients with IHHCC were reviewed retrospectively. Results: Of the 66 patients, 52 underwent surgical resection (radical resection in 38 and palliative in 14) and 8 patients abdominal exploration, while the other 6 cases received endoscopic retrograde biliary internal drainage and stent implantation. In this series, correct diagnosis of advanced stage was made during operation in 8 cases (8/60, 13.3%) and all of them (underwent unnecessary abdominal exploration, among them the positive rate of CA19-9 was 100%, and the positive rate of CEA was 87.6% (7/8), incidence rate of ascites was 100% and short-term significant weight loss was 100%, with median overall survival of only 4 months. Conclusion: Radical resection is mandatory for IHHCC patient to achieve long-term survival, the CT and MR imaging features of IHHCC being concentric enhancement. Patients with IHHCC have significant higher CA199 and significant higher CEA and short-term significant weight loss and ascites should be considered with advanced stage of IHHCC and unnecessary non-therapeutic laparotomies should be avoided.