Whole Brain Radiotherapy Combined with Stereotactic Radiotherapy Versus Stereotactic Radiotherapy Alone for Brain Metastases: a Meta-analysis

Duan, Lei,Zeng, Rong,Yang, Ke-Hu,Tian, Jin-Hui,Wu, Xiao-Lu,Dai, Qiang,Niu, Xiao-Dong,Ma, Di-Wa Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

Aim: This study was to evaluate the effect of whole brain radiation (WBRT) combined with stereotactic radiotherapy (SRS) versus stereotactic radiotherapy alone for patients with brain metastases using a meta-analysis. Materials and Methods: We searched PubMed, EMBASE, Cochrane Library from their inception up to October 2013. Randomized controlled trials involving whole brain radiation combined with stereotactic radiotherapy versus stereotactic radiotherapy alone for brain metastases were included. Statistical analyses were performed using RevMan5.2 software. Results: Four randomized controlled trials including 903 patients were included. The meta-analysis showed statistically significant lowering of the local recurrence rate (OR=0.29, 95%CI: 0.17~0.49), new brain metastasis rate (OR=0.45, 95%CI: 0.28~0.71) and symptomatic late neurologic radiation toxicity rate (OR=3.92, 95%CI: 1.37~11.20) in the combined group. No statistically significant difference existed in the 1-year survival rate (OR=0.78, 95%CI: 0.60~1.03). Conclusions: The results indicate that whole brain radiotherapy combined with stereotactic radiotherapy has advantages in local recurrence and new brain metastasis rates, but stereotactic radiotherapy alone is associated with better neurological function. However, as the samples included were not large, more high-quality, large-sample size studies are necessary for confirmation.

Characteristics of Micro-documentary in the Context of New Media in China

Duan Lei,Liu Huayan,Tan Yenteng 한중경제문화학회 2022 한중경제문화연구 Vol.20 No.-

One-step preparation of functionalized cotton exocarp-based sorbent for efficient Hg0 immobilization

Duan Xue-Lei,Yuan Chun-Gang,Jing Tian-Tian,Yuan Xiao-Dong 한국탄소학회 2022 Carbon Letters Vol.32 No.1

Activated carbon (AC) injection has been regarded as one of the most effective control technologies for Hg0 removal in flue gas. It is worthwhile to explore new and simple preparation methods for AC with low cost and high Hg removal capacity. In this study, a biomass based AC was successfully prepared from levant cotton exocarp using ZnCl2 activation. The mercury adsorption efficiency and mechanism were studied via the fixed bed experiments. Activator, reaction temperature and components of simulated coal-fired flue gas were investigated. Brunauer–Emmett–Teller (BET), scanning electron microscopy with energy-dispersive X-ray spectrometry (SEM–EDX) and X-ray photoelectron spectroscopy (XPS) were applied for morphology characterization of the prepared AC and discussion of the possible adsorption mechanism. The adsorbed mercury species and the physiochemical properties of prepared AC were discussed. The results showed that (1) Hg0 removal efficiency could reach up to 90% at 150 ℃ under simulated flue gas (SFG); (2) Hg0 adsorption was controlled by the combination of physical and chemical mechanisms.

Quantitative Susceptibility Mapping of Brain Iron Deposition in Patients With Recurrent Depression

Duan Xinxiu,Xie Yuhang,Zhu Xiufang,Chen Lei,Li Feng,Feng Guoquan,Li Lei 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.8

Objective Recurrence is the most significant feature of depression and the relationship between iron and recurrent depression is still lack of direct evidence in vivo.Methods Twenty-one patients with depression and twenty control subjects were included. Gradient-recalled echo, T1 and T2 images were acquired using a 3.0T MRI system. After quantitative susceptibility mapping were reconstructed and standardized, a whole-brain and the regions of interest were respectively analyzed.Results Significant increases in susceptibility were found in multiple recurrent depression patients, which involved several brain regions (frontal lobes, temporal lobe structures, occipital lobes hippocampal regions, putamen, thalamus, cingulum, and cerebellum). Interestingly, no susceptibility changes after treatment compared to pre-treatment (all p>0.05) and no significant correlation between susceptibility and Hamilton Depression Rating Scale were found. Besides, it was close to significance that those with a higher relapse frequency or a longer mean duration of single episode had a higher susceptibility in the putamen, thalamus, and hippocampus. Further studies showed susceptibility across the putamen (ρ²=0.27, p<0.001), thalamus (ρ²=0.21, p<0.001), and hippocampus (ρ²=0.19, p<0.001) were strongly correlated with total course of disease onset.Conclusion Brain iron deposition is related to the total course of disease onset, but not the severity of depression, which suggest that brain iron deposition may be a sign of brain damage in multiple recurrent depression.

중국 당내법규에 관한 연구: 회고와 전망

段磊 ( Duan Lei ) 한국외국어대학교 중국연구소 2018 中國硏究 Vol.75 No.-

The institutional characteristics of the party's laws and regulations in the Communist Party of China are embodied in the making subject, the system function and the implementation effect. From the perspective of the historical development, since the Eighteenth National Congress of the Communist Party of China, obvious achievements have been achieved in the aspects of concept, standardization, implementation and so on. The Communist Party of China has formed a basic framework of "1+4", which includes the party constitution, the party's organizational rules and regulations, the party's leading laws and regulations, the party's self building laws and regulations, and the party's supervision and guarantee system. Since the Eighteenth National Congress of the Communist Party of China, the research of Chinese inner party laws and regulations has focused on the four aspects of institutional construction: the strategic background, practical functions, basic requirements and systematic construction. It has formed a consensus on the nature of party laws and regulations, the relationship between the party laws and regulations and the national laws, the functions and roles of the party laws and regulations and other issues. The related research shows new characteristics in the academic community, research perspective, research scope and research method. The future related research in this field will be further expanded in terms of the party laws and regulations’ philosophical basis, methodology, systematization, the relationship between the party laws and regulations and the modernization of the country's governance systems and capabilities, the foreign party laws and regulations and the comparative study of party laws and regulations, etc.

Differences in the mandibular premolar positions in Angle Class I subjects with different vertical facial types

Jun Duan,Feng Deng,Wan-Shan Li,Xue-Lei Li,Lei-Lei Zheng,Gui-Yuan Li,Yan-Jie Bai 대한치과교정학회 2015 대한치과교정학회지 Vol.45 No.4

Objective: To compare the positions of the mandibular premolars in Angle Class I subjects according to vertical facial type. The results will provide a theoretical basis for predicting effective tooth movement in orthodontic treatment. Methods: Cephalometric parameters were determined using cone-beam computed tomography in 120 Angle Class I subjects. Subjects were categorized as short, normal, and long face types according to the Frankfort mandibular angle. Parameters indicating the position of the mandibular right premolars and the mandible were also measured. Results: The angle between the mandibular first premolar axis and buccal cortex, the distance between the root apex and buccal cortex, angle of vestibularization, arc of vestibularization, and root apex maximum movable distance were significantly greater in the short face type than in the long and norm face types. The angle between the mandibular second premolar axis and buccal cortex, the distance from root apex to buccal cortex, and the arc of vestibularization were significantly greater in the short face type than in the normal face type. Conclusions: There are significant differences in the mandibular premolar positions in Class I subjects according to vertical facial type.

Experimental evaluation of an inertial mass damper and its analytical model for cable vibration mitigation

Lei Lu,Gaston A. Fermandois,Xilin Lu,Billie F. Spencer, Jr.,Yuan-Feng Duan,Ying Zhou 국제구조공학회 2019 Smart Structures and Systems, An International Jou Vol.23 No.6

Cables are prone to vibration due to their low inherent damping characteristics. Recently, negative stiffness dampers have gained attentions, because of their promising energy dissipation ability. The viscous inertial mass damper (termed as VIMD hereinafter) can be viewed as one realization of the inerter. It is formed by paralleling an inertial mass part with a common energy dissipation element (e.g., viscous element) and able to provide pseudo-negative stiffness properties to flexible systems such as cables. A previous study examined the potential of IMD to enhance the damping of stay cables. Because there are already models for common energy dissipation elements, the key to establish a general model for IMD is to propose an analytical model of the rotary mass component. In this paper, the characteristics of the rotary mass and the proposed analytical model have been evaluated by the numerical and experimental tests. First, a series of harmonic tests are conducted to show the performance and properties of the IMD only having the rotary mass. Then, the mechanism of nonlinearities is analyzed, and an analytical model is introduced and validated by comparing with the experimental data. Finally, a real-time hybrid simulation test is conducted with a physical IMD specimen and cable numerical substructure under distributed sinusoidal excitation. The results show that the chosen model of the rotary mass part can provide better estimation on the damper’s performance, and it is better to use it to form a general analytical model of IMD. On the other hand, the simplified damper model is accurate for the preliminary simulation of the cable responses.

Leptonic mono-top from single stop production at the LHC

Duan, Guang Hua,Hikasa, Ken-ichi,Wu, Lei,Yang, Jin Min,Zhang, Mengchao Institute of Physics Pub 2017 The journal of high energy physics Vol.2017 No.3

Association Between XPD Asp312Asn Polymorphism and Esophageal Cancer Susceptibility: A Meta-analysis

Duan, Xiao-Li,Gong, Heng,Zeng, Xian-Tao,Ni, Xiao-Bing,Yan, Yan,Chen, Wen,Liu, Guo-Lei Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7

Objective: To investigate the association between xeroderma pigmentosum group D (XPD) Asp312Asn polymorphism and esophageal cancer (EC) susceptibility by meta-analysis. Methods: We searched PubMed up to April 9th, 2012, to identify relevant papers, and 8 published case-control studies including 2165 EC patients and 3141 healthy controls were yielded. Odds ratios (ORs) with relevant 95% confidence intervals (CIs) were applied to assess the association between XPD Asp312Asn polymorphism and EC susceptibility with the Comprehensive Meta-Analysis software, version 2.2. Results: Overall, the meta-analysis results suggested the XPD Asp312Asn polymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20, 95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR=1.15, 95%CI =1.01-1.31, p=0.04]. In the subgroup analysis by ethnicity and cancer type, significantly associations were found for Caucasian populations [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.26, 95%CI =1.08-1.47, p<0.001; Asp/Asn vs. Asp/Asp: OR=1.19, 95%CI =1.02-1.40, p=0.03] and esophageal squamous cell carcinoma [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.19, 95%CI=1.01-1.41, p=0.04]. There was no heterogeneity and no publication bias existed. Conclusions: This meta-analysis shows that the XPD Asp312Asn polymorphism may be a risk factor for developing EC, especially for Caucasian populations and esophageal squamous cell carcinoma.

Radioimmunoimaging with Mixed Monoclonal Antibodies of Nude Mice Bearing Human Lung Adenocarcinoma Xenografts

Duan, Dong,Li, Shao-Lin,Zhu, Yu-Quan,Zhang, Tao,Lei, Cheng-Ming,Cheng, Xiang-Hua Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

The present study was conducted to evaluate radioimmunoimaging (RII) and in vivo distribution of mixed antibodies $^{99m}Tc$-EGFR-mAb and $^{99m}Tc$-CD44-mAb in nude mice bearing human lung adenocarcinoma xenografts. Single and mixed applications of the two radiolabeled monoclonal antibodies (mAbs) were compared. Direct labeling of $^{99m}Tc$ was applied to radiolabel the EGFR and CD44 mAbs. The properties of the radiolabeled antibodies were then characterized. RII and assessment of the distribution of the antibodies in nude mice bearing lung adenocarcinoma xenografts were achieved by applying separate and combined doses of $^{99m}Tc$-EGFR-mAb and $^{99m}Tc$-CD44-mAb. The labeling rates of $^{99m}Tc$ for EGFR-mAb and CD44-mAb were $91.5%{\pm}3.8%$ and $92.3%{\pm}4.1%$ respectively, with specific activities of 2.8 and $2.9MBq/{\mu}g$, respectively, and radiochemical purities (RCP) of 96.5% and 96.2%. The radioactivity uptake of the combined application of both radiolabeled antibodies was clearly higher than with a single application of either alone. The relative values of target-to-nontarget (T/NT) measured through the regional interest (ROI) technique were $5.59{\pm}0.42$ (mixed antibodies), $2.78{\pm}0.20$ ($^{99m}Tc$-EGFR-mAb), and $2.28{\pm}0.16$ ($^{99m}Tc$-CD44-mAb) in the RII. The body distribution of the radiolabeled antibodies and their imaging results were basically identical. Application of the mixed antibodies with $^{99m}Tc$-EGFR-mAb and $^{99m}Tc$-CD44-mAb can increase the radioactivity uptake of tumor tissue, leading to more ideal target-to-nontarget ratios, and therefore superior results.