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Lee, Hyun,Bae, Kwang Soo,Lee, Chul Soo,Park, Chan Gyo 한국화학공학회 1991 NICE Vol.9 No.5
Empirical methods were developed for the predication of minimum transport velocity (MTV) of settling slurries through horizontal pipes. Multidisperse slurries of different particle sizes and densities were included in the development of correlation. the correlation is based on the separation of the general particle volume dependence and the limiting MTV at zero volume fraction. The latter was calculated assuming a monodisperse slurry of the east readily transportable group of particles in a hypothetical fluid. For pipe diameter less than 50 mm and total volume fraction of solid less than 0.15 the prediction showed satisfactory agreements with experimental values.
Lee, Hyun‐,Jung,Cha, Kyeung Eun,Hwang, Seong‐,Gyu,Kim, Jin Kyeoung,Kim, Gi Jin Wiley Subscription Services, Inc., A Wiley Company 2011 Journal of cellular biochemistry Vol.112 No.1
<P><B>Abstract</B></P><P>Stem cells have unique properties such as self‐renewal, plasticity to generate various cell types, and availability of cells of human origin. The characteristics are attentive in the toxicity screening against chemical toxicants. Placenta‐derived stem cells (PDSCs) have been spotlighted as a new cell source in stem cell research recently because they are characterized by their capacity to differentiate into multilineages. However, the use of PDSCs as an in vitro screening model for potential drug candidates has not yet been studied. Here, we analyzed the potentials for bone‐marrow‐derived mesenchymal stem (BM‐MSCs), which is a representative adult stem cells and PDSCs as an in vitro hepatotoxicity screening system, using well‐known hepatotoxicants. BM‐MSCs and PDSCs were analyzed to the potential for hepatogenic differentiation and were cultured with different concentrations of hepatotoxicants for time courses. The viability and ATP‐binding cassette (ABC) transporters were measured by the MTT assay and RT‐PCR, respectively. The sensitivities of PDSCs to hepatotoxicants are more sensitive than those of BM‐MSCs. The viability (IC<SUB>50</SUB>) to in PDSCs was less than that of BM‐MSCs after 48 and 72 h (<I>P</I> < 0.05) of CCl<SUB>4</SUB> exposure. The toxicities of CCl<SUB>4</SUB> were decreased by fourfold in hepatogenic differentiation inducing PDSCs compared to the undifferentiated cells. The alteration of ABCGs was observed in PDSCs during differentiation. These findings suggest that the naïve PDSCs expressing ABCGs can be used as a source for in vitro screening system as well as the expression patterns of ABCG1 and ABCG2 might be involved in the sensitivity of PDSCs to hepatotoxicants. J. Cell. Biochem. 112: 49–58, 2011. © 2010 Wiley‐Liss, Inc.</P>
LEE, Hyun,BAE, Jae-Sung,JIN, Hee Kyung Japanese Society of Veterinary Science 2010 The Journal of veterinary medical science Vol.72 No.6
<P>Niemann-Pick type C (NP-C) disease is a devastating developmental disorder with progressive and fatal neurodegeneration. We have used a mouse model of Niemann-Pick type C (NP-C) disease to evaluate the effects of direct intracerebral transplantation of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) on the progression of neurological disease in this order. Here, we show that hUCB-MSCs transplantation into NP-C mice prevents the loss of Purkinje neurons and inhibits cerebellar apoptotic cell death. Interestingly, these effects were associated with the modulation of inflammatory responses, as evidenced by increased anti-inflammatory cytokine IL-10, and reduced abnormal astrocytic activation. Furthermore, our results show that the hUCB-MSCs transplantation reduced the cholesterol accumulation level in neurons in NP-C mice compared with sham-transplanted animals. This study provides the first evidence that hUCB-MSCs can improve neurological symptoms in NP-C disease, suggesting it as a potential therapeutic agent against neurodegenerative diseases.</P>
Performance and Power Modeling of On-Chip Bus System for a Complex SoC
LEE, Hyun,LEE, Je-Hoon,CHO, Kyoung-Rok The Institute of Electronics, Information and Comm 2010 IEICE transactions on electronics Vol.93 No.10
<P>This paper presents latency and power modeling of an on-chip bus at the early stage of SoC design. The latency model is to estimate a bus throughput associated with bus configuration and behavioral model before the system-level modeling for a target SoC is established. The power model roughly calculates the power consumption of an on-chip bus including the power consumed by bus wire and bus logics. Thus, the bus architecture is determined by the trade-off between the bus throughput and power estimation obtained from the proposed bus model. We evaluate the target SoCs such as an MPEG player and a portable multimedia player so as to compare the estimated throughput from the proposed bus model to the result performed by a commercial system-level co-simulation framework. As the simulation results, the latency and power consumption of the proposed model shows 14% and 8% differences compared with the result from the validated commercial co-simulation tool.</P>
Lee, Hyun,Park, Myung Soo,Jung, Paul Eunil,Fong, Jonathan J.,Oh, Seung-Yoon,Verbeken, Annemieke,Lim, Young Woon Magnolia Press 2015 Phytotaxa Vol.205 No.3
<P>A new species belonging to Lactarius subg. Plinthogalus was discovered during a long-term project on the diversity of Korean Lactarius. This species is proposed here as Lactarius cucurbitoides. The status of L. cucurbitoides as a new species is supported by molecular data and morphological features. Phylogenetic analysis based on internal transcribed spacer (ITS) sequences shows that L. cucurbitoides is closely related to L. subplinthogalus, L. friabilis, and L. oomsisiensis, with pairwise distances of 2.8-4.3%. Morphological characters of L. cucurbitoides that distinguish it from these closely related species are a pale yellow to pale orange colored pileus and non-discoloration of white latex. The new species is described and illustrated in the present paper.</P>
Lee, Hyun,Jung, Hyun-Do,Kang, Min-Ho,Song, Juha,Kim, Hyoun-Ee,Jang, Tae-Sik Elsevier 2018 Materials & Design Vol.145 No.-
<P><B>Abstract</B></P> <P>Porous titanium (Ti) implants have been used in orthopedic and dental applications because of their superior mechanical properties. Sufficient pore interconnectivity is required for effective bone regeneration and growth inside the Ti scaffold pore structure. We proposed post-treatment with HF/HNO<SUB>3</SUB> to efficiently modify the internal pore structure of a Ti scaffold and achieve controllable mechanical properties with a pore neck structure. The porosity, pore size, wall thickness, and pore neck size were easily controlled by varying the acid treatment time, which produced a Ti scaffold with mechanical properties that were suitable for bone tissue engineering. As the mixed acid treatment time increased, internal isolated pores were gradually interconnected with adjacent pores. After 10min of treatment, nearly all the pores were interconnected. The post-treatment with HF/HNO<SUB>3</SUB> also affected the surface properties. Surface carbon contaminants were significantly reduced after treatment with no hydride formation. Micron-scale surface roughness was uniformly generated across the whole surface. The actual cell penetrability of the Ti scaffold was evaluated using a perfusion-based in vitro cell test. Over 90% of the surface pores depict cell penetrability with a sufficient number of cells attached to the wall surface of the pore after performing acid treatment for 12min.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Hydrofluoric acid and nitric acid mixture is introduced for tunable modification of the pore structure of a titanium scaffold </LI> <LI> The porosity, pore and pore neck sizes, and mechanical strength can be easily controlled by varying the acid treatment time </LI> <LI> The relationship between pore structure and actual cell penetrability is demonstrated using the cell perfusion technique </LI> <LI> Increases in internal pore interconnectivity and cell penetrability are conformed astreatment time increased up to 12min </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Hepatocyte-specific Prominin-1 protects against liver injury-induced fibrosis by stabilizing SMAD7
Lee Hyun,Yu Dong-Min,Bahn Myeong-Suk,Kwon Young-Jae,Um Min Jee,Yoon Seo Yeon,Kim Ki-Tae,Lee Myoung-Woo,Jo Sung-Je,Lee Sungsoo,Koo Seung-Hoi,Jung Ki Hoon,Lee Jae-Seon,Ko Young-Gyu 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Prominin-1 (PROM1), also known as CD133, is expressed in hepatic progenitor cells (HPCs) and cholangiocytes of the fibrotic liver. In this study, we show that PROM1 is upregulated in the plasma membrane of fibrotic hepatocytes. Hepatocellular expression of PROM1 was also demonstrated in mice (Prom1CreER; R26TdTom) in which cells expressed TdTom under control of the Prom1 promoter. To understand the role of hepatocellular PROM1 in liver fibrosis, global and liver-specific Prom1-deficient mice were analyzed after bile duct ligation (BDL). BDL-induced liver fibrosis was aggravated with increased phosphorylation of SMAD2/3 and decreased levels of SMAD7 by global or liver-specific Prom1 deficiency but not by cholangiocyte-specific Prom1 deficiency. Indeed, PROM1 prevented SMURF2-induced SMAD7 ubiquitination and degradation by interfering with the molecular association of SMAD7 with SMURF2. We also demonstrated that hepatocyte-specific overexpression of SMAD7 ameliorated BDL-induced liver fibrosis in liver-specific Prom1-deficient mice. Thus, we conclude that PROM1 is necessary for the negative regulation of TGFβ signaling during liver fibrosis.
Predicting Factors of Severe COVID-19 in Patients With Asthma: A Korean National Cohort Study
Lee Hyun,최하영,Lee Sun-Kyung,Park Tai Sun,박동원,Moon Ji-Yong,Kim Tae-Hyung,손장원,윤호주,김상헌 대한천식알레르기학회 2021 Allergy, Asthma & Immunology Research Vol.13 No.6
As there are limited data on the disease course of and factors predicting severe coronavirus disease 19 (COVID-19) in patients with asthma, this study aims to perform a detailed analysis of the clinical course of asthmatic patients with COVID-19 and evaluate factors related to severe infection. Of the 5,628 patients confirmed with COVID-19, 128 (2.3%) had asthma. Among the 128 asthmatic patients, 32 (25%) had severe COVID-19 and 96 (75%) had non-severe COVID-19. Among asthmatic patients, those with severe COVID-19 were significantly older and had more dyspnea and fever, more comorbidities, and lower lymphocyte and platelet counts than those with non-severe COVID-19. In multivariable logistic regression analysis, chronic obstructive pulmonary disease (adjusted odds ratio [aOR], 6.49; 95% confidence interval [CI], 1.18–41.81), low lymphocyte proportion (aOR, 0.91; 95% CI, 0.86–0.97), and low platelet count (aOR, 0.99; 95% CI, 0.98–0.99) were independently associated with severe COVID-19.