http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Ti-6Al-4V 합금의 동적변형특성과 탄도충격성능 : 1. 초고속 폭발충격 특성 1. Ultra-high-speed Exploding Properties
이유환,이동근,이성학,이종수,최준홍,허선무 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.10
The effects of microstructural morphology on ultra-high-speed exploding properties of Ti-6Al-4V alloy were investigated in this study. Exploding bridge wire (EBW) test was conducted on equiaxed and bimodal microstructures, which were processed by different heat treatments. From the test, moving velocity of free surface vs time profiles were obtained to measure strength at Hugoniot elastic limit (HEL) and spall strength and to subsequently predict ballistic mass efficiency. The EBW results indicated that impact resistance of the bimodal microstructure was better than that of the equiaxed microstructure when the measured strength at HEL and spall strength were considered. It was also learned from the observation of fractured EBW specimens that fracture occurred by the initiation and propagation of long cracks in the equiaxed microstructure, whereas a number of microcracks were formed and connected each other in a zig-zag pattern to reduce the driving force for crack propagation in the bimodal microstructure. Since the EBW test helped experimentally estimate ultra-high-speed deformation and fracture behavior, it could be effectively used for the prediction of ballistic impact performance.
유해 중금속 함유 슬러지의 고화처리시 수분함량 및 시멘트함량이 미치는 영향
이종화,박종안,장봉기,손부순,허준무 순천향대학교 기초과학연구소 1998 순천향자연과학연구 논문집 Vol.4 No.1
The purpose of this study was to investigate the effect of mix ratio on the compressive strength and the hazardous heavy metal leachability from the solidified waste. The solidification process utilized in this study was cement-based technique since its performance was superior to other process techniques. The mix ratio applied in this study varied from 0.05 to 0.30 because higher mix ratio need to large amount of cement and landfill area to be occupied by solidified waste. Sludge obtained from a electroplating industry was used for the solidification process. Moisture contents of the sludge were 30% and 60 % of sludge to be solidified. The moisture content of 30% was selected as a relatively low moisture content while 60% of moisture was a typical one in the solidification field. Typical hazardous metal such as lead, copper, cadmium was selected for leachability test. the results of the study indicated that there could be exist optimum mix ratio to exhibit the maximum compressive strength of the solidified waste especially when low moisture content of sludge was solidified. The same trend was observed when water/cement ratio was applied instead of mix ratio. The optimum mix ratio and water/cement ratio for the 30% of moisture content of sludge were 0.1 and 3, respectively. As the compressive strength of the solidified wasters increased, the leachability of Cu, Pb, and Cd was decreased. Pb may be bound into the silica matrix rather than being in the pores, while Cu and Cd could be bound by physical isolation of concrete matrix.
진행성 비호지킨 림프종 환자에서 ICE 구제 요법에 의한 조혈모세포 가동화 후 자가 말초혈액 조혈모세포이식
이제중,이병환,김여경,변정래,이일권,박무림,정익주,김형준 대한조혈모세포이식학회 2003 대한조혈모세포이식학회지 Vol.8 No.1
연구배경: 비호지킨 림프종에서 자가 말초혈액 조혈모세포이식술이 폭넓게 이용됨으로 인해서, 높은 치료효과뿐만 아니라 조혈모세포의 가동화 효율이 높은 구제 요법이 요구되었다. 방법: 본 연구에서는 진행성 비호지킨 림프종에서 ICE 요법을 이용하여 조혈모세포를 가동화시킨 후 자가 말초혈액 조혈모세포이식이 시행하였던 환자를 후향적으로 분석하였다. 결과: 대상 환자의 중앙 연령은 38세(범위, 16~61)였으며, ICE 요법은 환자당 4주기(범위, 1~6주기)가 투여되었고, 투여 간격은 중앙값이 24일(범위, 16~36일)이었다. 고위험도 관해군을 제외한 13예의 환자 중 완전반응은 7예(53.8%), 부분반응은 4예(30.8%), 진행성질환은 2예(15.4%)를 보였다. 치료에 따른 3~4등급의 혈액학적 독성은 중성구감소증이 13예(81.3%), 혈소판감소증이 7예(42.8%)에서 관찰되었다. 조혈모세포 채집은 ICE 요법 후 중앙값이 12일(범위, 6~20일)에 시행되었고, 각 ICE 요법당 채집한 단핵구치는 중앙값이 5.75× 10^(8)/체중, CD34^(+) 세포는 중앙값이 1.25× 10^(6)/체중, CFU-GM치는 중앙값이 1.19× 10^(5)/체중이었다. 조혈모세포이식은 11예에서 시행되었고, 중앙 추적기간 401일에 평가한 2년 전체생존율은 70.1±14.7%, 1년 및 2년 무사건생존율은 각각 60.7±15.4%와 32.3±17.1%를 보였다. 결론: ICE 요법은 재발성/불응성 비호지킨 림프종 환자에서 높은 치료 반응률과 만족할 만한 조혈모세포 가동화를 보여 주었지만, 치료에 대한 순응도가 낮아서 투여 간격이 연장되는 문제점을 안고 있어서, 우리나라 환자의 실정에 적합한 구제요법에 대한 연구가 필요할 것으로 생각된다. Background: Due to the extensive application of high-dose chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT), a salvage chemotherapeutic regimen with high response rate as well as effective capacity of PBSC mobilization is needed in non-Hodgkin's lymphoma (NHL). Methods: We analyzed the applicability of ICE (ifosphamide, carboplatin, and etoposide) regimen in NHL patients who underewent autologous PBSCT. Results: The median age was 38 years (range, 16~61 years), the patients received median 4 cycles (range, 1~6 cycles) of ICE regimen, and the median interval between each chemotherapeutic cycle was 24 days (range, 16~36 days). There were 7 (53.8%) complete responses, 4 (30.8%) partial responses, and 2 (15.4%) progressive diseases after ICE regimen. Toxicity included grade 3/4 neutropenia and throm bocytopenia in 13 (81.3%) and 7 (42.8%) patients, respectively. PBSC collection began on median day 12 (range, 6~20 days) after ICE therapy. The median number of mononuclear cells, CD34+ cells, and CFU-GM was 5.75× 10^(8)/kg, 1.25× 10^(6)/kg, and 1.19× 10^(5)/kg, respectively. With a median follow- up of 401 days, the patients who underwent autologous PBSCT had overall survival with 70.1±14.7% at 2 year and event free survival with 60.7±15.4% and 32.3±17.1% at 1 year and 2 years, respectively. Conclusion: ICE chemotherapy is an effective cytoreduction and mobilization regimen in patients with NHL, but profound myelosuppression with delayed recovery might pose difficulties in applying for Korean patients. Further evaluation for appropriate salvage regimens in Korean patients should be needed.
서울 소재 7개 종합병원 암환자들의 보완대체요법 이용양상
이은일,신유철,이주현,김순덕,김해준,조무성 대한보건협회 2002 대한보건연구 Vol.28 No.3
Objective of this study was to determine the prevalence and kinds of complementary and alternative medicine (CAM) used in cancer patients. Questionnaire survey was done by trained interviewers for use of CAM, demographic information, type of cancer and cancer stage for 512 cancer patients in 7 general hospitals in Seoul. Among the cancer patients, the total number of inpatients was 315 and outpatients 197. The results were as follows. Among cancer patients, 55.5% of them used CAM. The patients who were 30's and 40's showed high rate of CAM use(59.2%, 64,7%). Stomach cancer patients showed highest rate of CAM use(75.6%) among cancer patients. Liver cancer and breast cancer patients also showed high rate of CAM use(71.1%, 60.3%). The patients received chemotherapy showed higher rate of CAM use(60.6%) than the patients not received chemotherapy(43.7%). By multiple logistic regression, stomach cancer, liver cancer, and chemotheray were statistically significant variables for use of CAM. Among cancer patients, the use of herbs was highest(86.0%), followed by diet(46.5%) and chinese medicine(14.1%). Elm tree was the most frequently used(49.6%), however, total usage of mushrooms such as Sang-Whang, Young-Gee, Agaricus, Wooon-Gee were 57%. The number of CAM items used by cancer patients were limited and it is necessary for scientific data to prove the their effect.
위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동
이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.
동종 골수이식을 시행받은 환자에서 폐색성 세기관지염에 의하여 발생한 자발성 기종격동과 피하 기종
이병환,이제중,이연경,안재숙,김여경,황호인,박무림,조상희,정익주,김형준 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.2
저자들은 만성골수성백혈병으로 동종 골수이식과 이식편 부전으로 인하여 추가적인 말초혈액 조혈모세포이식을 시행 받은 환자에서 만성 이식편대숙주질환과 그 폐 합병증인 폐색성 세기관지염에 동반된 자발성 기종격동과 피하 기종이 병발한 1예를 경험하였기에 이를 보고하는 바이다. Obstructive lung disorders following after allogeneic bone marrow transplantation (BMT) in association with graft- versus-host disease (GVHD) contribute significant morbidity and mortality. We report a case of a 28-year-old man who developed spontaneous pneumomediatinum and subcutaneous emphysema complicating bronchiolitis obliterans after allogeneic BMT. He received an allogeneic BMT for chronic phase of chronic myeloid leukemia. Five months after BMT, he was boostered by allogeneic peripheral blood stem cells from the same donor due to graft failure. One month after the boostering, chronic GVHD developed and were treated with cyclosporine and steroid. The patients developed spontaneous pneumomediatinum and subcutaneous emphysema secondary to severe bronchiolitis obliterans 4 months after boostering donor cells. The air-leak syndromes were recovered by conservative management, including high-flow oxygen.
위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구
노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.
배추 시스테인 단백질 분해 효소 억제 유전자 BCPI-1의 발현과 종자 발아 및 유묘 생장과의 연관성
홍준기,이은영,김정률,양경애,최영주,정우식,김호일,윤대진,이상열,조무제,임체오 Plant molecular biology and biotechnology research 2003 Plant molecular biology and biotechnology research Vol.2003 No.-
Phytocystatins are protein inhibitors of cysteine proteinases of the papain family that have been identified in both monocot and dicot plants. A cDNA encoding a phytocystatin, BCPI-1 (Brassica Cysteine Proteinase Inhibitor-1) has been isolated from Chinese cabbage (Brassica campestris L. ssp. pekinensis) flower buds. Here, we tested whether BCPI-1 transcription is regulated by hormones, and could be involved in regulating cysteine proteinases during and after germination. BCPI-1 was sensitive to exogenous GA_(3) and ABA, which are important factors controlling seed germination, suggesting that the expression of BCPI-1 is hormonally regulated. We introduced a recombinant plasmid containing the full-length BCPI-1 cDNA under the control of cauliflower mosaic virus 35S promoter into rice embryogenic calli using the particle delivery method, and regenerated a number of transgenic rice plants. Constitutively over-expressed BCPI-1 caused changes in overall plant growth and development, including reduced germination and seedling growth. These data support the role of the BCPI-1 in the regulation of endogenous proteinases during both seed germination and subsequent seedling development. Phylocystatins은 papain계열의 cysteine 단백질 분해 효소 활성을 특이적으로 억제하는 억제자로 다양한 식물 종으로부터 분리되었다. 본고에서는, 배추 화아 cDNA library로부터 분리된 phytocystatin인 BCPI-1(Brassica Cysteine Proteinase Inhibitor-1)의 생체 내 기능에 대해 연구하였다. 먼저, BCPI-1 전사체는 발아 조절에 중요한 영향을 미치는 GA₃와 ABA에 의해 예민하게 증가, 혹은 감소되는 반응을 보임으로써, BCPI-1이 식물 호르몬의 영향을 받으며, 특히 발아나 유묘의 생장 조절에 관련이 있음을 알 수 있었다. Particle bombardment 방법을 통하여 BCPI-1을 벼의 배 형성 세포 내에 도입, 재분화 시켜 형질 전환 벼를 생성하였다. CaMV 35S promoter의 조절에 의해 지속적인 BCPI-1 발현을 보이는 형질 전환 벼의 경우, 발아와 유묘 생장이 현저히 지연되었다. 위의 결과들을 바탕으로, BCPI-1이 식물체 내에서 생성되는 cysteine 계열의 단밸질 분해 효소 활성을 조절하여 종자의 발아와 유묘의 생장에 영향을 미치는 것으로 추측한다.
세라믹튜브 및 패킹형 플라스틱 여재충전 혐기성 여상의 유가공 폐수 처리특성 및 반응조 내부거동
허준무,장봉기,서성철,박종안,이종화,배형석,김준현 순천향대학교 기초과학연구소 1997 순천향자연과학연구 논문집 Vol.3 No.2
This study was carried to develop of anaerobic reactor to be able to maximize the organic removal efficiency using laboratory-scale anaerobic filter. The ceramic tube and pall ring media were tested for the applicability as packing media of anaerobic filter for the treatment of a dairy waste. This study was conducted to determine the anaerobic treatability of a dairy waste, and investigate the effects of ceramic tube and pall ring media. Anaerobic filters were packed with packing volume of 65% of total working volume. When treating a dairy waste, the organic removal efficiency of anaerobic filter packed with pall rings was a little higher than that of anaerobic filter packed with ceramic tubes. This was because the reactor packed with ceramic tube had clogging problems and substrate transfer limitations. It seemed that the reactor packed with ceramic tubes had uneven packing due to structural characteristics. The COD removals of ceramic tube and pall ring anaerobic filters were greater than about 91% and 94%, respectively, at organic loading rate lower than 5kgCOD/㎥/d. The COD removals of both reactors decreased to 80% with organic loading rate of 10kgCOD/㎥/d. Biomass capture and solid-liquid-gas separation efficiency seemed to vary with the type of media.