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Yan Lan,Le-Gen Nong,Chuan-Dong Wei,Wen-Cheng Chen,Jun-Li Wang,Chun-Fang Wang,Guo-Gang Pan,Ye-Sheng Wei 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.2
Purpose: Although the polymorphisms of erythrocyte complement receptor type 1 (CR1) in patients with malaria have been extensively studied, a question of whether the polymorphisms of CR1 are associated with severe malaria remains controversial. Furthermore, no study has examined the association of CR1 polymorphisms with malaria in Chinese population. Therefore, we investigated the relationship of CR1 gene polymorphism and malaria in Chinese population. Materials and Methods:We analyzed polymorphisms of CR1 gene rs2274567 G/A, rs4844600 G/A, and rs2296160 C/T in 509 patients with malaria and 503 controls, using the Taqmangenotyping assay and PCR-direct sequencing. Results: There were no significantdifferences in the genotype, allele and haplotype frequencies of CR1 gene rs2274567 G/A, rs4844600 G/A, and rs2296160 C/T polymorphisms between patientswith malaria and controls. Furthermore, there was no association of polymorphismsin the CR1 gene with the severity of malaria in Chinese population. Conclusion:These findings suggest that CR1 gene rs2274567 G/A, rs4844600 G/A, and rs2296160 C/T polymorphisms may not be involved in susceptibility to malariain Chinese population.
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