Methylation of O⁶-Methyl Guanine Methyltransferase Gene Promoter in Meningiomas - Comparison between Tumor Grades I, II, and III

Larijani, Leila,Madjd, Zahra,Samadikuchaksaraei, Ali,Younespour, Shima,Zham, Hanieh,Rakhshan, Azadeh,Mohammadi, Foruzan,Rahbari, Ali,Moradi, Afshin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

Background: Meningiomas are the second most common primary intracranial tumors after gliomas. Epigenetic biomarkers such as DNA methylation, which is found in many tumors and is thus important in tumorigenesis can help diagnose meningiomas and predict response to adjuvant chemotherapy. We investigated aberrant O6-methyl guanine methyltransferase (MGMT) methylation in meningiomas. Materials and Methods: Sixty-one patients were classified according to the WHO grading, and MGMT promoter methylation status was examined via the methylation-Specific PCR(MSP) method. Results: MGMT promoter methylation was found in 22.2% of grade I, 35% of grade I with atypical features, 36% of grade II, and 42.9% of grade III tumors. Conclusions: There was an increase, albeit not statistically significant, in MGMT methylation with a rise in the tumor grade. Higher methylation levels were also observed in the male gender.

Lack of TNF-α Gene Polymorphism (rs1799724) Association with Sustained Virological Response in Iranian Patients with Chronic HCV Infection

Larijani, Mona Sadat,Bahiraei, Narges,Nikbin, Mehri,Mohajel, Nasir,Rad, Leila Naghizadeh,Baghbani, Fahimeh,Mapar, Maryam,Sadat, Seyed Mehdi Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8

Infection with the hepatitis C virus is a major public health concern which can lead to carcinoma and liver failure. It has been shown that single nucleotide polymorphisms can affect the level of gene activity of tumor necrosis factor (TNF) which has an important role, especially in viral infections which can lead to apaptosis of infected hepatocellular cells. We investigated the impact of three possible genotypes for rs1800629 or A/G single nucleotide polymorphism located downstream of $TNF{\alpha}$ gene promoter in groups of control (n=76) and chronic hepatitis C patients (n=89) focusing on the response to treatment among sensitive and resistant groups. Genomic DNA was extracted from $500{\mu}l$ prepheral whole blood and PCR and RFLP were used to amplify the region of interest and genotyping. With statistical analyzes a p-value <0.05 was considered meaningful. There was no significant difference in distribution of possible three genotypes among healthy individuals and patients (P=0.906, OR=1.194, CI=0.063-22.790). However, the frequency of G allele was higher in patients whereas A allele was more common among healthy individuals (p<0.0001). Further studies with more samples seem to be necessary.

Progressive collapse analysis of buildings with concentric and eccentric braced frames

Reza Jalali Larijani,Heydar Dashti Nasserabadi,Iman Aghayan 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.61 No.6

In this study, the susceptibility of different symmetric steel buildings with dual frame system to Progressive Collapse (PC) was assessed. Some ten-story dual frame systems with different type of braced frames (concentrically and eccentrically braced frames) were considered. In addition, numbers and locations of braced bays were investigated (two and three braced bays in exterior frames) to quantitatively find out its effect on PC resistance. An Alternate Path Method (APM) with a linear static analysis was carried out based on General Services Administration (GSA 2003) guidelines. Maximum Demand Capacity Ratio (DCR) for the elements (beams and columns) with highest DCRs (DCRmoment and DCRshear) is given in tables. The results showed that the three braced bays with concentric braced frames especially X-braced and inverted V-braced frame systems had a lower susceptibility and greater resistance to PC. Also, the results represented that the beams were more critical than columns against PC after the removal of column.

Risk factors of inadequate emergence following general anesthesia with an emphasis on patients with substance dependence history

Makarem Jalil,larijani Amir Hossein,Eslami Babak,Jafarzadeh Afshin,Karvandian Kasra,Mireskandari Seyed Mohammad 대한마취통증의학회 2020 Korean Journal of Anesthesiology Vol.73 No.4

Background: This study aims to define the incidence and risk factors of both emergence agitation and hypoactive emergence in adult patients and substance-dependent patients following general anesthesia to elaborate on the risk factors and precise management of them. Methods: The study recruited 1,136 adult patients who received elective surgeries under general anesthesia for this prospective observational study. Inadequate emergence was determined according to the Richmond Agitation-Sedation Scale (RASS). Emergence agitation was defined as a RASS ≥ +1 point, and hypoactive emergence was defined as a RASS ≤ –2 points. Subgroup analyses were then conducted on patients with substance dependence. Results: Inadequate emergence in the post-anesthesia care unit (PACU) occurred in 20.3% of patients, including 13.9% with emergence agitation and 6.4% with hypoactive emergence. Ninety-five patients had a history of substance dependence. Compared to divorced patients, never-married and presently married patients, who underwent gynecological and thoracic surgeries, had a lower risk of agitation. Neurologic disorders, intraoperative blood loss, intraoperative morphine, and PACU analgesic drug administration were associated with increased agitation risk. Hypertension and psychological disorders, intraoperative opioids, and PACU Foley catheter fixation were associated with increased hypoactive emergence risk. Substance-dependent patients had higher risk for agitation (21.1%, P = 0.019) and hypoactive emergence (10.5%, P = 0.044). Conclusions: Inadequate emergence in PACU following general anesthesia is a significant problem correlated with several perioperative factors. Patients with a history of substance dependence appear to be more at risk of inadequate emergence than the general population.

INVESTIGATING HYDROGEN STORAGE BEHAVIOR OF CARBON NANOTUBES AT AMBIENT TEMPERATURE AND ABOVE BY ION BEAM ANALYSIS

S. SAFA,M. MOJTAHEDZADEH LARIJANI,V. FATHOLLAHI,O. R. KAKUEE 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2010 NANO Vol.5 No.6

Hydrogen storage capacity of a carbon nanotube (CNT) sample is investigated using Elastic Recoil Detection Analysis (ERDA) at constant hydrogen uptake pressure of 5 bar and different adsorption temperatures within 30°C–500°C. The results of hydrogen concentration versus temperature revealed three distinct temperature intervals in which a certain adsorption or desorption mechanism is dominant. Moreover, the results showed that hydrogen storage capacity of CNTs at the applied conditions of pressure and temperature is about 0.1 wt.% which is well below the DOE requirements for a viable hydrogen storage system. The physidesorption activation energy is calculated using the Arrhenius plot to be 6 kJmol-1.

Estimating the Absorbed Dose to Critical Organs During Dual X-ray Absorptiometry

M Mokhtari-Dizaji,A A Sharafi,B Larijani,N Mokhlesian,H Hasanzadeh 대한영상의학회 2008 Korean Journal of Radiology Vol.9 No.2

Objective: The purpose of this study is to estimate a patient's organ dose (effective dose) during performance of dual X-ray absorptiometry by using the correlations derived from the surface dose and the depth doses in an anthropomorphic phantom. Materials and Methods: An anthropomorphic phantom was designed and TLDs (Thermoluminescent Dosimeters) were placed at the surface and these were also inserted at different depths of the thyroid and uterus of the anthropomorphic phantom. The absorbed doses were measured on the phantom for the spine and femur scan modes. The correlation coefficients and regression functions between the absorbed surface dose and the depth dose were determined. The derived correlation was then applied for 40 women patients to estimate the depth doses to the thyroid and uterus. Results: There was a correlation between the surface dose and depth dose of the thyroid and uterus in both scan modes. For the women's dosimetry, the average surface doses of the thyroid and uterus were 1.88 Gy and 1.81 Gy, respectively. Also, the scan center dose in the women was 5.70 Gy. There was correlation between the thyroid and uterus surface doses, and the scan center dose. Conclusion: We concluded that the effective dose to the patient's critical organs during dual X-ray absorptiometry can be estimated by the correlation derived from phantom dosimetry. Objective: The purpose of this study is to estimate a patient's organ dose (effective dose) during performance of dual X-ray absorptiometry by using the correlations derived from the surface dose and the depth doses in an anthropomorphic phantom. Materials and Methods: An anthropomorphic phantom was designed and TLDs (Thermoluminescent Dosimeters) were placed at the surface and these were also inserted at different depths of the thyroid and uterus of the anthropomorphic phantom. The absorbed doses were measured on the phantom for the spine and femur scan modes. The correlation coefficients and regression functions between the absorbed surface dose and the depth dose were determined. The derived correlation was then applied for 40 women patients to estimate the depth doses to the thyroid and uterus. Results: There was a correlation between the surface dose and depth dose of the thyroid and uterus in both scan modes. For the women's dosimetry, the average surface doses of the thyroid and uterus were 1.88 Gy and 1.81 Gy, respectively. Also, the scan center dose in the women was 5.70 Gy. There was correlation between the thyroid and uterus surface doses, and the scan center dose. Conclusion: We concluded that the effective dose to the patient's critical organs during dual X-ray absorptiometry can be estimated by the correlation derived from phantom dosimetry.

Translation and Validation of the Activities of Daily Living Scale with Iranian Elderly Cancer Patients Treated in an Oncology Unit

Khoei, Mahtab Alizadeh,Akbari, Mohammad Esmail,Sharifi, Farshad,Fakhrzadeh, Hossein,Larijani, Bagher Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Background: This study evaluated the validity and reliability of applying the Katz's Activities of Daily Living (ADL) scale in an Iranian sample of elderly oncologic patients following initial cancer treatment. Materials and Methods: The scale was translated with the forward-backward procedure to give an Iranian version. The ADL scale was then applied in a random sample of 400 oncologic patients aged 60 and older following initial cancer treatment. Assessment of the scale stability was twice, with a 14-days (two weeks) interval, to 30 (of the 400) eligible elderly cancer patients in March 2012. To measure treatment effects, the index was run with 150 patients in a three month recall, following oncology processing. Exploratory and confirmatory factor analysis was performed for assessment of construct validity of the Katz's ADL. Reliability was measured with internal consistency (Cronbach's alpha co-efficient), and test/retest (Spearman's r value) of the instrument. Criterion validity was evaluated by comparing the Katz with Physical Function (PF) subscale of SF 36. Known-group validity was approved by comparing of Katz' ADL between quartile groups of PF subscale of SF 36. Results: In our study the ADL demonstrated a high degree of internal homogeneity (Cronbach's alpha 0.923). There was a high correlation between scores of two time measurement of Katz's ADL (p value of two- related- samples test was 0.3). Construct validity showed a correlation coefficient of 0.572 between the ADL and PF scores. In factor analysis, 2 factors were extracted. Evidence for the reliability of the questionnaire was good and known group validity was approved by significant differences of ADL score between quartiles of the PF subscale of SF36. Conclusions: The results suggest that the Iranian version of ADL applied for oncologic older adult patients following initial cancer treatment is a reliable and a valid clinical instrument and comparable to those reported in other studies.

Intramolecular and Intermolecular Interactions of Protein Kinase B Define Its Activation InVivo

V?ronique, Calleja,Alcor, Damien,Laguerre, Michel,Park, Jongsun,Vojnovic, Borivoj,A.Hemmings, Brian,Downward, Julian,J.Parker, Peter,Larijani, Banafsh? 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

Assessment of quality of life and its affecting factors in osteosarcopenic individuals in the Iranian older adult population: Bushehr Elderly Health (BEH) program

Amir Mohammad Vahdani,Mahnaz Sanjari,Noushin Fahimfar,Mahbube Ebrahimpur,Gita shafiee,Kazem Khalagi,Mohammad Javad Mansourzadeh,Iraj Nabipour,Bagher Larijani,Afshin Ostovar 대한골다공증학회 2023 Osteoporosis and Sarcopenia Vol.9 No.4

Objectives: This cross-sectional study, conducted as part of the Bushehr Elderly Health program stage II in Bushehr, Iran, aimed to evaluate health-related quality of life (HR-QoL) in individuals aged ≥ 60 with osteosarcopenia, a condition characterized by the co-occurrence of osteopenia/osteoporosis and sarcopenia. Given the increasing elderly population worldwide, understanding the HR-QoL of this demographic is crucial, with osteosarcopenia being a significant factor. Methods: The study enrolled 2369 participants aged ≥ 60 and collected demographic and anthropometric data. Various questionnaires, including the Short Form 12, Patient Health Questionnaire-9, Activities of Daily Living, and Instrumental Activities of Daily Living, were administered. Comparisons were made between individuals with and without osteosarcopenia. Regression models were employed to identify variables associated with HRQoL in those with osteosarcopenia. Results: Key findings revealed that 22.5% of participants had osteosarcopenia. Significantly different HR-QoL measures were observed between the 2 groups, especially in physical functioning and physical component summary scores. Male gender, advanced age, and chronic illnesses were linked to lower physical and mental HRQoL scores among those with osteosarcopenia. In female participants, a history of fractures and physical disability were associated with reduced quality of life. Conclusions: This study underscores the negative impact of osteosarcopenia on HR-QoL, particularly in male participants, with a focus on physical aspects. It also highlights age and chronic disease as contributing factors to diminished HR-QoL in individuals with osteosarcopenia. These findings emphasize the importance of addressing osteosarcopenia in the elderly population to improve their overall well-being.