The origin, evolution, and application of the megapolitan area concept

Robert E. Lang,임재원,Karen A. Danielsen 서울시립대학교 도시과학연구원 2020 도시과학국제저널 Vol.24 No.1

The article explores the origin and evolution of the ‘megapolitan concept', the idea of a super-sized region that began in 1961 in Jean Gottmann's ‘megalopolis,' which he developed to explain large-scale urbanization in the Northeastern U.S. Jerome Picard, a researcher at the Urban Land Institute took up the megalopolis idea in 1967 and applied it to the entire U.S. and projected large-scale urban growth to 2000. The Regional Plan Association (RPA) also applied the megalopolis concept to The Second Regional Plan for New York in 1968. Lang in 2000s, then working with his colleagues at Virginia Tech developed the megapolitan concept and definition-in part to differential the concept from work being done by the University of Pennsylvania for RPA. Lang defined ‘megapolitan clusters’ as multiple megapolitan areas that are networked either by commuting, logistics, or dense air links, but where there is no more than three times the distance used to define a Megapolitan Area between anchor metropolitan areas at their furthest distance. The recent evolution of megapolitan area and megapolitan cluster concepts by Lang and the colleagues is applied to a series of projects, including ‘Sun Corridor’ in 2006 (Phoenix-Tucson) and the Southwest Triangle (SoCal-Sun Corridor-Las Vegas) in 2014. The article ends with the future application of megapolitan area concept in the rapidly growing Southwest Triangle megapolitan cluster.

Ex vivo Expansion of Bone Marrow Mesenchymal Stem Cells Using Microcarrier Beads in a Stirred Bioreactor

Lang Zhou,Jiantao Kong,Ying-ping Zhuang,Ju Chu,Si-Liang Zhang,Mei-Jin Guo 한국생물공학회 2013 Biotechnology and Bioprocess Engineering Vol.18 No.1

Bone marrow mesenchymal stem cells (bmMSCs)have recently gained attention as a useful resource in the fields of regenerative medicine and tissue engineering. However, the number of bmMSCs obtained from available donors is very low. Here we developed a culture strategy for in vitro expansion of bmMSCs in a 1.5 L stirred bioreactor with microcarrier beads. First, the microcarriers (Cytodex 3) were equilibrated in culture medium containing 3% fetal bovine serum (FBS) for at least 30 min prior to cell addition. After inoculation, the FBS concentration of the medium was maintained at 3% (v/v) in the first 24 h and thereafter maintained at 1% (v/v) and a developed feeding regimen was applied over 5 days. The maximum cell density of 2.6 × 106 cells/mL was achieved at day 5,corresponding to a 10.4 ± 0.8 fold increases in total cell number. Among the harvested cells, 98.95% expressed CD29and 84.48% expressed CD90, suggesting that the majority of expanded bmMSCs still retained their differentiation potential. Therefore, the developed microcarrier-based stirred bioreactor culture system is an effective method to generate significant numbers of bmMSCs for potential applications and research studies.

Complete Guide to Immunisation : Part Ⅲ: Adults, Elderly and Immunocompromised

Lang, Selwyn,Singh, Kumar P. Medical Publications Korea 1990 Medical Progress Vol.12 No.9

Opioid-induced constipation: a narrative review of therapeutic options in clinical management

Lang-Illievich, Kordula,Bornemann-Cimenti, Helmar The Korean Pain Society 2019 The Korean Journal of Pain Vol.32 No.2

Pain therapy often entails gastrointestinal adverse events. While opioids are effective drugs for pain relief, the incidence of opioid-induced constipation (OIC) varies greatly from 15% to as high as 81%. This can lead to a significant impairment in quality of life, often resulting in discontinuation of opioid therapy. In this regard, a good doctor-patient relationship is especially pivotal when initiating opioid therapy. In addition to a detailed history of bowel habits, patient education regarding the possible gastrointestinal side effects of the drugs is crucial. In addition, the bowel function must be regularly evaluated for the entire duration of treatment with opioids. Furthermore, if the patient has preexisting constipation that is well under control, continuation of that treatment is important. In the absence of such history, general recommendations should include sufficient fluid intake, physical activity, and regular intake of dietary fiber. In patients of OIC with ongoing opioid therapy, the necessity of opioid use should be critically reevaluated in terms of an with acceptable quality of life, particularly in cases of non-cancer pain. If opioids must be continued, lowering the dose may help, as well as changing the type of opioid. If these measures do not suffice, the next step for persistent OIC is the administration of laxatives. If these are ineffective as well, treatment with peripherally active ${\mu}$-opioid receptor antagonists should be considered. Enemas and irrigation are emergency measures, often used as a last resort.

Characterization of Two-Dimensional Transition Metal Dichalcogenides in the Scanning Electron Microscope Using Energy Dispersive X-ray Spectrometry, Electron Backscatter Diffraction, and Atomic Force Microscopy

Lang, Christian,Hiscock, Matthew,Larsen, Kim,Moffat, Jonathan,Sundaram, Ravi Korean Society of Microscopy 2015 Applied microscopy Vol.20 No.1

Here we show how by processing energy dispersive X-ray spectrometry (EDS) data obtained using highly sensitive, new generation EDS detectors in the AZtec LayerProbe software we can obtain data of sufficiently high quality to non-destructively measure the number of layers in two-dimensional (2D) $MoS_2$ and $MoS_2/WSe_2$ and thereby enable the characterization of working devices based on 2D materials. We compare the thickness measurements with EDS to results from atomic force microscopy measurements. We also show how we can use electron backscatter diffraction (EBSD) to address fabrication challenges of 2D materials. Results from EBSD analysis of individual flakes of exfoliated $MoS_2$ obtained using the Nordlys Nano detector are shown to aid a better understanding of the exfoliation process which is still widely used to produce 2D materials for research purposes.

Can Managerial Military Experience Affect Corporate Innovation? : Evidence from an Emerging Market

Lang, Xiangxiang,You, Dandan,Cui, Li,Peng, Zhe Institute of Management Research 2020 Journal of East Asia Management Vol.1 No.1

Military experience has a great impact on a soldier ability to handle risks. Therefore, when those soldiers become managers, they may behave differently in making risky corporate decisions, especially in activities like the R&D investment. However, studies on how military experience affect R&D have been largely missing in the largest emerging economy, i.e. China, despite that the country hires a higher percentage of military managers than the US. In addition, it remains a question whether military managers affect the state-owned enterprises (SOEs) in China, as many of the corporate decisions are made by the government. This paper tries to address these questions. The imprinting theory and the upper echelon theory suggest that managers' personal experience can affect their behaviour, which in turn influences their corporate decisions. In this paper, we examine whether managers with military experience lead to higher R&D investment and whether such an effect exists in state-owned enterprises. Based on a sample of listed firms in China's A-share market over 2008-2017, we make two findings. First, companies with military managers have high R&D investment. By dividing managers' military positions into high and low rank, we find that companies tend to have higher (lower) R&D investment if their managers hold a high-rank (low-rank) position. Second, the effect of high-rank military managers on R&D investment is more pronounced if the manager is also the founder and the company is a non-state-owned enterprise. For low-ranking military managers, a stronger effect on R&D investment is also observed if they are also the founder, but whether their companies are state-owned or not has no impact on R&D investment. This study identifies managers' military experience as a contributing factors to corporate R&D investment in the largest emerging economy. This paper tests an implication of the imprinting theory and the upper echelon theory, i.e., managers' personal experience can affect their behaviour, which in turn influences their corporate decisions. Specifically, we focus on one aspect of personal experience - military experience - and look at whether it is beneficial to firms' technological innovation, therefore enriches the literature of managerial heterogeneity. Our findings on the influence of managers' military experience on firms' technological innovation can help us better understand the role of managers play in corporate decision making, and how managers' individual traits interact with the firm's characteristics.

Anthropogenic Climate Change

lang G. Bryden,Peter K. J. Robertson,Detlef W. Bahnemann 한국에너지기후변화학회 2006 에너지기후변화학회지 Vol.1 No.1

HOW TO BRIDGE THE GAP BETWEEN BRAND RECOGNITION AND CUSTOMER PERCEIVED VALUE IN THE DIGITAL AGE?

Lang-lung Luke Chiang,Mia Hsiao-Wen Ho,Chun-Yueh Chang 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07

While social media marketing opens a variety of new windows for enlightening brand–customer relationships, a gritty puzzle is that brand recognition does not invariably echo with customers’ perceived value. This provokes the need to uncover the missing pieces in bridging the gap between brand recognition and customer perceived value. This research falls within the innovative new work in the marketing literature in positing co-creation as a crucial mediator in facilitating the impact of brand recognition on customers’ perceived value. Based on social identity theory, we also investigated how co-creation is moderated by virtual communication identification in influencing customers’ perceived value towards a brand. We conducted a survey via a sample of 386 current Gogoro customers. Gogoro is the biggest and most well-known Taiwanese producer of electric scooters. Our findings contribute to the extant marketing research by emphasizing that the key stimulus of increased customer perceived value towards a brand is active co-creation initiatives via virtual brand communities, and that the effects of co-creation are further strengthened when customers’ virtual communication identification is high.

Trimethoprim Comes of Age

Lang, Selwyn D.R. Medical Publications Korea 1978 Medical Progress Vol.5 No.4

Infective Endocarditis : Current Concepts in Treatment

Lang, S.D.R. Medical Publications Korea 1977 Medical Progress Vol.4 No.11