A Dermonutrient Containing Special Collagen Peptides Improves Skin Structure and Function: A Randomized, Placebo-Controlled, Triple-Blind Trial Using Confocal Laser Scanning Microscopy on the Cosmetic Effects and Tolerance of a Drinkable Collagen Supplem

Sabrina Laing,Stephan Bielfeldt,Carolin Ehrenberg,Klaus-Peter Wilhelm 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.2

The purpose of this randomized, placebo-controlled, triple-blind trial on 60 healthy female volunteers was to assess the cosmetic effects on skin quality of a food supplement containing special collagen peptides together with acerola extract, vitamin C, vitamin E, biotin, and zinc after an intake of 12 weeks (Elasten®, QUIRIS Healthcare, Germany). To reduce assessment bias maximally and increase the accuracy and objectivity of the outcomes, the trial design was triple blinded in a manner that neither the subjects nor the person administering the products nor the person who assessed the primary outcomes knew which subjects had received the test product and which had received the placebo. The expert grader assessing the confocal laser scanning microscopy images was additionally blinded regarding the time when the image was taken (on days 1 or 85). The objective, blinded, and validated image analyses using confocal laser scanning microscopy showed a significant improvement of the collagen structure of facial skin (primary endpoint) after intake of the test product, while no improvements were found after intake of the placebo. The proven positive nutritional effect on the collagen structure was fully consistent with positive subjective evaluations of relevant skin parameters such as elasticity, crinkliness/wrinkliness, and evenness in different body areas such as face, hands, décolleté, neck, backside, legs, and belly, all serving as secondary endpoints. The test product was found to be safe and very well tolerated. A cosmetically relevant improvement of the facial skin was demonstrated after administration of the collagen supplement.

Dynamic Transcriptome Repertoire of Streptomyces coelicolor

Yujin JEONG,Giselda BUCCA,Emma LAING,Ji-Nu KIM,Min Woo KIM,Sun Chang KIM,Byung-Gee KIM,Colin P. SMITH,Byung-Kwan CHO 한국생물공학회 2013 한국생물공학회 학술대회 Vol.2013 No.4

中文教與學處理學生學習差異的原則和策略

Tse Shek Kam,Wong Man Ying,Laing Victor,Wu Kam Fong,Tsui Pik Fong,To Heiken,Lam Lu Sai 단국대학교 한문교육연구소 2020 International Han-character Education Research Vol.3 No.1

홍콩에는 예부터 지금까지 파키스탄, 인도, 네팔 등에서 온 이민들을 포함하여, 비중국어권 아동들이 적지 않다. 평등교육의 이념을 표방하는 홍콩평등기회위원회(香港平等機會委員會)는 비중국어권 학습자들이 중국어권 학습자들과 같은 학교에서 학습하기를 건의하여 그들이 최대한 빠른 시일 내에 홍콩 사회로 융화되게 하려 하였다. 이로 인해, 비중국어권 아동들은 홍콩 현지의 일반 유치원을 다니게 되었는데, 홍콩의 교육 관할 당국도 적지 않은 자원을 투입하여 이들이 현지 교육과정에 적응할 수 있도록 협조하였으나, 그 효과를 즉각적으로 확인할 수는 없었다. 그 중 가장 큰 문제는 학습의 차이를 처리하는 것이었다. 비중국어권 아동들의 중국어 실력은 모국어 수준에 미치지는 못했다. 이들이 중국어권 아동들과 함께 중국어 수업에 참여할 때 적잖은 어려움이 발행했다. 또한, 비중국어권 아동들의 성장 배경도 각기 달랐다. 신이민자 가정의 아동도 있고, 현지에서 출생한 소수 민족 아동도 있어, 이러한 학습자 사이의 중국어 수준의 차이도 존재했다. 이밖에도 소수민족과 홍콩의 문화적 차이 또한 매우 커서 모든 교사와 아동은 ‘학습’과 ‘교수’ 두 측면에서 모두 여러 가지 차이로 인해 발생하는 문제들을 처리해야 했다. 이처럼 비중국어권 학습자들이 홍콩에서 중국어를 배우는 것은 매우 쉽지 않았다. 상술한 문제들을 해결하기 위해서 경마회 자선기금 및 다섯 단체의 공영교육 사회복지기구는 「경마회의 재밌는 중국어 배우기(賽馬會(有)友趣學中文)」 라는 프로젝트를 추진하여, 중국어를 모국어로 갖지 않는 학습자들이 효과적으로 중국어 학습 하여 빠르게 사회에 융화되도록 도왔다. 본 프로 젝트는 수준별 교육과정, 수준별 교재, 수준별 학습법, 수준별 교구, 수준별 평가와 다층적 교학법을 설계하고 지원하여 학습 차이에서 생기는 어려움을 해결하는 데 도움을 주었다. 본고에서는 연구 이론과 설계, 데이터 수집 및 연구 결과를 상세히 서술하고, 효과적인 사례에 대해 상세하게 서술하려고 한다. 이러한 연구 성과는 세계 각지에 광범위하게 적용될 수 있을 것이다. The majority of non-Chinese speaking (NCS) young students are studying in mainstream kindergartens. They are of ethnic groups, for instance, Pakistani, Indian, and Nepalese, who are new immigrants or offspring of immigrants in the past. The Equal Opportunities Commission encourages NCS students to study together with Chinese speaking students, for the sake of social inclusion in the long run. In recent years, the Education Bureau has allocated more resources in supporting NCS students for early adaption to the local education system. However, its effect is not predominant. It is believed that managing individual learning differences is one of the major challenges. NCS students is generally lagging behind those with Chinese as their mother tongue in the Chinese proficiency. Therefore, problems and complications arise as the result of the two groups of students studying in the same environment. Dissimilarities exist even among NCS students, some are new immigrants while some are born in Hong Kong. While there are obvious cultural differences between ethnic minorities and local Hong Kong students, teachers face challenges in handling these disparities. NCS students learning Chinese in Hong Kong is not an easy task. Regarding all these above, The Hong Kong Jockey Club Charities Trust in collaboration with three universities and two social welfare organizations have initiated the “C-for-Chinese@JC” project. It supported NCS students learning Chinese, as well as facilitated early social inclusion. The project developed differentiated school-based curriculum, differentiated teaching and learning materials, differentiated pedagogies and assessment, and varied support measures to kindergartens. Language development of non-Chinese speaking kindergarteners was tracked longitudinally in each of their pre-school years that composed of four language assessments. Significant improvement of language learning results was observed during the three years, which proved the effects of differentiate teaching and learning system. The system is able to alleviate the learning difficulties of NCS preschoolers and bridge the learning differences. This paper detailed research theories and design, data collection, research findings, and analysis of successful cases. The findings of this research could be applied in different settings internationally and be globally referenced.

Biogeochemistry of trace elements in the environment - Editorial to the special issue

Rinklebe, J.,Kumpiene, J.,Du Laing, G.,Ok, Y.S. Academic Press 2017 Journal of environmental management Vol.186 No.2

Early Generation Genetic Variation and Heritability of Yield and Related Traits among Tef Populations

Mizan Tesfay Abraha,Shimelis Hussein,Mark Laing,Kebebew Assefa 한국작물학회 2017 Journal of crop science and biotechnology Vol.20 No.5

The extent of genetic variation and heritability of a trait are among the major determinants of selection gains in plant breeding programs. The aim of this study was to determine the magnitude of genetic variation and inheritance of grain yield, and component traits of newly developed tef populations under moisture-stressed and non-stressed conditions for drought tolerance breeding. Seventeen crosses along with the parents were evaluated in the F2 generation under moisture-stressed and non-stressed conditions in northern Ethiopia during 2015 and 2016. There were marked genotypic and phenotypic variation among the crosses in the F2 generation for plant height, panicle length, peduncle length, number of productive tillers per plant, main shoot panicle seed weight, biomass yield, and grain yield under both test conditions, important for successful selection and genetic advancement. The families of DZ-Cr-387 x 207832 and DZ-Cr-387 x 222076 were high grain yielders with early maturity under both test conditions.

Robotic and Navigation Systems in Orthopaedic Surgery: How Much Do Our Patients Understand?

Shivan S Jassim,Harry Benjamin-Laing,Stephen L Douglas,Fares S Haddad 대한정형외과학회 2014 Clinics in Orthopedic Surgery Vol.6 No.4

Background: Technology in orthopaedic surgery has become more widespread in the past 20 years, with emerging evidence of its benefits in arthroplasty. Although patients are aware of benefits of conventional joint replacement, little is known on patients’ knowledge of the prevalence, benefits or drawbacks of surgery involving navigation or robotic systems. Methods: In an outpatient arthroplasty clinic, 100 consecutive patients were approached and given questionnaires to assess their knowledge of navigation and robotics in orthopaedic surgery. Participation in the survey was voluntary. Results: Ninety-eight patients volunteered to participate in the survey, mean age 56.2 years (range, 19 to 88 years; 52 female, 46 male). Forty percent of patients thought more than 30% of National Health Service (NHS) orthopaedic operations involved navigation or robotics; 80% believed this was the same level or less than the private sector. One-third believed most of an operation could be performed independently by a robotic/navigation system. Amongst perceived benefits of navigation/robotic surgery was more accurate surgery (47%), quicker surgery (50%), and making the surgeon’s job easier (52%). Sixty-nine percent believed navigation/robotics was more expensive and 20% believed it held no benefit against conventional surgery, with only 9% believing it led to longer surgery. Almost 50% would not mind at least some of their operation being performed with use of robotics/navigation. Conclusions: Although few patients were familiar with this new technology, there appeared to be a strong consensus it was quicker and more accurate than conventional surgery. Many patients appear to believe navigation and robotics in orthopaedic surgery is largely the preserve of the private sector. This study demonstrates public knowledge of such new technologies is limited and a need to inform patients of the relative merits and drawbacks of such surgery prior to their more widespread implementation.

Achievement Goal Orientation in Chinese Societies: Implications for College Counseling

Ching-Chen Chen,Wei-Wen Chen,George B. Richardson,Chia-Laing Dai,Jared Lau,Danica G. Hays 한국상담학회 2018 Journal of Asia Pacific counseling Vol.8 No.1

Achievement goal orientation has been linked to various academic and psychosocial outcomes within the United States and globally. As college counselors increasingly work with a diversified student body, it is imperative that they understand goal orientation and how it should be assessed among various cultures and subcultures. This study evaluated the functioning of the Achievement Goal Scale items across samples from Taiwan, Hong Kong, and Macau and tested whether metric (i.e., goal orientation dimensions had the same meanings) and scalar (i.e., means could be compared across groups) invariance held. Findings suggest that goal orientation can be assessed across Chinese societies and, therefore, used to inform the development of culturally appropriate counseling approaches when working with college students. Implications for counseling practice and research are provided.

Anosmin-1 contributes to brain tumor malignancy through integrin signal pathways

Choy, Catherine T,Kim, Haseong,Lee, Ji-Young,Williams, David M,Palethorpe, David,Fellows, Greg,Wright, Alan J,Laing, Ken,Bridges, Leslie R,Howe, Franklyn A,Kim, Soo-Hyun Bioscientifica Ltd 2014 Endocrine-related cancer Vol.21 No.1

<P>Anosmin-1, encoded by the <I>KAL1</I> gene, is an extracellular matrix (ECM)-associated protein which plays essential roles in the establishment of olfactory and GNRH neurons during early brain development. Loss-of-function mutations of <I>KAL1</I> results in Kallmann syndrome with delayed puberty and anosmia. There is, however, little comprehension of its role in the developed brain. As reactivation of developmental signal pathways often takes part in tumorigenesis, we investigated if anosmin-1-mediated cellular mechanisms associated with brain tumors. Our meta-analysis of gene expression profiles of patients' samples and public microarray datasets indicated that <I>KAL1</I> mRNA was significantly upregulated in high-grade primary brain tumors compared with the normal brain and low-grade tumors. The tumor-promoting capacity of anosmin-1 was demonstrated in the glioblastoma cell lines, where anosmin-1 enhanced cell motility and proliferation. Notably, anosmin-1 formed a part of active β1 integrin complex, inducing downstream signaling pathways. ShRNA-mediated knockdown of anosmin-1 attenuated motility and growth of tumor cells and induced apoptosis. Anosmin-1 may also enhance the invasion of tumor cells within the ECM by modulating cell adhesion and activating extracellular proteases. In a mouse xenograft model, anosmin-1-expressing tumors grew faster, indicating the role of anosmin-1 in tumor microenvironment <I>in vivo</I>. Combined, these data suggest that anosmin-1 can facilitate tumor cell proliferation, migration, invasion, and survival. Therefore, although the normal function of anosmin-1 is required in the proper development of GNRH neurons, overexpression of anosmin-1 in the developed brain may be an underlying mechanism for some brain tumors.</P>

총설 : 1930년대 평양지역의 수리지질 특성

오윤영 ( Yun Yeong Oh ),함세영 ( Se Yeong Hamm ),이충모 ( Chung Mo Lee ),( Wei Ming Laing ),김규범 ( Gyoo Beom Kim ),김문수 ( Moon Su Kim ) 대한지질공학회 2014 지질공학 Vol.24 No.4

본 연구에서는 1930년대 평양 대동강 유역의 남측(탄산염지역)과 북측(비탄산염지역)의 지하수와 지표수의 수질(pH, CaO, Fe, HCO3-, SO42-)을 비교 하였다. 그 결과 남측이 북측에 비해 pH와 SO42-의 농도는 높았고 HCO3-와 Fe의 농도는 낮게 나타났다. 이는 점토층 유기물의 산화에 의해 발생한 수소가 무기염류의 금속이온을 치환하여 산을 형성하는 반응에 그 원인이 있는 것으로 판단된다. The chemical properties and composition (pH, CaO, Fe, HCO3 -, and SO4 2-) of groundwater (GW) and surface water (SW) from the northern (non-carbonate bedrock) and southern (carbonate bedrock) sections of the Daedong River, Pyeongyang were analyzed and compared period of the 1930s. In the southern section, the GW and SW has a higher pH and SO4 2- concentration, but lower HCO3 - and Fe levels than in the north. This finding reflects a reaction that formed acid by replacing metal ions in inorganic salts by hydrogen, which resulted from the oxidation of organic material in a clay layer.

Lactobacillus (LA-1) and butyrate inhibits osteoarthrits through controling autophagy and inflammatory cell death in chondrocyte

Keun hyung Cho,Hyun-Sik Na,JooYeon Jhun,Jiyoung Kim,Seung Yoon Lee,Jeong soo Lee,In Gyu Um,Seok Jung Kim,Mi-La Cho 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7

Osteoarthritis (OA) is a disease that reduces quality of life due to pain caused by persistent joint destruction. In addition, as a representative chronic disease, it causes inflammation and affects immunity, and it is one of the diseases that is difficult to cure, so treatment and improvement methods are urgently needed. In a previous study, we published that LA-1 improves osteoarthritis and has cartilage protection by controlling inflammation. However, it was not known how LA-1 improves osteoarthritis in the body. So in this study, it was confirmed that the administration of LA-1 to the MIA-induced OA rat model reduces the pain threshold, protects cartilage, and regulates inflammation markers in the articular synovium. Additionally, collecting and analyzing the feces of the disease model, it affected the gastrointestinal system and improved the environment of the microbiome. Interestingly, by providing LA-1, it was confirmed that the diversity and abundance of microbiome in the intestine were changed, and that the bacteria that produced SCFAs increased. In addition, daily supply of butyrate, one of the SCFAs produced by certain bacteria, triggers autophagy activation and tends to decrease necroptosis. This suggests that systemic immunity as well as OA is regulated according to changes in the intestinal microbial community, and that activation of autophagy can indirectly reduce abnormal cell death. In addition, assuming that osteoarthritis is a chronic degenerative disease, cell analysis was performed using splenocyte and blood assuming that the immune system is deteriorated. As a result, both splenocytes and PBMCs confirmed that regulatory T cells increased and Th17 cells decreased. In summary, providing LA-1 leads to increased production of SCFAs by altering the microbes in the intestine. Accordingly, it is possible to suppress the progression of OA and control pain due to OA, and improve an abnormal joint environment by controlling autophagy and necroptosis.