http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Suggestive Evidence for Linkage of Schizophrenia to Chromosome 8p21-12 in Multiplex Korean Families
EunYoung Cho,YuSang Lee,KyeongSook Choi,YongLee Jang,SeungHee Cho,HyunOk Jeun,JongWon Kim,KyungSue Hong 대한신경정신의학회 2004 PSYCHIATRY INVESTIGATION Vol.1 No.1
Objectives-Chromosome 8p21-12 has been identified as a susceptibility locus for schizophrenia based on several genomewide linkage scans with Caucasian families. The purpose of this study is to investigate the linkage of this locus to schizophrenia in Korean families. Materials and Methods-We recruited ninety-one family members from twenty-seven multiplex schizophrenia families. Fifty-nine of them were affected individuals. Seven microsatellite markers of this region with 3cM intervals were genotyped. Non-parametric linkage analysis was performed by evaluating the levels of allele sharing between the affected relative pairs. Results-In the multi-point analysis, all the points tested within this area showed positive but non-significant non-parametric lod (NPL) scores with the peak occurring between D8S1820 and D8S1769. In the single point analysis, statistically significant allele sharing was observed at D8S1769 (NPL=1.65, p=0.049). Higher levels of NPL scores (the highest single point NPL=1.98, p=0.025) were observed when the same analyses were applied to a subgroup of families in which all of the affected individuals showed auditory hallucination. Conclusions-These findings support the previous evidence from Caucasian families for a locus predisposing to schizophrenia at 8p21-12. Further studies designed to screen positional candidate genes and their SNPs at this locus are warranted, in order to identify the specific causative genetic variation of schizophrenia.
Kyungsu Kang,Saet Byoul Lee,Sang Hoon Jung,Kwang Hyun Cha,Woo Dong Park,Young Chang Sohn,Chu Won Nho 한국분자세포생물학회 2009 Molecules and cells Vol.27 No.3
Phytoestrogens are the natural compounds isolated from plants, which are structurally similar to animal estrogen, 17β-estradiol. Tectoridin, a major isoflavone isolated from the rhizome of Belamcanda chinesis. Tectoridin is known as a phytoestrogen, however, the molecular mechanisms underlying its estrogenic effect are remained unclear. In this study we investigated the estrogenic signaling triggered by tectoridin as compared to a famous phytoestrogen, genistein in MCF-7 human breast cancer cells. Tectoridin scarcely binds to ER α as compared to 17β- estradiol and genistein. Despite poor binding to ER α, tectoridin induced potent estrogenic effects, namely recovery of the population of cells in the S-phase after serum starvation, transactivation of the estrogen response element, and induction of MCF-7 cell proliferation. The tectoridininduced estrogenic effect was severely abrogated by treatment with U0126, a specific MEK1/2 inhibitor. Tectoridin promoted phosphorylation of ERK1/2, but did not affect phosphorylation of ER α at Ser118. It also increased cellular accumulation of cAMP, a hallmark of GPR30- mediated estrogen signaling. These data imply that tectoridin exerts its estrogenic effect mainly via the GPR30 and ERK-mediated rapid nongenomic estrogen signaling pathway. This property of tectoridin sets it aside from genistein where it exerts the estrogenic effects via both an ERdependent genomic pathway and a GPR30-dependent nongenomic pathway.
Temperature-Aware Integrated DVFS and Power Gating for Executing Tasks With Runtime Distribution
Kyungsu Kang,Jungsoo Kim,Sungjoo Yoo,Chong-Min Kyung IEEE 2010 IEEE transactions on computer-aided design of inte Vol.29 No.9
<P>At high-operating temperature, chip cooling is crucial due to the exponential temperature dependence of leakage current. However, traditional cooling methods, e.g., power/clock gating applied when a temperature threshold is reached, often cause excessive performance degradation. In this paper, we propose a method for delivering lower energy consumption by integrating the cooling and running in a temperature-aware manner without incurring performance penalty. In order to further reduce the energy consumption, we exploited the runtime distribution of each sub-segment of a task called “bin” in an analytical manner such that time budget for cooling in each bin is allocated in proportion to the probability of the occurrence of the bin. We apply the proposed method to two realistic software programs, H.264 decoder and ray tracing and a benchmark program, equake. The experimental results show that the proposed method yields additional 19.4%-27.2% reduction in energy consumption compared with existing methods.</P>
Kyungsu Ha,Sangchul Lee 한국재난정보학회 2014 한국재난정보학회 논문집 Vol.10 No.2
이 연구에서는 ‘기계경비 112신고 기준’인 감독명령 제2013-1호를 분석하고 정책적 과제를 제시하였다. 이 감독명령은 기계경비업체의 출동대응의무 등 독자적인 범죄예방 능력 확보 와 통계기반 구축을 위해 확인신고를 원칙으로 하고 긴급신고의 대상을 특정하는 선별신고 제도의 시행을 규정하고 있다. 선별신고제도의 목적을 달성하기 위한 정책적 과제로 첫째, 통계기반의 구축을 위한 오경보와 오신고, 비상버튼과 감지신호에 대한 용어의 정립과 기 계경비원을 대체할 적절한 용어의 개발이 필요하다. 둘째, 기계경비업체는 이 감독명령의 112신고 기준을 준수하기 위한 대응체제를 구축하여야 한다. 셋째, 경찰은 선별신고제도의 긴급신고 대상 설정에 대한 재검토가 있어야 한다. 넷째, 이 감독명령을 엄정하게 시행하기 위한 행정규제와 감독의 강화가 요구된다.