Carbachol and Thapsigargin Increase Intracellular Calcium in Submandibular Acinar Cells ; Measurement with Microscope Photometry and Imaging Technique

Kyungpyo Park,Jae-Won Myung,Joong-Soo Kim,Jong-Heun Lee 대한구강생물학회 1997 International Journal of Oral Biology Vol.22 No.2

다중 감각 도움을 이용한 드럼 연주 기능 교육 시스템

홍경표(Kyungpyo Hong),이인(In Lee),한갑종(Gabjong Han),최승문(Seungmoon Choi) 한국HCI학회 2011 한국HCI학회 학술대회 Vol.2011 No.1

Minimum lattice length and ropelength of knots

Hong, Kyungpyo,Kim, Hyoungjun,Oh, Seungsang,No, Sungjong World Scientific 2014 Journal of knot theory and its ramifications Vol.23 No.7

글로벌 유·아동 애니메이션 색채 분석

이경표(KyungPyo Lee),박영경(YungKyung Park) 한국색채학회 2014 한국색채학회 논문집 Vol.28 No.1

다양한 문화 콘텐츠가 해외로 유통되고 있는 가운데 국내 유?아동 애니메이션도 중요한 고부가 가치산업으로서 관심이 증가하고 있다. 또한 수출입과 해외 공동 제작이 꾸준히 증가하고 있으며 폭 넓은 세계 시장 전략에 대해 모색 되고 있다. 전 세계적으로 애니메이션의 관심과 수요가 증가함에 따라 다양한 국가에서 그 나라만의 유일한 문화 및 색채 감성을 담은 유?아동 애니메이션을 제작하고 있으며 유·아동의 색채 감성에 중요한 영향을 미치고 있다. 이에 본 연구는 유·아동들의 색채 감성 발달에 영향을 미칠 수 있는 중요한 매체로서 국가별 유·아동 애니메이션의 색채의 특성을 분석하고 어떠한 요인이 영향을 미치고 있는지 알아보았다. 연구 결과는 다음과 같다. 영국의 유?아동 애니메이션은 기후의 영향이 작용된 것으로 색채 기호의 지역설(기후설)과 관계가 있음을 확인했다. 이탈리아의 애니메이션은 지역적 특성에 의한 기후에 영향을 받은 것으로 분석되었다. 한국은 기후의 영향에 따른 색채 선호가 영향을 미친 것으로 분석되었다. 중국의 경우 제작년도에 따라 톤의 분포가 변하는 경향이 보였다. 마지막으로 유·아동 애니메이션의 인물 캐릭터의 피부와 머리카락의 색채는 국가별로 차이가 있음을 확인했다. A variety of cultural contents have been distributed overseas and these contents are emerging as a higher value-added business. Among them, as interest in domestic animation for toddlers and children is also increasing as a key value-added business, exportation and importation and co-production with foreigners is steadily increasing, and extensive global market strategies are being sought. In addition, as interest in and demand for animation around the globe, animation for toddlers and children are being produced, which contain their own culture and color sensitivity in many countries to exert major effects on color sensitivity of toddlers and children. Findings of the study are as follows: By and large animation for toddlers and children produced in the UK tended to affected by the UK"s climate and is associated with the territory theory (the climate theory) of color tastes as the study found. Italian animation was analyzed that it"s because it was affected by the climate by regional characteristics of Italia. Korea were affected by the climate. In the case of China, it displays a tendency that the distribution of tones changes according to production years. Finally, it was observed that colors of skin and hair of characters in animation for toddlers and children are different by nation. It is considered that characteristics of people"s skin and hair colors by each country exerted effects.

가상현실을 이용한 페르소나 팽창의 시각화 연구

홍경표(Kyungpyo Hong),황인경(Chris I. Whang) 한국HCI학회 2022 한국HCI학회 학술대회 Vol.2022 No.2

인간은 본래의 모습과 다른 모습을 강요 받을 때 사회적 가면이 씌워지는데, 이러한 페르소나가 팽창되면 자아는 축소되고 왜곡되며 이는 다시 타인을 부정하고 매도하게 된다. 많은 현대인들이 이와 같은 페르소나의 팽창에 의해 정서적 질환을 겪고 있다. 이 프로젝트에서는 VR 게임을 통하여 현대인의 페르소나에 대한 문제점을 흥미롭게 전달한다.

Effects of Various Neurotransmitters on the Intracellular Cacium Concentration in Trigeminal Ganglion Neurons

Park, Kyungpyo,Kim, Joong-Soo,Lee, Jong-Heun Korean Academy of Oral Biology and the UCLA Dental 1997 International Journal of Oral Biology Vol.22 No.4

Functional neurotransmitter receptors which elevate intracellular free calcium concentration ([Ca^2+]_1) have been identified in freshly isolated trigeminal ganglion (TG) neurons in neonatal rat pups. Measurement of [Ca^2+]_1 was performed using fura-2 acetoxymethyl ester (Fura-2) based ratio microspectrofluorimetry. In our experiments only small sized neurons (<30μm) according to somatic diameter were used. In single intact neurons, the expression percentage and magnitudes of [Ca^2+]_1 increase responding to each agonist were determined. Application of bradykinin (BK), substance P (SP), calcitonin gene related peptide (CGRP), ATP and capsaicin elevated [Ca^2+]_1 in the expression percentages of 24%, 37%, 31%, 77% and 50%, respectively, and elevated [Ca^2+]_1 from 1.63±0.04 (Mean±S.E) to 1.92±0.05, from 1.36±0.08 to 1.88±0.12, from 1.33±0.03 to 1.61±0.09, from 1.35±0.04 to 2.2±0.15 and from 1.26±0.06 to 2.9±0.26, respectively. The purinergic receptor which respond to ATP was most frequently expressed (77%). A [Ca^2+]_1 increase in response to all neurotransmitters was transient in nature, except in response to capsaicin. Increase of [Ca^2+]_1 evoked by capsaicin was not transient: [Ca^2+]_1 was maintained at a higher concentration than the prestimulus level. The magnitude of [Ca^2+]_1 increase evoked by capsaicin was bigger than for any other neuroransmitters. Our results show that a subpopulation of trigeminal ganglion neurons with small diameter express functional receptors responsible for elevating [Ca^2+]_1 coexisting with other neurotransmitter receptors in the early neonatal stage. Our data may have implications for studying orofacial pain transmission which is associated with intracellular calcium increase.

Effects of Excitatory Amino Acid Antagonists on Locus Coeruleus Neuronal Activity

Park, Kyungpyo,Kim, Joong-Soo,Lee, Jong-Heun Korean Academy of Oral Biology and the UCLA Dental 1997 International Journal of Oral Biology Vol.22 No.2

It is known that firing rate of Locus coeruleus (LC) neurons is increased during opiate withdrawal and associated with the behavioral symptoms. The purpose of this study is to elucidate cellular mechanisms in LC neurons during opiate withdrawal. Rats were given morphine by daily subcutaneous injection (15㎎/㎏) for 5 days. Opiate withdrawal was induced by intraperitoneal naltrexone (NTX) adminstration (1㎎/㎏) on the fifth day. The resulting opiate abstinence syndrome was quantitated by the use of a composite score of five behaviors. Behavioral symptoms of abstinence were consistently elicited (n=7). Administration of physiological saline instead of NTX on the fifth day (n=4) or only NTX administraton without chronic morphine administration (n=4), both used as control goups, failed to induce opiate abstinence syndrome. After confirming opiate withdrawal through behavioral experiments, we investigated the effects of various excitatory amino acid (EAA) antagonists on LC neuronal activity induced by naloxone (NLX) administered intravenously (0.2㎎/㎏). NLX increased LC firing rates in most of morphine addicted rats. At the plateau of NLX-induced maximal activity of LC neuron, vehicle (artificial cerebrospinal fluid), as a control or EAA antagonists, i.e, kynurenic acid, 6-cyano-7-nitroquinoxaline-2, 3,-dione (CNQX) and 2-amino-5-phosphonopentanoic acid (AP-5), were administered intracerebroventricularlly. 1mM kynurenic acid, a non-specific EAA antagonist, and 0.5mM CNQX, a non-NMDA(N-methyl-D-aspartate) receptor antagonist, significantly decreased LC firing rate in contrast to vehicle injection, which had no effect on LC neuronal activity. AP-5, a NMDA receptor antagonist, was the least effective on the LC neuronal activity-neither 0.1mM nor 1mM of AP-5 had effect on LC firing rate. Only at the concentration of 5mM of AP-5 could decrease rate. These results indicate that daily subcutaneous injection of morphine could be one of opiate dependent models and LC hyperactivity during opiate withdrawal is mediated by an augmented EAA input to LC, mainly by acting on non-NMDA receptors.

2020년 미래 무선통신 유망기술 발굴

이경표(Kyungpyo Lee),송영근(Youngkeun Song),한우리(Woori Han),이성주(Sungjoo Lee) 한국통신학회 2013 韓國通信學會論文誌 Vol.38 No.1C

최근 효율적인 R&D와 경쟁력 확보를 목적으로, 미래기술을 예측하고 유망기술을 발굴하고자 하는 활동이 전 세계적으로 활발히 이루어지고 있다. 특히 무선통신 분야는 기술발전 속도가 빠르고 적용영역이 광범위하여 유망기술 발굴이 더욱 중요함에도 불구하고, 국내에는 관련연구나 사례가 부족한 실정이다. 이에 본 연구는 무선통신 분야의 미래유망기술 발굴 방법론을 개발하고 이를 적용하여 2020년 무선통신 분야 10대 유망기술을 도출해 보고자 한다. 이를 위해 첫째, STEEP 관점에서 미래 주요 이슈들을 도출하고, 둘째, 주요 이슈 별 사용자 니즈를 도출하였다. 셋째, 사용자 니즈를 만족시키기 위한 기술들로 유망기술 후보군을 구성한 뒤 기술성과 경제성 평가를 통해 이들의 우선순위를 도출하였으며, 마지막으로 10대 유망기술을 선정하고 선정결과의 타당성을 검토하였다. 본 연구는 기존 연구에서 주로 활용하던 기술주도(technology-push) 접근법 아닌 시장주도(market-pull) 접근법을 활용하여 유망기술을 발굴하고자 하였다는 점에서 방법론적 의의가 있을 것이며, 연구결과는 무선통신 산업 내 전략적, 정책적 의사결정을 지원할 것으로 기대된다. Recently, it becomes essential for firms or nations to forecast the future and identify emerging technologies in order to improve R&D efficiency and gain a competitive advantage. Particularly, the mobile communications industry is characterized by rapid advance and wide application of its technology and thus identifying emerging technologies is more important in the industry than in others. Nevertheless, few attempts have been made to explore its emerging technologies. Therefore, this research aims to develop a methodology to identify the future and emerging technologies especially for the industry and applied it to list top ten emerging technologies for 2020 in the industry. For this purpose, firstly, we focused the key issues in the future targeting 2020 and identified user needs relating to them. Then, candidates of emerging technologies were defined from a set of technologies to meet the needs, for which technological and economic feasibility is assessed to determine their priorities. Finally, the top ten most important technologies were selected and verified. This research is distinct from the previous studies in that it takes a market-pull approach instead of a technology-push approach. The research results are expected to provide valuable information to support strategy- and policy-makings in the mobile communications industry.

Enumeration on graph mosaics

Hong, Kyungpyo,Oh, Seungsang World Scientific 2017 Journal of knot theory and its ramifications Vol.26 No.5

<P>Since the Jones polynomial was discovered, the connection between knot theory and quantum physics has been of great interest. Lomonaco and Kauffman introduced the knot mosaic system to give a definition of the quantum knot system that is intended to represent an actual physical quantum system. Recently the authors developed an algorithm producing the exact enumeration of knot mosaics, which uses a recursion formula of state matrices. As a sequel to this research program, we similarly define the (embedded) graph mosaic system by using 16 graph mosaic tiles, representing graph diagrams with vertices of valence 3 and 4. We extend the algorithm to produce the exact number of all graph mosaics. The magnified state matrix that is an extension of the state matrix is mainly used.</P>

K^+ Channels in Mucous Cells Isolated from the Rat Sublingual Gland

Park, Kyungpyo,Kim, Joong-Soo,Lee, Jong-Heun Korean Academy of Oral Biology and the UCLA Dental 1998 International Journal of Oral Biology Vol.23 No.1

The basolateral, voltage dependent K^+ channels of mucous cells dissociated from rat sublingual gland were studied using the patch-clamp technique. In the cell-attached mode, two types of K^+ channels could be observed in these cells. One had a large conductance of 222±13 pS (mean±SEM, n=4), and the other had a small conductance of 43±7 pS (n=3). Acetylcholine (ACh; 10^-5 M) activated both K^+ channels by increasing the open probability (Po). Open probability for the large conductance channel increased from 0.18 in the control solution to a maximum value of 0.85 after addition of Ach. Whereas, Po for the small conductance channels increased from 0.002 in the control solution to a maximum value of 0.31. K^+ channel activation by 10^-5 M Ach was observed in 2 other mucous cells. When the osmolarity of bath solution was reduced to 60% of control, both large and small conductance K^+ channels were activated. Open probability for the large and small conductance K^+ channels increased significantly (P<0.05) from 0.006±0.001 (n=4) and 0.002±0.001 (n=4) in the control solution to a maximum value of 0.30±0.04 and 0.12±0.03 in the hypotonic solution, respectively. It is concluded that both K^+ channels may play a crucial role in secretion induced by muscarinic receptor activation and in regulatory volume decrease (RVD).