한국인 환자에서 Vancomycin의 집단약동학 (Population Pharmacokinetics)에 관한 연구

유경상,배균섭,이주연,조주연,장인진,신상구,신완균 大韓臨床藥理學會 1998 臨床藥理學會誌 Vol.6 No.2

서방형 Diltiazem제제의 개발을 위한 약동학/약력학적 특성 검토

유경상,배균섭,조주연,장인진,신상구 大韓臨床藥理學會 1998 臨床藥理學會誌 Vol.6 No.2

내진성능보강을 위한 능력스펙트럼법을 이용한 마찰감쇠기 설계

김형섭,민경원,이상현,정란 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

The main objective of this paper is to propose a retrofitting method using Coulomb friction dampers. The seismic performance of an existing building is evaluated, and an additional necessary damping is calculated using capacity spectrum method(CSM) if the evaluated performance level of the building is below the target level. The coefficients of the Coulomb friction damper are then calculated using the proposed formula, which is derived from the concept of hysteresis loop. Numerical simulations are made to demonstrate the effectiveness of the proposed method.

서울 서남부지역 노인 인구에서 비만증 유병률과 고지혈증과의 상관성

최경묵,조영직,김경오,김동림,김난희,백세현,안정천,서홍석,오동주,최동섭 대한노인병학회 2000 Annals of geriatric medicine and research Vol.4 No.3

단체행위모형에 관한 고찰

沈京燮,韓鍾洙,許鎭九 단국대학교 1992 論文集 Vol.26 No.-

We have developed a formal model of collective action which brings together features associated in particular with the work of Elster, Schelling and Akerlof. We would argue that the model is capable of application to a wide range of empirical contexts involving issues of collective action where the free-rider problem renders conventional economic analysis inadequate. The approach offers insights into the historical development of such groups as trade unions and could be empirically tested against such processes. As Hardin(1982) has shown the results obtained here can carry over from the issue of collective action to that of the multi-person prisoner's dilemma. A number of aspects of the model deserve further development. Here we indicate two such aspects. First, we have treated the ε^1 distribution as determined exogenously. Alternatively, we could follow Jones(1984) and make our ε^1 parameter endogenous within the model. One way of doint this would be to make ε^1 itself dependent upon the individual's decision with respect to membership of collective action. Or we could think of the individual as influenced by a vector of social norms with his/her attitude to each affected throughεi by his/her behavior with respect to the others. Second, we have abstracted from the economic structure or game in which the collective action is, or is not, taking place. Clearly, a complete model needs to specify the interactions between the economic parameters and social custom inuluences on collective action. We have tried this elsewhere for the issue of trade union membership and wage determination(see Naylor(1989)) but do not pursue this here as any particularisation is likely to be context-specific.

韓國의 地價變動에 관한 硏究 : A Study on Land Price Fluctuations in Korea

沈京燮,韓鍾洙 단국대학교 산업연구소 1996 산업연구 Vol.19 No.-

골수구성 백혈병 환자에게 발생한 결핵성 림프절염

이창섭,송진수,최평균,조재현,방지환,박경화,박완범,김홍빈,김남중,윤성수,박선양,김병국,오명돈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

혈액질환 가운데 결핵 발생이 증가한다고 알려진 것은 호지킨 림프종을 포함한 림프증식성질환 그리고 모양세포성 백혈병 등이 있다. 또한 동종 골수이식을 받은 환자에서도 결핵은 증가한다고 알려져있다. Kaplan 등은 골수구성 백혈병 환자에서 결핵 발생이 증가한다고 보고하였다. 그러나 골수구성 백혈병 환자에서 결핵의 발생이 증가하는 이유에 대해서는 아직까지 정확하게 밝혀지지 않았다. 저자들이 2년 동안 후향적으로 조사한 180명의 성인 골수구성 백혈병 환자들 가운데 결핵이 발생한 환자는 4명이었고, 발생 부위는 모두 림프절이었다. 결핵은 골수구성 백혈병의 특정 아형에만 국한되어 발생하지 않았지만, 50%에서 FAB 분류에 의한 M4였다. 림프절이 종대된 골수구성 백혈병 환자에서 특히, 결핵의 유병율이 높은 나라에서는 결핵성 림프절염도 감별진단에 포함시켜야 한다. During the neutropenic phase, leukemia patients receiving chemotherapy are prone to bacterial and, fungal infections; occasionally mycobacterial, viral and protozoal organisms may also cause infections. Mycobacterium tuberculosis infection was reported very rarely in these patients. This report describes four patients with M. tuberculosis infection identified from 185 adult patients who were diagnosed myelogenous leukemia between January 2003, and December 2004. There was no patient with M. tuberculosis infection from 44 lymphoid leukemia and 11 acute biphenotypic leukemia patients. Sites of infection were all lymph nodes. Three among four patients were presented with lymphadenopathy at initial diagnosis of leukemia, and the other one presented with lymphadenopathy after induction chemotherapy. There was no patient presented with lymphadenopathy during the neutropenic phase. Tuberculous lymphadenitis was presented in a patient with three acute myelogenous leukemia (FAB class 2 M4, 1 M2) and a chronic myelogenous leukemia, accelerated phase. An acute myelogenous leukemia patient had a leukemic cell and tubercle bacilli in the same lymph node. Tuberculosis should also be included as a differential diagnosis in myelogenous leukemia patient with lymphadenopathy, especially in the countries in which the disease is endemic.

소아 여성 요도탈출증

이경섭,최병기,배한익 東國大學校 1993 東國論叢 Vol.32 No.-

Urethral prolapse in female patients is a characterized by the protrusion of the urethral mucosa through the external urethral meatus. It is a rare pathological condition that generally occurs in prepubertal black girls and in postmenopausal white women. We experienced a case of urethral prolapse in a 12-year-old girl at Pohang hospital of Dongguk University. The clinical characteristics and treatment of the urethral prolapse are discussed with references.

백서에서 동종 신경이식시 항 T임파구 단일클론항체 분포에 관한 조직화학적 연구

홍창섭,김경욱,임창준,정대현 단국대학교 치의학연구소 1991 논문집 Vol.3 No.-

Nerve allografts as a bridge through which lost nerve can regenerate is useful in the repair of peripheral nerve defect resulting from trauma, neoplasm and leprosy. But immunological rejection and complicated scar formation is an unaboidable problem in the application of allogenic nerves. This article is intended to study histopathological and immunohistochemical response after fresh allogenic sciatic nerve grafts in rats. 12 male Sprague- Dawley rats were used as the experimental animals. A 2cm skin incision was made on the lateral aspects of limb, parallel to the femur. 1cm-long sciatic nerve trunk taken from the one rat was resected at the middle of the to high, and it was transplanted to the same area of the other rat with perineural suture method. Observation was made at the postoperative 1, 3, 8, 16 day. The results were as follows. 1. Histopathologically, destruction of the perineural sheath was observed only in 1-day group. 2. Mild degenerative changes of the nucleus and cytoplasm of Schwann cells were ovserved in the 1-day and 3-day groups. These changes gradually resolved. 3. Hollow space phenomena of the nucleus and cytoplasm of schwann cells were observed. The response was mild in the 1 day and 3 day groups, and moderate in the 8 day group. The phenomena were not identified in the 16 day group. 4. Immunohistochemical studies revealed pan T cells and cytotoxic T cells in the 1 day group. Increased numbers of cytotoxic T Cells and helper T cells were observed in the 3 and 8 day groups. 5. According to these results, after transplantation of fresh allogenic sciatic nerve an inflammatory response was observed up to 8 days and then gradually resolved. Degenerative changes were more severe up to 8 days, but an the 16th day they had resolved histopathologically and immunopathologically.

Streptomyces sp. YB-9가 생산하는 균체외 β-galactosidase의 특성

이경섭,김창진,윤기홍 한국응용생명화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.4

토양으로부터 lactose의 가수분해를 촉매하는 균체외 -galactosidase를 생산하는 YB-9가 분리되었다. 분리균 YB-9는 분리균의 배양, 형태, 생리적 특성을 조사한 결과 Streptomyces속 균주로 동정되었다. 분리균의 배양상등액을 ammonium sulfate(15-70%)로 처리하고 투석하여 부분정제된 -galactosidase를 para-nitrophenyl- -D-galactopyranoside(pNP- Gal)와 lactose를 기질로 하여 반응특성을 분석하기 위해 조효소액으로 사용하였다. -Galactosidase는 pH6.0~6.5와 60℃에서 최대활성을 보였다. pNP- Gal과 lactose에 대한 -galactosidased의 가수분해 활성은 galactose에 의해 감소되었다. Lactose에 대한 가수분해활성은 glucoxe에 의해 미미하게 감소하였으나, glucose에 의해 pNP- Gal에 대한 활성은 1.3배 증가하였다. 특히, xylose에 의한 lactose의 가수분해 활성에는 영향이 없었고, pNP- Gal에 대한 활성은 1.6배 증가시켰다. A strain YB-9 was isolated from soil as a producer of the extracellular β-D-galactosidase, which catalyzes the hydrolysis of lactose. The strain YB-9 was identified as Streptomyces sp. on the basis of its cultural, morphological and physiological properties. After treating culture supernatant of the isolate with ammonium sulfate (15~70%), the precipitated protein was used as a crude β-galactosidase for analyzing its reaction properties with para-nitrophenyl-β-D-galactoside (pNP-βGal) and lactose as substrates. The β-galactosidase showed its maximal activity at pH 6.0~6.5 and 60℃. The hydrolyzing activity of β-galactosidase for both pNP-βGal and lactose was decreased by galactose. Its hydrolyzing activity for lactose was slightly decreased by glucose, but the activity for pNP-βGal was increased to 1.3-folds by glucose. Especially, its hydrolyzing activity was not affected for lactose and was increased to 1.6-folds for pNP-βGal by xylose.