자궁경부암에서 혈관 내피 성장인자 ( VEGF ) 및 VEGF Mrna 의 발현에 대한 연구

이선경(Seon Kyung Lee),김승보(Seung Bo Kim),지성길(Sung Gil Chi),염윤석(Yoon Seok Yum),이주희(Ju Hee Lee) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.1

N/A Objective : Angiogenesis, the formation of blood vessels by sprouting from pre-existing ones, is essential for the growth of solid tumors beyond 2~3mm in diameter and for tumor metastasis. Vascular endothelial growth factor (VEGF), is known as vascular permeability factor(VPF) and mediates vascularization and tumor-induced angiogenesis. This study examined the potential of growth, invasion, and metastasis of uterine cervical carcinomas associated with neovascularization. Methods : From January 1996 to December 1999, at the Department of Obstetrics and Gynecology, Kyung-Hee University Hospital, 37 uterine cervical carcinomas and 7 normal cervical tissues were obtained and the samples were immediately frozen and stored at -70℃. Immunohistochemical staining for VEGF was carried out to study VEGF localization, and the levels of VEGF subtype mRNAs were determined by quantitative RT-PCR in specimens. The relation between VEGF subtypes expression of cervical cancers was analysed. Results : The positive staining for VEGF is seen dominantly in the cytoplasm of the cancer cells, and faintly in interstitial cells. The intensity of staining was stronger in squamous carcinomas than in adenocrcinomas, but there was no significant difference (p>0.05). Quantitative RT-PCR analysis demonstrated significantly increased VEGF121/VEGF165 mRNA expression levels (>0.56/>0.72) in 21 (56.8%) and 15 (40.5%) of 37 cervical carcinomas comparing to control groups (mean: 0.28/0.36). There was no obvious relationship between VEGF121/VEGF165 mRNA expression levels and the clinical parameters examined including age, pathology, differentiation, tumor size, lymphovascular space invasion, LN involvement and invasion depth except clinical stage (p<0.05). Conclusions : The overexpression of VEGF mRNA may be an important contributing factor in cervical carcinomas. There is no significant differenece of VEGF mRNAs levels according to clinical parameters, so it seems that the expression of VEGF is involved in the promotion of angiogenesis on cervical cancer and plays an important role in early invasion.

The diagnosis of coronoid impingement using computed tomography

Baik, Jee-Seon,Huh, Kyung-Hoe,Park, Kwan-Soo,Park, Moo-Soon,Heo, Min-Suk,Lee, Sam-Sun,,Choi, Soon-Chul 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.4

Coronoid impingement can cause limitation of mouth opening. In many cases, it appears to be related to the coronoid hyperplasia. We present a case of mouth opening limitation caused by coronoid impingement on the posterior surface of the zygomatic bone without coronoid hyperplasia. The bony changes in coronoid and zygoma including surface irregularity and discontinuity of the cortex and sclerotic change of inner medullary space were noted on computed tomography (CT) scans in different level of axial planes. Through another CT scans in open mouth position could demonstrate that those bony changes were caused by the contact of both surfaces against each other. In case coronoid impingement is suspected of the many possible causes, the open mouth CT scans will be needed to reveal the direct impingement of coronoid on zygoma even without coronoid hyperplasia.

실리카흄을 흔입한 고강도 콘크리트 개발

홍창우,김태경,김경진,김성환,김남윤,심도식,이정호,윤청호,백민경,원치문,박제선,이주형,정경일 강원대학교 석재복합신소재제품연구센터 1996 석재연 논문집 Vol.1 No.-

콘크리트 구조물이 대형화됨에 따라 설계단면이 증대되어 상대적으로 많은 경제적 손실을 부담하게 된다. 따라서 단면을 감소시키면서도 소요의 하중에 안전한 구조물을 건설하기 위해서는 우선적으로 구조물 건설에 기초가 되는 고품질, 고내구성의 고강도 콘크리트 개발이 절실히 요구된다 본 연구에서는 일정 시멘트비 및 혼화재 비율하에서 소요의 워커빌리티가 확보되는 고강도 콘크리트를 시간과 온도의 변화에 따라 증기 양생하여, 압축, 인장, 휨강도 뿐만 아니라 파괴특성을 실험적으로 연구하였다. 시료 제작시 시멘트 입자 사이의 공극 및 불연속 영역을 충전하여 고밀도화하기 위한 콘크리트용 혼화재로 시멘트 비표면적이 상당히 작은 초미립 분말인 실리카흄을 이용하였다. 또한 AE감수제 및 고성능 유동화제를 사용하여 혼화재의 첨가에 의하여 발생될 수 있는 워커빌리티의 감소를 방지하였다. 실험결과에 의하면 일정 양생 지속 시간하에서 온도의 증가에 따라 콘크리트의 압축, 인장 및 휨강도가 전반적으로 증가하였다. 동일하게 일정 온도하에서 양생 지속시간이 커짐에 따라 강도들이 증가됨을 알 수 있었다. 따라서 상대적으로 높은 온도와 긴 지속 양생 조건하에서 파괴에 대한 저항력이 크게 나타났다. The compressible, tensible, and flexibleresistance of the high strength concrete is analyzed by the experimentation in the present study. For the test, we cure several samples with the silica fume as a mixture being become dense the spaces between the particle of cement under the variation of both the temperature and the curing-interval. Then, the superplasticizer and the ezcon are also used to satisfy the required workability for construction. The compressible, tensible, and flexible resistances to a stress are increased as increasing the temperature and the time interval for the curing. Therefore it is concluded that the overal fractural and mechanical properties is improved by mixing the silica fume into the cement.

얼굴 연조직 강화를 위한 자가지방 이식 후 발생한 급성 경계부위 뇌경색

민경현, 이혜림, 여민주, 김지선, 이성현, 이상수, 신동익 충북대학교 의과대학 충북대학교 의학연구소 2016 忠北醫大學術誌 Vol.26 No.1

본문참고

SHS법으로 TiAl 금속간 화합물의 제조시 첨가원소에 따른 기계적 성질에 관한 연구

宣炅杓,李龍鎬 弘益大學校 科學技術硏究所 1998 科學技術硏究論文集 Vol.9 No.2

TiAl intermetallic compounds are very attractive for high temperature structural applications because of their high specific strength, high temperature oxidation resistance, and superior creep characteristics. In this study, processing of TiAl using self-propagating high temperature synthesis was investigated. The effects of processing varibles including holding temperature and pressure, and alloying element on the microstructure, mechanical properties of TiAl were studied. It was demonstrated that the SHS process could yield TiAls with properties comparable with those of TiAl produced via the ingot metallurgy route.

한국사회의 노인부양에 관한 연구 : 주거 측면에서 in the view point of housing

장선경 제주한라대학 1993 論文集 Vol.17 No.-

The purpose of this study was to discuss the necessity of family services for the ??derly and housing model for the future Korean culture. The library research method was used. The elderly population has been incerasing and Korea is now facing a serious elderly ??oblem in the near future. To cope with the coming elderly problem, social welfare services and elderly housing ??ed to be carefully prepared. The trend towards smaller families, the increase in the proportion of women in ??bor market, the decrease of birth rate, attitudinal change with regard to responsibility ??r care of aged parents and revision of family law have influence on relationship ??ween elderly parents and their married children. There was a strong preference ?? the elderly to live together with their married children, whereas their married ??ildren preferred to live independently, separated from their old parents. Housewives the younger generation recognized many advantages or good points of the three ??meration living together. However, they pointed out many disadvantages as well. ??ost of the good points were related to the psychological comfortableness steming ??om living close to each other, while most of the bad points were related to behavioral ??nstraints steming from living together in one residential unit. This suggested that a new type of housing, which provides privacy for each ??meration as well as the feeling of closeness between the two generations, needs ?? be developed to disseminate positive aspects of the three generation family culture. ??he Korean cultural housing alternative is a housing type which has been developed from the Korean traditional family type. That is the three generation family in accordance with the government policy in which the elderly is cared for by their families first and then supported by sociery principle. Therefore, the cultural housing alternative was verified as a major elderly housing alternative in Korea. It is expected to contribute to the promotion of a new housing cultures with ethnical identity, integrated well into the policy of elderly welfare whose principle is 'family first and social support next'.

저체중출생아 어머니의 퇴원 1주일 후 교육요구도 조사 연구

권미경,최선정 관동대학교 의과학연구소 2000 關東醫大學術誌 Vol.4 No.1

This study was researched the education needs of LBW infant's mother at one week after the discharge far development of the educational program. The subjects of this study consisted of 40 mothers of LBW infant's at one week after the discharge. They were selected by convenience from 3 general hospitals and 1 pediatric hospital in Seoul, Kangnung. The data were collected during the period from January, 5 to March 15, 2000. The results of this study were as follows : 1.At one week after the discharge, the education need score of LBW infant's mother is 3.77 ±0.49 2.When each item was analyzed by the general characteristics of subject, there was significant differences according to delivery type. 3.The scores of categories are that unusual behavior is 3.97±0.55, disorder management is 3.96±0.51, attachment between mother and infant is 3.80±0.65, infant care is 3.71 ±0.62, environment is 3.55 ±0.65, feeding is 3.52 ±0.65. There were two items that represented the highest educational needs in all items. They were 'when infant has a seizure, what can I do?(4.25±0.78)' and 'when infant has a gastro-intestinal trouble, what can I do?(4.25 ±0.63)'.

유압 윈치 CLD시스템의 제어

조중선,정경욱 國立 昌原大學校 産業技術硏究所 1995 産技硏論文集 Vol.9 No.-

Control of an electro-hydraulic servo-controlled winch system which has no distinct performance specifications is investigated in this paper. Because of the lack of the performance specification, the research is focused to finding effective parameters which give clear physical meanings for the behavior of the system. Two new parameters named "settling rotation angle" and "settling safety ratio" are proposed for the control of general winch system. The physical meanings of the two parameters are explained precisely. Performance specifications for the target winch system are derived by using the proposed two parameters and a controller is designed to meet the performance specifications. Simulation results show that the designed controller gives responses which can be accepted for the target winch system. The concepts of the new design parameters proposed in this paper can be applied to any kind of servo-controlled winch systems.

가족과 청소년정책에 관한 연구

장선경 제주한라대학 1994 論文集 Vol.18 No.-

The purpose of this study was to discuss the concept of adolescents and adolescents policy for the modern Korean society. The library research method was used. The captalistic economic system has brought the change in the family system and its interaction patterns and emotional relationship. Also the concept of 'the adolescents' and that policy has been influenced by the progress of industrialization. Comtemporary society is the young people's age. Adolescents are not existences of transitional stage, but existences of developmental, essential stage. It must be prepared to recognize of the adolescents generation, standing out the importance of adolescents. It will be to emphsize of social responsibility for Adolescent Services. If countries are concerned about their future, as every country is, then clearly they must be concerned about their future citizens and their future labor force and that means they must be concerned about children and adolescents. There is no way that a country can be concerned about the well-being of adolescents without paying attention to the well-being of family and, therefore, family policy is a critical component of a country's social development policies generally.

행정민주화를 위한 공무원 노사관계 활성화 방안

김선호,조경호 울산대학교 1998 사회과학논집 Vol.8 No.2

본 논문은 우리나라의 공무원 노사관계를 개략적으로 살펴 보고, 최근 공포된 공무원 직장협의회법의 성격을 알아 보고 이것이 향후 공무원 노사관계에 어떠한 영향을 줄 것인가, 그리고 한국 공무원 노동조합구성에 대한 인식조사를 바탕으로 공무원 노사관계를 어떻게 발전시켜 나가야할 것인가 모색하여 보았다. This paper reviewed public sector labor relations in Korea briefly, discussed about the nature and impact of recently promulgated the Public Employees' Association Act, andexplored how to develop public secotr labor relations based on the survey about organizaing Korean public employee union.