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기관내삽관과 기관절개술을 시행한 환자에서의 폐흡인에 관한 연구
인광호(Kwang Ho In),안태훈(Tae Hoon Ahn),유진목(Zin Moc Yu),강경호(Kyung Ho Kang),유세화(Se Hwa Yoo) 대한내과학회 1988 대한내과학회지 Vol.35 No.3
N/A Aspiration is a well recognized source of pulmonary infection. In most clinical situations, however, the actual incidence of aspiration has not been well documented, We investigated the incidence of pulmonary aspiration and the factors affecting aspiration in patients with intubation and tracheostomy. Aspiration was evaluated by applying Evans blue dye to the posterior tongue just after each formula tube feeding for 24 hours. Bluish discoloration and elevated glucose concentration of the material suctioned from the artificial airway were regarded as evidence of aspiration. The results obtained were as follows: 1) The incidence of pulmonary aspiration in patients with intubation or tracheostomy was high (69%), 2) Unconscious patients tended to aspirate frequently, but the presence or absence of ventilatory support, tracheostomy or intubation did not play a significant role in the development of aspiration. 3) There was only a weak correlation between the Evans blue dye test and the glucose oxidase reagent strip method in detecting pulnonary aspiration. In conclusion, the incidence of pulmonary aspiration in patients with intubation and tracheostomy is very high. These findings suggest that even in the case of intubation and tracheostomy, careful observation of pulmonary aspiration is necessary
A Cyclophilin A CPR1 Overexpression Enhances Stress Acquisition in Saccharomyces cerevisiae
Kim, Il-Sup,Kim, Hyun-Young,Shin, Sun-Young,Kim, Young-Saeng,Lee, Dong-Hee,Park, Kyung-Moc,Yoon, Ho-Sung Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.29 No.6
Cyclophilins are conserved cis-trans peptidyl-prolyl isomerase that are implicated in protein folding and function as molecular chaperones. We found the expression of cyclophilin A, Cpr1, changes in response to exposure to yeast Saccharomyces cerevisiae to abiotic stress conditions. The effect of Cpr1 overexpression in stress responses was therefore examined. The CPR1 gene was cloned to the yeast expression vector pVTU260 under regulation of an endogenous alcohol dehydrogenase (ADH) promoter. The overexpression of Cpr1 drastically increased cell viability of yeast in the presence of stress inducers, such as cadmium, cobalt, copper, hydrogen peroxide, tert-butyl hydroperoxide (t-BOOH), and sodium dodecyl sulfate (SDS). The Cpr1 expression also enhanced the cell rescue program resulting in a variety of antioxidanr enzymes including thioredoxin system (particularly, thioredoxin peroxidase), metabolic enzymes (glucose-6-phosphate dehydrogenase and glyceraldehyde-3-phosphate dehydrogenase), and molecular chaperones (Hsp104, Hsp90, Hsp60 and Hsp42). Thus, our study illustrates the importance of Cpr1 as a molecular chaperone that improves cellular stress responses through collaborative relationships with other proteins when yeast cells are exposed to adverse conditions, and it also premises the improvement of yeast strains.
Expression of Yeast Cyclophilin A (Cprl) Provides Improved Stress Tolerance in Escherichia coli
( Il Sup Kim ),( Sun Young Shin ),( Young Saeng Kim ),( Hyun Young Kim ),( Dong Hee Lee ),( Kyung Moc Park ),( Ing Nyol Jin ),( Ho Sung Yoon ) 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.6