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24시간 혈청농도를 이용한 lithium 치료량 예측법의 평가
박언규,김광일 大韓神經精神醫學會 1981 신경정신의학 Vol.20 No.4
Lithium salt is a primary therapeutic and prophylactic agent for manic depressive disorder. But, safety range of the lithium salt is relatively narrow and the dosages to maintain optimum therapeutic serum level vary among individuals. By these reasons, it has been suggested that the application of lithium should start from low dosage and increase gradually by close observations of therapeutic effects and side reactions. This method, however, takes relatively longer period to reach the effective serum lithium level and manifests possible lithium toxicity. In 1973, Cooper and his colleagues reported the 24-hour serum lithium level as a prognosticator of dosage requirements for rapid and safe use of lithium salt. The authors attempted to evaluate the accuracy of this method as prognosticator of dosage requirements. Subjects of the study was 25 cases of manic depressive disorder. According to Cooper's method 600mg of lithium carbonate was administered orally to the patients and blood was sampled 24-hours later. The required dosages of lithium carbonate to reach therapeutic serum level (0.6∼1.2mEq/L) had been given orally and serum lithium levels were checked on the 7th and 14th days respectively after initial medication. The results are as follows: 1. Sensitivity of Cooper's method could be proved to be 0.80∼0.84. If th range of optimum serum lithium level is assumed to be 0.6∼1.5mEq/L, the sensitivity would be 0.96∼1.00. 2. After the Cooper's method, the 7th day serum checking seems to be sufficient to confirm therapeutic serum level. From the above results, the Cooper's method was proved to be useful prognosticator of dosage-requirement for rapid and safe lithium treatment.
반복적인 두드러기를 주소로 내원한 4세 남아에서 발견된 글루텐 알레르기 1례
김규언 ( Kyu Earn Kim ),박현빈 ( Hyun Bin Park ),최봉석 ( Bong Seok Choi ),김미나 ( Mi Na Kim ),홍정연 ( Jeong Yeon Hong ),이경은 ( Kyung Eun Lee ),이용주 ( Young Ju Lee ),백지영 ( Ji Young Beak ),김경원 ( Kyung Won Kim ),손명현 ( 대한소아알레르기호흡기학회 2010 소아알레르기 및 호흡기학회지 Vol.20 No.4
Wheat is the most widely cultivated grain and an important source of food and dietary protein. Wheat proteins are classified based on extraction in different solvents, which are albumin, globulin, prolamin (gliadin) and glutenin. The term `gluten` contains approximately equal amounts of gliadin and glutenin and is the major determinant of the properties of wheat flour conferring cohesiveness and viscoelasticity that allows its dough to be processed into many kinds of food. Gluten is known to be responsible for triggering celiac disease and wheat allergy. Wheat allergy is primarily an IgE-mediated response. Clinical manifestations of wheat allergy are similar to those of other food allergies, with symptoms on the skin, gut and respiratory tract. Recent studies have shown that IgE to gliadin can be an indicator for risk of severe immediate reaction-like anaphylaxis and wheat- dependent, exercise-induced anaphylaxis (WDEIA). However, current in vitro test reagents for the diagnosis of wheat allergy mainly contain water-soluble wheat protein and a small amount of gluten, so there are some limitations to diagnose gluten allergy. Furthermore, there is no acceptable method to measure gluten in food products for preparing effective gluten-free diet. To overcome these limitations and to improve quality of life of wheat allergy sufferers, more work is needed. We report a case of a 4-year-old boy with gluten allergy who presented with urticaria after ingestion kneaded wheat flour with a brief review of the literature. [Pediatr Allergy Respir Dis(Korea) 2010;20:292-296]
우리나라 신문 기사를 통해 살펴본 알레르기질환 (1920-1972년)
김규언 ( Kyu Earn Kim ) 대한천식알레르기학회(구 대한알레르기학회) 2018 Allergy Asthma & Respiratory Disease Vol.6 No.S
Purpose: This study aimed to investigate which Korean newspaper articles were reported on allergic diseases before the establishment of the Korean Academy of Asthma, Allergy and Clinical Immunology (KAAACI). Methods: This study was performed in 3 newspapers, Chosun Ilbo, DongA Ilbo, and JoongAng Ilbo, which were founded and used the databases established before the establishment of KAAACI in 1972. The databases were searched using 42 keywords associated with allergic diseases (allergy, asthma, rhinitis, etc.). Results: Among the 42 keywords, there were only 7 that were able to search: allergy, urticaria, asthma, dermatitis, rhinitis, pollen and eczema. The total number of articles related to allergic diseases were 62, as follows: allergy (n=21), urticaria (n=15), asthma (n=8), dermatitis (n=8), rhinitis (n=5), pollen (n=3), and eczema (n=2). There were 31 articles in Chosun Ilbo, 9 in DongA Ilbo, and 22 in JoongAng Ilbo. The first allergic disease published in the newspapers was asthma on the article entitled “Treat the cause of asthma” (on page 8 of November 10, 1960 DongA Ilbo). The first article that used the term allergy appeared in a column entitled, “Childhood illness and allergy” (on page 4 of May 30, 1960 DongA Ilbo). Conclusion: Since 1920, articles related to allergic diseases published in the Korean newspapers increased every year. These articles may have appeared due to the increase in the prevalence of allergic disease and the pioneering efforts of senior allergy researchers. (Allergy Asthma Respir Dis 2018;6 Suppl 1:S85-89)
김규언(Kyu Earn Kim),강혜영(Hye Young Kang),한부현(Boo Hyun Han),이수영(Soo Young Lee),정병주(Byung Ju Jeoung),이기영(Ki Young Lee) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1994 소아알레르기 및 호흡기학회지 Vol.4 No.2
N/A EIA represents a transient airflow obstruction following strenuous exercise and can cause physical and psychological problems in children. It is very important to prevent EIA with pharmacologic or non-pharmachologic methods. To compare the preventive effects of such methods, it is essential that these methods be tried for same individual. We compared the preventive effects of inhaled beta2-agonist, oral beta2-agonist, cromolyn sodium and warm-up by cross-over study on EIA in 45 children (27 boys and 18 girls aged 6 to 15 years). They were diagnosed as EIA by exercise loading test (up and down stairs method for 6 minutes). The changes in pulmonary function were measured by peak expiratory flow rate (FEFR). The results are as follows: 1. The preventive effects were 93.3% in inhaled beta2-agonist, 66.7% in warm-up, 62.2% in cromolyn sodium, and 33.3% in oral beta2-agonist. 2. When we analyzed the preventive effects according to the severity of EIA, we had the following results: warm-up, cromolyn sodium, and oral beta2-agonist were only effective in mild EIA, while inhaled beta2-agonist was effective in all cases of EIA. In conclusions, regardless of severity of EIA inhaled beta2-agonist was the most effective in the prevention of EIA. And warm-up and cromolyn sodium were followed. Oral beta2-agonist was effective only in mild cases of EIA.
김규언(Kyu Earn Kim),정병주(Byung Ju Jeoung),이기영(Ki Young Lee) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1995 소아알레르기 및 호흡기학회지 Vol.5 No.2
N/A Food allergy is one of the common allergic diseases and the incidence and principal foods are different among countries. Therefore we reviewed clincal history in 3,320 children with atopic asthma and performed skin test with food allergens. L. Of the 3,320 children with asthma, 379 (11.4%) had clinical history of food allergy. These 379 patients showed a total of 554 allergic reactions to 58 foods (1.5 allergic reactions/patient). 2. The ten most common foods implicated in allergic reactions were egg (22.7%), pork(14.8%), peach(14.0%), mackerel(12.7%), chicken(11.1%), milk(10.0%), buckwheat(7.4%), crab(6.3%), wheat(4.7%) and tomato(4.7%) in order of frequency. 3. Although the common foods implicated in allergic reactions were similar amomg the various age groups, peach was the most common food in children over 10 years old. 4. The rate which positive skin test corresponded to the clincaI history was collectively very low (22.6%), but it was the highest in buckwheat (92.9%). In conclusion, the incidence of food allergy is 11.4% and the ten most common foods are as follows; egg, pork, peach, mackerel, chicken, milk, buckwheat, crab, wheat and tomato in order of frequency
최원규(Won Kyu Choi),강혜영(Hye Young Kang),정병주(Byeung Ju Jeoung),김규언(Kyu Earn Kim),이기영(Ki Young Lee) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1994 소아알레르기 및 호흡기학회지 Vol.4 No.2
N/A Clinical data and findings of 105 cases of atelectasis in children which were confirmed by chest X-ray at Yonsei University Hospital during the period of January 1989 to December 1993 were reviewed. The result were briefly summerized as follows: 1) Atelectasis was seen most frequently below 1 year in 46 cases(43.8%) and 76 cases(72.4%) of all patients were below 5 years of age. 2) The main clinical symptom was cough in 74 cases(70.5%). The other complains were abundant expectoration in 42 cases(40%) and fever in 40 cases (38.1%). Rales were heard in 31 cases(29.5%) decreased breathing sound in 29 cases(27.6%), retraction in 20 cases(19%) and no signs in 28 cases(26.7%). 3) The involvement of the lung was usually the right upper lobe in 53 cases (50.5%) the right middle lobe in 13 cases(11.4%) and right lower lobe in 10 cases(9.5%). 4) Identifiable etiologic factors were pneumonia in 37case(35.2%) neuromuscular disease in 15 cases(14.3%), bronchiolitis in 11 cases(10.5%), asthma in 10 cases (9.5%), congenital heart disease in 10 cases(9.5%), pulmonary tuberculosis in 9 cases(8.6%), foreign body aspiration in 6 cases(5.7%), pulmonary anomaly in 5 cases(4.8%), and bronchiectasis in 2 cases(1.9%).