위발성 위장관 악성림프종 환자에서 항암치료의 효과

김찬규,신영록,김현정,배상병,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Purpose: The gastrointestinal (GI) tract is the most common site of extranodal non-Hodgkin's lymphoma (NHL), which is increasing in incidence, but there is no established optimal treatment modality. Thus, this study was investigated the clinicohistologic feature, the therapeutic modalities, and the prognosis for GI-NHL, as well as the factors affecting it. Methods: We retrospectively analyzed 45 patients who had been diagnosed as having GI-NHL and had been followed up from July 1994 to February 2005 at Soonchunhyang University Hospital. The patients were divided into groups according to the site of origin and to various other features, and the survivals of the various groups were compared. The modified Ann Arbor system and WHO classification were adopted for staging and histopathologic classification, respectively. Results: GI-NHL of the stomach, small bowel, ileocecal region, and colon occurred in 28 patients (62.2%), 5 patients (11.1%), 3 patients (6.7%), and 8 patients (17.8%), respectively, In one patient, the entire gastrointestinal tract was diffusely involved. The median age of patients was b5 years (25~78 years), and male-to-female ratio was 1:1.1. Fourteen patients were in stage Ⅰ, 24 in stage Ⅱ, 4 in stage Ⅲ, and 3 in stage Ⅳ. Surgical resection was performed in 19 patients, and combination chemotherapy was performed in 43 patients. Surgical resection only was performed in 4 patients, Chemotherapy only was performed in 26 patients. The expected overall 5 year survival of 45 patients was 39.6%, and there was a significant survival difference between the stages, but between sites of origin (p=0.842). The most important factors influencing the survival was the stage and other factors were not significant. Conclusion: The stomach was the most common site of GI-NHL. Most GI-NHL were localized Stage was the most important prognostic factor. However, Prospective randomized studies are needed to approve the therapeutic modality.

<기생충>에 드러난 자본과 공간 연구

조규찬(Cho Kyu―Chan) 한국비평문학회 2020 批評文學 Vol.- No.75

<기생충>은 21세기 자본주의 사회에서 자본의 소유 여부에 따라서 각각의 집단의 삶이 이루어지는 공간의 양상이 얼마나 달라질 수 있는지를 극명하게 보여준다. 개인이 소유한 자본의 양은 그들을 상위 또는 하위 집단이라는 차이를 강제적으로 구별하며, 이는 공간의 고착으로 이어질 수밖에 없다. 본고는 <기생충>을 통하여 드러나는 21세기 자본주의 사회의 문제점을 자본과 공간으로 인식하고, 등장 인물들에게 발생하는 구별 짓기를 통한 집단 간의 차이와 공간의 고착이 이루어지는 과정 및 집단 간 또는 집단 내 충돌이 비극적인 결말로 드러날 수밖에 없음을 살펴보았다. 먼저 <기생충>은 자본의 차이가 개인의 의지와는 관계없이 그들을 상위 또는 하위 집단으로 규정하며 위계적인 관계를 발생시킴을 보여준다. 하위 집단의 인물들은 상위 집단의 인물들과 위계적인 관계를 맺는 과정에서 생계를 연명하기 위하여 기생하는 선택을 할 수밖에 없다. 반면, 상위 집단의 인물들은 더 많은 자본을 바탕으로 하위 집단 인물들의 생계를 위협하며 자신들의 이익만 추구한다. 결국, 하위 집단의 인물들은 생계유지를 위하여 집단 내 충돌을 발생시키고, 그 과정에서 집단 간 충돌마저 망설이지 않는 모습을 드러낸다. <기생충>은 집단 내 또는 집단 간의 충돌을 비극적인 결말로 보여줌으로써 21세기 자본주의 사회가 직면한 자본과 공간의 문제점이 지닌 심각성에 관한 경종을 울린다는 점에서 의의를 지닌다. <Parasite> clearly shows how much the aspects of space in which each group’s lives take place can differ depending on the ownership of capital in the 21st century capitalistic society. The amount of capital owned by individuals forcibly distinguishes the difference of upper or lower groups, which inevitably results in the fixation of space. This paper acknowledges the problems of 21st capitalistic society as revealed in <Parasite> as that of capital and space, and examines how the differences in class through the categorization that applied to the characters, the process of how space becomes set in and the inter-groups or intra-group conflict can only meet with a tragic ending. Foremost, <Parasite> shows how the differences in capital define characters into either upper or lower group regardless of individual will and result in a hierarchical relationship. Characters in the lower group forms a hierarchical relationship with the characters in the upper group and must choose the life as parasites in order to keep living. On the contrary, the characters in the higher group threaten the lives of lower group characters with more capital and only pursue their interests. Ultimately, the characters of the lower group generate intra―group conflict in order to continue to make a living and in this process are not hesitant towards inter-group conflict. <Parasite> is significant because it rings the alarm on the significance of the problems of capital and space faced by 21st century capitalistic society by showing how intra-group or inter-group conflicts lead to tragic ending.

재발 또는 불응성 비호즈킨 림프종 환자에서 CDME 구제항암화학요법 후 고용량 항암화학요법 및 자가말초혈액 조혈모세포이식의 효과

김세형,한강원,배상병,김찬규,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Background and objectives : The long-term survival in patients with non-Hodgkin's lymphoma (NHL) after conventional dose chemotherapy is about 35% and the rest of the patients tend to have relapse. So, in relapsed or refractory NHL, we compared the outcome of patients undergoing high-dose chemotherapy with autologous peripheral blood stem cell transplantation(APBSCT) with only salvage chemotherapy of cisplatin, dexamethasone, mitoxantrone, and etoposide(CDME). Materials and methods : From June 1993 to December 1999, 25 patients with relapsed or resistant NHL were treated with CDME regimen as salvage chemotherapy. Twelve patients were received four cycles of CDME chemotherapy, and 13 patients were received high-dose chemotherapy with APBSCT following two cycles of CDME chemotherapy. Results : The median follow-up duration was 12.8 months(range:4-68). The overall response rate was 41.7% (complete response rate 25%, partial response rate 16.7%) in 12 patients with CDME only. Thirteen patients who were treated with high-dose chemotherapy with APBSCT achieved 61.5% complete response rate and 15.4% partial response rate, with an overall response rate of 76.9%. The estimated 3-year progression-free survival rate was significantly higher among patients who received high-dose therapy than patients who received CDME only(41.5% vs 20.0%, p<0.05). And, 3-year overall survival rate was significantly higher among patients who received high-dose therapy(51.3% vs 25.0%, p <0.05). Conclusions : In relapsed or refractory NHL, CDME chemotherapy is an effective salvage chemotherapy and allow peripheral blood stem cell collection. Also, high-dose chemotherapy with APBSCT following CDME is superior to CDME salvage chemotherapy only.

흉선종 제거후에 발생한 재생 불량성 빈혈 : 증례보고

전원선,이상철,김현정,배상병,김찬규,이남수,박노진,이규택,박성규,홍대식,박희숙,원종호 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

Thymoma is associated with myasthenia gravis, Pure red cell aplasia, and autoimmune diseases such as autoimmune hemolytic anemia, aplastic anemia, and hypogammaglobulinemia. It's association with aplastic anemia is rare and aplastic anemia appearing after surgical removal of thymoma is especially rare. The authors hereby report a case of aplastic anemia occuring in a patient who was diagnosed with thymoma and myasthenia gravis and had the tumor surgically removed. The patient was treated with anti-thymocyte globulin, cyclosporin, and prednisolone, and showed partial remission with hematologic improvements after 12 months.

The Generalization and Application of Hadamard and CNOT Operators for n-dimensional Quantum States

배규찬 대구대학교 사범대학 부설 교육연구소 2007 敎育硏究 Vol.2 No.2

We generalize the Hadamard and CNOT operators for n-dimensional quantum states. Using these generalizations, we propose the generalized scheme of quantum teleportation and quantum secure direct communication (QSDC) for arbitrary n-dimensional system.

정전 용량형 RF Switch의 제작 및 동작특성

구찬규,장호경 慶山大學校 基礎科學硏究所 2003 基礎科學 Vol.7 No.1

본 연구에서는 정전 용량형 RF switch의 제작 및 동작특성에 대하여 연구하였다. 최근 MEMS 기술의 발달로 새로운 스위칭 알고리즘에 의해 micromechanical switch의 설계와 제작이 가능해졌다. micromechanical switch는 반도체 스위치들과 비교해 더 낮은 삽입손실, 극히 적은 전력소모, 좋은 절연성을 가진다. 제안된 스위치는 전기도금 기술, 낮은 온도 프로세스 및 wet etching 시스템을 사용해 제작되었다. membrane-type upper 전극 스위치는 구동 전압이 12V 일 때 20㎓에서 -218㏈의 삽입손실과 -2.1의 절연성을 가진다. 이와 같은 결과는 고주파 무선통신에 적용할 수 있음을 알 수 있으며, 정전 용량형 PF switch에 마이크로파의 적용도 가능 할 것으로 기대된다. This paper presents a CPW shunt RF Switch using MEMS. Recent development in MEMS technoloy has made possible the design and fabrication of micromechanical switches as new switching elements. The micromechanical switches have low insertion loss, negligible power consumption, good isolation compared to semiconducter switches. The proposed switches are fabricated using electropatling technique, low temperture process, and wet etching system. The switch with a membrane-type upper electrode has an insertion loss of -2.1㏈ at 25㎓ and an isolation -18㏈ at 25㎓ when active voltage of 12V is applied. In this process, micromachined capacitive switches for microwave applications are designed and fabricated to good isolation.

핸드볼 페날티 드로우시 표적에 따른 상지 분절의 역할

임규찬 한국운동역학회 2001 한국운동역학회지 Vol.11 No.1

This study was conducted to investigate the differences in the instantaneous contributions of anatomical rotations of trunk, upper arm, forearm, and hand to ball speed according to the targets based on the upper right corner, lower right corner, upper left corner, and lower left corner of handball goal post respectively and to quantify the three-dimensional angular kinematics of the trunk and throwing arm during handball penalty throws motion by eight male subjects. The penalty throws were filmed using two video cameras, and data were collected through the DLT method of three dimensional cinematography. The data were verified using one-way ANOVA at level of significance .05 whether there were significant differences in the contributions ratios and angular kinematic data among the four targets. In general, The largest contributors to predicted ball speed |(v_B)'| at release were a counterclockwise twisting rotation of the trunk and a linear velocity of the ball relative to the right knuckle perpendicular to the plane of the hand. There were significant differences in the only x · y · z components of the linear velocity of the ball relative to the right knuckle among the four targets in the contributors to predicted ball speed at release. There were significant differences in the maximum clockwise twisting rotation angle of the trunk and the maximum extension angular velocity of the forearm in the address motion. There significant differences in the front somersaulting angle of the trunk and the counterclockwise twisting rotation angle of the trunk at release.

수상관의 밝기 및 해상도를 고려한 기준 백색 설정

최덕규,한찬호,정영헌 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(C)

Reference white in color television receiver can be achieved by adjusting the RGB gun current ratio and it is necessary to provide additional gain ratio adjustment for the RGB video signal. Generally, the gun current density profile has a Gaussian distribution and the gain-bandwith product of RGB channel amplifier is constant. Therefore brightness and spatial resolution are changed with variations in reference white of receiver. In this paper, the effect of RGB gun current and channel gain ratios on brightness and resolution of CPT is analyzed. Brightness is increased with the color temperature of reference white because of Holmholtz-Kohlrausch effect. The change in light output is more abrupt and spatial resolution is improved with unity current ratio. For more bright and improved resolution we also present the range of color temperature of reference white for P22 phosphors.

장대 높이뛰기의 이지 후 공중자세 동작분석

임규찬 한국운동역학회 2001 한국운동역학회지 Vol.11 No.3

This study was conducted to investigate the total times, CM height and velocity, pole chord length and angle, whole body angular velocity, and stride length of pole vault. The pole vaults of four male elite vaulters including current national player were filmed using two video digital cameras at 60 Hz, and data were collected through the DLT method of three dimensional cinematography. In general, All vaulter need to reduce last stride and a low CM during the foot support, and need to increase horizontal velocity at take-off, maintain high grip, and well timed angular momentum. MI vaulters except one need to position the take-off foot below top of the grips, to position the hips early parallel to the bar at the time of pole release, and to push the pole more downward.

地方大都市의 都市開發問題에 관한 小考 : 大田市의 經驗을 中心으로 Local City -A Case Study for Dae-Jeon City

朴贊圭 忠南大學校 産業技術硏究所 1989 산업기술연구논문집 Vol.4 No.1

Korean local cities have been grown and developed at fast speed through the process of industrialization and urbanization in the past several decades. Recent years, local governments have expressed the strong will that they try to develope and improve their own cities according to their local charactes, riding the waves of localization movement. Dae-Jeon city has also experienced many changes in urban development. It had chances of success or failure in the development process. In order to plan and build a healthy city, urban planners and decision makers should reflect the valuable lessons from the past experiences in the process of urban development. In this point of view, the author reviewed the several problems in the urban development process of Dae-Jeon city for past several years, including environmental conservation, commercialism and urban design regulations.