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TEAM VARIATION AND TEAM CONVERGENCE AS DRIVERS OF IMPROVISATION IN NEW PRODUCT DEVELOPMENT
Kyriakos Kyriakopoulos,Marcel van Birgelen 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
Improvisation is an important firm competence in product innovation as firms increasingly face inherent uncertainty in new product development (NPD) process and frequent jolts in the external environment. While there is some empirical and conceptual work on the value of improvisation for several new product outcomes, there is lack of empirical research on the antecedents of improvisation in innovation studies. We attempt to address this gap by studying the role of team variation and team convergence traits in the occurrence of improvisation in a sample of 118 NPD teams from manufacturing firms.
A rare complication of capsule endoscopy, retained in diverticula: A report of two cases
Melissa Kyriakos Saad,Elias Fiani,Imad El Hajj,Elias Saikaly 소화기인터벤션의학회 2021 Gastrointestinal Intervention Vol.10 No.1
Capsule endoscopy is being widely used to identify the origin of an obscure gastrointestinal bleeding. Capsule retention is one of its complications. Herein, we present 2 cases of a retained capsule one in a gastric diverticula that was managed endoscopically, and one in jejunal diverticula managed by small bowel resection.
A rare complication of capsule endoscopy, retained in diverticula: A report of two cases
Melissa Kyriakos Saad,Elias Fiani,Imad El Hajj,Elias Saikaly 소화기인터벤션의학회 2021 International journal of gastrointestinal interven Vol.10 No.1
Capsule endoscopy is being widely used to identify the origin of an obscure gastrointestinal bleeding. Capsule retention is one of its complications. Herein, we present 2 cases of a retained capsule one in a gastric diverticula that was managed endoscopically, and one in jejunal diverticula managed by small bowel resection.
Alexandros Giakoustidis,Kyriakos Neofytou,Mafalda Costa Neves,Dimitrios Giakoustidis,Eleni Louri,David Cunningham,Satvinder Mudan 한국간담췌외과학회 2018 Annals of hepato-biliary-pancreatic surgery Vol.22 No.3
Backgrounds/Aims: It is important to point out that the identification of inflammation is an essential component of the pathogenesis and the progression of cancer. In this study, we analysed the neutrophil-to-lymphocyte ratio (NLR) and the platelets-to-lymphocyte ratio (PLR), with an overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC), who were treated with a resection following or not following a procedure of neoadjuvant chemotherapy/chemoradiation. We intended to identify the significance of the role of NLR and PLR, as prognostic markers in patients undergoing surgery for PDAC. Methods: There were 127 patients enrolled in the study. The NLR and PLR were calculated on the basis of the pre-treatment blood cell count. An NLR>4 and a PLR >120 were considered to be elevated as measured. OS was analysed in relation to the NLR and PLR values, by using both the Kaplan-Meier and multivariate Cox-regression methods. Results: Both high the NLR and high PLR were associated with a decreased OS in the univariate analysis. In the multivariate analysis, the high NLR, but not the high PLR, was an independent predictor of a decreased OS. When we divided patients into three groups (group 1: normal both NLR and PLR, group 2: high NLR or high PLR, group 3: high both NLR and PLR), the three-years OS rates for these groups were 48%, 32%, 7% (p=0.001) respectively. Conclusions: It is noted that the pre-treatment NLR is an independent adverse prognostic factor, and considered to be superior to the PLR, in patients who undergo a resection for PDAC following or not neoadjuvant chemotherapy/chemoradiation.
Mutual Recognition of National Military Airworthiness Authorities
Leon Purton,Kyriakos I. Kourousis,Reece Clothier,Kevin Massey 한국항공우주학회 2014 International Journal of Aeronautical and Space Sc Vol.15 No.1
The Air and Space Interoperability Council (ASIC) has adopted the European Defence Agency (EDA) process for interregulatory military airworthiness authority recognition. However, there are gaps in the application of this process to nations outside of the European Union. This paper proposes a model that can effectively map diverse technical airworthiness regulatory frameworks. This model, referred to as the Product-Behaviour-Process (PBP) Bow-Tie model, provides the systematic structure needed to represent and compare regulatory frameworks. The PBP Bow-Tie model identifies key points of difference that need to be addressed, during inter-agency recognition between the two regulatory authorities. With the intention to adopt global use of the EDA process, the proposed PBP Bow-Tie model can be used as a basis for the successful recognition of regulatory frameworks outside of the European Union. Iris plots produced from the implementation of this model are presented, and proposed as a suitable means of illustrating the outcome of an assessment, and of supporting the comparisons of results. A comparative analysis of the Australian Defence Force and New Zealand Defence Force airworthiness regulatory frameworks is used as a case study. The case study clearly illustrates the effectiveness of the model in discerning regulatory framework differences; moreover, it has offered an opportunity to explore the limitations of the Iris plot.
Yun, SungDae,Kyriakos, Walid E.,Chung, Jun-Young,Han, Yeji,Yoo, Seung-Schik,Park, HyunWook Wiley Subscription Services, Inc., A Wiley Company 2007 Journal of magnetic resonance imaging Vol.25 No.3
<B>Purpose</B><P>To develop a novel approach for calculating the accurate sensitivity profiles of phased-array coils, resulting in correction of nonuniform intensity in parallel MRI.</P><B>Materials and Methods</B><P>The proposed intensity-correction method estimates the accurate sensitivity profile of each channel of the phased-array coil. The sensitivity profile is estimated by fitting a nonlinear curve to every projection view through the imaged object. The nonlinear curve-fitting efficiently obtains the low-frequency sensitivity profile by eliminating the high-frequency image contents. Filtered back-projection (FBP) is then used to compute the estimates of the sensitivity profile of each channel. The method was applied to both phantom and brain images acquired from the phased-array coil.</P><B>Results</B><P>Intensity-corrected images from the proposed method had more uniform intensity than those obtained by the commonly used sum-of-squares (SOS) approach. With the use of the proposed correction method, the intensity variation was reduced to 6.1% from 13.1% of the SOS. When the proposed approach was applied to the computation of the sensitivity maps during sensitivity encoding (SENSE) reconstruction, it outperformed the SOS approach in terms of the reconstructed image uniformity.</P><B>Conclusion</B><P>The proposed method is more effective at correcting the intensity nonuniformity of phased-array surface-coil images than the conventional SOS method. In addition, the method was shown to be resilient to noise and was successfully applied for image reconstruction in parallel imaging. J. Magn. Reson. Imaging 2007;25:588–597. © 2007 Wiley-Liss, Inc.</P>
Mutual Recognition of National Military Airworthiness Authorities: A Streamlined Assessment Process
Purton, Leon,Kourousis, Kyriakos I.,Clothier, Reece,Massey, Kevin The Korean Society for Aeronautical and Space Scie 2014 International Journal of Aeronautical and Space Sc Vol.15 No.1
The Air and Space Interoperability Council (ASIC) has adopted the European Defence Agency (EDA) process for inter-regulatory military airworthiness authority recognition. However, there are gaps in the application of this process to nations outside of the European Union. This paper proposes a model that can effectively map diverse technical airworthiness regulatory frameworks. This model, referred to as the Product-Behaviour-Process (PBP) Bow-Tie model, provides the systematic structure needed to represent and compare regulatory frameworks. The PBP Bow-Tie model identifies key points of difference that need to be addressed, during inter-agency recognition between the two regulatory authorities. With the intention to adopt global use of the EDA process, the proposed PBP Bow-Tie model can be used as a basis for the successful recognition of regulatory frameworks outside of the European Union. Iris plots produced from the implementation of this model are presented, and proposed as a suitable means of illustrating the outcome of an assessment, and of supporting the comparisons of results. A comparative analysis of the Australian Defence Force and New Zealand Defence Force airworthiness regulatory frameworks is used as a case study. The case study clearly illustrates the effectiveness of the model in discerning regulatory framework differences; moreover, it has offered an opportunity to explore the limitations of the Iris plot.
Fragiska Sigala,George Galyfos,Kyriakos Stavridis,Konstantinos Tigkiropoulos,Ioannis Lazaridis,Dimitrios Karamanos,Vangelis Mpontinis,Nikolaos Melas,Ioulia Zournatzi,Konstantinos Filis,Nikolaos Saratz 대한혈관외과학회 2018 Vascular Specialist International Vol.34 No.4
Purpose: Aim of this study is to report real-life experience on the treatment of peripheral artery disease (PAD) with a specific drug-coated balloon (DCB), and to evaluate potential prognostic factors for outcomes. Materials and Methods: This is a retrospective study reporting outcomes in patients with PAD who were treated with the Lutonix DCB during a four-year period. Major outcomes included: all-cause mortality, amputation, clinical improvement, wound healing and target lesion revascularization (TLR). Mean follow-up was 24.2±2.3 months. Results: Overall, 149 patients (mean age: 68.6±8.3 years; 113 males) were treated, either for intermittent claudication (IC) (n=86) or critical limb ischemia (CLI) (n=63). More than half the target lesions (n=206 in total) were located in the superficial femoral artery and 18.0% were below-the-knee lesions. CLI patients presented more frequently with infrapopliteal (P=0.002) or multilevel disease (P=0.0004). Overall, all-cause mortality during follow-up was 10.7%, amputation-free survival was 81.2% and TLR-free survival was 96.6%. CLI patients showed higher all-cause mortality (P=0.007) and total amputation (P=0.0001) rates as well as lower clinical improvement (P=0.0002), compared to IC patients. Coronary artery disease (CAD), gangrene and infrapopliteal disease were found to be predictors for death whereas CLI and gangrene were found to be predictors for amputation, during follow-up. Conclusion: PAD treatment with Lutonix DCBs seems to be an efficient and safe endovascular strategy yielding promising results. However, CAD, gangrene, CLI and infrapopliteal lesions were found to be independent predictors for adverse outcomes. Larger series are needed to identify additional prognostic factors.