The Efficacy and Safety of 4-n-butylresorcinol 0.1% Cream for the Treatment of Melasma: A Randomized Controlled Split-face Trial

( Sun Young Huh ),( Jung Won Shin ),( Jung Im Na ),( Chang Hun Huh ),( Sang Woong Youn ),( Kyoung Chan Park ) 대한피부과학회 2010 Annals of Dermatology Vol.22 No.1

Background: Melasma is a common acquired symmetrical hypermelanosis that occurs on sun-exposed areas, and it is frequently observed among women. Various treatment modalities have been tried, but none are completely satisfactory. 4-n-butylresorcinol, which is a resorcinol derivative that has an inhibitory effect on both tyrosinase and tyrosinase-related protein-1, was introduced in 1995 and it has received increasing attention as a new hypopigmenting agent. However, the hypopigmenting effect of 4-n-butylresorcinol in human subjects has only been shown in a few studies. Objective: The aim of this study was to investigate the hypopigmenting efficacy and safety of 4-n-butylresorcinol 0.1% cream for the treatment of melasma. Methods: Twenty patients with melasma were enrolled to this randomized, double-blind, vehicle-controlled, split-face comparative study. The patients were instructed to apply 4-n-butylresorcinol 0.1% cream or vehicle to each side of the face twice daily for 8 weeks. Mexameter measurements were performed along with photography at baseline, 4 weeks and 8 weeks. Adverse events were observed and recorded throughout the study. Results: All the patients completed the study. Mexameter measurements demonstrated that the melanin index of the treated side showed a significant decrease when compared with that of the vehicle-treated side after 4 weeks (p=0.006) and after 8 weeks (p<0.0005). All the adverse reactions were mild and transient. Conclusion: 4-n-butylresorcinol 0.1% cream showed rapid efficacy and it was well tolerated when used for the treatment of melasma. (Ann Dermatol 22(1) 21∼25, 2010)

문학번역 연구 현황과 과제: 엄마를 부탁해 영역본 연구를 중심으로

윤선경 ( Sun Kyoung Yoon ) 한국현대영어영문학회 2013 현대영어영문학 Vol.57 No.3

The English version of Shin Kyung-sook`s novel Please Look after Mom has appealed to many English readers and has become a bestseller since it saw the light of day. It was translated by Kim Chi-young and published by Knopf, a division of the major publisher Random House in the U. S. in 2011. Kim was commissioned to translate the Korean novel into English by the publisher. In 2011 it was selected as ‘Best of the Month’ in Amazon and won the Man Asian Literary Prize. In this context, many Korean Translation Studies scholars have expressed their academic interest in Kim`s translation: Lee Hyung-jin, Cheong Ho-jeong, Kim Young-shin and Yoon Sun Kyoung. Recently, they have produced articles on the English version from similar but different perspectives. This article examines the current tendency of literary translation research in Korea by looking at those scholars` articles from five different perspectives. It also seeks to suggest some thoughts on how to contribute to the development of Korean literary translation research: the introduction of the ‘cultural turn’ into Korea beyond the heavy focus on the evaluation and fidelity issues of translation. (Hankuk University of Foreign Studies)

경남지방의 향토요리에 관한 연구 : 탕류를 중심으로

김경자,강선희,곽연주,김명진 한국조리과학회 1990 한국식품조리과학회지 Vol.6 No.3

Currentry, the originality of traditional soups in Kyoung-Nam province is vanishing by the inflex of processed and instant food, food industrial development. Especially, such factors as the influence of alien cooked, the develoment of transportation, the movement of population have made it hard to preserve the traditionnal food preparations. The purpose of this thesis was to seek out the various kinds of Kyoung-Nam province soups preparation. To do this, about 60 kinds of soups recipe were reviewed and charactered into several categories. The findings of the study are as follows. 1) Soup is made by fish or shellfish, freshwater fish. Meat and fowls is rarely used in Kyoung-Nam province (coastal region). 2) Soups of inland area is made by most vegetables and these soup were always harmonized with soybean powder or perilla powder. 3) Various soup season with the mag-jang, mul-jang sauce, hab-ja-jang sauce. 4) These soups were in general to make much red pepper and much salt.

Acitretin으로 치료된 다발성 거대각질가시세포종 1예

권은선 ( Eun Sun Kwon ),이경근 ( Kyoung Geun Lee ),고병용 ( Byoung Yong Koh ),명기범 ( Ki Bum Myung ),정승현 ( Seung Hyun Cheong ) 대한피부과학회 2017 대한피부과학회지 Vol.55 No.4

Giant keratoacanthoma is an uncommon variant of keratoacanthoma, which may increase to a diameter of several centimeters. Although keratoacanthomas usually resolve spontaneously, giant keratoacanthoma can be invasive and destructive. A 49-year-old man presented with a 5-year history of multiple large hyperkeratotic and crusted plaques and nodules on sun-exposed areas such as the face, ear, hand, and forearm. Some lesions involuted spontaneously, whereas others became rather enlarged. The biopsy specimen revealed horn-filled crater formation, epidermal extending resembling a buttress, and an eosinophilic glassy appearance in the keratinocytic cytoplasm. We treated the lesions with acitretin, and they almost completely resolved after 13 weeks. Here we describe a case of multiple giant keratoacanthoma treated with acitretin. (Korean J Dermatol 2017;55(4):249∼252)

유아 영어교육에 대한 교사의 인식 조사

김경철(Kim Kyoung-Chul),홍정선(Hong Jeong-Sun) 한국어린이미디어학회 2002 어린이미디어연구 Vol.1 No.-

본 연구는 유치원에서의 영어교육 실시와 적합한 영어교육 방법에 대한 유치원 교사의 인식과 현재 유치원에서의 영어교육 실시현황을 알아봄으로써 유아교육과 유아 영어교육이 앞으로 나아가야 할 방향을 설정하는 데 기초 자료를 제공하는 것이 목적이다. 서울ㆍ경기 지역의 공사립 유치원에 근무하는 유치원 교사 114명을 대상으로 질문지를 통해 조사하였다. 연구 결과, 유아 영어교육은 시대적 요구와 흐름에 따라 실시되어야 하며, 올바른 실시를 위해 준비가 되어야 한다고 인식하였다. 조사된 기관의 과반수 이상의 유치원에서 유아 영어교육을 실시하고 있었으며, 대부분 사립유치원이 실시하고 있는 것으로 조사되었다. 또한 적합한 유아 영어교육은 한국인 영어 교사가 담당하여, 다른 영역의 수업과 유사하게 실시되어야 한다고 인식하고 있었다. The purpose of this study was to suggest the basic information of which Early childhood Education and English Education in Kidergarten should advance by investigating teachers' awareness and practice of English Education in Kindergarten. This study examined the results of the survey which was done by 114 public and private kindergarten teachers in Seoul and Kyoung-gi province. As a result of the study, Kindergarten teachers recognized that English Education in Kidergarten should be carried out keeping the pace with needs and trends of the time and be prepared for its right practice. More than a half of the kindergartens which was investigated carried out English Education and most of them was private kindergarten. And teachers recognized that appropriate English Education in Kindergarten should be carried out similarly to the activities of other domains by Korean teacher.

달맞이꽃 뿌리의 성분에 관한 연구

최윤수,석경순,이경선,전숙경 대구효성가톨릭대학교 1992 연구논문집 Vol.45 No.1

Oenothera odorata Jacquin(Onagraceae), native to south America, is naturalized and grows wild in Korea. The seed oil, named evening primerose oil, of this plants is used for prophylacsis of adult disease. From the roots of this plant, β-sitosterol, β-sitosterol-3-O-D-glucopyranoside and asiatic acid were isolated. The structures were elucidated by spectrometric methods and chemical transformation.

한국 전통장류가 한우 반힘줄모양근(M. Semitendinosus)으로 제조한 건염햄의 육질 특성에 미치는 영향

성필남,조수현,강근호,김동훈,박범영,강선문,박경미,Seong, Pil-Nam,Cho, Soo-Hyun,Kang, Geun-Ho,Kim, Dong-Hoon,Park, Beom-Young,Kang, Sun-Moon,Park, Kyoung-Mi 한국축산식품학회 2013 한국축산식품학회지 Vol.33 No.6

This study was conducted to develop a processing method for dry-curing beef ham with Korean traditional sauces and to investigate the quality properties of the dry-cured beef hams. Semitendinosus muscle from Hanwoo was spread with sundried salt (C), sun-dried salt mixed with red pepper paste (T1), and sun-dried salt mixed with soybean paste (T2), and inserted into washed Hanwoo large intestine. It was then dried and fermented for 75 d. Moisture contents of the hams were 46-48%, without any significant differences. T1 showed the lowest pH among the three dry-cured hams, while water holding capacity (WHC) of T2 was found the lowest (p<0.05). In mechanical color determination, C showed higher CIE $a^*$ and CIE $b^*$ than T1 and T2 (p<0.05), however CIE $L^*$ did not show any significant difference. In texture, T1 demonstrated significantly lower springiness than C (p<0.05). The sensory properties of all dry-cured hams did not show any significant difference, but T1 indicated a higher taste, saltiness and overall acceptability than others, whereas C gathered the highest score in color and flavor. In conclusion, the dry-curing by combination of sun-dried salt mixed with red pepper sauce (T1) showed higher quality properties of the Hanwoo dry-cured ham. 우리나라 전통장류를 건염햄 제조에 접목한 건염햄의 제품을 개발하기 위해 염지과정에서 첨가한 고추장과 된장이 건염햄 품질에 미치는 영향을 조사하고자 실시하였다. 천일염(C), 천일염+고추장(T1), 천일염+된장(T2)을 한우의 반힘줄모양근(m.emitendinosus)의 표면에 골고루 발라주고 세척한 한우 대장에 충진한 후 75일 동안 건조 및 발효시켰다. 한우 반힘줄모양근 건염햄 품질을 조사한 결과, 건염햄 수분함량은 46.45-48.04% 수준으로 유의적인 차이는 없었다. T1은 모든 처리구 중에서 pH가 가장 낮았고 T2는 WHC가 가장 낮았다(p<0.05). 기계적 육색 측정에서 C가 $a^*$와 $b^*$가 전통장류 처리(T1, T2)보다 높았으나(p<0.05), $L^*$은 유의적인 차이가 없었다. 조직감에서 T1은 C보다 탄력성이 유의적으로 낮았다(p<0.05). 관능평가 결과 모든 처리구에서 유의적인 차이가 없었고 C는 제품색과 향미가 높은 점수를 받은데 반해, T1은 높은 맛, 짠맛, 그리고 전체적 기호도가 다른 처리구에 비해 높았다.

전립선의 횡문근육종

김경미,양기화,강석진,김병기,김선무 대한병리학회 1992 Journal of Pathology and Translational Medicine Vol.26 No.4

혼합형 자가면역성용혈성빈혈과 동반된 Evans 증후군 1례

선길홍,윤찬영,박상곤,박경희,우정주,한경택,김진화,김영훈,정춘해,박치영 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Evans syndrome is defined as a simultaneous or sequential occurrence of autoimmune hemolytic anemia and autoimmune thrombocytopenia. Autoimmune hemolytic anemia (AIHA) is usually induced by IgG warm autoantibody or cold-active IgM antibodies reacting specifically with antigens associated with a patient's RBC. AIHA is a fairly uncommon disorder, with estimates of the incidence at 1 to 3 cases per 100,000 per year. Mixed-type AIHA is a relatively uncommon form of AIHA, with studies noting the incidence of 7-8% among cases of AIHA. We experienced a patient, 46-year-old woman who was diagnosed having a very rare clinical presentation of mixed warm and cold antibody mediated Evans syndrome. She was treated with corticosteroid therapy only and has been maintaining a complete response for 15 weeks. 저자들은 혼합형의 자가면역성 용혈성 빈혈과 자가면역성 혈소판 감소증이 동시에 발생한 혼합형 Evans 증후군으로 진단하고 스테로이드 요법 후 혈액학적으로 회복된 상태로 15주가 지난 현재 steroid 5 mg/일 까지 감량한 상태에서 추적 관찰 치료중인 46세 여자 환자를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

중학교 과학영재 담당교사의 PCK 요소의 특징과 관련성

김선경,민희정,방은정,백성혜 韓國英才學會 2011 영재교육연구 Vol.21 No.4

중학교 과학영재 담당교사의 수업을 관찰하여 Pedagogical Content Knowledge(PCK)의 요소 를 분석하고, 요소간의 관련성을 알아보았다. 연구 대상은 대도시 지역의 중학생 대상 영재교 육원에서 과학을 가르치는 교사 4명이었으며, 전공은 각각 물리, 화학, 생물, 지구과학이고 2 명은 전임교사, 2명은 겸임교사였다. 또한 전임교사들은 영재학생들만 가르쳤고, 겸임교사들 은 보통 일반학생들을 가르쳤고, 특별히 주 1회 영재학생들을 가르쳤다. 수업관찰, 반구조화 된 인터뷰를 실시하였으며, 문서자료를 수집하여 질적으로 분석하였다. 연구 결과, 과학영재 담당교사의 PCK 요소의 몇 가지 특징이 나타났다. 교사들의 과학교수지향은 PCK의 요소들 과 긴밀하게 상호작용하고 있었다. 교사들의 교육과정지식은 교사에 따라 상이했지만, 학습 유형의 선택은 교사의 영재 교육 및 수업의 목표와 관련되어 있었다. 또한 이러한 교육과정 지식은 학생에 대한 이해의 영향을 받았다. 교사들은 교육과정지식과 학생에 대한 이해에 따 라 수업에서 서로 다른 교수전략을 사용하고 있었다. 또한 PCK의 요소들의 관계는 밀접했으 며 방향성을 가지고 있었다. 이러한 연구결과를 바탕으로 PCK의 요소와 관계성을 설명하기 위해 사면체 모델을 제안했다. In this study, we analyzed the characteristics of Pedagogical Content knowledge(PCK)'s components through actual course of teachers of science gifted students in the middle school. For this study, four middle school science teachers of gifted students belonging to the gifted education professional organizations in a metropolis were selected, each of them was physics, chemistry, biology, and earth science teacher. Two of them were full-time teachers to teach only gifted students and two were part-time teachers who had taught general students in ordinary time and specially had taught the gifted students once a week. Qualitative data were collected through classroom observations, interviews, and documents. As a result, some unique characteristics of PCK's components were identified. The teachers' orientations to teaching science were closely correlated with PCK's components. The teachers' knowledges of science curriculum were different individually. But the decisions about type of teaching(acceleration or enrichment) were connected with the objectives of gifted education and lesson objectives. Also, the teachers' knowledges of science curriculum were influenced by the knowledge of students' understanding. Teachers used different instructional strategies according to the knowledge of science curriculum and the knowledge of students' understanding. We found that PCK's components were so closely connected and could show the direction of relationships among those PCK's components. We suggested teachers' PCK model which was named "Tetrahedron Model of PCK", to explain the characteristics and relationships of PCK's components.