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Inhibitory Effect of Myrica Bark on Lipase Activity in Mouse Plasma and Gastrointestinal Tract
Kyoko Kobayashi,Satomi Ihara,Ayumi Kobata,Kana Itoh,Nae Kusunoki,Fumihiko Yoshizaki 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.2
As the methanol extract of Myricabark inhibited the activity of lipase in isolated mouse plasma in vitro, theinfluence of the extract on this enzyme in the gastrointestinal tube was investigated after oral intake. The methanol extractdepressed the elevation of blood triglyceride level in olive oil-fed mice. Myricetin and gallic acid were suspected to be re-sponsible for the inhibition of the lipase activity in isolated mouse plasma in vitro. The contents of myricetin and gallic acidin the methanol extract seemed to be insufficient for the appearance of the depressive activity of the extract on lipase in thegastrointestinal tract in vivo. Myricitrin, which is present in abundance in the methanol extract (about 61%), did not show theinhibitory activity. However, this material suppressed the elevation of blood triglyceride level to a slightly smaller extent com-pared with the methanol extract by oral administration. Consequently, it was proposed that myricitrin may function as a pro-drug, which reveals its activity after conversion to myricetin, the active substance, by enterobacilli in the gastrointestinal tract.
Kyoko Nishikimi,Shinichi Tate,Ayumu Matsuoka,Satoyo Otsuka,Makio Shozu 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.3
Objective: Splenectomy with or without distal pancreatectomy is occasionally performed during cytoreductive surgery for advanced ovarian cancer. We investigated pre-, intra-, postoperative risk factors and predictors of clinically relevant postoperative pancreatic fistula (CR-POPF) in patients who underwent cytoreductive surgery for advanced ovarian cancer. Methods: We investigated 165 consecutive patients with ovarian, fallopian tube, and peritoneal carcinoma categorized as stage III/IV disease, who underwent splenectomy with or without distal pancreatectomy as a component of cytoreductive surgery performed as initial treatment at Chiba University Hospital. Patient characteristics, clinical factors, and surgical outcomes were compared between those with and without CR-POPF. Results: CR-POPF occurred in 20 patients (12%). There were no significant intergroup differences in the characteristics between patients with CR-POPF and patients without CR-POPF except for operative time, intraoperative blood loss, amylase (AMY) levels in drain fluid on postoperative day (POD)1 and POD3, and pancreatic stump thickness. Multivariate analysis showed that the POD3 drain fluid AMY level was the only significant risk factor and predictor of CR-POPF in patients who underwent cytoreductive surgery for advanced ovarian cancer. The receiver operating characteristic curve of the POD3 drain fluid AMY level, which predicted development of CR-POPF showed an area under the curve of 0.77, and the optimal cut-off value of AMY was 808 U/L. A pancreatic fistula did not occur in patients with POD3 drain fluid AMY levels <130 U/L. Conclusion: The POD3 drain fluid AMY level can be early diagnostic predictor CR-POPF after splenectomy with or without distal pancreatectomy for advanced ovarian cancer.
Kyoko Kato,Toshio Kimura 한국세라믹학회 2006 한국세라믹학회지 Vol.43 No.11
Textured Bi0.5(Na,K)0.5TiO3-BiFeO3 ceramics were prepared by the reactive-templated grain growth proces, using platelikeBi4Ti3O12 particles. The effects of chemical composition in Bi0.5(Na,K)0.5TiO3 on texture development an d densification were exam-ined. Textured ceramics were obtained by using Bi 0.5K0.5TiO3 as an end member of the solid solution but densification was lim-ited. Dense ceramics were obtained by using Bi 0.5Na 0.5TiO3 but texture did not develop. Dense, textured ceramics were obtainedby using Bi (Na0.5K0.5)0.5TiO3.
A New Concept of Diesel Engine Fuel Injection System with DDVC Hydraulic Actuator
Kyoko Narukawa,Feifei Zhang,Masanori Ito 제어로봇시스템학회 2008 제어로봇시스템학회 국제학술대회 논문집 Vol.2008 No.10
One of the most important subjects for the ship in recent years is to decrease the environmental impact by the exhaust from diesel engine. This research proposes a new composition of a simple, cheap, efficient fuel injection system by using the Direct Drive Volume Control actuator. It is well known that fuel injection pressure, injection timing and injection pattern has big influence for efficient combustion and this study shows the proposed injection system has availability to optimize those parameters.
Well-trained gynecologic oncologists can perform bowel resection and upper abdominal surgery safely
Kyoko Nishikimi,Shinichi Tate,Kazuyoshi Kato,Ayumu Matsuoka,Makio Shozu 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.1
Objective: This study was performed to examine the safety of bowel resection and upper abdominal surgery in patients with advanced ovarian cancer performed by gynecologic oncologists after training in a monodisciplinary surgical team. Methods: We implemented a monodisciplinary surgical team consisting of specialized gynecologic oncologist for advanced ovarian cancer. In the initial learning period in 65 patients with International Federation of Gynecology and Obstetrics (FIGO) III/IV, a gynecologic oncologist who had a certification as a general surgeon trained 2 other gynecologic oncologists in bowel resection and upper abdominal surgery for 4 years. After the initial learning period, the trained gynecologic oncologists performed surgeries without the certificated general surgeon in 195 patients with FIGO III/IV. The surgical outcomes and perioperative complications during the 2 periods were evaluated. Results: The rates of achieving no gross disease after cytoreductive surgery were 80.0% in the initial learning period and 83.6% in the post-learning period (p=0.560). The incidence of anastomotic leakage after rectosigmoid resection, symptomatic pleural effusion or pneumothorax after right diaphragm resection, and pancreatic fistula after splenectomy with distal pancreatectomy in the 2 periods were 2 of 34 (6.0%), 1 of 33 (3.0%), and 3 of 15 (20.0%) patients in the initial learning period, and 12 of 147 (8.2%), 1 of 118 (0.8%), and 11 of 84 (13.1%) patients in the post-learning period, respectively. There were no significant differences between the 2 groups (p=0.270, p=0.440, p=0.520, respectively). Conclusion: Bowel resection and upper abdominal surgery can be performed safely by gynecologic oncologists.