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Kyeongsoon Park(박경순) 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
Macrophage-derived foam cells paly critical roles in the development of atherosclerosis. Thus, they are considered as important target biomarkers for atherosclerosis therapy. Our group has developed a macrophage mannose receptor (MMR)-targeted nanodrug loaded with lobeglitazone (MMR-Lobe). The MMR-Lobe had a high binding affinity to foam cells, and it could efficiently promote cholesterol efflux via LXRα, ABCA1, and ABCG1 pathways, and inhibit pro-inflammatory mediators. Using optical diffraction tomography, we identified lipid droplets in foam cells and quantitatively evaluated the therapeutic effects of MMR-Lobe. Also, long-term delivery of MMR-Lobe markedly reduced both plaque burden and inflammation in atherogenic mice without undesirable systemic effects. Furthermore, short-term treatment of MMR-Lobe showed a robust acute anti-inflammatory effect on inflamed plaque in coronary-sized arteries and shifted the plaque composition to a stable phenotype.
3D-HEVC를 위한 컨투어 분할 기반 깊이영상 부호화 회로 설계
조경순(Kyeongsoon Cho),권용욱(Yongwook Kwon) 대한전자공학회 2018 전자공학회논문지 Vol.55 No.12
3D-HEVC는 2개 이상의 시점을 이용해서 중간시점들을 생성하며, 각 시점은 텍스쳐영상과 깊이영상으로 이루어진다. DMM4는 깊이영상을 부호화하는 기법들 중 하나로서, PU 블록을 임의의 형태를 갖는 2개의 영역으로 분할하고 각각의 영역을 1개의 대표값 CPV로 표현한다. 분할된 영역은 1과 0의 조합으로 구성된 비트 패턴으로 나타내며, 이를 컨투어라고 부른다. 원본 PU 블록과의 왜곡을 줄이기 위하여 각 컨투어에 속한 화소들의 평균값을 시작점으로 하여 최적 CPV를 찾기 위한 거시적 탐색과 미시적 탐색을 수행한다. 주어진 PU 블록의 왼쪽과 위쪽에 위치한 주변화소로부터 예측 CPV를 구한 다음, 예측CPV와 최적 CPV의 차이인 델타 CPV, 원본 PU 블록과 최적 CPV의 차이인 레지듀얼을 계산한다. 제안한 회로는 병렬 구조와 파이프라인 기법을 바탕으로 이 과정을 실시간으로 처리한다. 130nm 표준 셀 라이브러리를 이용하여 합성한 결과, 면적은 97,219게이트이며 최대 동작주파수는 250MHz로서 UHD급 영상을 초당 34.4∼78.1 프레임의 속도로 처리한다. The 3D-HEVC synthesizes intermediate views using two or more views and each view consists of texture and depth map. The DMM4 is one of the techniques to encode the depth map. It divides a PU block into two regions with arbitrary shape and represents each region with one CPV. This region, which is called contour, is expressed by a bit pattern consisting of a combination of 1 and 0. The coarse and refinement searches for the optimized CPV are performed to reduce the distortion from the original PU block. The starting point of the search is the average value of the pixels in each contour. The predicted CPV is derived from the left and top neighboring pixels of the given PU block. Then, the delta CPV and residuals are obtained by computing the difference between the predicted CPV and optimized CPV, and the difference between the original PU block and optimized CPV. The proposed circuit processes these procedures in real time by using parallel architecture and pipeline technique. The synthesized circuit using 130nm standard cell library consists of 97,219 gates and processes UHD images at the rate of 34.4∼78.1 frames per second with the maximum operating frequency of 250MHz.
Park, Kyeongsoon,Lee, Ga Won Springer 2011 Nanoscale research letters Vol.6 No.1
<P>High-quality Ca<SUB>0.8</SUB>Dy<SUB>0.2</SUB>MnO<SUB>3 </SUB>nano-powders were synthesized by the solution combustion process. The size of the synthesized Ca<SUB>0.8</SUB>Dy<SUB>0.2</SUB>MnO<SUB>3 </SUB>powders was approximately 23 nm. The green pellets were sintered at 1150-1300°C at a step size of 50°C. Sintered Ca<SUB>0.8</SUB>Dy<SUB>0.2</SUB>MnO<SUB>3 </SUB>bodies crystallized in the perovskite structure with an orthorhombic symmetry. The sintering temperature did not affect the Seebeck coefficient, but significantly affected the electrical conductivity. The electrical conductivity of Ca<SUB>0.8</SUB>Dy<SUB>0.2</SUB>MnO<SUB>3 </SUB>increased with increasing temperature, indicating a semiconducting behavior. The absolute value of the Seebeck coefficient gradually increased with an increase in temperature. The highest power factor (3.7 × 10<SUP>-5 </SUP>Wm<SUP>-1 </SUP>K<SUP>-2 </SUP>at 800°C) was obtained for Ca<SUB>0.8</SUB>Dy<SUB>0.2</SUB>MnO<SUB>3 </SUB>sintered at 1,250°C. In this study, we investigated the microstructure and thermoelectric properties of Ca<SUB>0.8</SUB>Dy<SUB>0.2</SUB>MnO<SUB>3</SUB>, depending on sintering temperature.</P>
Heparin–deoxycholic acid chemical conjugate as an anticancer drug carrier and its antitumor activity
Park, Kyeongsoon,Lee, Gee Young,Kim, Yoo-Shin,Yu, Mikyung,Park, Rang-Woon,Kim, In-San,Kim, Sang Yoon,Byun, Youngro Elsevier 2006 Journal of controlled release Vol.114 No.3
<P><B>Abstract</B></P><P>A chemically modified heparin–DOCA (HD) conjugate was developed as a drug carrier for cancer therapy. HD conjugate was found to have markedly low anticoagulant activity and to form self-assembled nanoparticles in aqueous condition. We observed that HD conjugate prevented squamous cell carcinoma (SCC) and human umbilical vascular endothelial cell (HUVEC) proliferation during BrdU incorporation assays. Here, we prepared doxorubicin-loaded heparin nanoparticles by entrapping doxorubicin into the amphiphilic HD conjugate by physical interaction and characterized the properties of these nanoparticles using Dynamic Light Scattering (DLS) and Atomic Force Microscope (AFM). In this study, doxorubicin-loaded heparin nanoparticles were designed to improve the antitumor effects of nano-sized particles (range of 180 to 210?nm) at high drug-loading efficiencies in the range 64% to 96%. These doxorubicin-loaded heparin nanoparticles displayed sustained drug release patterns. It was confirmed in vivo toxicity studies that HD conjugate did not induce unexpected side effects and that DHN 20 was safer than free DOX. An in vivo study showed that HD conjugate, doxorubicin and DHN 20 (one of doxorubicin-loaded heparin nanoparticles) induced tumor volume reductions of 43%, 56% and 74%, respectively, relative to the saline treated control. These results suggest that the drug-entrapped with heparin nanoparticles might provide a novel therapy for SCC.</P>
Park, Kyeongsoon,Kim, Jong-Ho,Nam, Yun Sik,Lee, Seulki,Nam, Hae Yun,Kim, Kwangmeyung,Park, Jae Hyung,Kim, In-San,Choi, Kuiwon,Kim, Sang Yoon,Kwon, Ick Chan Elsevier 2007 Journal of controlled release Vol.122 No.3
<P><B>Abstract</B></P><P>To improve the <I>in vivo</I> tumor targeting characteristics of polymeric nanoparticles, three glycol chitosan (GC-20?kDa, GC-100?kDa, and GC-250?kDa) derivatives with different molecular weights were modified with cholanic acid at the same molar ratio. The resulting amphiphilic glycol chitosan–cholanic acid conjugates self-assembled to form glycol chitosan nanoparticles (GC-20?kDa-NP, GC-100?kDa-NP, and GC-250?kDa-NP) under aqueous conditions. The physicochemical properties of all three glycol chitosan nanoparticles, including degree of substitution with cholanic acid, surface charge, particle size and <I>in vitro</I> stability, were similar regardless of molecular weight. <I>In vivo</I> tissue distribution, time-dependent excretion, and tumor accumulation of glycol chitosan nanoparticles labeled with the near-infrared (NIR) fluorophore, Cy5.5, were monitored in SCC7 tumor-bearing mice, using NIR fluorescence imaging systems. Glycol chitosan nanoparticles displayed prolonged blood circulation time, decreased time-dependent excretion from the body, and elevated tumor accumulation with increasing polymer molecular weight. The results collectively suggest that high molecular weight glycol chitosan nanoparticles remain for longer periods in the blood circulation, leading to increased accumulation at the tumor site. Accordingly, we propose that enhanced tumor targeting by high molecular weight glycol chitosan nanoparticles is related to better <I>in vivo</I> stability, based on a pharmacokinetic improvement in blood circulation time.</P>