Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice

Tae Kyeong Shin,Mi Sun Kang,Ho Youn Lee,Moo Sang Seo,Si Geun Kim,Chi Dae Kim,Won Suk Lee 대한생리학회-대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3

This study aimed to investigate whether selective serotonin reuptake inhibitors (SSRIs) attenuate brain injury and facilitate recovery following photothrombotic cortical ischemia in mice. Male ICR mice were anesthetized and systemically administered Rose Bengal. Permanent focal ischemia was induced in the medial frontal and somatosensory cortices by irradiating the skull with cold light laser. The animals were treated with fluoxetine or sertraline once a day for 14 d starting 1 h after ischemic insult. Treatment with fluoxetine and sertraline significantly reduced the infarct size. The Evans blue extravasation indices of the fluoxetine- and sertraline-treated groups were significantly lower than that of the vehicle group. Treatment with fluoxetine and sertraline shifted the lower limit of the mean arterial blood pressure for cerebral blood flow autoregulation toward normal, and significantly increased the expression of heme oxygenase-1 (HO-1) and hypoxia-inducible factor-1Ձ (HIF-1Ձ) proteins in the ischemic region. These results suggest that SSRIs, such as fluoxetine and sertraline, facilitate recovery following photothrombotic cortical ischemia via enhancement of HO-1 and HIF-1Ձ proteins expression, thereby providing a benefit in therapy of cerebral ischemia.

Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice

Shin, Tae-Kyeong,Kang, Mi-Sun,Lee, Ho-Youn,Seo, Moo-Sang,Kim, Si-Geun,Kim, Chi-Dae,Lee, Won-Suk The Korean Society of Pharmacology 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3

This study aimed to investigate whether selective serotonin reuptake inhibitors (SSRIs) attenuate brain injury and facilitate recovery following photothrombotic cortical ischemia in mice. Male ICR mice were anesthetized and systemically administered Rose Bengal. Permanent focal ischemia was induced in the medial frontal and somatosensory cortices by irradiating the skull with cold light laser. The animals were treated with fluoxetine or sertraline once a day for 14 d starting 1 h after ischemic insult. Treatment with fluoxetine and sertraline significantly reduced the infarct size. The Evans blue extravasation indices of the fluoxetine- and sertraline-treated groups were significantly lower than that of the vehicle group. Treatment with fluoxetine and sertraline shifted the lower limit of the mean arterial blood pressure for cerebral blood flow autoregulation toward normal, and significantly increased the expression of heme oxygenase-1 (HO-1) and hypoxia-inducible factor-1 ${\alpha}$ (HIF-1 ${\alpha}$) proteins in the ischemic region. These results suggest that SSRIs, such as fluoxetine and sertraline, facilitate recovery following photothrombotic cortical ischemia via enhancement of HO-1 and HIF-1 ${\alpha}$ proteins expression, thereby providing a benefit in therapy of cerebral ischemia.

석청(Mad-honey) 복용 후 유발된 부정맥 1예

김용철,김남호,김승환,최준호,박은미,이상재,이은미,유남진,윤경호,오석규,정진원 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

석청에 포함된 grayanotoxin에 의해 독성 작용이 나올 수 있으며, 이러한 독성 작용은 일반적으로 24시간 이내 저절로 회복된다. 최근에 본 저자들은 석청 복용 후 발생한 심실빈맥을 경험하였기에 보고하는 바이다. 49세 남자가 호흡곤란으로 내원하였으며, 내원당시 분당 40회 정도의 동성 서맥이 관찰되었고, 수액을 투여하던 중 심실 빈맥이 발생하였다. 항부정맥제를 투여 후 정상 동율동으로 전환되었으며, 특별한 이상 없이 4일 후 퇴원하였다. Mad-honey intoxication caused by the consumption of honey producted from the nectar of rhododendrons. The grayanotoxins cause the intoxication. The toxic effects of mad-honey poisoning are rarely fatal and generally last for no more than 24 hours. We experienced one case, a 49 years-old man who presented with dyspnea after ingestion of mad-honey. He showed marked sinus bradycardia with < 40 beats per minute on admission. The cardiac rhythm was changed to ventricular tachycardia immediately. These features resolved completely in 24 hours with continuous infusion of amiodarone(600 mg per day) and fluids. We report the case of intoxication of mad-honey as a presentation of fatal cardiac arrhythmia.

응급의료센터 과밀화 해소를 위한 환자 전원

이경룡,구홍두,박인철,김승환,장석준,심호식 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2

To reduce the degree of overcrowding in level Ⅲ emergency care centers, authors have conducted a prospective study of patient who were transferred to level Ⅰ or Ⅲemergency center based on the non-emergent patient guideline currently used at the severance Hospital, level Ⅲ emergency center, during the period of 65 days from Jan. 1st 1995 to Mar. 6th 1995. Followings are guideline for non-emergent patient described by the Korean government low: 1) systolic blood pressure greater than 80/100 of normal. 2) respiration rate between 10 to 24 per minute. 3) pulse rate between 60 to 100 per minute. 4) body temperature between 36 to 37.5℃ by rectal. 5) relatively alert mental status. 6) patient not requiring emergency operation at the time of examination. The results were as follows: 1. Among the total 5,301 patients, 464 patients ranged from age of 1 to 82 years old were transferred to level Ⅰor Ⅱ emergency center after simple treatment. 2. Among the 464 patients, 276 patients were treated in expected hospital with medical problems in 101 (36.6%) patients, and 175 (63.4%) patients had surgical problems. 3. Among the 276 patients, 122 (44.2%) patients were admitted, 145 (52.9%) patients were discharged from the emergency room after adequate treatment. 4. Among the transferred patients, simple laceration (33.0%) were most common, acute gastroenteritis (12.0%), and simple contusion (10.5%) were followed. These results suggest that about 10% of patients visiting level Ⅲ emergency care center, can be safely transferred to nearest level Ⅰor Ⅱ emergency centers on the bases of non-emergent patient guideline described by Emergency Medical Service law. These guideline, if put into proper use, can reduce the degree of overcrowding problems in level Ⅲ emergency care center through out the country.

GFRP판으로 보강된 R/C 슬래브의 진동해석

김경진,이정호 충주대 산업과학기술연구소 1998 産業科學論文集 Vol.6 No.-

The problem of deteriorated reinforced oncrete(R/C) slab is very serious all over the world. Before making any decision on repair work, reliable non-destructive evaluation is necessary. One of the dependable methods is to evaluate the in-situ stiffness with the one obtaining the natural frequency. By comparing the in-situ stiffness with the one obtained at the design stage, the degree of damage can be estimated rather accurately. In this paper, the strengthening method is introduced by the natural frequency, and the result of vibration analysis of R/C slab strengthened with GFRP is presented.

고흥반도 연안에 분포하는 浮遊性 卵·仔稚魚 종조성의 계절변동

한경호,신영호,황동식 한국어류학회 2002 韓國魚類學會誌 Vol.14 No.1

전라남도 고흥군 녹동연안에서 2000년에 계절별로 총 4회에 걸쳐 만조시 채집된 浮遊性 卵·仔種魚의 종조성 및 양적변동을 조사하였다. 조사기간 동안 채집된 浮遊性 卵은 총 8개 분류군이 출현하여 7개 분류군은 種 수준까지, 1개 분류군은 기타난으로 동정되었다. 그 중에선 멸치(Engraulis japonica)가 전체 출현량의 52.1%를 차지하여 가장 우점하였으며, 다음으로 기타난이 13.2%, 주둥치(Leiognat husnuchalis)가 12.3% 보리멸(Sillago sihama)이 8.6%, 앨퉁이(Maurolicus muelleri) 4.0%, 전어 (Konosirus punctatus) 1.0%, 참서대(Cynoglossus joyneri) 0.2%을 차지하였다. 仔種魚는 총 8目 26科 33屬 37개 분류군의 仔種魚가 출현하여,33개 분류군은 種 수준, 2개 분류군은 屬수준, 2개 분류군은 科 수준까지 동정되었다. 조사기간 동안 출현한 仔種魚 중에서 멸치가 31.7%를 차지하여 최우점하였으며, 망둑어科(Gobiidae)에 속하는 어류는 46.2%, 베도라치(Pholis nebulosa)와 실고기(Syngnathus schlegeli)는 각각 5.4%와 2.3%를 차지하였다. 조사기간 동안 출현한 仔種魚 중에서 이들 4개 분류군이 차지한 비율은 85.6%를 차지하였다. The ichthyoplankton were sampled during four different months (2000) to study their seasonal variations and species composition off Kohung Peninsula. During the study, the fish eggs were identified to eight taxa, seven of which were identified to species level, and one identified to order. The most dominant species. Engraulis japonicus, accounted for 52.1% of the total fish eggs, followed by Leiognathus nuchalis(4.0%), Sillago sihama(8.6%), Maurolicus muelleri(8.6%), Sardinops melanostictus(4.0%), Konosirus punctatus(1.0%), Cynoglossus joyneri(0.2%). The collected larvae and juveniles were identified to 37 taxa (33 genera, 26 families, 8 orders). Of these, 33 were identified to species level, and two were identified to genus and family level, respectively. The dominant species, Engraulis japonicus, accounted for 31.7% of the total larvae and juveniles; it was followed by Gobiidae(46.2%), Pholis nebulosa(5.4%) and Syngnathus schlegeli(2.3%). These four taxa constituted 85.6% of the total collected larvae and juveniles.

스파크 플라즈마 소결에 의한 구조 세라믹스의 최근 연구동향

백성호,조경식 금오공과대학교 산업기술개발연구원 2000 産業技術開發硏究 Vol.16 No.-

Recently the spark plasma sintering(SPS) have been developed for fabrication of metal, ceramics and composites. It is similar to conventional hot pressing, in that it is carried out in a graphite die, but the heating is by means of direct current of about 1000 to 8000A, pulsed by a power generator, applied through electrodes at the top and bottom of the die punch. The powders are heated initially by spark discharge between the particles. The SPS method was found that structural ceramics with excellent mechanical properties could be obtained at lower sintering temperatures and in shorter holding times, compared with hot pressing and hot isostatic pressing. This paper reports as a resent development in structural ceramics by SPS.

위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

자폐증상이 있는 혈우병 A 환아의 전신 마취를 통한 치과적 치험례

박경순,이긍호 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.3

본 증례의 혈우병 및 자폐증 환아의 치료를 통해 다음과 같은 결론을 얻었다. 1. 혈우병 환자의 내원시 내과의사나 소아과의사 및 혈액학자에게 의뢰를하여 출혈정도 및 부족인자 보충 등에 관한 자문을 얻어야 한다. 2. 매우 심한 중증의 혈우병 환자이거나 외과적 수술등으로 인해 많은 출혈이 예상될 경우에는 포괄적인 환자 관리를위해 입원 치료를 해주어야 한다. 3. 자폐증으로인한 행동조절이 어렵거나 그외 다른 요인에 의해 행동조절이 불가능한 혈우병 환자의 경우 입원치료가 필요하다. 4. 치과 시술을 행할때에는 최소의 관혈적인 치과치료 행하도록 노력해야 하며, 응급상황을 대비해서 국소적인 지혈방법을 습득해야 한다. 5. 치과 시술시 환자의 동통 완화 및 소염작용을 위한 약물 처치시에도 주의를 요한다. Non-steroidal anti-inflammatory drugs는 혈소판응집을 방해하기 때문에 동통완화를 위해서는 aspirin 대신에 acetaminophen을 사용하며, 소염효과를 위해서는 steroid 계통의 약물을 사용하며 ibuprofen, indomethacin, phenylbutazone 등의 약제 사용은 금 한다. 6. 혈우병 환자라고 해서 두려워하거나 치과치료의 질을 변경해서는 안된다. This case report is a treatment of patient with hemophilia A and autism. The patient's chief complaint was treatment of dental caries on entire dentition and he has an impacted mesiodens located on the apex of the upper right primary central incisor. The patient was consulted with pediatrician and anesthetist about the detailed discussion of the complexities of hemorrhagic disorder. Because he had some problems of behavior management and bleeding, the treatment was done under the gerneral anesthesia. The following results were obtained. 1. Consult with the patient's physician and hematologist about the replacement therapy and bleeding tendency. 2. For the severe hemophiliac child who requires extensive or surgical treatment, general anesthesia may be indicated for the comprehensive care. 3. For the hemophiliac child who has a behavior management problem due to autism and other defects, general anesthesia may be considerable. 4. Care must be taken during dental procedures not to causing a bleeding. 5. Local hemostatic methods must be acquired for the emergency state. 6. Neve prescribe aspirin or non-steroidal anti-inflammatory drugs such as ibuprofen, indomethacin, and phenylbutazone. These drugs affect platelet aggregation and exaggerate the bleeding defect. 7. Do not be afraid of hemophiliac patient, and never compromise quality of dental care.

도서분류자동화를 위한 지식베이스의 설계에 관한 연구

이경호 大邱大學校 社會科學硏究所 1992 社會文化硏究 Vol.11 No.-