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      • 자외선 조사에 의한 인체 각질형성세포 세포고사 방어인자에 관한 연구

        박수홍,박준홍,이종석,황규왕,김계정 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

        Back ground: Human skin is continuously exposed to UV irradiation. Ultraviolet irradiation of human skin cause sunburn cell which is relevant to the apoptosis of keratinocytes. In the epidermis, apoptosis inducing factors and anti-apoptotic factors probably exist to maintain the integrity of keratinocytes. Objective: The purpose of this study was to investigate the exsistence of apoptosis inducing factors and anti-apoptotic defence factors by evaluation of UV induced apoptosis in cultured human keratinocyte and other keratinocyte cell lines(A-431 cells, KB cells) and its susceptibility of UV induced apoptosis in various conditions. Method: In this study, the percentages of apoptosis, necrosis and cell viability of irradiated human keratinocytes and othe keratinocyte cell lines by MMT assay and AO/EO stain. The percentages of those were measured before UVB irradiation and 8, 24, 48 hours after UVB irradiation. Also, the same evaluations were performed with irradiated human keratinocytes cultured without growth factor and with enough growth factors, both results were compared with each other. And the effect of cycloheximide, a protein synthesis inhibitor was evaluated. Also that of aurintricarboxylic acid(ATA), an inhibitor of endonucleases which play an important role in inducing apoptosis of human keratinocytes was evaluated. Result: Human keratinocytes and other keratinocyte cell lines(A-431 cells, KB cells) were cultured in vitro developed maximal apoptosis 48 hours after irradiation, keratinocytes were more resistant to UV induced apoptosis than the others. The withdrawal of growth factors from keratinocyte and addition of cycloheximide decreased the cell survival rate following UV irradiation and increased the induction of apoptosis. And ATA inhibited UV induced apoptosis. Conclusion: These results indicate that human keratinocytes have both anti-apoptotic factors and apoptosis inducing factors to maintain the homeostasis. And survival signals mediated through growth factors or cellular proteins are responsible for the resistance to apoptosis observed in keratinocytes in vitro.

      • 고강도 콘크리트 레미콘 제조 및 실용화 개발

        이계학,김학수 호남대학교산업기술연구소 1997 산업기술연구논문집 Vol.4 No.-

        최근에 이르러 건축구조물의 고층화, 다양화, 공사현장의 품질관리의 증진 그리고 혼화제의 개발에 따라 콘크리트의 고강도화가 실효성을 가져오기에 이르렀다. 본 연구는 현재 레미콘공장에서 사용하고 있는 여러가지 재료를 이용하고 배합설계를 통하여 고강도콘크리트 실용화에 따른 다양한 문제를 해결하려는데 목적을 두었다. 특히, 본 연구결과에서 슬럼프 10㎝, 고성능감수제(2.0%), 부순골재 약 20㎜, 그리고 W/(C+SF) 25%, 보통 포틀랜드 시멘트의 배합상태에서 700∼800㎏/㎤ 강도를 얻을 수 있었다. 따라서 본 연구의 여러 가지 실험데이타는 앞으로 레미콘회사에서 고강도 콘크리트를 생산하는데 많은 참고와 도움이 될 것으로 기대된다. Recently, it is fairly easy to make high strength concrete according to high-rising of buildings, improvement of field supervion, and development of water reducing admixtuer (high range water reducer). The objective of this paper is to solve the various problems related to the practical use of high strength concrete by use of materials and mix proportion design as used in the remicon company. From the result of this experiment, it is found that the high strength concrete (more than 700∼800㎏/㎤) can be obtained by using slump(10㎝), high water reducer (2.0%), crushed stone (about 20㎜), and water-cement ratio(W/C+SF):25%) with common portland cement. The results of this paper are expected to be helpful in producing of high strength concrete at remicon company.

      • KCI등재

        조직확장술및 장골이식을 이용한 하악골 결손부의 재건

        이계영,민경인,정수일,박재범,안재진,김도균,김철환 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.4

        Soft tissue expansion is widely used technique in oral & maxillofacial reconstruction and provide new method of reconstruction in posttraumatic alopecia, post burn, wide scar, congenital deformity, benign tumor, tattoo, etc. Expanded tissue flaps have the advantage of increased vascularity, proximity to the defect, and similarity of color and texture. They also preclude the need to advance flaps from distant sites. Tissue expansion can be used to form a well vascularized cavity to accomodate and nourish bone grafts. The following report describes the uses of tissue expanders by allowing bone grafting to correct both soft and bony defects of mandibular region

      • SCOPUSKCI등재

        여대생과 직장여성들의 사회적지지, 우울, 음주, 흡연에 대한 비교 연구

        김옥수,김계하 성인간호학회 2001 성인간호학회지 Vol.13 No.3

        The purpose of the study was to investigate social support, depression, drinking and smoking in college and working females. The convenience sample consisted of 169 college females and 133 working females. Data were collected from March to May 2000. Social support was measured by the 6-item Social Support Questionnaire which assesses the size of the emotional social support network and satisfaction with social support. The Center for Epidemiologic Studies Depression scale was utilized to measure the level of depression symptoms. The average number of drinks and cigarettes smoked per week during the previous month was assessed. Results indicated that college students had more social support than working females. However there were no significant differences in satisfaction with their support. depression. drinking and smoking between two groups. College females who smoked cigarettes were more depressed and had less social support than those who did not smoke. Also college females who drank alcohol were more depressed than those who did not drink during the previous month. However, the level of social support and depression were not associated with drinking and smoking among working females. Based on the results, it is suggested the application of various interventions to deal with drinking and smoking behavior among college and working females.

      • KCI등재

        기업의 교육·훈련 투자 실적과 성과요인과의 관련성 연구

        박계홍,권혁수 한국중소기업학회 2002 中小企業硏究 Vol.24 No.3

        교육·훈련 투자비와 기업성과요인들과의 관련성을 연구하기 위하여 2000년 말 현재 우리나라 제조업 500여개 업체를 대상으로 우편조사를 실시하여 분석이 가능한 49개 업체를 중심으로 분석하였다. 교육·훈련 투자비와 성과요인들과의 관련성에 대한 기존 연구의 검토와 이론정리를 통해 가설을 설정하고, 실증분석을 실시하였다. 교육·훈련 투자비를 종속변수로 한, 비용함수를 추정하여 교육·훈련 투자가 생산성에 어느 정도 영향을 주고 기업의 고용안정성에도 어느 정도 기여하는지 조명하였다. TheAn Empirical study on the relationship of the important factors determining the performance of organization(employment separation rate, average monthly real wage, labour productivity) as they have influenced on the existence, growth and the development of an organization. Therefore, this study was conducted to provide suggestion for a future research by establishing the most important factors determining the success of organization relations among in terms of factors affecting the efficiency of Cost Education Vocational Training they provide centering on the influence caused by such factors. On the basis of this theoretical observation we established models and hypotheses of research. We carried out at the same time positive analysis with a survey by questionnaire in order to verify the research hypotheses(Manufacturing 49 unit). We proceeded to the survey by questionnaire after confirming relevancy of the research model in preliminary examination. We performed statical disposition and analysis of the samples based on this. Before verifying the research hypotheses We conducted analysis of factors to secure the soundness and reliability of measuring tools. Then, We carried out descriptive statistical analysis of the distribution and statistical amount of the variables used in this study. Finally, We utilized such statistical analysis as multiple regression analysis, parameter regression analysis and process analysis.

      • 시각언어로서의 Pictogram에 관한 연구

        명계수 건국대학교 부설 조형연구소 1993 조형연구 Vol.2 No.-

        Today we experience chaos. The waste of human and material resource and the canalization of almost all creative effort into blind alleys bear witness to the fact that our common life has lost its coherency. Development industrial and advanced in science and technology have created a new dimension. Today, all people of the world are neighbors, and neighbors resources on a hitherto undreamed of scale are within the potential reach of all. The inherited structure of a smaller, outgrown world, however, stands in the way of the integration of our lives in the terms of the present wider dimension. And to achieve a livable life today, then, we must reorient ourselves, and create forms in terms of present historical conditions. Instead of allowing both a further haphazard accumulation of scientific discoveries and a planless technological expansion. it is our task of establish an organic interconnection of the new frontiers of knowledge. Integration, planning, and form are the key words of all progressive efforts today the goal is new vital structure order, a new form (visual language) on a social plane, in which all present knowledge and technological possessions may function unhindered as a whole. The pictogram as visual communication, the language of vision, is one of the strongest potenitial means both to reunite man and his knowledge and to re-form man into an integrated being. The visual language is capable of disseminating knowledge more effectively than almost any other communication media. With it, man can express and relay his experiences in object form. Visual communication is universal and international-it knows no limits of tongue, vocabulary, or grammar, and it can be perceived by the illiterate as well as by the literate. A pictogram can convery facts and ideas in a wider and deeper range than almost any other means of communication. It can reinforce the static verbal concept with the sensory vitality of dynamic imagery. It can interpret the new understanding of the physical world and social events because dynamic inter-relationships interpenetration, which are significant of every advanced scientific understanding of today, are intrinsic idioms of the contemporary medias of visual communication.

      • 멀티미디어 시대의 광고 유형에 관한 연구 : Centered Around Advertisement on the Internet 인터넷 광고를 중심으로

        명계수 건국대학교 조형연구소 1999 조형연구 Vol.7 No.-

        It has often been said that the biggest mass media are TV, Radio, Newspaper, Magazine. In America the fifth media next to the four kinds of media is Computer or the Technique Concerning to Computer. In the new media age rushing to us there has been great changes in the world of advertisement. As the words 'new media' literally means, it demand avoidance from the traditional ad style and initiation to the new lifestyle and approaches totally different from the old ones for all media, agent, and customers. The rapid progress to the worldwide new media times links with the development of splendid new media times(multimedia times in the narrow sense) through commercial on-line service. CD-Rom, PCtelecommunication, internet, etc. Multimedia functions not only as new media but also plays such roles as advertisement, sales promotion, salesman and money collection, and management and marketing communication. These days internet has been growing rapidly because of its advantage for telecommunication, entertainment, and media for education as well as of its strength for the means of electronic trade. Internet is being used widely in all economic fields, e.g. cooperation with suppliers, management of goods and stocks, reduction of purchase expenses, amangement of goods and stocks, reduction of purchase expanses, management of new customers. As for media, we could distinguish the existing media, such as media for prints, image, and movies from the new media without such traditional form, i. e. multimedia computer. CD-Rom, laser disk, up-to-date faximile, portable PCS, electronic publishing, etc. These new services pertain the technical features of Computerization in common, which have changed the existing one-way services into two-way modes. The advertisement through these new media Internet has been rising up rapidly as new ad-media because of its possibility of two-way communication and prompt purchase right after receiving the advertisement.

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