머리염색이 인체에 미치는 영향

윤형식,황성호,이현륭,김수호,박연석,권낙현,정호진,김동훈,노현주,홍성호,박병찬,이관,정해관 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.1

일상생활에서 모발염색은 흔히 접할 수 있는 미용의 한 종류로 특히 젊은층을 중심으로 폭발적으로 유행하고 있다. 염색을 위항 사용하는 약제는 표백제와 발색제 등 각종 화학약품이 사용되고 있으나 이로 인한 건강장해에 대한 연구는 그리 많지 않다. 저자들은 염색이 인체의 모발건강에 미치는 영향을 파악하기 위하여 염색과 관련된 주관적 증상과 모발의 변화에 대한 실험적 연구를 시행하였다. 동국대학교 경주 캠퍼스 재학생 80명을 대상으로 설문조사를 시행하여 염색 유 ·무 및 염색 후에 경험한 증상에 대해 설문 조사하였고, 의과대학 재학생 46명을 대상으로 피부 반응 테스트를 실시하였다. 또한 염색 전후의 모발 탄성도를 측정하였고 모발의 상태를 파악하기 위해 전자 현미경검사를 실시하였다. 설문조사 결과 염색 전에 비하여 염색 후 안구혼탁, 안구건조, 시력저하, 발진 및 접촉성 피부염, 모발손상, 모근손상 등의 증상을 더 많이 경험한다고 호소하였다(p<0.05). 모발손상과 모근손상은 헤어드라이어 사용 빈도에 따라 증가하는 것으로 조사되었다(p<0.05). 피부반응검사에서 가려움증이 가장 많은 증상이었으며 이는 여성보다는 남성에서 높은 것으로 조사되었다. 염색 전후의 모발장력은 염색 전 134.5±10.37g, 염색 128.0±30.69g, 염색 이틀 후 112.5±19.69g으로 나타났다. 염색 전후의 모발의 전자현미경 케라틴 층이 현저히 감소하고 모발이 가늘어지는 차이를 보였다. 염색은 모발손상, 모발 케라틴 손상 및 모근 손상, 발진 및 접촉성 피부반응, 안구혼탁, 안구건조, 시력 저하를 유발한다. 따라서 염색약으로 인한 손상에 대한 주의와 예방이 필요하다고 생각한다. 예방대책으로 염색 전 피부테스트를 통한 적합성 여부를 판단하는 것이 필요하며 가급적 염색을 피하는 것이 좋을 것이다. 염색약에 발암물질이 포함되어있다는 보고도 있어 염색 제조사의 철저한 실험과 염색 물질의 선별이 염색으로 인한 부작용을 최소화하는데 중요한 역할을 할 것이다. Hair coloring has became one of the most popular cosmetic activities to younger generations during last decade. However, there are few studies on the health effect of widespread use of chemical dyes. This study was conducted to study the effects of hair coloring dye on hair and other systems. We conducted a questionnaire survey of 80 persons in Kyongju campus, Dongguk University. We have done open patch skin test on 46 medical students. We also conducted scanning electron microscopy to examine the hair strength and structure before and after hair coloring process. Injury of hair and hair bulb, contact dermatitis, turbid eyes, xerophthalmia, and poor visual acuity were the main symptoms complained after hair coloring (p<0.05). Injury of hair and hair bulb were increased by frequency of hair-dryer use(p<0.05). In open patch test, pruritus was complanined by more than half of the subjects. Mean strength of hairs before and after hair coloring was as follows; 134.5 (SD 10.37)g before hair coloring, 128.0 (SD 30.69)g immediately after hair coloring, and 112.5 (SD 19.69)g after two days. The scanning electron microscopic findings of hair surface before and after hair coloring showed decreased keratin layer and thinning of the hair. Hair coloring induces injury to hair, its keratin layer, and hair bulb as well as contact dermatitis, turbid eyes, xerophthalmia, and poor visual acuity. Therefore, we think that precaution is needed in use of hair coloring dye. To prevent complications induced by hair coloring dye, it is necessary, especially to those with allergy or skin disorders, to perform skin test before action and avoid hair coloring whenever possible. Longterm health effects of hairdye should be studied and manufacturing companies should try to minimize complications induced by hair coloring dye.

동종 골수이식 후 만성 이식편대숙주질환과 동반되어 신증후군으로 발현된 IgA 신병증 1예

정철권,김현수,박준성,정성현,조도연,최진혁,남동기,임호영,김명성,신규태,임현이,김효철 대한조혈모세포이식학회 1999 대한조혈모세포이식학회지 Vol.4 No.2

동종 골수이식 후 발생하는 신기능부전은 원인이 다양하여 감별에 어려움이 있다. 만성 GVHD는 흉선의 기능저하에 따른 면역관용의 실패로 발생되는 자가면역현상에 의해 발생되는 것으로 알려져 있으며 드물게 신장을 침범하여 신증후군을 일으키기도 한다. CaA의 용량을 줄이거나 투약중지 후 발생한 만성 GVHD에 동반된 신증후군의 경우 조기에 신조직검사를 시행하여 감별진단하고 CsA의 용량을 증량하거나 재투약하여 좋은 치료 결과를 보일 것으로 기대된다. 저자들은 문헌고찰을 통해 동종 골수이식 후 발생된 신증후군이 유사한 임상양상을 보이며 발생기전에 만성 GVHD와 자가면역현상이 연관되어 있음을 확인하였으며 동종 골수이식 후 신증후군의 임상양상을 보이는 환자에서 병리조직학적으로 lgA 신병증을 진단하고 이러한 lgA 신병증이 발생기전에 만성 GVHD와 자가 면역현상이 연관되어 있을 가능성을 최초로 확인하였으며 CsA를 이용하여 성공적으로 치료한 경험을 하였기에 보고하는 바이다. Renal insufficiency is occasionally encountered in allogeneic bone marrow transplantation and its cause is difficult to ascertain. Chronic graft-versus-host disease (GVHD) related to thymic dysfunction is immune-mediated and involves autoreactivity of T-lymphocytes derived from donor marrow to recipient's major histocompatibility complex(MHC) minor antigens. The clinical mainifestations of chronic GVHD are similar to those of autoimmune disease but kidney involvement is rare. Few cases of nephrotic syndrome with membranous nephropathy or minimal change nephrotic syndrome have been reported to be associated with chronic GVHD in allogeneic bone marrow transplant recipient especially after cyclosporine A(CsA) withdrawal, and these cases have responded well to CsA. Therefore, it is prudent to differentiate the cause of post-transplant renal insufficiency using renal biopsy and to start CsA in a case of nephrotic syndrome associated with chronic GVHD as early as possible. We report a case who had a massive proteinuria during the post-allogeneic marrow transplantation period. The cause of nephrotic syndrome was diagnosed as IgA nephropathy by renal biopsy. The patient was successfully treated with reintroduction of CsA.

안면신경 마비 환자에 있어서의 측두근 및 근막피판을 이용한 안면근 기능 회복 증례보고

정창주,권혁도,엄인웅,우승철,민승기,정호용 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.1

Generally, the totally paralyzed face can never be made normal by any of the current methods of reconstruction. Careful selection of patients based on sound judgment of what can and cannot be achieved by the proposed surgical technique is paramount to a successful operation and a satisfied patient. The results are related to time of delayed between injury and repair : the shorter the delay the better are the results. The objectives in correcting facial paralysis are to achieve normal appearance at rest ; symmetry with voluntary motion ; control of the ocular, oral, and nasal sphincter; symmetry with involuntary emotion and controlled balance when expressing when expressing emotion ; and no significant functional deficit secondary to the reconstructive surgery. It must be employed a number of concepts, for treatment of the paralyzed face by surgeon, depending on the cause, time interval, and wound characteristics, as well as the availability of and necessity for neuromuscular substitution. Nerve grafts, crossovers, muscle transfers, free muscle and nerve-muscle grafts, micronuerovascular muscle transfers, and regional muscle transpostion are the principal methods being developed. We applied the tmporal musle transposition for reanimation of unilatrally paralyzed faces for long times on two patients. The results of muscle transposition can be enhanced by the patient's learning to activate the transposed muscle by voluntary effort, and are best in patients who are motivated to learn the necessary motor-sensory coordination techniques.

혐기성 변성 아크릴계 접착제의 제조 및 접착 특성

주혁종,오인석,권호길,최돈묵 忠南大學校 産業技術硏究所 1991 산업기술연구논문집 Vol.6 No.2

An experimental study was performed to prepare the anaerobic acrylic adhesives with TEGDMA(Trietylene Glycol Dimethacrylate), acrylic acid, p-benzoquinnone and CTBN(Carboxyl Terminated Butadiene Nitrile) To characterize the anaerobic modifided acrylic adhesives, tensile shear adhesion strength, DSC, FT-IR, water resistance, chemicals resistance and oil resistance of adhesives were tested. The results obtained in this study could be summerized as follows; 1. Tensile adhesion shear strength was increased with increasing the adding amounts of p-benzoquinone up to 75kgf/㎠ when 0.163wt% added. 2. After a water resistance test for 72hrs, tensile shear adhension strength maintenance was dominant(about 72%) in the C-3 as compared with the others and alkaline solution resistance of adhesives was excellent on the whole as compare to acid solution. 3. The gasoline, light oil resistance of adhesives were very good enough that could be used in the field of mechanical connecting parts.

한국인 몸쪽 정중-자신경연결(Martin-Gruber anastomosis)의 해부학적 연구

이규석,김호정,권오헌 關東大學校 醫科大學 醫科學硏究所 2004 關東醫大學術誌 Vol.8 No.2

This study was performed to clarify the morphological characteristics of the Marin-Gruber anastomosis(MGA) in Korean adults. Dissection with surgical microscope was carried out in 95 cadaveric upper limbs. MGA was found in 36 upper limbs(37.9%). These anastomosis were classified to the four types. Type Ⅰ is the communication between the anterior interosseous nerve and the ulnar nerve(n=7, 19.4%). Type Ⅱ is the communication between the median nerve and the ulnar nerve(n=14, 38.9%). Type Ⅲ is the communication between the muscular branches distributing to the flexor digitorum profundus muscle(n=7, 19.4%). Type Ⅳ is the mixed patterns of type Ⅰ and Ⅲ or type Ⅱ and Ⅲ(n=8, 22.2%). The anatomical frequency of MGA in Korean adults was found to be higher than other races except in Russian. The levels of the anastomosis from the line connecting epicondyles of the humerus were average 4.8(range 0.6-8.8) cm at the median nerve and average 5.6(range 2.5-12.2) cm at the ulnar nerve. The thickness of the communicating branches was average I.2(range 0.4-2.1) mm. These metric data may be a guide to hand surgeon dealing with the electrodiagnosis and surgical practice.

MgO/Fe₂O₃복합금속산화물 표면에서의 CCl₄분해와 H₂O흡착에 의한 morphology의 변화

김혜진,박동곤,권호진 숙명여자대학교 자연과학연구소 1996 자연과학논문집 Vol.- No.7

임계상태 건조법과 진공하 열처리에 의하여 합성한 MgO의 nanocrystal위에 Fe₂O₃층을 조성하여 MgO/Fe₂O₃이중층 복합금속산화물을 합성함에 따라, 표면에 CCl₄가 흡착분해되는 효율이 큰폭으로 증가하는 것이 관찰되었으며, 거의 모든 MgO가 정량적으로 MgCl₂로 전환되는 것이 관찰되었다. 이와같은 초미립자 시료는 그 표면에 H₂O가 흡착되면 시료의 일부 혹은 전부가 금속 hydroxide로 전환되면서 표면적이 크게 감소되고 기공의 평균크기와 형태도 변화되는 것이 관찰되었다. Nanocrystalline MgO was synthesized by vacuum-heating Mg(OH)₂ aerogel prepared by supercritically drying corresponding alcogel. When Fe₂O₃ layer was applied on the surface of the MgO, forming MgO/Fe₂O₃ double layered composite oxides, the efficiency of the destructive adsorption of CCl₄ was greatly enhanced, and it was observed that the conversion of MgO to MgCl₂ was almost stoichiometric. When H₂O was adsorbed on the surface of these nanocrystals, a part or all of the MgO was converted to Mg(OH)₂ and concomitant decrease in the surface area and change of pore morphology were observed.

빌트인 모터를 이용한 2축 제어 미세 가공기 개발

김건희,김효식,양순철,이상용,국명호,이선규,김윤중,홍권희 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-

This paper describes development of low cost precision machine that has combined the Build-in Motor with a vacuum chuck. This study mainly aims to find out a cutting condition for maintaining optimum surface condition and to examine cutting characteristics of the precision machine that is equipped by diamond bites. The cutting materials is Al alloy. Several experiments were carried out to find out the main factors that affect the surface roughness such as principal axis RPM(rotation per minute), feeding speed, and cutting depth. As a result, we obtain The optimum cutting condition of the developed precision machine.

이면성 및 도플러 심초음파도를 이용하여 진단한 선천성 거대 좌회선지-좌심실 관동맥루

진승원,박준철,이영중,유병현,박현옥,김용주,윤호중,김재형,홍순조,최규보,권종범,원용순,박건 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

Experimental study on the method of estimating the vertical design wave force acting on a submerged dual horizontal plate

Kweon, Hyuck-Min,Oh, Sang-Ho,Choi, Young-Hwan The Society of Naval Architects of Korea 2013 International Journal of Naval Architecture and Oc Vol.5 No.4

A steel-type breakwater that uses a submerged dual horizontal porous plate was originally proposed by Kweon et al. (2005), and its hydrodynamic characteristics and design methodology were investigated in a series of subsequent researches. In particular, Kweon et al. (2011) proposed a method of estimating the vertical uplift force that acts on the horizontal plate, applicable to the design of the pile uplift drag force. However, the difference between the method proposed by Kweon et al. (2011), and the wave force measured at a different time without a phase difference, have not yet been clearly analyzed. In this study, such difference according to the method of estimating the wave force was analyzed, by measuring the wave pressure acting on a breakwater model. The hydraulic model test was conducted in a two-dimensional wave flume of 60.0 m length, 1.5 m height and 1.0 m width. The steepness range of the selected waves is 0.01~0.03, with regular and random signals. 20 pressure gauges were used for the measurement. The analysis results showed that the wave force estimate in the method of Kweon et al. (2011) was smaller than the wave force calculated from the maximum pressure at individual points, under a random wave action. Meanwhile, the method of Goda (1974) that was applied to the horizontal plate produced a smaller wave force, than the method of Kweon et al. (2011). The method of Kweon (2011) was already verified in the real sea test of Kweon et al. (2012), where the safety factor of the pile uplift force was found to be greater than 2.0. Based on these results, it was concluded that the method of estimating the wave force by Kweon et al. (2011) can be satisfactorily used for estimating the uplift force of a pile.

Experimental study on the method of estimating the vertical design wave force acting on a submerged dual horizontal plate

Hyuck-Min Kweon,Sang-Ho Oh,Young-Hwan Choi 대한조선학회 2013 International Journal of Naval Architecture and Oc Vol.5 No.4

A steel-type breakwater that uses a submerged dual horizontal porous plate was originally proposed by Kweon et al. (2005), and its hydrodynamic characteristics and design methodology were investigated in a series of subsequent researches. In particular, Kweon et al. (2011) proposed a method of estimating the vertical uplift force that acts on the horizontal plate, applicable to the design of the pile uplift drag force. However, the difference between the method proposed by Kweon et al. (2011), and the wave force measured at a different time without a phase difference, have not yet been clearly analyzed. In this study, such difference according to the method of estimating the wave force was analyzed, by measuring the wave pressure acting on a breakwater model. The hydraulic model test was conducted in a two-dimensional wave flume of 60.0 m length, 1.5 m height and 1.0 m width. The steepness range of the selected waves is 0.01~0.03, with regular and random signals. 20 pressure gauges were used for the measurement. The analysis results showed that the wave force estimate in the method of Kweon et al. (2011) was smaller than the wave force calculated from the maximum pressure at individual points, under a random wave action. Meanwhile, the method of Goda (1974) that was applied to the horizontal plate produced a smaller wave force, than the method of Kweon et al. (2011). The method of Kweon (2011) was already verified in the real sea test of Kweon et al. (2012), where the safety factor of the pile uplift force was found to be greater than 2.0. Based on these results, it was concluded that the method of estimating the wave force by Kweon et al. (2011) can be satisfactorily used for estimating the uplift force of a pile.