Clinical implications of anti-thyroglobulin antibody measurement before surgery in thyroid cancer

( Kwanhoon Jo ),( Dong-jun Lim ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.6

Thyroglobulin antibody (TgAb) is a class G immunoglobulin and a conventional marker for thyroid autoimmunity. From a clinical perspective, TgAb is less useful than thyroid peroxidase antibodies for predicting thyroid dysfunction. However, TgAb is found more frequently in differentiated thyroid cancer (DTC) and can in-terfere with thyroglobulin (Tg) measurements, which are used to monitor the re-currence or persistence of DTC. Recent studies suggested a small but consistent role for preoperative TgAb in predicting DTC in thyroid nodules, and in reflect-ing adverse tumor characteristics or prognosis, including lymph node metastasis, but this is still controversial. Postoperative TgAb can serve as a biomarker for remnant thyroid tissue, so follow-up measures of TgAb are useful for predicting cancer recurrence in DTC patients. Since high serum TgAb levels may also affect the fine needle aspiration washout Tg levels from suspicious lymph nodes of DTC patients, it is important to use caution when interpreting the washout Tg levels in patients who are positive for TgAb.

Characteristics and Clinical Outcomes of Elderly Patients with Trauma Treated in a Local Trauma Center

Kwanhoon Park,Geonjae Cho,Sungho Lee,Kang Yoon Lee,Ji Young Jang 대한외상중환자외과학회 2023 Journal of Acute Care Surgery Vol.13 No.1

Purpose: This study aimed to investigate the characteristics of elderly patients who visited a non-regional trauma center to examine the effects of old age on the clinical outcomes of patients. Methods: The medical charts of 159 patients with trauma who visited the National Health Insurance Service Ilsan Hospital between March 2020 and February 2022 were retrospectively analyzed. Results: Of the 159 patients, 41 were assigned to the elderly patient group (EPG) and 118 were assigned to the non-elderly patient group (NEPG). The average age of patients in each group was 75.5 and 38.2 years in the EPG and the NEPG, respectively. Comparing the injury mechanism between the two groups, pedestrian traffic accidents (TA) were the most common (24.4%), followed by slipping (19.5%), motorcycle TA, and bicycle TA (14.6%) in EPG. In the NEPG, motorcycle TA (28.0%) was the most common, followed by car TA (27.1%), and fall injury (16.9%), with a significant difference between the two groups (p < 0.001). The significant differences between the two groups were the injury severity score (ISS; p = 0.004), severe trauma (p = 0.045), intensive care unit admission (p = 0.028), emergency operation (p = 0.034), and mortality (p = 0.013). The statistically significant risk factors for mortality were old age (p = 0.024) and chest injury (p = 0.013). Conclusion: Patients in the EPG compared with the NEPG group showed different injury mechanisms. The EPG has a higher severity and mortality rate than the NEPG.

Korean Red Ginseng Water Extract Restores Impaired Endothelial Function by Inhibiting Arginase Activity in Aged Mice

Kwanhoon Choi,Jeongyeon Yoon,Hyun Kyo Lim,Sungwoo Ryoo 대한생리학회-대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.2

Cardiovascular disease is the prime cause of morbidity and mortality and the population ages that may contribute to increase in the occurrence of cardiovascular disease. Arginase upregulation is associated with impaired endothelial function in aged vascular system and thus may contribute to cardiovascular disease. According to recent research, Korean Red Ginseng water extract (KRGE) may reduce cardiovascular disease risk by improving vascular system health. The purpose of this study was to examine mechanisms contributing to age-related vascular endothelial dysfunction and to determine whether KRGE improves these functions in aged mice. Young (10±3 weeks) and aged (55±5 weeks) male mice (C57BL/6J) were orally administered 0, 10, or 20 mg/mouse/day of KRGE for 4 weeks. Animals were sacrificed and the aortas were removed. Endothelial arginase activity, nitric oxide (NO) generation and reactive oxygen species (ROS) production, endothelial nitric oxide synthase (eNOS) coupling, vascular tension, and plasma peroxynitrite production were measured. KRGE attenuated arginase activity, restored nitric oxide (NO) generation, reduced ROS production, and enhanced eNOS coupling in aged mice. KRGE also improved vascular tension in aged vessels, as indicated by increased acetylcholine-induced vasorelaxation and improved phenylephrine-stimulated vasoconstriction. Fur-thermore, KRGE prevented plasma peroxynitrite formation in aged mice, indicating reduced lipid peroxidation. These results suggest KRGE exerts vasoprotective effects by inhibiting arginase activity and augmenting NO signaling and may be a useful treatment for age-dependent vascular diseases.

Wider reference ranges of serum thyroid stimulating hormone in pregnant Korean women: is it time to stop overtreatment?

( Kwanhoon Jo ),( Dong-jun Lim ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.3

방사성 의약품 자동합성장치용 단채널 감마선 분광기 보드의 설계 및 제작

송관훈(Kwanhoon Song),김광수(Kwangsoo Kim) 대한전자공학회 2014 전자공학회논문지 Vol.51 No.4

본 논문에서는 방사성 의약품의 자동합성장치에 사용되는 단채널 감마선 분광기를 보드 형태로 설계, 제작하고 그 특성을 측정 분석하였다. 감마선 검출을 위해 CZT (CdZnTe) spear 검출기를 이용하였고 아날로그 방식을 적용한 신호처리 보드의 형태로 감마선 분광기를 제작하였다. 측정을 위하여 방사성 물질인 Co-60을 시료로 사용하였으며, 최대 1173keV까지의 감마선 에너지 스펙트럼을 얻을 수 있었다. 아날로그 보드는 CZT spear 검출기에서 감마선을 검출하여 출력하는 신호를 적절히 변화시켜주기 위한 SF (shaping filter) 및 PHA (peak and hold amplifier)와 수치화된 감마선 신호 데이터를 계산하기 위한 ADC (analog to digital converter)와 FPGA (field programmable gate array)로 구성되었다. In this paper, the prototype of one-channel gamma-ray spectroscope for automatic radiopharmaceutical systhesis system was designed and characterized. The prototype employed CZT (CdZnTe) spear detector for gamma-ray detection and employed analog-type signal processing method. A radioactive sample Co-60 was used for measuring performance of the gamma-ray spectroscope and energy spectrum is gained with bandwidth of 1173keV. The analog board is made up of SF (shaping filter) and PHA (peak and hold amplifier) for shaping CZT output signal appropriately and ADC (analog to digital converter) and FPGA (field programmable gate array) for drawing gamma-ray spectrum by counting the digitalized gamma-ray signal data.

멀티 테넌트 환경에서 이종 워크로드 간 성능 간섭 영향 분석

이관훈(Kwanhoon Lee),이경운(Kyungwoon Lee),윤유림(Yurim Yoo),유혁(Chuck Yoo) 한국정보과학회 2021 한국정보과학회 학술발표논문집 Vol.2021 No.6

Lowered cutoff of lymph node fine-needle aspiration thyroglobulin in thyroid cancer patients with serum anti-thyroglobulin antibody

Jo, Kwanhoon,Kim, Min-Hee,Lim, Yejee,Jung, So-Lyung,Bae, Ja-Seong,Jung, Chan-Kwon,Kang, Moo-Il,Cha, Bong-Yun,Lim, Dong-Jun BioScientifica Ltd. 2015 European journal of endocrinology Vol.173 No.4

<P><B>Objective</B></P><P>Fine needle aspiration cytology (FNAC) and measurement of thyroglobulin (Tg) in needle washout (FNA-Tg) are recommended for the diagnosis of metastatic or recurrent lymph nodes (LNs) in differentiated thyroid cancer (DTC). However, the effect of serum Tg antibody (TgAb) on FNA-Tg levels still remains unclear in the preoperative setting. We analyze the interference of serum TgAb on FNA-Tg levels as proof of concept in the diagnostic advantage of serum TgAb combined with FNA-Tg.</P><P><B>Subjects and methods</B></P><P>A total of 370 suspicious cervical LNs from 273 patients with DTC were included. The primary tumor was confirmed as DTC on preoperative pathology in all patients. We performed FNA-Tg measurement and FNAC on suspicious LNs and evaluated the diagnostic performance of FNAC and FNA-Tg according to TgAb status. Final diagnoses were confirmed by histological examination of excised specimens or by follow-up ultrasonography for at least 6 months.</P><P><B>Results</B></P><P>Data from 273 subjects with suspicious 370 LNs were evaluated. Fifty-five LNs (14.9%) were from TgAb+ positive serum TgAb (TgAb+) patients. Serum Tg and FNA-Tg levels were significantly lower in patients with TgAb+ than in those with TgAb-negative (TgAb−). Final pathology confirmed 109 LNs (29.5%) asmalignant. Diagnostic performance of FNA-Tg at the same cutoff level was lower in the TgAb+ than TgAb− group. FNA-Tg cutoff levels determined by ROC curve were lower in the TgAb+ group.</P><P><B>Conclusion</B></P><P>The results suggested that the cutoff value of FNA-Tg should be lowered in suspicious LN before thyroidectomy in thyroid cancer patients with TgAb.</P>

Korean Red Ginseng Water Extract Restores Impaired Endothelial Function by Inhibiting Arginase Activity in Aged Mice

Choi, Kwanhoon,Yoon, Jeongyeon,Lim, Hyun Kyo,Ryoo, Sungwoo The Korean Society of Pharmacology 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.2

Cardiovascular disease is the prime cause of morbidity and mortality and the population ages that may contribute to increase in the occurrence of cardiovascular disease. Arginase upregulation is associated with impaired endothelial function in aged vascular system and thus may contribute to cardiovascular disease. According to recent research, Korean Red Ginseng water extract (KRGE) may reduce cardiovascular disease risk by improving vascular system health. The purpose of this study was to examine mechanisms contributing to age-related vascular endothelial dysfunction and to determine whether KRGE improves these functions in aged mice. Young ($10{\pm}3$ weeks) and aged ($55{\pm}5$ weeks) male mice (C57BL/6J) were orally administered 0, 10, or 20 mg/mouse/day of KRGE for 4 weeks. Animals were sacrificed and the aortas were removed. Endothelial arginase activity, nitric oxide (NO) generation and reactive oxygen species (ROS) production, endothelial nitric oxide synthase (eNOS) coupling, vascular tension, and plasma peroxynitrite production were measured. KRGE attenuated arginase activity, restored nitric oxide (NO) generation, reduced ROS production, and enhanced eNOS coupling in aged mice. KRGE also improved vascular tension in aged vessels, as indicated by increased acetylcholine-induced vasorelaxation and improved phenylephrine-stimulated vasoconstriction. Furthermore, KRGE prevented plasma peroxynitrite formation in aged mice, indicating reduced lipid peroxidation. These results suggest KRGE exerts vasoprotective effects by inhibiting arginase activity and augmenting NO signaling and may be a useful treatment for age-dependent vascular diseases.

The Occurrence of a Thyroid Storm in a Patient with Recurrent Refractory Peptic Ulcer: A Case Report

Park Kwanhoon,Jang Ji Young,Lee Sungho 대한외상중환자외과학회 2022 Journal of Acute Care Surgery Vol.12 No.1

A thyroid storm is a rare complication of hyperthyroidism. Although a thyroid storm rarely presents with symptoms similar to those of an acute abdomen, and in cases where emergency surgery is needed, the thyroid function test is not performed routinely. In this study, we report a case in which hyperthyroidism was diagnosed after surgery in a patient with recurrent refractory peptic ulcer disease. Although peptic ulcer disease and hyperthyroidism rarely coexist, when the patient's initial condition was reviewed in the Emergency Department, the findings were reasonable for panperitonitis due to peptic ulcer perforation, which is considered as a condition suitable for a thyroid storm. This isolated case indicates a logical leap in the correlation between peptic ulcer and thyroid storm. In recurrent refractory peptic ulcer disease, the thyroid function test may be helpful as a routine laboratory test before emergency surgery.

적대적 M&A과정에서 주주의 역할

곽관훈(Kwak, KwanHoon) 한양법학회 2011 漢陽法學 Vol.33 No.-

In the case of the hostile M&A, target company tries to protect the M&A so as to maintain the independence of a target company. In this time, therefore, it is common for the target company to employ various defensive measures. Major defensive measures available to a target company include poison pill, lock-up, and so on. But, it is impossible that the target company has prepare defensive measures of hostile M&A in Korea. Because the Corporate Act in Korea has been not permitted to introduce defensive measures for hostile M&A. The past decade has witnessed extraordinary growth in the assets held by institutional investors, specially pension funds. Institutional investors have both greater incentives to intervene in management than the individual shareholder, and that intervention by them is much more practicable. Therefore, institutional investors, specially pension funds, have a great role to improve of corporate governance in our markets. For this reason, expectation role of shareholder has been changed. It is important that the shareholder of target company has prepare defensive measures of hostile M&A. Therefore our corporate law should permit for shareholder to introduce defensive measures for hostile M&A. In this article, I would like to explore the expectation role of shareholder, and then necessity to introduce defensive measures for hostile M&A.