정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Adamkiewicz 동맥의 폐색에 의한 척수경색 1례

이광훈,이종걸,이태연,신동익,이성현,이상수,한설희,차상훈 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

Sezary증후군과 병발된 용혈성 빈혈 1예

유광하,진춘조,김홍승,이종인,심영학,정순희,이창훈 건국대학교 의과학연구소 1997 건국의과학학술지 Vol.- No.7

남해주민들의 운동행동변화단계에 따른 변화과정, 의사결정균형 및 자기효능감

천광훈,고광욱,김윤지,신용현 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Background: The purpose of this study was to examine the differences of the process of change, decisional balance. self-efficacy and perception of subjective health according to the stages of exercise behaviors suggested by transtheoretical medals among Namhae resident. For systemic continuos health promotion initiatives of public health center, basic information about exercise behaviors in need. Method: The stage of change, decision balance, self efficacy and other health-related information was surveyed from systematic sample of Namhae population. Result: The result of process of change was precontemplation (32.4%), contemplation (18.8%), preparation (18.8%), action (11.0%), and Maintenance (23.6%). Conclusion: There are corroborative evidence about the need for interpersonal organizational intervention to exercise behaviors of Namhae population and social alternative for the exercise behavior.

Practical experiences and requirements on workflow

김광훈,장병옥,백수기 경기대학교교육대학원 1997 경기교육논총 Vol.6 No.-

瓦松이 家兎의 腎機能에 미치는 影響

申炳勳,金光鎭 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.1

Orostachys malacophyllus Fischer(Tsume renge) is a plant to grow on the tiled roof of the house, and in the field or the mountain. And the compositions of the plant have not been known yet. But it has transmitted to this time as a kind of medical plant from remote antiquity. Sometimes, it is used in the folk remedies for the treatment of the malignant diseases. But it is not clear in the therapeutic effect. This study was attempted to investigate the effect of the water extract of Tsume renge on the renal function of rabbits. Physiological saline was infused into the jugular vein for the hydration of rabbit(30ml/hr), and the urine and blood were collected to take the control values after the steady state. Samples were collected by the regular interval of time during the infusion of 0.5% solution of Tsume renge water extract in the physiological saline. The results obtained were summarized as follows: 1. The urine volume, glomerular filtration rate, and renal plasma flow were 0.095±0.013 ml/min. 5.66±0.39 ml/min. and 21.01±1.52 ml/min, respectively. But their flow rates were decreased significantly during the infusion of the solution of water extract. 2. The water extract of Tsume renge had no any effects on the renal tubular reabsorption of the osmolar substances and the electrolytes. 3. The negative free water clearance was decreased significantly during the infusion of the water extract of Tsume renge. From the above results, it was suggested that the water extract of Tsume renge affected to the renal hemodynamics and the mechanism of water reabsorption in the renal tubules.

주의력결핍 과잉행동장애 아동에 있어서 연속수행검사의 진단적 유용성

구본훈,박형배,이희정,송창진,김진성,이광헌 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

서 론: 본 연구는 주의력결핍 과잉행동장애(이하 ADHD) 아동과 정상대조군의 연속수행검사(이하CPT) 결과 양상을 비교하여 CPT의 진단적 유용성을 알아보고자 하였다. 그리고, ADHD 아동의 연령과 성별, 지능, 그리고, 장애의 유형 등과 같은 변수에 따른 CPT의 결과양상을 비교하여, CPT가 ADHD의 어떤 특성을 잘 반영해주는가를 알아보고자 하였다. 대상 및 방법: DSM-Ⅳ의 진단기준에 의하여 진단이 내려진 ADHD 실험군 68명과 정상대조군 30명을 선정하였으며, 두 군간의 연령과 성별을 통제하였다. 실험군과 정상대조군 모두 환아의 부모가 ADHD 평가척도(ADDES-HV)를 작성하였으며, 환아에게 직접 CPT를 실시하였고 지적 능력을 평가하기 위해 K-ABC를 시행하였다. 결 과: 실험군과 정상대조군에서의 CPT 결과 양상을 비교하였을 때, 실험군과 정상대조군 사이에 민감도가 유의한 차이를 나타내었고, 반응 기준도 유의한 차이를 나타내었다(p<0.05). ADHD 아동을 대상으로 연령과 지능의 변화에 따른 CPT의 결과 양상을 비교하였을 때, 연령과 지능이 증가함에 따라 CPT각각의 결과들도 대체로 수행력이 호전되는 경향을 나타내었다. 주의력결핍 과잉행동 장애의 유형을 과잉행동을 동반한 군과 과잉행동을 동반하지 않은 군으로 나누어 비교분석을 한 결과, CPT 각각의 결과에서 유의한 차이는 나타나지 않았다. CPT 결과 양상에 있어서 남녀간 차이점을 비교하였을 때, 오경보오류와 정반응시간의 표준편차, 표준편차의 다양성, 그리고, 민감도가 유의한 차이를 나타내었다(p<0.05). CPT 각각의 8가지 결과 변수들에 대해 판별분석을 실시한 결과, 각각의 결과 변수들에 있어서 진단에 대한 전체 판별력이 모두 50%이상을 나타내었다. 그 중, 정반응시간의 표준편차와 표준편차의 다양성, 그리고, 민감도는 진단에 대한 전체 판별력이 모두 60%이상을 나타내었다. 결론 및 고찰: 이러한 결과들은 CPT가 ADHD의 진단에 있어서 어느 정도의 유용성을 가지고 있다는 점을 보여준다 하겠다. 즉, ADHD에 있어서 CPT는 비교적 선별검사와 같은 목적으로는 유용할 것으로 생각되며, 이는 또한 CPT가 장애의 진단에 있어서 보조적인 검사도구임을 나타낸다 하겠다. Objectives: The purpose of this study was to examine to diagnostic availability of CPT in children with ADHD, and what factors are affected to CPT results in the diagnosis of ADHD. Method: CPT, ADHD scales(ADDES-HV), K-ABC were administered to 68 ADHD patients and 30 normal elementary school students as the control group. Also, ages and sex are controlled between two groups. Results: In the differences of the results of CPT between ADHD patients and normal subjects, attentiveness and risk taking are significantly different(p<0.05). In the differences of the results of CPT between ages in ADHD patients, usually as more aged children are better performances in CPT. Also, in the differences of the results of CPT between intelligence in ADHD patients, usually as higher intelligent children are better performances in CPT. There are no differences of the results of CPT between types of ADHD in ADHD patients. In the differences of the results of CPT between sex in ADHD patients, commission error, hit reaction time standard error, variability of standard error, and attentiveness are significantly different between male and female patients(p<0.05). The correlations between ADHD scales and the results of CPT show that inattention subscale is significantly related to hit, omission error, hit reaction time standard error, and variability of standard error. In the discriminant ability between ADHD patients and normal children by the results of CPT, accuracy rates are more than 50% in all results of CPT. Especially, the accuracy rate of hit reaction time standard error, and the accuracy rate of variability of standard error, and also, the accuracy rate attentiveness are more than 60%. Conclusion: In this point of view, this study suggest that CPT is relatively valuable method in the diagnosis of ADHD. For instances, CPT is more likely to screen the ADHD from normal children, or to use as assisted method of diagnosis of ADHD in clinical settings.

Gd₂O₃doped CeO₂에서의 Al₂O₃ 및 Ga₂O₃의 고용도한

최광훈,이주신 경성대학교 공학기술연구소 2002 공학기술연구지 Vol.9 No.-

The solid solubility limits of Al_2O_3 and Ga_2O_3 in Gd_2O_3 doped CeO_2 were determined by X-ray diffraction and scanning electron microscope measurements. The solubility limit of Al_2O_3 in Gd_2O_3 doped CeO_2 was found to be 2 mol%, and Ga_2O_3 was found to be 5 mol%. It is expected that the determination of the solid solubility limits will give an important information in a study on the promotion of the sintering properties with sintering aids addition.

NC 공작기계에서의 임의곡면가공에 관한 연구

이광희,노승훈,정선환 金烏工科大學校 1991 論文集 Vol.12 No.-

Many parts of the automobiles, ships and airplanes have complicated shapes and surfaces which are difficult to be defined analytically. These shapes are mostly expressed using wire-frame models, surface models, solid models, etc.. Many researches have also been done for defining surfaces by Bezier, Ferguson, Coons, et al.. All the above mentioned methods are basically point-connecting techniques, and consequently it is not easy to obtain the tool paths. In this study, therefore, the effort was concentrated on developing a soft-ware which can automatically define a tool path as a function from the data set obtained from a practical model. It can also help PC send the information to the machine tool much more effectively.

터어보機械 回轉翼에서 亂動後流의 數値解析

金炅勳,安光憲 慶熙大學校 1983 論文集 Vol.12 No.-

The wakes of turbomachinery rotor blade are turbulent, three dimensional, and are subjected to curvature and rotation effects. The objective of this study is to predict the development of such wakes and compare the predictions with the existing data. A finite difference precedure in employed in the numerical analysis of the wake utilizing the continuity, momentum, and turbulence closure equation in the rotating curvilinear and non-orthogonal coordinate system. The effects of curvature and rotation on the turbulence structure are accounted for with this turbulence closure model. The predictions from the present turbulence model agree well with the mean velocity and the turbulence wake data.