조산의 예측 지표로서의 fetal fibronectin의 유용성

정집광,이해혁,이정재,이석민,이순곤,남계현,이임순,이권해 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Objective: The purpose of this study was to evaluate clinical efficacy of fetal fibronectin as a marker to predictor of preterm labor. Materials & Methods: The study group consisted of sixty-eight healthy pregnant women, at gestational age between 24 and 36 weeks, who visited our department with vaginal discharge from April, 1995 to December, 1997. For comparison, we divided all of the pregnant women into two groups by the result of ROM-Check^®, positive groups(N=21) and negative groups(N=47). When preterm labor appeared, 50mg of ritodrine hydrochloride(Yutopar^®) mixed I liter of 5% dextrose solution was administered slowly intravenously. Results: 1) The gestational age at delivery and the interval time from admission to delivery in the positive groups were significantly shorter than those of the negative groups(p<0.05). 2) The positive groups had significantly lower birth weight and Apgar scores than the negative groups(p<0.05). 3) Among the negative groups, in case of tocolytics administration, the interval time from admission to delivery significantly delayed more than that time in case of no tocolytics administration(p<0.05). Conclusions: The detection of the fetal fibronectin in vaginal discharge had a useful method as a predictor of preterm labor. Tocolytics was more effective in the negative groups than in the positive groups.

폐경기 여성에서 호르몬 대치 요법시 병행 투여된 프로제스토젠 투여 방법에 따른 혈청 지질 및 지단백에 미치는 영향

이임순,전섭,이순곤,이해혁,이권해,정집광,이석민 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

Objective : The purpose of our study is to evaluate the effect of different administration method of progestogen on lipid profiles including total cholesterol, LDL(low density lipoprotein)-cholesterol, HDL(high density lipoprotein)-cholesterol, triglycerides during hormone replacement therapy in postmenopausal women. Methods and Materials : Seventy-one postmenopausal women who were assigned to following groups (Group I : conjugated equine estrogen(CEE), 0.625 mg/day plus continuous medroxyprogesterone acetate (MPA), 2.5mg/day, Group II : CEE, 0.625 mg/day plus cyclic MPA, 5mg/day for 12days/month. And we measured serum total cholesterol, high density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol, and triglycerides before hormone replacement therapy(HRT) and 12 months later after hormone replacement therapy. Results: 1. Total cholesterol decreased in group I,III. 2. HDL-cholesterol increased in group I,II,III. 3. LDL-cholesterol decrease in group I,II. 4. Triglycerides increased in group I,II,III. There was significance in serum total cholesterol and LDL-cholestrerol among three groups. Conclusions : Estrogen alone or in combination with progestogen both in cyclic and continuous use improves lipid profiles, so medroxyprogesterone acetate(MPA) does not seem to blunt estrogenic effect on lipid profiles.

대전시 노은 도매시장 채소류의 농약 잔류 실태 및 식이섭취량 추정

한국탁,이규승,이은경,이용재,고광용,원동준,이정원,권순덕 한국환경농학회 2003 한국환경농학회지 Vol.22 No.3

대전시 노은 도매시장에서 채취한 6종의 채소류 중 농약잔류량을 조사한 후 이에 대한 위해성 평가를 실시하였다. 전체 100건의 분석시료 중 농약이 검출된 시료의 비율은 46.0%이었고, 잔류허용기준 초과비율은 6.0% 이었다. 검출비율이 높은 시료는 상추(85.0%), 깻잎(80.0%), 오이(60.0%) 순이었고, 상추 3건, 깻잎 3건이 허용기준을 초과하였다. 살균제는 dicar-boximide계, 유기염소계, azole계 농약, 살충제는 유기인계, 합성 pyrethroid계 농약이 많이 검출되었다. 검출빈도가 높은 성분은 procymidone, chlorpyrifos, chlorothalonil, cypermethrin, EPN의 순이었다. 위해성을 평가하기 위해서 각 농작물에 대한 농약의 추정 섭취량과 ADI를 비교한 결과, 허용기준을 초과한 깻잎의 bitertanol, triflumizole, iprobenphos가 다른 성분에 비하여 높은 비율을 보였다. 그러나 각 농산물의 식이섭취량이 적어 ADI에 대한 추정섭취량의 비율이 0.46%이하로 나타나 그 영향이 매우 낮은 것으로 판단되었다. Pesticide residues in some vegetables collected at Noeun wholesale market in Daejeon were surveyed and assessed their risk In 100 samples, the detection rate of pesticide was 46.0% and the rate exceed MRL was 6.0%. Commodities showing high detection rate were lettuce(85.0%), perilla leaf(80.0%) and cucumber(60.0%). Dicarboximide, organochlorine, and azole fungicides and organophosphorus and pyrethroid insecticides were detected. Detection frequency of pesticide was in the order of procymidone, chlorpyrifos, chlerothalonil, cypermethrin and EPN. When the estimated intake amount of the pesticides were compared with ADI to assess their risk, bitertanol, triflumizole and iprobenphos in perilla leaf were higher rate than the other vegetables. However the total amounts of intake of pesticides were estimated to less than 0.46% of ADI.

전격성 경과를 취한 만성 호산구성 폐렴 환자 1예

윤호상,진춘조,유광하,이상엽,이수인,정상만,김선두,이순제,이길도,전혜정 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Chronic eosinophilic pneumonia(CEP) is a rare disease of unknown etiology characterized by chronic infiltration of the lung with eosinophils. It presents with profound systemic symptoms comprising fever, night sweats, weight loss, dyspnea and blood eosinophilia with nonsegmental air-space consolidation confined to the outer third of the lung, the "photographic negative of pulmonary edema". Histopathologic features of chronic eosinophilic pneumonia are intraalveolar and interstitial infiltrations with eosinophils, histiocytes, giant cells, scattered lymphocytes and plasma cells. Glucocorticoid therapy cause prompt resolution of symptoms as well as disappearans of blood eosinophils, elevated serum Ig E levels and the roentgenographic lesions. Infrequent radiographic findings include nodular infiltrates, consolidations, cavitations, atelectasis and pleural effusions. Deaths from CEP although rare, have been reported, but the majorities of CEP have benign courses and do not need a therapy with ventilator. We report a case of chronic eosinophilic pneumonia, which had a sudden course associated with diffuse pneumonic consolidations on the both lung and bilateral pleural effusion.

Rocuronium의 애별투여방법이 모지내전근의 이완에 미치는 영향

최영균,김승수,이원진,조광래,이상은,김영환,임세훈,이정한,이근무,정순호,김영재,신치만 인제대학교 2009 仁濟醫學 Vol.30 No.-

Objective : There are controversies in pnmmg technique of rocuronium whether it can or can't shorten the onset time. We want to compare the effects of two different priming doses and intervals of rocuronium. Materials and Methods : After giving propofol, 50 patients were randomly assigned to 5 groups. Group I received a placebo, followed 3 min later by rocuronium 0.6 mg/kg. Priming doses and intervals of Group II, Ill, N, V were 0.06 rng/kg and 2 min, 0.12 mg/kg and 2 min, 0.06 rug/kg and 3 min, 0.12 mg/kg and 3 min, respectively. Total dose of rocuronium was 0.6mg/kg. Train of four (TOF) count or ratio and 1st twitch height of TOF (T1) were monitored with 15 secondsintervals. TOF ratio of each groups just before bolus injection, duration for TOF count to reach zero and duration for Tl to reach 95% depression after bolus injection were compared. Results : Duration for TOF count to reach zero and duration for Tl to reach 95% depression after bolus injection were decreased in priming groups compared to Group 1 (P < 0.01) In group V, significant depression of TOF ratio just before bolus injection was seen (P < 0.05). Conclusion : Priming technique with rocuronium is effective method to shorten the onset of neuromuscular block. But priming dose of rocuronium itself could cause hypoxia and aspiration in awake patients and should be used carefully. Priming dose of rocuronium 0.06 mg/kg and 2 minutes interval maybe relatively safe method.

텍실브로모보란-메틸 설피드 착물의 합성과 환원특성

이재철,이광우,차진순,김진억 嶺南大學校附設 基礎科學硏究所 1985 基礎科學硏究 Vol.5 No.-

A new reducing agent, thexylbromoborane-methyl sulfide complex (ThxBHBr.SMe₂), was synthesized from the reaction of tetramethylethylene and monobromoboranemethyl sulfide complex. The reducing characteristics of the reagent to the representative organic compounds have been studied systematically under the standardized conditions (0℃, methylene chloride). Thus, the reagent appeared as a mild selective reducing agent, especially on the partial reduction of carboxylic acids to the corresponding aldehydes.

TiO₂미세분말 제조에 관한 연구

이광래,안순철,송근호,김종수 강원대학교 석재복합신소재제품연구센터 1998 석재연 논문집 Vol.3 No.-

역마이셀 기법에 의하여 TiO₂ 분말을 제조하였으며, TiO₂ 분말 제조에 미치는 공정변수들인 계면활성제의 종류 및 보조계면활성제가 생성입자의 입도분포에 미치는 영향을 규명하였다. 비이온계면활성제인 Span 80을 사용하였을 경우에는 입도분포가 unimodal형태였으나, 음이온계면활성제인 Aerosol-OT(AOT)를 사용하였을 경우, bimodal형태를 나타내었다. 에탄올(ethanol)을 cosurfactant로 첨가한 계로 부터 생성된 입자는 평균입경이 0.12㎛ 으로서 미세할 뿐아니라 입도분포도 매우 좁은 것을 알 수 있다. Titanium dioxide (TiO₂) fine particles were produced by the reverse micelle technique. The effects of process variables such as surfactant and cosurfactant on particle size distribution were investigated. The particle size distribution curve was unimodal for a nonionic surfactant (Span80), but was bimodal for an anionic surfactant (AOT). The addition of ethanol as a cosurfactant resulted in narrow particle size distribution and 0.12㎛ of smaller average particle diameter.

확장된 Huckel 이론에 의한 이원자 분자의 고찰

李廣純,洪宗基 聖心女子大學校 1987 論文集 Vol.19 No.-

원자간의 반발력을 고려하여 이원자 분자의 에너지와 전화분포등을 확장된 Huckel이론으로 구하였다. 이들 반발에너지는 Hellmann-Feynnlnn 이론으로 계산하였으며 전자의 비편재에너지는 일-전자 문제로 처리하여 구하였다. 이들 결과를 근거로 이 이론으로 고체표면에 흡착된 분자상태를 고찰하고 있다. Molecular energies of N₂ and CO isoelectron molecule are calculated by using the ASED -MD theory which is take into account of repulsion energy resulting from a molecule followed by the superposition of the rigid atom. The repulsion energies are calculated by Hellmann-Feyman electrostatic theorem. The electron delocalization energy ?? give rise by the Extended Huckel theory using one-electron Hamiltionian. We are now testing an applying this theory to the solid surface systems.

유구치 Stainless Steel Crown 주위의 치은염 치은열구 삼출액 및 치면세균막 부착도에 관한 연구

이광기,손동수 大韓小兒齒科學會 1985 大韓小兒齒科學會誌 Vol.12 No.1

The study was performed to evaluate the status of the marginal gingival tissue surrounding the Stainless Steel Crowned teeth comparing to the overall marginal gingival tissue of the same children use of plaque Index, Gingival Index and Gingival Crevichlar Fluid flow rate. The selected subjects for this study were 38 children (boys 18, girls 20) aged from 3 year - 5 month to 12 year - 3 month who have more than one Stainless Steel Crown in their mouth. The obtained results were as follows; 1. There was little deleterious effect on the marginal gingiva after delivery of Stainless Steel Crown. 2. In case of Satisfactory Stainless Steel Crown there was no deleterious effect on the marginal gingiva but in case of Unsatisfactory Stainless Steel Crown there was a little deleterious effect on the marginal gingiva. 3. In Plaque Index Stainless Steel Crowned teeth exhibited a little lower score than the natural teeth of control group but statistically there was no significant differences (p>0.05). 4. A strong positive correlation existed between the two of Gingival Index, Plaque Index and Gingival Crevicular Fluid flow rate. 5. 38.03% of examined Stainless Steel Crown was satisfactory and errors in crown crimp were the most common, with defects in crown length, position, contour, polish, contact and cementation following in order of decreasing frequency.

우측 대장에 발생한 연소성 용종 1예

이준식,박성한,홍현진,안광순,김지연,배용목,이은영,박선자 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Juvenile polyp, also known as a retention polyp because they contain mucin cysts, is a relatively common hamartomatous lesion in chlidhood. It occurs in 1-2% of children and young adults; however it is uncommon in adulthood. Juvenile polyp is rare in the first year of life and is thus presumed to be acquired and not congenital. It is pedunculated, 2-3 cm in size, red-tan in colour, smooth and always shows fluid filled cystic spaces on cut surface. Histologically, Juvenile polyps are hamartomatous with distended, mucus-filled glands, often with cystic dilatation and edematous lamina propria containing abundant vasculature. The most common manifestation is rectal bleeding produced by auto-amputation of the polyp. Juvenile polyp has been considered not to be at increased risk of developing carcinoma. However, atypical epithelium is observed in some lesions, especially in larger polyps, which may give rise to adenoma and subsequent malignant transformation. Therefore the diagnosis of solitary juvenile polyp should not be made only with colonoscopy and biopsy, but should be totally resected endoscopically for pathologic evaluation. About 90% of the lesions are solitary and localized within 20cm from anal verge. In Korea, there are some reports of juvenile polyps located in the rectosigmoid colon. We report one case of juvenile polyp in adolescent that presented as a hematochezia & abdominal pain, which is located at right colon.