Recent Trends in the Biosorption of Heavy Metals: A Review

Sag, Yesim,Kutsal, Tulin The Korean Society for Biotechnology and Bioengine 2001 Biotechnology and Bioprocess Engineering Vol.6 No.6

Considerable attention has been focused in recent years upon the field of biosorption for the removal of metal ions from aqeous effluents. Compared to other technologies, the advan-tages of biosortption are the high purity of the treated waste water and the cheap raw material. Really, the first major challenge for the biosorption field is to select the most promising types of biomass. Abundant biomass types either generated as a waste by-product of large-scale industrial fermentations particularly fungi or certain metal-binding seaweeds have gained importance in re-cent years due to their natural occurrence, low cost and, of course good performance in metal biosorption. Industrial solutions commonly contain multimetal systems or several organic and in organic substances that form complexes with metals at relatively high stability forming a very complex environment. When several components are present, interference and competition phe-nomena for sorption sites occur and lead to a more complex mathematical formulation of the process. The most optimal configuration for continuous flow-biosorption seems to the packed-bed column which gets gradually from the feed to the solution exit end. Owing to the com-petitive ion exchange taking place in the column, one or more of the metals present even at trace levels may overshot the acceptable limit in the column effluent before the breakthrough point of the trargeted metal. Occurrence of 'overshoot's and impact on havey metal removal has not been analyzed enough. New trends in biosorption are discussed in this review.

Effect of bolted splice within the plastic hinge zone on beam-to-column connection behavior

Cüneyt vatansever,Kutay Kutsal 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.28 No.6

The purpose of this study is to investigate how a fully restrained bolted beam splice affects the connection behavior as a column-tree connection in steel special moment frames under cyclic loading when located within the plastic hinge zone. The impacts of this attachment in protected zone are observed by using nonlinear finite element analyses. This type of splice connection is designed as slip-critical connection and thereby, the possible effects of slippage of the bolts due to a possible loss of pretension in the bolts are also investigated. The 3D models with solid elements that have been developed includes three types of connections which are the connection having fully restrained beam splice located in the plastic hinge location, the connection having fully restrained beam splice located out of the plastic hinge and the connection without beam splice. All connection models satisfied the requirement for the special moment frame connections providing sufficient flexural resistance, determined at column face stated in AISC 341-16. In the connection model having fully restrained beam splice located in the plastic hinge, due to the pretension loss in the bolts, the friction force on the contact surfaces is exceeded, resulting in a relative slip. The reduction in the energy dissipation capacity of the connection is observed to be insignificant. The possibility of the crack occurrence around the bolt holes closest to the column face is found to be higher for the splice connection within the protected zone.

Prognostic Significance of Nestin Expression in pT1 High-Grade Bladder Urothelial Carcinoma Patients Treated with Intravesical BCG

Sen, Volkan,Bozkurt, Ozan,Demir, Omer,Tuna, Burcin,Yorukoglu, Kutsal,Ellidokuz, Hulya,Mungan, Ugur Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24

Background: Possible roles of nestin expression in terms of predicting intravesical BCG therapy response in T1 high grade bladder cancer patients were investigated. Materials and Methods: T1 high grade bladder cancer patients who were treated with intravesical BCG between 1990-2009 were included. Immunohistochemical staining for nestin expression was performed. Nestin(+) and nestin(-) patients were compared in terms of recurrence and progression rates. Results: Sixty-three patients were included and median follow-up time was twenty-five months. After staining; 33 patients (52.4%) were classified as nestin (+) and 30 (47.6%) as (-). Nestin (+) patients were more likely to recur compared to nestin (-) patients (60.6% vs. 30%, p<0.05). Progression rates were also higher in nestin (+) patients, although this result did not reach statistical significance (15.2 % vs. 10 %, p=0.710). Conclusions: Nestin expression, which seems effective in predicting recurrence, appears to have a potential role in the urothelial carcinoma tumorigenesis. Patients with high grade bladder cancer and positive nestin expression need close follow-up and might be informed about more tendency to recur. Further comprehensive studies including larger patient cohorts may clarify the role of nestin in bladder cancer.

Can Recurrence and Progression be Predicted by HYAL-1 Expression in Primary T1 Bladder Cancer?

Mammadov, Elnur,Aslan, Guven,Tuna, Burcin,Bozkurt, Ozan,Yorukoglu, Kutsal Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23

Background: Molecular prognostic markers have been under investigation for the last decade and no validated marker to date has been proven to be used in daily clinical practice for urinary bladder cancers. The aim of the present study is to evaluate the significance of HYAL-1 expression in prediction of recurrence and progression in pT1 urothelial carcinomas. Materials and Methods: Eighty-nine urothelial carcinoma cases staged as T1 according to 2004 WHO classification were studied. Representative sections from every case were stained immunohistochemically for HYAL-1 and scored between 0 and +3, according to staining density, and graded as low and high for the scores 0-1 and 2-3, respectively. Results: Of the 89 pT1 bladder cancer patients, HYAL-1 expression was high in 92.1% (82 patients; 72 patients +3 and 10 patients +2) and low in 7.9% (only 7 patients; 6 patients +1 and 1 patient 0) of the cases. Of the 89 patients, 38 (42.7%) had recurrence and 22 (24.7%) showed progression. HYAL-1 staining did not show significant characteristics for tumor grade, accompanying CIS, multiplicity, tumor size, age and sex. HYAL-1 expression did not have any prognostic value in estimating recurrence or progression. Conclusions: HYAL-1 expression was found to be high, but did not have any prognostic importance in T1 bladder urothelial carcinomas.

Prostate Cancer Incidence in Turkey: An Epidemiological Study

Zorlu, Ferruh,Divrik, Rauf Taner,Eser, Sultan,Yorukoglu, Kutsal Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21

Background: This study aimed to determine the incidence of prostate cancer in Turkey in a population-based sample, and to determine clinical and pathological characteristics of the cases. Materials and Methods: All newly diagnosed prostate cancer patients were included in this national, multi-centered, prospective and non-interventional epidemiological registry study conducted in 12 cities representing the 12 regions of Turkey from July 2008 to June 2009. The population-based sample comprised 4,150 patients with a recent prostate cancer diagnosis. Results: Age-adjusted prostate cancer incidence rate was 35 cases per 100,000 in Turkey. At the time of diagnosis, median age was 68, median PSA level was 10.0 ng/mL. Digital rectal examination was abnormal in 36.2% of 3,218 tested cases. Most patients had urologic complaints. The main diagnostic method was transrectal ultrasound guided biopsy (87.8%). Gleason score was ${\leq}6$ in 49.1%, 7 in 27.8% and >7 in 20.6% of the cases. There was a statistically significant positive correlation between serum PSA level and Gleason score (p=0.000). The majority of patients (54.4%) had clinical stage T1c. Conclusions: This is the first population-based national data of incidence with the histopathological characteristics of prostate cancer in Turkey. Prostate cancer remains an important public health concern in Turkey with continual increase in the incidence and significant burden on healthcare resources.