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Kumarasinghe Arachchigey Sriyani,Nalika Gunawardena,Sudharshani Wasalathanthri,Priyadarshika Hettiarachchi 한국간호과학회 2016 Asian Nursing Research Vol.10 No.3
Purpose: To validate the Cardiff Wound Impact Schedule (CWIS) to assess the health-related quality of life (HRQoL) of Sri Lankan patients with diabetic leg and foot ulcers. Methods: English version of CWIS was examined for cultural compatibility, translated into Sinhala and pretested. The Sinhala versionwas administered in parallel with the validated Sinhala version of SF-36 by an interviewer to all patients (n ¼ 140) at baseline to determine the construct validity. Reliability of CWIS was measured by internal consistency and test-retest stability. The instrument was readministered in 2 weeks on 33 patients with nonhealing ulcers to determine the test-retest stability and in 3 months on 50 patients with healed ulcers to determine the ability of CWIS to discriminate HRQoL between patients with healed versus nonhealed ulcers. Acceptability of CWIS was assessed by the response rate, completion rate and the average time taken to complete a single interview. Results: The construct validity demonstrated moderately significant correlations between related subscales of CWIS and SF-36 (Spearman’s r = .32 .51, p = .021 to p < .001) for the whole study sample. Internal consistencies (Cronbach a = .68 .86) and test-retest stability (.56 .70) were acceptable. The tool was sensitive in discriminating the impact of the wound on HRQoL in healed versus nonhealed status (p ≤ .001). The tool showed good acceptability. Conclusions: The Sinhala version of CWIS is valid, reliable and acceptable for assessing the impact of wound on HRQoL. This instrument is sensitive in detecting the differences of the impact of healed and nonhealed ulcers on QoL in patients with diabetic leg and foot ulcer.
Kumarasinghe R.K.K.G.R.G.,Kumarasinghe P.K.K.,Wijesundera R.P.,Dassanayake B.S. 한국물리학회 2022 Current Applied Physics Vol.33 No.-
CdCl2 treatment is crucial in the fabrication of highly efficient CdS/CdTe thin-film solar cells. This study reports a comprehensive analysis of thermal evaporated CdS/CdTe thin-film solar cells when the CdTe absorber layer is CdCl2 annealed at temperatures from 340 to 440 ◦C. Samples were characterized for structural, optical, morphological and electrical properties. The films annealed at 400 ◦C showed better crystallinity with a cubic zinc blende structure having large grains. Higher refractive index, optical conductivity, and absorption coefficient were recorded for the CdTe films annealed at 400 ◦C with CdCl2. Optimum photoactive properties for CdS/ CdTe thin-film solar cells were also obtained when samples were annealed at 400 ◦C for 20 min with CdCl2, and the best device exhibited VOC of 668.4 mV, JSC of 13.6 mA cm 2, FF of 53.9% and an efficiency of 4.9%.
Synthesis, Characterization and Antimicrobial Activity of Garcinol Capped Silver Nanoparticles
( H. N. Fernando ),( K. G. U. R. Kumarasinghe ),( T. D. C. P. Gunasekara ),( H. P. S. K. Wijekoon ),( E. M. A. K. Ekanayaka ),( S. P. Rajapaksha ),( S. S. N. Fernando ),( P. M. Jayaweera ) 한국미생물 · 생명공학회 2019 Journal of microbiology and biotechnology Vol.29 No.11
Garcinol, a well-known medicinal phytochemical, was extracted and isolated from the dried fruit rinds of Garcinia quaesita Pierre. In this study, garcinol has successfully used to reduce silver ions to silver in order to synthesize garcinol-capped silver nanoparticles (G-AgNPs). The formation and the structure of G-AgNPs were confirmed by UV-visible spectroscopy, transmission electron microscopy and Fourier transform infrared spectroscopy. The antimicrobial activity of garcinol and G-AgNPs were investigated by well diffusion assays, broth micro-dilution assays and time-kill kinetics studies against five microbial species, including Staphylococcus aureus (ATCC 25923), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 25922), Candida albicans (ATCC 10231) and clinically isolated methicillin-resistant Staphylococcus aureus (MRSA). The formation of G-AgNPs is a promising novel approach to enhancing the biological activeness of silver nanoparticles, and to increase the water solubility of garcinol which creates a broad range of therapeutic applications.
Khor, Tze Sheng,Alfaro, Eduardo E.,Ooi, Esther M. M.,Li, Yuan,Srivastava, Amitabh,Fujita, Hiroshi,Park, Youn,Kumarasinghe, Marian Priyanthi,Lauwers, Gregory Yves Lippincott Williams Wilkins, Inc. 2012 The American journal of surgical pathology Vol.36 No.3
Dysplasia in Barrett esophagus has been recognized to be morphologically heterogenous, featuring adenomatous, foveolar, and hybrid phenotypes. Recent studies have suggested a tumor suppressor role for CDX-2 in the metaplasia-dysplasia-carcinoma sequence. The phenotypic stability and role of CDX-2 in the neoplastic progression of different types of dysplasias have not been evaluated. Thirty-eight endoscopic mucosal resections with dysplasia and/or intramucosal carcinoma (IMC) arising in Barrett esophagus were evaluated for the expression of MUC5AC, MUC6, MUC2, CD10, and CDX-2. The background mucosa was also evaluated. The results were correlated with morphologic classification and clinicopathologic parameters. Of 38 endoscopic mucosal resections, 23 had IMC and dysplasia, 8 had IMC only, and 7 had dysplasia only. Among dysplastic lesions, 73% were foveolar, 17% were adenomatous, and 10% were hybrid. Twenty of 23 cases with dysplasia and adjacent IMC showed an identical immunophenotype of dysplasia and IMC comprising 16 gastric, 3 intestinal, and 1 mixed immunophenotype. Three cases showed discordance of dysplasia and IMC immunophenotype. These findings suggest that most Barrett-related IMC cases are either gastric or intestinal, with phenotypic stability during progression supporting separate gastric and intestinal pathways of carcinogenesis. CDX-2 showed gradual downregulation of expression during progression in adenomatous dysplasia but not in foveolar or hybrid dysplasia, supporting a tumor suppressor role, at least in the intestinal pathway. CDX-2 was also found to be expressed to a greater degree in intestinal metaplasia compared with nonintestinalized columnar metaplasia. Consistent with CDX-2 as a tumor suppressor, this suggests that nonintestinalized columnar metaplasia may be an unstable intermediate state at risk for neoplastic progression.