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Electron spin resonance in Eu-based iron pnictides
Krug von Nidda, H.-A.,Kraus, S.,Schaile, S.,Dengler, E.,Pascher, N.,Hemmida, M.,Eom, M. J.,Kim, J. S.,Jeevan, H. S.,Gegenwart, P.,Deisenhofer, J.,Loidl, A. American Physical Society 2012 Physical review. B, Condensed matter and materials Vol.86 No.9
Optimizing the Local Embedding of Renewable Energy Plants
Michael Krug,Dörte Ohlhorst 한국환경정책학회 2019 環境政策 Vol.27 No.S
In this article we ask about the factors that promote acceptance of local renewable energy plants and about the specific role nature conservation plays in the concert of other acceptance factors. We explored to what extent trade-offs between climate protection, nature and species protection, protection of local residents and local value creation can be realigned. The article provides an overview of the key acceptance factors identified and derives a set of trust and acceptance building measures. It has a specific focus on wind energy. Our findings suggest that nature conservation rationales have definitively a role to play as a local acceptance factor, but other acceptance factors are closely linked or more important. Particularly, economic factors, the attitudes towards the energy transition, trust in key actors and planning and development processes were identified as key preconditions for local acceptance.
<i>δ</i>-exceedance records and random adaptive walks
Park, Su-Chan,Krug, Joachim IOP 2016 JOURNAL OF PHYSICS A-MATHEMATICAL AND THEORETICAL Vol.49 No.31
<P>We study a modified record process where the <I>k</I>th record in a series of independent and identically distributed random variables is defined recursively through the condition <img ALIGN='MIDDLE' ALT='${Y}_{k}\gt {Y}_{k-1}-{\delta }_{k-1}$' SRC='http://ej.iop.org/images/1751-8121/49/31/315601/jpaaa2634ieqn1.gif'/> with a deterministic sequence <img ALIGN='MIDDLE' ALT='${\delta }_{k}\gt 0$' SRC='http://ej.iop.org/images/1751-8121/49/31/315601/jpaaa2634ieqn2.gif'/> called the handicap. For constant <img ALIGN='MIDDLE' ALT='${\delta }_{k}\equiv \delta $' SRC='http://ej.iop.org/images/1751-8121/49/31/315601/jpaaa2634ieqn3.gif'/> and exponentially distributed random variables it has been shown in previous work that the process displays a phase transition as a function of <I>δ</I> between a normal phase where the mean record value increases indefinitely and a stationary phase where the mean record value remains bounded and a finite fraction of all entries are records (Park <I>et al</I> 2015 <I>Phys. Rev.</I> E <A HREF='http://dx.doi.org/10.1103/PhysRevE.91.042707'> <B>91</B> 042707</A>). Here we explore the behavior for general probability distributions and decreasing and increasing sequences <img ALIGN='MIDDLE' ALT='${\delta }_{k}$' SRC='http://ej.iop.org/images/1751-8121/49/31/315601/jpaaa2634ieqn4.gif'/>, focusing in particular on the case when <img ALIGN='MIDDLE' ALT='${\delta }_{k}$' SRC='http://ej.iop.org/images/1751-8121/49/31/315601/jpaaa2634ieqn5.gif'/> matches the typical spacing between subsequent records in the underlying simple record process without handicap. We find that a continuous phase transition occurs only in the exponential case, but a novel kind of first order transition emerges when <img ALIGN='MIDDLE' ALT='${\delta }_{k}$' SRC='http://ej.iop.org/images/1751-8121/49/31/315601/jpaaa2634ieqn6.gif'/> is increasing. The problem is partly motivated by the dynamics of evolutionary adaptation in biological fitness landscapes, where <img ALIGN='MIDDLE' ALT='${\delta }_{k}$' SRC='http://ej.iop.org/images/1751-8121/49/31/315601/jpaaa2634ieqn7.gif'/> corresponds to the change of the deterministic fitness component after <I>k</I> mutational steps. The results for the record process are used to compute the mean number of steps that a population performs in such a landscape before being trapped at a local fitness maximum.</P>
Mutations of CEP83 Cause Infantile Nephronophthisis and Intellectual Disability
Failler, M.,Gee, H.,Krug, P.,Joo, K.,Halbritter, J.,Belkacem, L.,Filhol, E.,Porath, Jonathan D.,Braun, Daniela A.,Schueler, M.,Frigo, A.,Alibeu, O.,Masson, C.,Brochard, K.,Hurault de Ligny, B.,Novo, R University of Chicago Press [etc.] 2014 American journal of human genetics Vol.94 No.6
Ciliopathies are a group of hereditary disorders associated with defects in cilia structure and function. The distal appendages (DAPs) of centrioles are involved in the docking and anchoring of the mother centriole to the cellular membrane during ciliogenesis. The molecular composition of DAPs was recently elucidated and mutations in two genes encoding DAPs components (CEP164/NPHP15, SCLT1) have been associated with human ciliopathies, namely nephronophthisis and orofaciodigital syndrome. To identify additional DAP components defective in ciliopathies, we independently performed targeted exon sequencing of 1,221 genes associated with cilia and 5 known DAP protein-encoding genes in 1,255 individuals with a nephronophthisis-related ciliopathy. We thereby detected biallelic mutations in a key component of DAP-encoding gene, CEP83, in seven families. All affected individuals had early-onset nephronophthisis and four out of eight displayed learning disability and/or hydrocephalus. Fibroblasts and tubular renal cells from affected individuals showed an altered DAP composition and ciliary defects. In summary, we have identified mutations in CEP83, another DAP-component-encoding gene, as a cause of infantile nephronophthisis associated with central nervous system abnormalities in half of the individuals.
Optical and Magnetic Properties of MBE-Grown Manganese Sulfide Layers
W. Heimbrodt,L. Chen,H.-A. Krug Von Nidda,A. Loidl,P. J. Klar,L. David,K. A. Prior 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.5
Metastable zinc-blende MnS layers of various thicknesses from 1:8 nm to 8:6 nm have been grown by molecular beam epitaxy on (100) GaAs between ZnSe cladding layers. We studied the dependences of the optical and the magnetic properties on the layer thickness. On the one hand, the non-exponential decay of the Mn internal transition is found to be faster for thick erlayer,which is a size effect and not caused by the interfaces. On the other hand, the Neel-temperature is not altered with decreasing layer thickness, but the phase-transition-induced shift of the internal Mn transitions is smaller for thinnerMnSlayers. Thisisexplainedbythedominatingin uenceofMn ions at the interface, which possess a reduced number of Mn neighbors. SQUID measurements in a weak external magnetic eld conrm the optical observations in zero field. However, applying a strong magnetic field reveals the metamagnetic character of these zinc-blende MnS layers. An antiferromagnetic-to-erromagnetic phase transitionis found with increasing external field. Metastable zinc-blende MnS layers of various thicknesses from 1:8 nm to 8:6 nm have been grown by molecular beam epitaxy on (100) GaAs between ZnSe cladding layers. We studied the dependences of the optical and the magnetic properties on the layer thickness. On the one hand, the non-exponential decay of the Mn internal transition is found to be faster for thick erlayer,which is a size effect and not caused by the interfaces. On the other hand, the Neel-temperature is not altered with decreasing layer thickness, but the phase-transition-induced shift of the internal Mn transitions is smaller for thinnerMnSlayers. Thisisexplainedbythedominatingin uenceofMn ions at the interface, which possess a reduced number of Mn neighbors. SQUID measurements in a weak external magnetic eld conrm the optical observations in zero field. However, applying a strong magnetic field reveals the metamagnetic character of these zinc-blende MnS layers. An antiferromagnetic-to-erromagnetic phase transitionis found with increasing external field.
antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters
Weber, Tilmann,Blin, Kai,Duddela, Srikanth,Krug, Daniel,Kim, Hyun Uk,Bruccoleri, Robert,Lee, Sang Yup,Fischbach, Michael A,Mü,ller, Rolf,Wohlleben, Wolfgang,Breitling, Rainer,Takano, Eriko,Medema, Oxford University Press 2015 Nucleic acids research Vol.43 No.w1
<P><B>Abstract</B></P><P>Microbial secondary metabolism constitutes a rich source of antibiotics, chemotherapeutics, insecticides and other high-value chemicals. Genome mining of gene clusters that encode the biosynthetic pathways for these metabolites has become a key methodology for novel compound discovery. In 2011, we introduced antiSMASH, a web server and stand-alone tool for the automatic genomic identification and analysis of biosynthetic gene clusters, available at http://antismash.secondarymetabolites.org. Here, we present version 3.0 of antiSMASH, which has undergone major improvements. A full integration of the recently published ClusterFinder algorithm now allows using this probabilistic algorithm to detect putative gene clusters of unknown types. Also, a new dereplication variant of the ClusterBlast module now identifies similarities of identified clusters to any of 1172 clusters with known end products. At the enzyme level, active sites of key biosynthetic enzymes are now pinpointed through a curated pattern-matching procedure and Enzyme Commission numbers are assigned to functionally classify all enzyme-coding genes. Additionally, chemical structure prediction has been improved by incorporating polyketide reduction states. Finally, in order for users to be able to organize and analyze multiple antiSMASH outputs in a private setting, a new XML output module allows offline editing of antiSMASH annotations within the Geneious software.</P>