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Jolanta Krajewska,Michal Jarzab,Aleksandra Kukulska,Agnieszka Czarniecka,Jozef Roskosz,Zbigniew Puch,Zbigniew Wygoda,Ewa Paliczka-Cieslik,Aleksandra Kropinska,Aleksandra Krol,Daria Handkiewicz-Junak,B 대한핵의학회 2019 핵의학 분자영상 Vol.53 No.5
Purpose Although postoperative radioiodine (RAI) therapy has been used in patients with differentiated thyroid carcinoma (DTC) for many years, there is still lack of data defining the timing of RAI administration. A retrospective analysis was carried out to answer the question whether the time of postoperative RAI treatment demonstrated any impact on long-term outcomes, particularly in low-risk DTC. Material The analyzed group involved 701 DTC patients staged pT1b-T4N0-N1M0, who underwent total thyroidectomy and postoperative RAI therapy. According to the time interval between DTC diagnosis and RAI administration, patients were allocated to one of three groups: up to 9 months (N = 150), between 9 and 24 months (N = 323), and > 24 months (N = 228). Median follow-up was 12.1 years (1.5–15.2). Results Based on an initial DTC advancement and postoperative stimulated thyroglobulin concentration patients were stratified as a low-, intermediate-, and high-risk group. Low-risk patients, who received RAI therapy up to 9 months, demonstrated significantly lower risk of relapse comparing to those, in whom RAI was administered between 9 and 24 months and after 24 months since DTC diagnosis: 0%, 5.5%, and 7.1%, respectively. Regarding intermediate- and high-risk groups, the differences in the timing of postoperative RAI treatment were not significant. Conclusion If postoperative RAI treatment is considered in low-risk DTC, any delay in RAI administration above 9 months since diagnosis may be related to poorer long-term outcomes.
Front-end investigations of the coated particles of nuclear fuel samples –ion polishing method
Zuzanna M. Krajewska,Tomasz Buchwald,Tomasz Tokarski,Wacław Gudowski 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.6
The investigations of the coated-particles of nuclear fuel samples are carried out in three stages: frontend, irradiation in the reactor core, and post-irradiation examination. The front-end stage is the initialanalysis of the failures rates of produced samples before they are placed in the reactor core. The purposeof the verification is to prepare the particles for an experiment that will determine the degree of damageto the coated particles at each stage. Before starting experiments with the samples, they must beproperly prepared. Polishing the samples in order to uncover the inner layers is an important, initialexperimental step. The authors of this paper used a novel way to prepare samples for testing - byapplying an ion polisher. Mechanical polishing used frequently for sample preparations generatesadditional mechanical damages in the studied fuel particle, thus directly affecting the experimentalresults. The polishing methods were compared for three different coated particles using diagnosticmethods such as Raman spectroscopy, scanning electron microscopy, and confocal laser scanning microscopy. Based on the obtained results, it was concluded that the ion polishing method is better becausethe level of interference with the structures of the individual layers of the tested samples is much lowerthan with the mechanical method. The same technique is used for the fuel particles undergone ionimplantation simulating radiation damage that can occur in the reactor core.
Predictive Modelling of Lactobacillus casei KN291 Survival in Fermented Soy Beverage
Zielińska Dorota,Kołożyn-Krajewska Danuta,Goryl Antoni,Ilona Motyl 한국미생물학회 2014 The journal of microbiology Vol.52 No.2
The aim of the study was to construct and verify predictivegrowth and survival models of a potentially probiotic bacteriain fermented soy beverage. The research material includednatural soy beverage (Polgrunt, Poland) and the strainof lactic acid bacteria (LAB) – Lactobacillus casei KN291. To construct predictive models for the growth and survivalof L. casei KN291 bacteria in the fermented soy beveragewe design an experiment which allowed the collection ofCFU data. Fermented soy beverage samples were stored atvarious temperature conditions (5, 10, 15, and 20°C) for 28days. On the basis of obtained data concerning the survivalof L. casei KN291 bacteria in soy beverage at different temperatureand time conditions, two non-linear models (r2=0.68–0.93) and two surface models (r2=0.76–0.79) were constructed;these models described the behaviour of the bacteriain the product to a satisfactory extent. Verification of the surfacemodels was carried out utilizing the validation data - at7°C during 28 days. It was found that applied models werewell fitted and charged with small systematic errors, whichis evidenced by accuracy factor - Af, bias factor - Bf and meansquared error - MSE. The constructed microbiological growthand survival models of L. casei KN291 in fermented soybeverage enable the estimation of products shelf life period,which in this case is defined by the requirement for the levelof the bacteria to be above 106 CFU/cm3. The constructedmodels may be useful as a tool for the manufacture of probioticfoods to estimate of their shelf life period.
Kim, Hyung‐,Ryong,Chae, Han‐,Jung,Thomas, Michael,Miyazaki, Tadaaki,Monosov, Anna,Monosov, Edward,Krajewska, Maryla,Krajewski, Stan,Reed, John C. Federation of American Society for Experimental Bi 2007 The FASEB Journal Vol.21 No.1
<P>Death-associated protein-3 (DAP3) is a GTP binding protein previously implicated in both intramitochondrial protein synthesis and apoptosis. To explore the in vivo roles of DAP3, we generated and characterized DAP3-deficient mice. Homozygous dap3-/- embryos died at approximately day 9.5 in utero. The dap3-/- embryos and placentas were markedly shrunken. Embryos had arrested development, displaying severe growth restriction and lack of axial turning. Transmission electron microscopy analysis revealed abnormal, shrunken mitochondria with swollen crystae in dap3-/- embryos. Levels of cytochrome c oxidase-I, a protein encoded in the mitochondrial genome, were reduced in dap3-/- embryos, consistent with a role for DAP3 in intramitochondrial protein synthesis. A requirement for DAP3 in mitochondrial respiration was also revealed by oxygen consumption measurements using cultured cells treated with DAP3-specific small interfering RNA (siRNA). Studies of cultured cells from dap3-/- embryos confirmed a role in apoptosis induced by stimuli that trigger the extrinsic (TNFalpha, TRAIL, anti-Fas antibody) but not intrinsic (mitochondrial) cell death pathway. Thus, DAP3 joins a growing list of bifunctional proteins that play roles in normal mitochondrial physiology and in apoptosis.</P>