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Joanna Słomko,Monika Zawadka-Kunikowska,Mariusz Kozakiewicz,Jacek J. Klawe,Małgorzata Tafil-Klawe,Julia L. Newton,Paweł Zalewski 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.9
This study aimed to analyze the impact of sleep deprivation (SD) on cardiac, hemodynamic, and endothelial parameters and todetermine whether these are sustained with increased periods of SD. The study included 60 healthy men (mean: age 31.2±6.3years; body mass index 24.6±2.6 kg/m2). Hemodynamic parameters, parameters of myocardial contractility, spectral analysis ofheart rate (HR) and blood pressure (BP) variability, and the sensitivity of arterial baroreflex function were evaluated. Biochemicaltests were performed to assess L-arginine (L-Arg) and asymmetric dimethylarginine (ADMA) levels in reflection of endothelialnitric oxide synthase ability. Measurements of cardiovascular system parameters were obtained at 9 a.m. (baseline) on the firstday of the study and 9 a.m. (24-h SD), 1 p.m. (28-h SD), and 5 p.m. (32-h SD) on the second day. Blood samples for evaluatingbiochemical parameters were obtained at baseline and after 24-h SD. ANOVA Friedman’s test revealed a significant effect fortime in relation to HR (χ2=26.04, df=5, p=0.000), systolic BP (χ2=35.98, df=5, p=0.000), diastolic BP (χ2=18.01, df=5, p=0.003), andmean BP (χ2=28.32, df=5, p=0.000). L-Arg and ADMA levels changed from 78.2±12.9 and 0.3±0.1 at baseline to 68.8±10.2 and0.4±0.1 after 24-hr SD, respectively (p=0.001, p=0.004). SD in healthy men is associated with increases in BP, which appear to occurafter 24 hours of SD and are maintained over increasing periods of SD. The observed hemodynamic changes may have resulteddue to disordered vascular endothelial function, as reflected in alterations in L-Arg and ADMA levels.