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Investigation of Bioactivity Mechanism of Flavonoids in Cancer Cells
( Kosei Yamauchi ),( Ayaka Tsuchiya ),( Tohru Mitsunaga ) 한국목재공학회 2021 한국목재공학회 학술발표논문집 Vol.2021 No.1
Quercetin is a flavonoid present as a glycoside in various fruits, vegetables as well as wood. Numerous studies have demonstrated that quercetin exhibits a variety of pharmacological effects including antioxidant, anti-inflammatory, and anti-cancer properties. The melanogenesis stimulatory activity and metastasis inhibitory activity of the quercetin derivatives were elucidated. Nineteen quercetin derivatives have been synthesized in order to investigate structure-activity relationships on the effect of melanogenesis and metastasis in B16 melanoma cells. 3,4’,7-O-trimethylquercetin (TMQ) significantly stimulated the extracellular melanin production. The compound stimulated melanosome transportation as well as the melanin synthesis in the cells. TMQ inhibited the migration in B16 melanoma cells. Additionally, it also inhibited migration and invasion in human ovarian cancer cell lines due to regulating the expression of MMP-2 and uPA that is relating to the metastasis. The target proteins of the methylquercetin were isolated and identified using pull down method in order to elucidate the direct mechanism. The investigation of binding site and energy between quercetin derivatives and the protein were under going.
Kosei Tamura,Tohru Kamiya,Masafumi Oda,Yasuhiro Morimoto 제어로봇시스템학회 2022 제어로봇시스템학회 국제학술대회 논문집 Vol.2022 No.11
Root resorption is a pathological condition which is characterized by the loss of the tooth root. Root resorption is not painful in its early stages. As a result, many people who are potentially affected and the condition are often left untreated until it is detected during regular check-ups. If detected early, good treatment results can be achieved, whereas failure to treat the condition properly can lead to tooth extraction. However, the root resorption is currently difficult to detect on panoramic radiographs and may be treated as caries after it becomes painful. The aim of this paper is to identify root resorption from panoramic X-ray images using a deep metric learning algorithm. As a loss function for distance learning, it is known that the loss function in angle space is consistent. Therefore, a loss function is defined and trained using the cosine value of the angle between the feature and the center position to improve the discrimination performance. We obtained experimental results based on 150 image sets with 0.80 of accuracy, 0.62 of TPR, 0.19 of FPR and 0.78 of AUC, respectively.
Kosei Ono,Takayoshi Shimizu,Shunsuke Fujibayashi,Bungo Otsuki,Koichi Murata,Akio Sakamoto,Shuichi Matsuda 대한척추신경외과학회 2021 Neurospine Vol.18 No.1
Objective: Spinal meningioma is mostly benign, but they can exhibit neurological deficit. The relationship between neurological impairment and its radiographic findings, including intratumor magnetic resonance imaging (MRI) gadolinium enhancement and calcification in computed tomography (CT) scan, has not been studied. The purpose of this study was to investigate the association of preoperative image findings with neurological status in spinal meningioma. Methods: Patients histologically diagnosed with spinal meningioma (n=24), with an average age of 65.4 years, were included. The patients were classified into 2 groups, the homogeneous and heterogeneous groups, based on the contrast-enhanced T1-weighted MRI findings. Further, baseline demographics (age, sex, presence of preoperative paralysis [manual muscle testing 3 or worse neurological deficit in upper and/or lower limbs], tumor level, tumor length, and tumor occupation ratio), histological findings (Ki-67 index and histological subtypes), and CT findings (presence of intratumor calcification and Hounsfield unit [HU] value) were examined. Results: Preoperative paralysis was observed in 33.3% (8 of 24) of the patients. These patients exhibited frequent heterogeneous contrast-enhanced MRI findings than those without preoperative paralysis (57.1% vs. 14.3%, p=0.040). Further, preoperative paralysis did not associate with tumor level, tumor length, tumor-occupied ratio, Ki-67 index, and histological subtypes. The heterogeneous group showed 100% intratumor calcification and higher maximum HU than the homogeneous group (1,109.8 vs. 379.2, p=0.001). Conclusion: The heterogeneous contrast-induced MRI findings in the spinal meningioma were significantly associated with preoperative neurological impairment. Moreover, the intratumor contrast-deficient region in the heterogeneously enhanced tumors reflected marked calcification. The tumor hardness due to calcification may be related to preoperative neurological deficit.