Solid-state reactivity and structural transformations involving coordination polymers

Kole, Goutam Kumar,Vittal, Jagadese J. The Royal Society of Chemistry 2013 Chemical Society reviews Vol.42 No.4

<P>This tutorial review discusses recent literature on coordination polymers and metal–organic frameworks (MOFs) that exhibit solid-state reactivity and structural transformation under various experimental conditions. Removal or exchange of solvents and guest molecules, exposure to reactive vapours, and external stimuli such as heat, light or mechanochemical force cause such structural transformations and these are often manifested by various physical properties such as colour, magnetism, luminescence, chirality, porosity, <I>etc.</I> due to change in coordination number and geometry, dimensionality, interpenetration, <I>etc.</I> More drastic transformations related to the exchange of metal ions, pillar ligands and insertion of additional ligands between the layers have also been demonstrated. The vast area of dynamic behaviour of coordination polymers and their stimuli-responsive properties have also been addressed briefly.</P> <P>Graphic Abstract</P><P>Recent advances in solid-state reactivity and structural transformations involving the formation and breakage of chemical bonds in coordination polymers are discussed. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2cs35234f'> </P>

Nanoencapsulation of inactivated-viral vaccine using chitosan nanoparticles: Evaluation of its protective efficacy and immune modulatory effects in olive flounder (<i>Paralichthys olivaceus</i>) against viral haemorrhagic septicaemia virus (VHSV) infecti

Kole, Sajal,Qadiri, Syed Shariq Nazir,Shin, Su-Mi,Kim, Wi-Sik,Lee, Jehee,Jung, Sung-Ju ACADEMIC PRESS LTD 2019 FISH AND SHELLFISH IMMUNOLOGY Vol.91 No.-

<P><B>Abstract</B></P> <P>Viral haemorrhagic septicaemia virus (VHSV), a (−) ssRNA virus belonging to the genus <I>Novirhabdovirus</I> of rhabdoviridae family, is the aetiological agent of viral haemorrhagic septicaemia (VHS) disease which causes huge economic losses in farmed olive flounder (<I>Paralichthys olivaceus</I>) and significant mortalities among several other marine fish species in Korea, Japan, and China. Previously, we developed an inactivated vaccine viz., formalin-inactivated VHSV mixed with squalene as adjuvant which was effective in conferring protective immunity (58–76% relative percentage survival) against VHSV but the mode of administration was intraperitoneal injection which is not feasible for small sized fingerling fish. To overcome this limitation, we presently focused on replacing the injection route of vaccine delivery by oral and immersion routes. In this context, we encapsulated the inactivated VHSV vaccine with chitosan nanoparticles (CNPs-IV) by water-in-oil (W/O) emulsification method. After encapsulation, two sets of <I>in vivo</I> vaccination trials were conducted viz., preliminary trial-I and final trial-II. In preliminary trial-I, olive flounder fingerlings (10.5 ± 1.7 g) were vaccinated with CNPs-IV by different delivery strategies involving oral and immersion routes (single/booster dose) followed by challenge with VHSV (1 × 10<SUP>6</SUP> TCID<SUB>50</SUB> virus/fish) to evaluate an effective method amongst different applied delivery strategies. Subsequently, a final trial-II was conducted to better understand the immune mechanism behind the efficacy of the employed delivery strategy and also to further improvise the delivery mechanism with prime-boost (primary immersion and oral boosting) combination in order to improve the transient anti-VHSV response in the host. Evaluation of RPS analysis in trial-I revealed higher RPS of 46.7% and 53.3% in the CNPs-IV (immersion) and CNPs-IV (immersion/immersion) groups, respectively compared to 0% RPS in the CNPs-IV (oral) group and 20% RPS in the CNPs-IV (oral/oral) group when calculated against 100% cumulative mortality percentage in the NVC (non-vaccinated challenged) control group, whereas, in the trial-II, RPS of 60% and 66.6% were obtained for CNPs-IV (immersion/immersion) and CNPs-IV (immersion/oral) groups, respectively. In addition, specific (anti-VHSV) antibody titre in the fish sera, skin mucus and intestinal mucus of the immunized groups were significantly (p < 0.05) enhanced following vaccination. Furthermore, CNPs-IV immunized fish showed significant (p < 0.05) upregulation of different immune gene transcripts (IgM, IgT, pIgR, MHC-I, MHC-II, IFN-γ, and Caspase3) compared to control, in both the systemic (kidney) and mucosal (skin and intestine) immune compartments of the host post immunization as well as post challenge. To conclude, mucosal immunization with CNPs-IV vaccine can orchestrate an effective immunization strategy in organizing a coordinative immune response against VHSV in olive flounder thereby exhibiting higher protective efficacy to the host with minimum stress.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Encapsulation of inactivated VHSV in chitosan NPs for preparation of CNPs-IV vaccine. </LI> <LI> Olive flounder fingerlings immunized with CNPs-IV through mucosal routes. </LI> <LI> CNPs-IV vaccinated fish exhibited high RPS (60–66.6%) post VHSV challenged. </LI> <LI> CNPs-IV immunized group showed higher specific antibody response in sera and mucus. </LI> <LI> Immune genes were significantly upregulated in immunized fish. </LI> </UL> </P>

Photoreactivity of Ag(I) Complexes and Coordination Polymers of Pyridyl Acrylic Acids

Kole, Goutam Kumar,Tan, Geok Kheng,Vittal, Jagadese J. American Chemical Society 2012 Crystal Growth & Design Vol.12 No.1

<P>An attempt has been made to orient the C?C bonds in <I>trans</I>-3-(3′-pyridyl)acrylic acid (3-PAH) and <I>trans</I>-3-(4′-pyridyl)acrylic acid (4-PAH) in the hydrogen-bonded coordination complexes and coordination polymers of Ag(I), utilizing the argentophilic interaction. Both neutral and deprotonated ligands were employed to synthesize the following compounds: [Ag(3-PAH)<SUB>2</SUB>](BF<SUB>4</SUB>) (<B>1</B>), [Ag(3-PAH)<SUB>2</SUB>](ClO<SUB>4</SUB>) (<B>2</B>), [Ag(4-PAH)<SUB>2</SUB>](ClO<SUB>4</SUB>)·H<SUB>2</SUB>O (<B>3</B>), [Ag(3-PA)]·1.5H<SUB>2</SUB>O (<B>4</B>), and [Ag(4-PA)] (<B>5</B>). Of these, <B>1–2</B> are isotypical hydrogen-bonded polymers of Ag(I) complexes and <B>3</B> is a hydrogen-bonded dimer, whereas <B>4</B> and <B>5</B> are coordination polymers. Compounds <B>1–4</B> undergo photodimerization in <I>head-to-head</I> fashion in the solid state. The photoreactivity of these compounds in solution was also investigated. The <I>head-to-head</I> photodimerized product of 4-PAH, namely, 3,4-bis(4′-pyridyl)cyclobutane-1,2-dicarboxylic acid (HH-4,4-BPCD), has been shown to be a potential ligand for synthesizing coordination polymers, by the isolation of [Ag<SUB>2</SUB>(HH-4,4-BPCD)(H<SUB>2</SUB>O)]·(2H<SUB>2</SUB>O)(<SUP>1</SUP>/<SUB>2</SUB>MeOH), which has a two-dimensional polymeric structure in the solid state.</P><P>Of the five Ag(I) coordination compounds synthesized from <I>trans</I>-3-pyridylacrylic acid and <I>trans</I>-4-pyridylacrylic acid, three hydrogen-bonded coordination complexes and a one-dimensional coordination polymer have been found to undergo a [2 + 2] cycloaddition reaction in the solid state under UV light. In these photoreactive compounds, the ligand pairs are aligned in head-to-tail fashion and sustained by argentophilic interactions.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cgdefu/2012/cgdefu.2012.12.issue-1/cg201119c/production/images/medium/cg-2011-01119c_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cg201119c'>ACS Electronic Supporting Info</A></P>

A new ligand for metal–organic framework and co-crystal synthesis: mechanochemical route to <i>rctt</i>-1,2,3,4-tetrakis-(4′-carboxyphenyl)-cyclobutane

Kole, Goutam Kumar,Koh, Lip Lin,Lee, So Young,Lee, Shim Sung,Vittal, Jagadese J. Royal Society of Chemistry 2010 Chemical communications Vol.46 No.21

<P>A novel method to access <I>rctt</I>-1,2,3,4-tetrakis-(4′-carboxyphenyl)-cyclobutane in quantitative yield from an environmentally benign route is presented. The cyclobutane derivative is demonstrated as a potential candidate to serve as an organic building block for making co-crystal and MOF.</P> <P>Graphic Abstract</P><P>A salt with aligned C&z.dbd;C bond pairs obtained by mechanical grinding yielded a dimerized product quantitatively by solid-state photochemical reaction. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0cc00012d'> </P>

Immune checkpoint inhibitors for solid organ transplant recipients: clinical updates

Shun Kawashima,Kole Joachim,Maen Abdelrahim,Ala Abudayyeh,Kenar D. Jhaveri,Naoka Murakami 대한이식학회 2022 Korean Journal of Transplantation Vol.36 No.2

Transplant care continues to advance with increasing clinical experience and improve- ments in immunosuppressive therapy. As the population ages and long-term survival improves, transplant patient care has become more complex due to comorbidities, frailty, and the increased prevalence of cancer posttransplantation. Immune check- point inhibitors (ICIs) have become a standard treatment option for many cancers in non-transplant patients, but the use of ICIs in transplant patients is challenging due to the possibility of disrupting immune tolerance. However, over the past few years, ICIs have gradually started to be used in transplant patients as well. In this study, we review the current use of ICIs after all solid organ transplantation procedures (kidney, liver, heart, and lung). Increasing data suggest that the type and number of immunosuppres- sants may affect the risk of rejection after immunotherapy. Immunotherapy for cancer in transplant patients may be a feasible option for selected patients; however, prospec- tive trials in specific organ transplant recipients are needed.

Correlation dynamics between agglutination titer with scuticociliatosis derived symptoms in immunized olive flounder (Paralichthys olivaceus)

Su-mi Shin,Sajal Kole,Sung-Ju Jung 한국수산과학회 양식분과 2022 한국수산과학회 양식분과 학술대회 Vol.2022 No.10

Sustainable approach for development of antimicrobial textile material using nanoemulsion for wound care applications

Vijay D. Gotmare,Sushant S. Kole,Rajani B. Athawale 한국의류학회 2018 Fashion and Textiles Vol.5 No.1

Development of nanostructured textile material using sustainable finishing route and to evaluate its performance in the areas like wound management is challenging task. Stable and eco-friendly o/w nanoemulsion of tetrahydroxy curcumin derivative was developed by using high pressure homogenization method. The stable nanoemulsion for the selected drug was developed and evaluated for appearance, particle size distribution (100–300 nm), zeta potential (− 30.1 to − 31.1 mV) and drug content (80–83.3%). Nanoemulsion containing antimicrobial drug were impregnated on the textile material by exhaust methods using β-cyclodextrin and polycarboxylic acid as a crosslinking agent. Treated textile material is evaluated for its antimicrobial activity against standard antimicrobial strip using both AATCC 147 and AATCC 100, treated samples shows positive results against both positive and negative bacteria. Current eco-friendly technique would be innovative step towards development of medical textile for wound care applications.

Automatic Feature Extraction for Social Touch Classification

Songha Ban,Ngoc Doan,Ruben Kole,Michon Zeegers,Gokce Kuscu 한국정보과학회 2020 한국정보과학회 학술발표논문집 Vol.2020 No.7

Solid‐State Structural Transformations from 2D Interdigitated Layers to 3D Interpenetrated Structures

Medishetty, Raghavender,Koh, Lip Lin,Kole, Goutam Kumar,Vittal, Jagadese J. WILEY‐VCH Verlag 2011 Angewandte Chemie Vol.123 No.46

<P><B>Lichtbauweise:</B> Eine [2+2]‐Cycloaddition überführt ein 2D‐Koordinationspolymer unter Einkristall‐zu‐Einkristall‐Umwandlung in eine 3D‐Struktur. In diesem Beispiel kann man die Bildung der resultierenden 3D‐Struktur direkt auf die 2D‐Schichtverbindung zurückverfolgen (siehe Schema; Zn rot, 4‐Styrylpyridin blau/türkis).</P>

Evaluation of metal contamination and phytoremediation potential of aquatic macrophytes of East Kolkata Wetlands, India

Amina Khatun,Sandipan Pal,Aloke Kumar Mukherjee,Palas Samanta,Subinoy Mondal,Debraj Kole,Priyanka Chandra,Apurba Ratan Ghosh 환경독성보건학회 2016 환경독성보건학회지 Vol.31 No.-

Objectives The present study analyzes metal contamination in sediment of the East Kolkata Wetlands, a Ramsar site, which is receiving a huge amount of domestic and industrial wastewater from surrounding areas. The subsequent uptake and accumulation of metals in different macrophytes are also examined in regard to their phytoremediation potential. Methods Metals like cadmium (Cd), copper (Cu), manganese (Mn), and lead (Pb) were estimated in sediment, water and different parts of the macrophytes Colocasia esculenta and Scirpus articulatus. Results The concentration of metals in sediment were, from highest to lowest, Mn (205.0±65.5 mg/kg)>Cu (29.9±10.2 mg/kg)>Pb (22.7±10.3 mg/kg)>Cd (3.7±2.2 mg/kg). The phytoaccumulation tendency of these metals showed similar trends in both native aquatic macrophyte species. The rate of accumulation of metals in roots was higher than in shoots. There were strong positive correlations (p <0.001) between soil organic carbon (OC) percentage and Mn (r =0.771), and sediment OC percentage and Pb (r=0.832). Cation exchange capacity (CEC) also showed a positive correlation (p <0.001) with Cu (r=0.721), Mn (r=0.713), and Pb (r=0.788), while correlations between sediment OC percentage and Cu (r=0.628), sediment OC percentage and Cd (r=0.559), and CEC and Cd (r=0.625) were significant at the p <0.05 level. Conclusions Bioaccumulation factor and translocation factors of these two plants revealed that S. articulatus was comparatively more efficient for phytoremediation, whereas phytostabilization potential was higher in C. esculenta .