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Precise Manufacturing and Performance Validation of Paper-Based Passive Microfluidic Micromixers
Mahdee Samae,Pawarit Ritmetee,Somyot Chirasatitsin,Sanja Kojić,Tijana Kojić,Jovana Jevremov,Goran Stojanović,Hani Al Salami 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.3
Micromixers are one of the most frequently used components in microfluidics. Passive micromixers are an emerging type with unique features in terms of reliability, robustness and efficiency. Hence, this study aimed to design, fabricate and test new multilayered passive micromixers consisting of three ad hoc layers, by means of a precise and cost-effective xurography manufacturing technique. The first and third layers are PVC foils, whereas the second layer is paper, incorporating microchannels of straight line or zig-zag configuration. Three different types of papers were analyzed as materials for the middle layer. Results demonstrated that immersing the papers into paraffin wax resulted in significantly improved physical characteristics, including solidification and intactness that reduced leakage of fluids into inside channels, thereby enhancing internal efficacy and delivery mechanisms. Subsequent assessments were carried out on mixing performance at various flow rates, pattern-related flow rates at various pressures and paper types, and results showed the impact of a zig-zag versus straight line configuration, demonstrating the importance of flow patterns on features of micromixers and their applications in microfluidic devices. Furthermore, image analysis was conducted to determine mixing efficiency of the proposed microfluidic micromixers.
Temperature Sensors Manufactured from Edible Materials Intended for Oral Cavity Operation
Goran M. Stojanović,Milan Radovanović,Sanja Kojić,Lazar Milić,Mitar Simić,Naturality Company,Raphael Georges Duval,Jelena Vukmirović,Bojan Petrović 한국정밀공학회 2024 International Journal of Precision Engineering and Vol.11 No.1
Following the circular economy concept, all areas of science, including electronics, require individual approach. The green electronics approach implies processing natural based materials for development of electronic components even for single use, so that waste does not exist. This paper describes the production of thermistors from 3 different types of edible materials, their testing in laboratory conditions, as well as the application for measuring the temperature in the human oral cavity. To make the thermistor, three types of natural materials were used (carrageenan, polyvinyl alcohol and apple pomace-based). After fabrication, materials were poured into molds. Aluminium foil contacts were placed so that the electrical characterization of the materials could be performed. Several parameters were measured: resistance (R), impedance (Z) and the phase angle (θ) as a function of frequency. In order to determine whether the thermistors have a positive or negative temperature coefficient and to determine their sensitivity, measurements were conducted at three different temperatures: 25 ℃ (room temperature), 37 ℃ (human body temperature), and 50 ℃. The thermistors demonstrated negative temperature coefficient behaviour. Additionally, it was demonstrated that the apple pomace-based thermistor can successfully measure healthy volunteer's temperature.
Automatic Segmentation of Phalanges Regions on MR Images Based on MSGVF Snakes
Koji SHIGEYOSHI,Seiichi MURAKAMI,Hyoungseop KIM,Joo Kooi TAN,Seiji ISHIKAWA 제어로봇시스템학회 2015 제어로봇시스템학회 국제학술대회 논문집 Vol.2015 No.10
In recent years, medical imaging is important in medical diagnosis for early detection of lesions. However, a large number of images increases the stress to the radiologist. Therefore, CAD (Computer Aided Diagnosis) system is expected to reduce such burden. In diagnostic imaging of phalanges, X-ray photographs, CT (Computed Tomography) are used to evaluate the value of phalanges destruction. Whereby, the MRI (Magnetic Resonance Imaging) that is used mainly to diagnose the lesion in the soft tissue is more effective in a certain case, which is one of the important CAD systems to develop. However, studies on CAD system using MR images are not as much as the studies using CT. In this paper, we propose an automatic segmentation algorithm of phalanges regions on MR images. Although it has three dimensional information, this is the method for two dimensional algorithm. In other words, we propose for each slice of MR Images. Firstly, phalanges regions in MR images are segmented for coarse regions mainly by watershed algorithm. Next, the segmented results from the previous phase are set as the initial contour. Ultimately, the accurate segmentation of the phalanges on MR images are acquired based on MSGVF snakes.