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방선균 WCM-9가 생산하는 Polyene 항진균성 항생물질(AF1)의 생물학적 성상
신운섭,정선호,이동희,이경호,김수기,박주영,고춘명 대한의진균학회 1996 대한의진균학회지 Vol.1 No.1
Background: Pathogenic fungi infect humans, especially immunocompromised patients, with superficial or deeply invasive pattern. In the past 20 years, fungal infections have been increased dramatically resulted by increment of organ transplantation, cancer, AIDS patients, or use of broad-spectrum antibacterial agents. Fungal infections are now important causes of morbidity and mortality of hospitalized patients. but there is no effective antifungal antibiotics as well as antibacterial antibiotics Objective: Effective new antifungal antibiotics are needed for the treatment of mycosis. So in an effort to develop effective antifungal antibiotics, we screened over 600 isolates of Streptomyces spp. from soil. Methods: Antifungal producing strain was selected using disk diffusion method, An antifungal substance (AF1) was purified with ethyl acetate extraction, silica gel column chromatography and reverse phase HPLC. MICs of AF1 were detected by agar dilition method. Results: The compound showed UV maxima of 307, 321, 340, 359 nm indicating methylpentaene. Minimum inhibitory concentrations of the AF1 were 3.7 ㎍/ml against mold, and 3.7 - 7.4 ㎍/ml against Candida species. AF1 was also active against Cryptococcus neoformans, with MIC of 0.9 ㎍/ml. The concentration of AF1 for K^+ ion release from human red blood cell and hemolysis were 5 ㎍/ml. Conclusion: The antibiotic purified from culture broth of Streptomyces sp. WCM-9 was a polyene antifungal antibiotic which have broad spectrum antifungal activity.
顎矯正術을 받은 顎顔面 寄形患者의 SKELETAL PATTERN의 變化에 關한 硏究
조원표,조병욱,고백진,이용찬 大韓顎顔面成形再建外科學會 1990 Maxillofacial Plastic Reconstructive Surgery Vol.12 No.3
In the treatment of dentofacial deformities, analysis of skeletal pattern, with evaluation of plaster dental case, is essential procedure. This study was based on 20 patients with dentofacial deformity who were admitted to the department of oral and maxillofacial surgery Kngnam sacred heart Hospital during the period of Jan 1989. We studied serial cephalometric radiogarphs of patients (pre-op, postop immediately, postop 6 moth). The obtained results indicates the good resistance of rigid fixation against relapse in orthognathic surgery.
배양 조건이 Candida albicans의 phospholipase 생성에 미치는 영향
신운섭,이경호,박주영,고춘명 대한의진균학회 1997 대한의진균학회지 Vol.2 No.2
Background : The dimorphic yeast, Candida albicans, is considered as a dangerous opportunistic pathogen in immunocompromised hosts. Several phospholipases of C. albicans are known to be secreted into the culture medium. Phospholipases have been proposed as a virulence factor in the pathoenesis of Candida infections. Objective : In order to investigate enzyme production, we examined culture condition of secreted phospholipase production from C. albicans. Methods : C. albicans ATTCC 10231 was cultivated in various media at 37℃ for 3 days. Phospholipase activity was measured by fatty acid soap precipitaiton in plate containing 0.04T lecithin, 0.1 M citrate buffer, pH 4.2 and 1.5% noble agar. Results : Phospholipase was highly induced when C. albicans was cultivated in broth medium(containing glucose 2%, albumin 0.2% and Fe^++ ion 0.01%) and Saboulaud's dextrose agar supplemented with 0.01% sodium deoxycholate. Conclusion : Highly induction of secreted phospholipase by albumin from C. albicans may be play an importans role in tissue invasion in the pathogenesis of C. albicans.
이순자,고대희,최운정 서강대학 지역발전연구소 1998 지역발전연구 : 서강전문대 Vol.4 No.2
This study was made to find out the relationship between the body mass index (BMI) and food habit among 68 male and 304 female college students. A self-report questionnaire was used about the height, weight and food habit. The summary of the results are as follows : The average age of the male subjects is 20.52, female subjects is 19.64. Almost all of the subjects were in the criteria of standard weight group and low weight group. However female subjects regard themselves more obese than their actual body shape and male subjects regard themselves more thinner than their actual constitution. Almost of the subjects were lack of exercise and the correlation between BMI, regular exercise and regular eating was significant. Food habit score was within the category of Fair or Poor group. All the male and female subjects have highest score in green-yellow vegetables intake and the lowest score in seaweeds intake. Therefore nutrition education for the desirable dietary life management of college students should be carried out with respect to the correct perception of ideal body shape and actual self body shape and the adequate weight control diet.
Koh-Woon Kim,In-Seung Lee,Won-Jae Lee,Jiyoung Park,Won Seok Chung,Jae-Heung Cho,Sung-Lim Lee,Hyeung-Jin Jang,Seok-Hee Chung,Hyeung-Jin Jang,Seok-Hee Chung 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.4
The present study investigated the effect of Cortex mori radicis (CMR) and Patrinia saniculaefolia (PS) on the osteogenic differentiation of the human mesenchymal stem cell. CMR and PS have been used as herbal medicine in traditional Korean medicine for a long time. Mesenchymal stem cells that can differentiate into adipocyte, chondrocyte and osteocyte recently issued as a therapeutic agent for degenerative disease. Here, mesenchymal stem cells isolated from synovial fluid of osteoarthritis patient, were cultured in specific media to differentiate into osteogenesis. Osteogenic differentiated mesenchymal stem cells were confirmed using Von Kossa and Arizarion Red S staining. And, the cells were divided into 4 groups: control group, CMR treated group, PS treated group and mixture treated group. To determine the effect of the herbal samples on the osteogenic mesenchymal stem cell, OCT4, SOX2 and NANOG mRNA expressions, known as the key maintenance factors of mesenchymal stem cell was measured using real-time Polymerase Chain Reaction (PCR). As a result, the maintenance factors, OCT4, SOX2 and NANOG, were more increased in cells treated by CMR, PS and the mixture of two herbs than control group. Therefore, we confirmed the enhancing effect of CMR, PS and their mixture on the osteogenic differentiation of mesenchymal stem cells which derived from the synovial fluid of osteoarthritis patient. This study demonstrates that the effect of the herbal samples on the osteogenic differentiation of human mesenchymal stem cell may have a possibility to be a therapeutic agent for the osteoarthritis patients.