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Pancreas transplant in type 1 diabetes mellitus: the emerging role of islet cell transplant
Kochar Inderpal Singh,Jain Rakhi 대한소아내분비학회 2021 Annals of Pediatirc Endocrinology & Metabolism Vol.26 No.2
Pancreas transplant, both whole pancreas and islet cell, is a known therapeutic option for treatment of type 1 diabetes mellitus. Islet cell transplant began as an experimental therapy but is emerging to be quite beneficial due to less surgical risk and fewer complications. It is also considered a promising option in pediatric patients. In this review the authors discuss the indications, procedure, and benefits of islet cell transplant along with newer strategies for improving outcomes.
Physiologic Assessment of Coronary Artery Disease by Cardiac Computed Tomography
Minisha Kochar,James K. Min 대한심장학회 2013 Korean Circulation Journal Vol.43 No.7
Coronary artery disease (CAD) remains the leading cause of death and morbidity worldwide. To date, diagnostic evaluation of patients with suspected CAD has relied upon the use of physiologic non-invasive testing by stress electrocardiography, echocardiography, myocar-dial perfusion imaging (MPI) and magnetic resonance imaging. Indeed, the importance of physiologic evaluation of CAD has been high-lighted by large-scale randomized trials that demonstrate the propitious benefit of an integrated anatomic-physiologic evaluation meth -od by performing lesion-specific ischemia assessment by fractional flow reserve (FFR)-widely considered the “gold” standard for ischemia assessment-at the time of invasive angiography. Coronary CT angiography (CCTA) has emerged as an attractive non-invasive test for ana-tomic illustration of the coronary arteries and atherosclerotic plaque. In a series of prospective multicenter trials, CCTA has been proven as having high diagnostic performance for stenosis detection as compared to invasive angiography. Nevertheless, CCTA evaluation of ob-structive stenoses is prone to overestimation of severity and further, detection of stenoses by CCTA does not reliably determine the he-modynamic significance of the visualized lesions. Recently, a series of technological innovations have advanced the possibility of CCTA to enable physiologic evaluation of CAD, thereby creating the potential of this test to provide an integrated anatomic-physiologic assess-ment of CAD. These advances include rest-stress MPI by CCTA as well as the use of computational fluid dynamics to non-invasively cal-culate FFR from a typically acquired CCTA. The purpose of this review is to summarize the most recent data addressing these 2 physiolog-ic methods of CAD evaluation by CCTA.
KAUR, Kulvinder Kochar,ALLAHBADIA, Gautam,SINGH, Mandeep Korea FoodHealth Convergence Association 2019 식품보건융합연구 (KJFHC) Vol.5 No.3
The incidence of both obesity and Type 2 Diabetes Mellitus( DM) is increasing proportionately so that causes of deaths from these has overtaken from that of malnourishment. Hence it has been recommended to treat the 2 in parallel considering the role of diabesity on health. Important causes of T2DM are insulin resistance (IR) and /or inadequate insulin secretion. Protein tyrosine phosphatase 1B(PTPIB) has a negative impact in insulin signaling pathways and hence plays crucial role inT2DM,since its overexpression might induce IR. Thus PTPIB is considered a therapeutic target for both obesity and T2DM, there has been a search for novel ,promising natural inhibitors. We conducted a pubmed search for articles related to PTPIB inhibitors from natural causes be it marine sources or other natural sources. Out of 988 articles we selected 100 articles for review. Thus various bioactive molecules isolated from marine organisms that can acts as PTPIB Inhibitors and thus possess antidiabetic activity both in vitro/ in vivo studies ,besides products from fruits like Chinese raspberry or curcumin used as routine spices are described with their chemical classes, structure-activity relationships and potency as assessed by IC 50 values are discussed. More work is required to make this a reality.