http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential
Munehiro Kitada,Daisuke Koya 대한당뇨병학회 2013 Diabetes and Metabolism Journal Vol.37 No.5
The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide. Therefore, a novel therapeutic strategy by which to prevent T2DM is urgently required. Calorie restriction (CR) can retard the aging processes, and delay the onset of numerous age-related diseases including diabetes. Metabolic CR mimetics may be therefore included as novel therapeutic targets for T2DM. Sirtuin 1 (SIRT1), a NAD+-dependent histone deacetylase that is induced by CR, is closely associated with lifespan elongation under CR. SIRT1 regulates glucose/lipid metabolism through its deacetylase activity on many substrates. SIRT1 in pancreatic β-cells positively regulates insulin secretion and protects cells from oxidative stress and inflammation, and has positive roles in the metabolic pathway via the modulation in insulin signaling. SIRT1 also regulates adiponectin secretion, inflammation,glucose production, oxidative stress, mitochondrial function, and circadian rhythms. Several SIRT1 activators, including resveratrol have been demonstrated to have beneficial effects on glucose homeostasis and insulin sensitivity in animal models of insulin resistance. Therefore, SIRT1 may be a novel therapeutic target for the prevention of T2DM, implicating with CR. In this review, we summarize current understanding of the biological functions of SIRT1 and discuss its potential as a promising therapeutic target for T2DM.
1MHz Variable Sampling Deadbeat Control for PM motor using FPGA
Asahi Kitada,Kota Miyata,Kota Tsuchiya,Hiroki Sato,Tomoki Yokoyama 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6
A new digital control method for permanent magnet synchronous motor based on deadbeat control using FPGA based hardware controller is proposed. Using the discrete time model of PMSM, the deadbeat control law is derived using a model inverse solution. The superior calculation capability of FPGA realize the ideal digital control feedback system without any sampling compensation method. The verification of the proposed method were carried out through simulations and experiments.
Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy
Shinji Kume,Munehiro Kitada,Keizo Kanasaki,Hiroshi Maegawa,Daisuke Koya 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.2
Caloric restriction prolongs the lifespan ofmany species. Therefore, investigators have researched theusefulness of caloric restriction for healthy lifespan extension. Sirt1, an NAD?-dependent deacetylase, was identifiedas a molecule necessary for caloric restriction-related antiagingstrategies. Sirt1 functions as an intracellular energysensor to detect the concentration of NAD?, and controlsin vivo metabolic changes under caloric restriction andstarvation through its deacetylase activity to many targetsincluding histones, nuclear transcriptional factors, andenzymes. During the past decade, investigators havereported the relationship between disturbance of Sirt1activation and the onset of aging- and obesity-associateddiseases such as diabetes, cardiovascular disease and neurodegenerativedisorders. Consequently, a calorie restriction-mimetic action of Sirt1 is now expected as a newtherapy for these diseases. In addition, recent studies havegradually clarified the role of Sirt1 in the onset of kidneydisease. Its activation may also become a new target oftreatment in the patients with chronic kidney diseaseincluding diabetic nephropathy. In this article, we wouldlike to review the role of Sirt1 in the onset of kidney diseasebased on previous studies, and discuss its possibility as thetarget of treatment in diabetic nephropathy.
( Yukihiro Yano ),( Hiroyuki Kagawa ),( Seigo Kitada ),( Masahide Mori ),( Soichiro Yokota ),( Ryoji Maekura ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: To date, the clinical signifi cance of Mycobacterium (M.) gordonae isolated from respiratory specimens has not been well investigated. This study aimed to determine the clinical signifi cance of M. gordonae isolated from respiratory specimens and the validity of the diagnostic guideline for pulmonary nontuberculous mycobacterial (NTM) disease as applied patients with M. gordonae. Methods: A retrospective observational study was conducted on all patients from whom M. gordonae was isolated between 2003 and 2013 in our institution, which is a specialist hospital for respiratory disease in Osaka, Japan. M. gordonae was identifi ed by the DNA-DNA hybridization method. We identifi ed patients who met diagnostic criteria according to the guideline of the American Thoracic Society (ATS) for pulmonary NTM disease and confi rmed fi nal defi nitive diagnosis of such patients. Results: M. gordonae isolates were found in respiratory specimens from 152 patients who were examined multiple times. A total of 10 patients met the diagnostic criteria based on pulmonary symptoms, abnormal radiographic fi ndings, and multiple identifi cations of M. gordonae from respiratory specimens. Among these 10 patients, only 2 were confi rmed as having pulmonary disease caused by M. gordonae. Colonization or contamination was diagnosed in the remaining 150 patients. The ratio of patients confi rmed as having pulmonary disease caused by M. gordonae to those from whom M. gordonae was isolated, was 2/152 (1.32%). The positive predictive value of the ATS guideline for pulmonary NTM disease when applied to patients with M. gordonae was 20% (2/10 patients). Conclusions: Occurrence of pulmonary disease caused by M. gordonae was rare and the present ATS guideline for pulmonary NTM disease may be inappropriate when applied to patients with M. gordonae.