New linyphiid spider(Aranei, Linyphiidae)from East Siberia

Kirill Y,Eskov,Yuri M,Marusik 한국거미연구소 1990 한국거미 Vol.6 No.2

Social, Economic, and Medical Factors Associated With Solifenacin Therapy Compliance Among Workers Who Suffer From Lower Urinary Tract Symptoms

Kirill Vladimirovich Kosilov,Loparev Sergay Alexandrovich,Kuzina Irina Gennadyevna,Shakirova Olga Viktorovna,Zhuravskaya Natalia Sergeevna,Ankudinov Ivan Ivanovich 대한배뇨장애요실금학회 2016 International Neurourology Journal Vol.20 No.3

Purpose: The prevalence of hyperactive-type lower urinary tract symptoms is 45.2%, with shares of overactive bladder (OAB) and urge incontinence (UI) symptoms of 10.7% and 8.2%, respectively. We investigated the possible impact of a wide range of social, economic, and medical factors on compliance with solifenacin treatment in the working population. Methods: Social, economic, and medical factors as well as the Overactive Bladder questionnaire – the OAB-q Short Form (OAB-q SF), bladder diaries, and uroflowmetry of 1,038 people who were administered solifenacin for a year were gathered from employer documentation. Results: Among the subjects, 32% maintained their compliance with solifenacin treatment throughout the year. Only 65% of the patients had compliance exceeding 80%, and 17% of patients had compliance of ≥50%, yet less than 80% were still taking solifenacin 12 months after the beginning of this experiment. Working people whose compliance level was, at least, 80% had reliably higher (P≤0.01) average age, annual salary, and treatment efficacy, and a greater treatment satisfaction level, as well as a lack of satisfaction with other antimuscarinic treatments and higher rate of urge UI diagnosis. The same cohort also featured a lower level (P≤0.01) of caffeine abuse and lower share of salary spent purchasing solifenacin. Conclusions: This study has shown that compliance with solifenacin treatment is associated with a number of significant medical, social, and economic factors. The medical factors included the type of urination disorder, severity of incontinence symptoms, presence of side effects, treatment efficacy and patients’ satisfaction with it, and experience using other antimuscarinic treatments. Among the social and economic factors, those with the strongest correlation to compliance were patient age, employment in medicine and education, annual income level, percentage of solifenacin purchase expenditures, and caffeine abuse. Factors with a weaker, but still significant, association were gender, employment in the transportation industry, and monthly income level.

Silica biominerals of three marine algae species from Korea

Kirill Golokhvast,Bao Le,Seung Hwan Yang,Sangmi Sun 한국수산과학회 양식분과 2019 한국수산과학회 양식분과 학술대회 Vol.2019 No.5

Investigating the Impact of Customer Service Priority on Optimizing the Location Problem of Hierarchical Allocation of Crowded Facilities in the Framework of Queue Systems

Kirill Yu. Kurilov 대한산업공학회 2021 Industrial Engineeering & Management Systems Vol.20 No.2

Location and allocation in queuing systems is one of the most important decisions to improve the quality of service. Optimizing these two important decisions can have many positive effects on customer service. In this research, the problem of location-hierarchical allocation of facilities has been investigated by considering the priority of customers in the framework of queuing systems. To this end, a multi-objective nonlinear mathematical model has been developed. The objective functions of this issue include reducing the total waiting time of customers and maximizing the unemployment of facilities. To solve this mathematical model, a multi-objective genetic algorithm has been used. Also, the parameters of this algorithm are adjusted using Taguchi method. The results show that the establishment of customer priority system reduces the average waiting time of all customers. Therefore, it can be concluded that in the design of hierarchical facilities, if the goal is to reduce the waiting time of a particular segment of customers, they should be prioritized.

On black holes and wormholes in a brane world

Kirill A. Bronnikov,김성원 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.1

The general solution to the trace of the 4-dimensional Einstein equations for static, spherically symmetric configurations is used for finding general classes of black hole (BH) and wormhole metrics which may be asymptotically at or have any other prescribed asymptotics. The procedure generically leads to families of solutions unifying globally regular BHs with a Kerr-like global structure and symmetric wormholes. The BH event horizons are generically simple or double, but inside matter distributions, they can be of any order under some special conditions. A few simple examples are discussed. A natural application of the above results, is the brane world concept, in which the trace of the 4D gravity equations is the only unambiguous equation for the 4D metric, and its solutions can be continued into the 5D bulk according to the embedding theorems.

Influence of the Short-term Intake of High Doses of Solifenacin and Trospium on Cognitive Function and Health-Related Quality of Life in Older Women With Urinary Incontinence

Kirill Kosilov,Irina Kuzina,Sergay Loparev,Yuliya Gainullina,Liliya Kosilova,Alexandra Prokofyeva 대한배뇨장애요실금학회 2018 International Neurourology Journal Vol.22 No.1

Purpose: The aim of this study was to investigate the safety and the effects of elevated doses of solifenacin and trospium on cognitive function and health-related quality of life (HRQoL) in elderly women receiving treatment for urinary incontinence. Methods: The study included 312 women aged 60–83 years (mean age, 69.4 years). All participants had scored at least 24 points on the Mini-Mental State Examination (MMSE) scale, and all of them had been diagnosed with urge urinary incontinence (UUI) or mixed urinary incontinence (MUI). The women were randomly assigned to 3 groups: group A, individuals who were simultaneously administered solifenacin at a high dosage of 20 mg per day and trospium at a high dosage of 60 mg per day; group B, persons taking solifenacin and trospium at the usual dosage of 10 and 30 mg per day, respectively; and group C, persons who received a placebo. Participants’ cognitive status was assessed by the MMSE, Controlled Oral Word Association Test, Wechsler Adult Intelligence Scale-Revised, Wechsler Memory Scale III, Colour Trails Test, and California Verbal Learning Test scales. The HRQoL assessment was performed using the Medical Outcomes Study 36-Item Health Survey. Results: The cognitive function parameters did not differ at the start and end of the study across the groups (P>0.05). Additionally, the cognitive function parameters did not differ significantly within each group between the start and end of the study (P>0.05). The values of most HRQoL parameters regarding the functional state of the lower urinary tract (LUT) after the termination of treatment significantly improved in groups A and B (P<0.05). A significant correlation between cognitive status and HRQoL or LUT parameters was absent (r<0.3), while the correlations between HRQoL and LUT parameters were r=0.31–0.83, P<0.05. Conclusions: The use of elevated doses of solifenacin and trospium did not increase the risk of cognitive impairment in women with UUI and MUI. The combination of solifenacin and trospium at a double dosage may be recommended to elderly women with treatment-resistant symptoms of UUI and MUI. However, the safety of combining antimuscarinic drugs in women with an increased volume of residual urine requires further study.

Why (not) Marry a Reindeer Herder? Gender Displacement and Gender Replacement among Izhma-Komi Reindeer Herders of Bol´shezemel´skaia Tundra

Kirill V. Istomin 한국외국어대학교(글로벌캠퍼스) 러시아연구소 2022 REGION Vol.11 No.1

The reasons for and possible consequences of so-called gender displacement—the outflux of young women from the communities of native northerners leading traditional ways of life, which turns tundra and taiga into a specific "male space"—represent a topic of great concern and interest in modern Arctic anthropology. The fieldwork data on Komi reindeer herders presented in this paper suggests, however, that there is also an opposite process: some girls from settled families choose to marry reindeer herders and join them in their migrations through tundra and taiga. Based on ethnographic interviews, this paper explores the reasons and possible cultural consequences of this process, for which the term "gender replacement" is suggested. The interviews indicate that these girls were attracted by the relative economic stability of the reindeer herding way of life and the relatively low risk of divorce, infidelity, and alcoholism as well as by the romantic image of the nomadic way of life. Although the rate of gender replacement is certainly insufficient to offset the consequences of gender displacement, the influx of "settled wives" to the tundra effects important changes in the life of reindeer herders. It can be supposed that the phenomenon of gender replacement also exists in other regions and ethnic groups, which makes it an important object for anthropological research.

Long-term adherence to antimuscarinic drugs when treating overactive bladder in the older: Subjective reason and objective factors

Kirill Vladimirovich Kosilov,Sergay Alexandrovich Loparev,Irina Gennadyevna Kuzina,Boris Izrailevich Geltser,Olga Viktorovna Shakirova,Natalya Sergeevna Zhuravskaya,Alexandra Lobodenko 대한비뇨의학회 2017 Investigative and Clinical Urology Vol.58 No.2

Purpose: Comparison of subjective reasons for the refusal of antimuscarinic treatment and the state of objective economic, social, psychological and health status markers in the elderly with overactive bladder. Materials and Methods: One thousand seven hundred thirty-six (1,736) patients participated in the experiment: 1,036 or 59.7% of women, and 700 or 40.3% of men aged over 60 years (average age, 68.1 years) who took antimuscarinic (AM) drugs during the year. The control of objective parameters was carried out by studying patients' medical records, the use of overactive bladder questionnaire short form and Medical Outcomes Study 36-item Shor-Form Health Survey, voiding diaries, uroflowmetry, as well as income certificates from the Tax Inspectorate, support documentation for expenses on drugs. Results: Fifty-two point six percent (52.6%) of patients preserved adherence to treatment during the first 6 months, 30.1% – during the follow-up period. The average time of reaching a 30-day break in the AM drugs administration was 174 days. In 36.5% of cases of the refusal of treatment, patients referred to medical reasons for the refusal, in 31.6% of cases disturbance was established in objective health status markers (differences were significant in 30% of the follow-up time). The percentage of refusals of treatment for social and psychological reasons (13.2%) was significantly lower (p≤0.05), than the percentage of individuals with statuses altered objectively (21.9%). Conclusions: A significant share of elderly patients taking AM drugs when treating overactive bladder is inclined to overestimate the importance of health factors influencing their decisions and to underestimate the importance of social and psychological factors, and an urologist should take it into account for the efficacy evaluation.

Two-Objective Mathematical Model Considering Competitive Location, Distribution Scheduling and Priority Demand Points under Uncertainty

Kirill Yu. Kurilov 대한산업공학회 2021 Industrial Engineeering & Management Systems Vol.20 No.2

In the last two decades, competition between companies in the supply of goods and services has become a great reality for their development. Today, companies and factories need to integrate and flex all production activities from the supply of raw materials to the delivery of the final product to the consumer, in the process of supply and distribution of products. Distribution and support systems are part of the supply chain process, so that the efficient and efficient flow of storage of goods, services and related information is planned, implemented and controlled from the starting point to the point of consumption in order to meet customer needs. The problem of locating distribution centers focuses on how to select distribution centers from a potential set so that the relevant total costs are minimized. This study aims to minimize transportation costs in the supply chain by choosing the best way to deliver the product to the customer and location costs. In this model, a multi-objective function is used, which in the first objective seeks to maximize the profit from sales, and the second objective function seeks to minimize the distribution schedule.

Maintenance of the Therapeutic Effect of Two High-Dosage Antimuscarinics in the Management of Overactive Bladder in Elderly Women

Kirill Kosilov,Sergey Loparev,Marina Ivanovskaya,Liliya Kosilova 대한배뇨장애요실금학회 2013 International Neurourology Journal Vol.17 No.4

Purpose: To improve the long-term efficiency of the pharmacologic management of overactive bladder (OAB) in elderly women. Methods: The study comprised 229 women (mean age, 66.3 years; range, 65–77 years) with urodynamically and clinically confirmed OAB. All patients received the most effective treatment regimen based on the data obtained in the initial part of the study (trospium 60 mg/day + solifenacin 40 mg/day, for 6 weeks), and positive results similar to those in the first phase were obtained. They were then divided into four groups, based on the maintenance therapy: group А (59 women), trospium (60 mg/day) + solifenacin (40 mg/day) for 1 month; group В (51 women), electrical stimulation of the detrusor muscle for 1 month; group С (63 women), laser puncture for 1 month; group D (56 women), placebo. Maintenance therapy was administered 2.5 months after completion of primary treatment. The patients’ condition was monitored through the OAB questionnaire for 1 year and by urodynamic examination at months 6 and 7 from the start of the study. Results: In group A, the clinical and urodynamic results achieved after the initial + main treatment phase (two high-dosage antimuscarinics of different generations, trospium and solifenacin, for a total of 2.5 months) were maintained for at least 7 months. Electrical stimulation of the urinary bladder as a method of maintenance therapy proved to be less effective. In groups C and D, deterioration in results was observed at 6–8 months, which led us to conclude that laser puncture was an inefficient method of maintenance therapy in elderly women with OAB. Conclusions: Maintenance treatment of OAB in elderly women with a combination of high-dosage antimuscarinics is an effective method for reducing the risk of recurrence of the disease.