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Tolga Han Efe,Çağrı Yayla,Burak Açar,Göktuğ Ertem,Kadriye Gayretli Yayla,Engin Algül,Sefa Ünal,Murat Bilgin,Tolga Çimen,Özgür Kirbaş,Ekrem Yeter 대한심장학회 2017 Korean Circulation Journal Vol.47 No.1
Background and Objectives: The recently discovered myokine irisin has a proposed role in adipose tissue metabolism. The aim of this study was to evaluate the relationship between serum irisin level and the coronary artery severity in patients with stable coronary artery disease (CAD). Subjects and Methods: Sixty-three patients who underwent coronary angiography (CA) diagnosed with stable CAD and twenty-six patients with normal coronary artery (NCA) were enrolled in the study. Stable CAD patients were divided into two groups as high synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score (≥23) and lower SYNTAX score (<23). Serum irisin level measurement was carried out using human irisin colorimetric enzyme-linked immunosorbent assay (ELISA) commercial kit (AG-45A-0046EK-KI01, Adipogen, San Diego, CA, USA) as recommended by the manufacturer’s protocol. Results: The patients with stable CAD with a higher SYNTAX score (score ≥23) had significantly lower serum irisin levels (127.91±55.38 ng/mL), as compared the patients with a low SYNTAX score (score <23) (224.69±92.99 ng/mL) and control group (299.54±123.20 ng/mL). Irisin levels showed significant differences between all groups (p<0.001). Conclusion: Serum irisin level is an independent predictor of coronary artery severity in patients with stable CAD.
( Ismail Kirbas ),( Alper Karahan ),( Abdullah Sevin ),( Cuneyt Bayilmis ) 한국인터넷정보학회 2013 KSII Transactions on Internet and Information Syst Vol.7 No.8
Recently, the use of wireless body area networks (WBAN) has been increasing rapidly in medical healthcare applications. WBANs consist of smart nodes that can be used to sense and transmit vital data such as heart rate, temperature and ECG from a human body to a medical centre. WBANs depend on limited resources such as energy and bandwidth. In order to utilise these resources efficiently, a very well organized medium access control (MAC) protocol must be considered. In this paper, a new, adaptive and energy-efficient MAC protocol, entitled isMAC, is proposed for WBANs. The proposed MAC is based on multi-channel communication and aims to prolong the network lifetime by effectively employing (i) a collision prevention mechanism, (ii) a coordinator node (WCN) selection algorithm and (iii) a transmission power adjustment approach. The isMAC protocol has been developed and modelled, by using OPNET Modeler simulation software. It is based on a networking scenario that requires especially high data rates such as ECG, for performance evaluation purposes. Packet delay, network throughput and energy consumption have been chosen as performance metrics. The comparison between the simulation results of isMAC and classical IEEE 802.15.4 (ZigBee) protocol shows that isMAC significantly outperforms IEEE 802.15.4 in terms of packet delay, throughput and energy consumption.
G발표장 : 유동층1 ; G-14 : Study on gas-solid flow behavior in high-density circulating fluidized beds
( Sung Won Kim ),( Gorkem Kirbas ),( Hsiaotao Bi ) 한국화학공학회 2007 화학공학의이론과응용 Vol.10 No.1
Flow behavior, structures and flow regime were determined in a circulating fluidized bed riser (0.203 m i.d.×5.9 m high) of FCC particles (dp = 70 μm, ρs = 1700 kg/m3). A momentum probe was used to measure radial momentum flux profiles and to distinguish between local net upward and downward flow regions.Time-mean dynamic pressure decreases towards the wall and, the fast fluidization flow regime was observed to coexist with dense suspension upflow (DSU) in the range Ug = 5-8 m/s, Gs = 10-340 kg/m2s. The annular downflow layer disappears locally with increasing solids mass flux (Gs) at a constant Ug, with achievement of the DSU regime. New correlations are developed to predict the thickness of solids down-flowing layer based on solids mass flux and momentum flux. They account for the effect of height on the thickness, and cover high Gs ranges near the onset of the DSU regime. Also, a new flow regime map is proposed distinguishing the fast fluidization, DSU and dilute pneumatic transport flow regimes.
Cure, Medine Cumhur,Cure, Erkan,Kirbas, Aynur,Yazici, Tarkan,Yuce, Suleyman Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12
Aims: To investigate the incidence of ordering tests for tumor markers which are used in cancer diagnosis, follow-up treatment and detection of recurrence, the rate of elevation in benign diseases and which clinics order them frequently. Materials and Method: Data for the tumor markers carbohydrate antigen 19-9 (CA 19-9), carcinoembryonic antigen (CEA), cancer antigen 125 (CA 125), cancer antigen 15-3 (CA 15-3) and alpha-fetoprotein (AFP) that were ordered by all the clinics in our Hospital between 2010 and 2011 were screened. When excluding repeated orders the results of 3,416 patients were available. It has been determined that in which benign diseases were the tumor markers frequently ordered and which of these conditions had high levels of them. Results: CA 19-9 was ordered for 1,858 patients 191 (10.3%) were malignant while 1667 (89.7%) were ordered in benign diseases. For CEA the total was 1,710, 226 (13.2%) malignant and 1484 (86.8%) benign, and for CA 125 1267, 111 (8.8%) malignant and 1156 (91.2%) benign. AFP was ordered for 1687 cases, 80 (4.7%) malignant but 1607 (95.3%) benign. CA 15-3 was ordered 1449 times, 174 (12%) for malignant and 1275 (88%) for benign diseases. In all cases, considerable proportions were positive. Conclusions: It was shown that clinicians frequently order tumor markers for benign conditions. The findings of this study has shown that tumor markers are used widely without indications as cancer screening tests.