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Park, Kyeng Min,Yang, Jeong-A,Jung, Hyuntae,Yeom, Junseok,Park, Ji Sun,Park, Keun-Hong,Hoffman, Allan S.,Hahn, Sei Kwang,Kim, Kimoon American Chemical Society 2012 ACS NANO Vol.6 No.4
<P>A facile <I>in situ</I> supramolecular assembly and modular modification of biocompatible hydrogels were demonstrated using cucurbit[6]uril-conjugated hyaluronic acid (CB[6]-HA), diaminohexane-conjugated HA (DAH-HA), and tags-CB[6] for cellular engineering applications. The strong and selective host–guest interaction between CB[6] and DAH made possible the supramolecular assembly of CB[6]/DAH-HA hydrogels in the presence of cells. Then, the 3D environment of CB[6]/DAH-HA hydrogels was modularly modified by the simple treatment with various multifunctional tags-CB[6]. Furthermore, we could confirm <I>in situ</I> formation of CB[6]/DAH-HA hydrogels under the skin of nude mice by sequential subcutaneous injections of CB[6]-HA and DAH-HA solutions. The fluorescence of modularly modified fluorescein isothiocyanate (FITC)-CB[6] in the hydrogels was maintained for up to 11 days, reflecting the feasibility to deliver the proper cues for cellular proliferation and differentiation in the body. Taken together, CB[6]/DAH-HA hydrogels might be successfully exploited as a 3D artificial extracellular matrix for various tissue engineering applications.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2012/ancac3.2012.6.issue-4/nn204123p/production/images/medium/nn-2011-04123p_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn204123p'>ACS Electronic Supporting Info</A></P>
Park, Kimoon,Yoon, Sanghwa,Kim, Jiwon,Lim, Jae-Hong,Yoo, Bongyoung The Electrochemical Society 2018 Journal of the Electrochemical Society Vol.165 No.11
<P>The shape transition and growth of electrochemically synthesized cubic and non-cubic Co(x)Fe(1-x )nanocrystals (NCs) were investigated. The shapes of the prepared CoxFe1-x NCs were found to be affected by the NC compositions. More specifically, the cubic CoxFe1-x NCs enclosed by {100} facets appeared when the Fe content was >50%. In contrast, non-cubic hemispherical CoxFe1-x NCs appeared when the Co content was >50%. In addition, a reduction in the particle density was observed during NC growth. This phenomenon was illustrated using the interparticle diffusion coupling mechanism, which explains broadening of the particle size distribution and electrochemical Ostwald ripening. (C) 2018 The Electrochemical Society.</P>
Kimoon Son,Taechul Park,SoEun Eom,Ji-won Jeong,Jung-Joon Park 한국응용곤충학회 2023 한국응용곤충학회 학술대회논문집 Vol.2023 No.10
Since the importance of integrated pest management to minimize environmental damage and maximize pest control effectiveness has emerged, efforts to put it into practice have continued. To implement IPM, it is necessary to estimate the economic injury level to determine the control method by identifying pests and weeds that damage the quantity and quality of crops in the field, investigating the occurrence level, and calculating the ratio of cost and effectiveness. Also, damage to host plants caused by increased density of insect pests appears to change plant’s health that key factor for managing crops. Therefore, understanding the relationship between the density of pests and the damage to the host plants is necessary. This study aims to analyze the causal relationship between the density of insect pests and damage to the host plants for estimating the economic injury level of insect pests on the host plants and investigating the possibility of pest control decision-making using plant health status.
Taechul Park,SoEun Eom,Kimoon Son,Ji-won Jeong,Jung-Joon Park 한국응용곤충학회 2023 한국응용곤충학회 학술대회논문집 Vol.2023 No.10
A causality exists between insect density and plant health, where plant health is affected by both the plant’s potential and environmental factors. In other words, causality is possible between insect density and environmental factors, allowing for the analysis of insect density based on these environmental factors. Machine learning enables studying insect density alongside environmental factors, providing insights into the causality between insects, the environment, and plant health. Machine learning is a methodology that involves the design of models by learning patterns from input data. This study aims to predict F. occidentalis density by sampling environmental factors and applying them to machine learning models.
Jung, Hyuntae,Park, Ji Sun,Yeom, Junseok,Selvapalam, Narayanan,Park, Kyeng Min,Oh, Kyunghoon,Yang, Jeong-A,Park, Keun Hong,Hahn, Sei Kwang,Kim, Kimoon American Chemical Society 2014 Biomacromolecules Vol.15 No.3
<P>Despite a wide investigation of hydrogels as an artificial extracellular matrix, there are few scaffold systems for the facile spatiotemporal control of mesenchymal stem cells (MSCs). Here, we report 3D tissue engineered supramolecular hydrogels prepared with highly water-soluble monofunctionalized cucurbit[6]uril–hyaluronic acid (CB[6]-HA), diaminohexane conjugated HA (DAH-HA), and drug conjugated CB[6] (drug-CB[6]) for the controlled chondrogenesis of human mesenchymal stem cells (hMSCs). The mechanical property of supramolecular HA hydrogels was modulated by changing the cross-linking density for the spatial control of hMSCs. In addition, the differentiation of hMSCs was temporally controlled by changing the release profiles of transforming growth factor-β3 (TGF-β3) and/or dexamethasone (Dexa) from the hydrolyzable Dexa-CB[6]. The effective chondrogenic differentiation of hMSCs encapsulated in the monoCB[6]/DAH-HA hydrogel with TGF-β3 and Dexa-CB[6] was confirmed by biochemical glycosaminoglycan content analysis, real-time quantitative PCR, histological, and immunohistochemical analyses. Taken together, we could confirm the feasibility of cytocompatible monoCB[6]/DAH-HA hydrogels as a platform scaffold with controlled drug delivery for cartilage regeneration and other various tissue engineering applications.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2014/bomaf6.2014.15.issue-3/bm401123m/production/images/medium/bm-2013-01123m_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bm401123m'>ACS Electronic Supporting Info</A></P>