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Low hemoglobin A1C increases the risk of disability in community-dwelling older non-diabetics adults
Kim, K. I.,Kim, S.,Kim, K. W.,Jang, H. C.,Kim, C. H.,Chin, H. J. Springer International 2016 European archives of oto-rhino-laryngology Vol.274 No.11
<P>Objective: To describe the health characteristics of individuals with low HbA1c levels and evaluate the association between HbA1c level and disability or all-cause mortality in non-diabetic older adults. Design: Prospective observational cohort study. Setting: Seongnam, Gyeongi Province, Korea. Participants: Among the 1,000 community-dwelling Koreans >= 65 years of age who were followed for 5 years, 760 non-diabetic individuals were analyzed. Measurements: Activities of Daily Living (ADL) and Instrumental ADL (IADL) were evaluated and mortality data were obtained from the National Statistics Office of Korea. Results: The mean age was 76.3 (SD 9.0) years, and 319 subjects (42.0%) were male. Lower level of HbA1c was associated with less frequent hypertension and less frequent use of aspirin or statin, and lower values of body mass index, hematocrit, total iron-binding capacity, albumin, and cholesterol level. The participants were categorized into 3 groups according to their HbA1c (group I, <5.5%; group II, 5.5 +/- 5.9%; and group III, 6.0 +/- 6.4%). Although, there was no significant difference in functional status according to baseline HbA1c level, disability was more frequently observed as the HbA1c level decrease (18.3% in group I, 12.5% in group II, and 5.3% in group III, p=0.029) at the 5-year follow-up evaluation. There were 172 deaths (22.6%) during the follow-up period. There was no significant difference in mortality among the groups, however, group I had a 2.071-fold higher risk for the incident disability or mortality over group III after adjusting age, gender, and possible confounder (95% CI: 1.040 +/- 4.124, p=0.038). Conclusions: Lower level of HbA1c was associated with an increased risk of disability in non-diabetic older adults.</P>
Evaluations of hydrogen permeation on TiN-5wt.%Ni membrane by spark plasma sintering
Kim, K.I.,Hong, T.W. Pergamon Press ; Elsevier Science Ltd 2010 International journal of hydrogen energy Vol.35 No.23
The TiN-5wt.%Ni membrane was researched for gasification of coal technique, separating hydrogen from fossil fuel. In general, Pd and Pd-based alloy membranes of separating hydrogen were reported to have the good property of hydrogen selectivity at high temperature, but they has some problems such as hydrogen embrittlement and high material costs. Therefore, materials with good properties of hydrogen selectivity are needed instead of Pd. In this research, we fabricated membranes for hydrogen permeation that are highly resistant to acids, chemically steady, and composed of the economical substance, TiN. Our laboratory investigated hydrogen selectivity. TiN powder was milled for 30, 60, and 240 min by a vibration mill, respectively. Afterwards, the samples underwent operate spark plasma sintering and was characterized by XRD, BET, and SEM. Also, hydrogen selectivity was measured by Sievert's type hydrogen permeation membrane equipment. In this report, the hydrogen permeability of the TiN-5wt.%Ni membrane was measured to be 7.8x10<SUP>-8</SUP>, 1.7x10<SUP>-7</SUP>, and 1.4x10<SUP>-7</SUP> mol/m.s.Pa<SUP>1/2</SUP> at 473, 573, and 673K under 0.2 MPa H<SUB>2</SUB> atmosphere, respectively.
Kim, Ki‐,Jin,Ahn, Kwang‐,Ho Wiley Subscription Services, Inc., A Wiley Company 2007 MICROWAVE AND OPTICAL TECHNOLOGY LETTERS Vol.49 No.3
<P><B>Abstract</B></P><P>The high isolated dual‐band inverted‐F diversity systems for portable devices, operating in 2.4 GHz band (2400–2484 MHz) and 5.2 GHz band (5150–5350 MHz), are presented. To reduce the mutual coupling and get high isolation between two internal dual‐band antennas, we proposed the small N‐section resonators in the form of slots on the ground plane. The optimized small size resonators for high isolation, antenna radiation efficiency, and high effective diversity are analyzed. Because of their small size, N‐section resonators can be widely used in small diversity systems that require high isolation between antennas. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 731–734, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22238</P>
Kim, K. I.,Cha, S. J.,Lee, C.,Baek, H.,Hwang, S. D.,Cho, M. Y.,Jee, B. Y.,Park, M. A. Springer-Verlag 2016 Archives of virology Vol.161 No.8
<P>Infectious hematopoietic necrosis virus (IHNV; n = 18) was identified in the Korean national surveillance program between February 2013 and April 2015, suggesting that IHNV is a major viral pathogen in cultured salmonids. By phylogeny analysis, we found that the JRt-Nagano and JRt-Shizuoka groups could each be further subdivided into three distinct subtypes. The Korean strains were genetically similar to Japanese isolates, suggesting introduction from Japan. Interestingly, the amino acid sequences of the middle glycoprotein gene show that distinct Korean subtypes have circulated, indicating that the settled IHNVs might be evolved stably in cultured salmonid farm environments.</P>
Microstructural characterization of U‐Zr alloy fuel slugs for sodium‐cooled fast reactor
Kim, Ki‐,Hwan,Oh, Seok‐,Jin,Kim, Sun‐,Ki,Lee, Chong‐,Tak,Lee, Chan‐,Bock John Wiley Sons, Ltd 2012 Surface and interface analysis Vol.44 No.11
<P>In order to investigate a fabrication process of metallic fuel for sodium‐cooled fast reactor, U‐Zr fuel slugs were fabricated with gravity casting and injection casting. In order to reduce the formation of radioactive wastes, and to have a fine microstructure, spherical powder of U‐Zr alloy was also fabricated by centrifugal atomization. The microstructural characteristics were investigated by using electron microscopes and energy‐dispersive electron X‐ray spectroscope. U‐10wt.%Zr fuel slugs had some dispersion phases of Zr precipitates and Zr compounds of about 5 µm in size. The matrix was composed of fine laminar structure of about 0.15 µm in thickness. U grains became finer from about 30 µm in conventionally cast fuel slug to about 2 µm in atomized powder. Laminar structure became so fine from 0.2 µm in conventionally cast fuel slug to 0.1 µm in atomized powder. It is possible for atomized metallic fuel to have a fine microstructure, resulting in a higher fission gas release rate during irradiation. Copyright © 2012 John Wiley & Sons, Ltd.</P>
Significance of molecular markers in survival prediction of oral squamous cell carcinoma
Kim, Ki–,Yeol,Li, ShengJin,Cha, Jeong–,Dan,Zhang, Xianglan,Cha, In–,Ho Wiley Subscription Services, Inc., A Wiley Company 2012 Head & neck Vol.34 No.7
<P><B>Abstract</B></P><P><B>Background</B></P><P>An accurate system for predicting the survival of patients with oral squamous cell carcinoma (OSCC) will be useful for deciding appropriate therapies. The prediction accuracy of prediction models can be improved by using molecular biomarkers. We constructed a nomogram for predicting the survival of patients with OSCC using clinical variables and molecular markers.</P><P><B>Methods</B></P><P>Protein 53 (p53), insulin‐like growth factor II mRNA‐binding protein 3 (IMP3), cyclooxygenase 2 (COX2), and HuR were localized immunohistochemistry in 96 patients with primary OSCC who underwent surgical resection between January 1994 and June 2003 at the Yonsei Dental Hospital in Seoul, Korea.</P><P><B>Results</B></P><P>On univariate and multivariate analysis, the expression of IMP3 was significantly associated with the risk of death. P53 was also significantly associated with survival of OSCC in the case of negative IMP3 and the prediction accuracy was improved by including these 2 factors in the prediction model.</P><P><B>Conclusion</B></P><P>Survival in OSCC can be predicted more accurately by using biomarkers. The constructed nomogram predicted survival after treatment for an individual patient with OSCC, and it can be practically used as a tool to help decide which adjuvant treatment is most appropriate. © 2011 Wiley Periodicals, Inc. Head Neck, 2012</P>
Inhibitory effect of 5-iodotubercidin on pigmentation
Kim, K.I.,Jeong, H.B.,Ro, H.,Lee, J.H.,Kim, C.D.,Yoon, T.J. Academic Press 2017 Biochemical and biophysical research communication Vol. No.
Melanin pigments are the primary contributors for the skin color. They are produced in melanocytes and then transferred to keratinocytes, eventually giving various colors on skin surface. Although many depigmenting and/or skin-lightening agents have been developed, there is still a growing demand on materials for reducing pigmentation. We attempted to find materials for depigmentation and/or skin-lightening using the small molecule compounds commercially available, and found that 5-iodotubercidin had inhibitory potential on pigmentation. When HM3KO melanoma cells were treated with 5-iodotubercidin, pigmentation was dramatically reduced. The 5-iodotubercidin decreased the protein level for pigmentation-related molecules such as MITF, tyrosinase, and TRP1. In addition, 5-iodotubercidin decreased the phosphorylation of CREB, while increased the phosphorylation of AKT and ERK. These data suggest that 5-iodotubercidin inhibits melanogenesis via the regulation of intracellular signaling related with pigmentation. Finally, 5-iodotubercidin markedly inhibited the melanogenesis of zebrafish embryos, an in vivo evaluation model for pigmentation. Together, these data suggest that 5-iodotubercidin can be developed as a depigmenting and/or skin-lightening agent.