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Bupivacaine과 ropivacaine이 Xenopus oocyte에 발현된 HERG 전류에 미치는 영향
김국성,이규승,김효신,손숙진,이상도,김광진,전병화,김윤희,박진봉 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1
Bupivacaine is an amide-type local anesthetic widely used for regional anesthesia. Ropivacaine is developed as a less cardiotoxic alternatives to bupivacaine. In the present study, we have analyzed the effects of bupivacaine and ropivacaine on HERG currents expressed in Xenopus oocytes. Bupivacaine and ropivacaine(3∼1,000μM) blocked HERG currents in a concentration dependent manner. EC_(50) was 26.1±3.1μM(n_(R) 0.65±0.04) and 43.5±7.9μM(n_(H) 0.99±0.13) in bupivacaine and ropivacaine, respectively. Bupivacaine and ropivacaine did not affect the activation and deactivation kinetics of HERG channels. However, the drugs decreased the slope conductance measured from fully activated current-voltage relationship curves. These results suggest that bupivacaine and ropivacaine have a similarinhibitory effect on HERG channels, which could be a possible cellular mechanism of LQT or ventricular arrythmia by the drugs.
저강도 펄스형 초음파를 이용한 개의 슬개골 탈구 치료 효과
조성진,김남수,김화영,김선균,이성호,김병수 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10
The effect of low-intensity ultrasonography on dislocation of the patella and fracture healing is controversial, and current management of that does not generally involve the use of ultrasound therapy. Nine patients with dislocation of the patella were treated with low-intensity ultrasonography(l5 mW/㎠, 1∼3.3 MHz) per 10-15 min/days, with an interval of 3 days during the last 3 weeks, at Family Animal Hospital(in Kunsan city). Ultrasound therapy may be beneficial to dislocation of the patella and healing. This finding is of considerable importance in that treatment with a low-intensity pulsed ultrasound signal may reduce healing time and could yield substantial cost savings and decreases in disability associated with delayed healing of dislocation of the patella.
김재원,김정화,김병조 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2
Objectives : The purpose of this study is to examine the psychosocial and obstetric factors associated with postpartum de-pressive symptoms in Korea. Methods : At the 1-week and 4-week postpartum visit, 61 postpartum women completed Edinburgh Postnatal Depression Scale (EPDS), Beck Depression Inventory (BDI), Stait-Trait Anxiety Inventory (STAI), and Symptom Check List-90-Revised (SCL-90-R). Data related to psychiatric and obstetric characteristics, pregnancy and delivery related events were collected from standard medical records. 42 women without a history of pregnancy or delivery within 6 months were recmited as a control group. The postpartum group were divided into depressive and non-depressive groups according to the EPDS and BDI results of 4-week postpartum. Results : Compared to the normal control group, the mean scores of EPDS and BDI at 1-week postpartum were significantly higher (p<.05 and p<.01, respectively) in the postpartum group. The postpartum group also scored significantly higher in the somatization, Psychoticism, and global severity index profiles according to the SCL-90-R results (p<.05). The mean score of BDI at 4-week postpartum was significantly higher (p<.01) in the postpartum group. There were significant correlations (p<.01) between the EPDS and BDI reports at 1- and 4-week postpartum. The rates of having experienced severe emotionalstress during pregnancy and of smokers and drinkers before pregnancy were significantly higher (p<.05) in the postpartum depressive group (EPDS ≥10 and BDI ≥ 10) compared to the postpartum non-depressive group. The rate of having experi-enced depressive symptoms at 1-week postpartum was also significantly higher in the postpartum group. The depressive sym-ptomatology at 1-week postpartum was identified as a significant risk factor for the depressive symptoms of 4-week postpartum when multiple logistic regression analysis was performed after controlling for age and education level. Conclusion : These findings suggest that postpartum women in Korea have many psychiatric problems such as depressive mood and somatization which necessitate proper care and assessment during the early postpartum period. Stress management during pregnancy may be helpful as a measure of preventing postpartum depression.
이병화,김세환 江原大學校附設體育科學硏究所 2002 江原大學校附設體育科學硏究所論文集 Vol.- No.25
My researching targets are the girls' high school students. The objects of my research are to grope out the improvement course of the effective physical education guidances as examining the avoiding factors closely and classifying, studying and analyzing the attitudes in the physical education classes with two variables - the independent variable, dependent one. The former is the participating attitudes in the study hour under the menstruation. The latter is the main factors such as physical, characteristic, psychological, athletic items and facilities and teacher's factor. The conclusion is as follows. 1. Physical factor- The more active the students are in the class attitude under the menstruation, the more they are influenced by the physical pains, everyday life, schoolwork and physical activities. 2. Characteristic factor - the extrovert students have a tendency to be passive in the studying attitude. 3. Psychological factor - the menstruating students who are participating actively in the class tend to feel much anxiety. 4. Factor of the athletic items - the menstruating students who are participating actively in the class tend to be hindered in the factor of the athletic items and facilities. 5. Teacher factor - the menstruating students who are participating actively in the class would like to go to the nursing room and take part in the light exercises
이정화,김창환,김병완 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.6
The purpose of this study is to examine how much effect the Meditation could make on Middle School students' stress and to search the possibility of applying mediation on real education. The subject of this study were randomly assigneed to either experimental group or control group, 20 in each group. The experimental group had five minute meditation five times per week for seven weeks at auditorium their independent study period. At the same time, the control group studied individually. The stress test was done statistically through t-test and analysis of Covariance total points. Based on the above result, the conclusion is as follows: Firstly, the parents, friend, teacher and school, environment related stress in experimental group applying meditation is lower than that in control group. Secondly, home management, learning related stress in experimental group applying meditation had similarly to control group. However, The stress in experimental group applying meditation is lower than that in control group. Based on the results, it can be concluded that the meditation is effective in reducing middle school students' stress a little. For more profound results, I need to study the new training method of the group counseling, the development of new program and the pertinent training of guidance teachers.
전치부 개방교합과 정상교합자의 근활성도에 관한 비교연구
전병화,김광원 대한치과교정학회 1993 대한치과교정학회지 Vol.23 No.1
This study was undertaken to compare the activity of masticatory muscle between normal occlusion and anterior openbite. 33 subjects without the experience of orthodontic treatment, missing teeth and the symptom of T. M. disorders were selected for this study : 25 subjects were normal occlusion and 8 subjects were anterior openbite. The ten items were measured from the cephalometric headplates, and EMG recordings of the anterior temporal and masseter muscle were taken at rest position and during maximum clenching at centric occlusion. All data were analyzed and processed with the computer statistical method. The following results were obtained : 1. At rest position, the muscle activities of both temporal and masseter muscle were higher in anterior openbite than in normal occlusion. 2. During maximum clenching, the muscle activities of both temporal and masseter muscle were prominently lower in anterior openbite than in normal occlusion. 3. At rest position, the temporal muscle of anterior openbite showed the highest activity, but showed the lowest muscle activity during maximum clenching. 4. Anterior openbite showed closer interrelationship between facial morphology and the muscle activity, and the muscle activity was more influenced by the form of mandible than that of maxilla.
타이타늄 임플란트와 상부구조물의 갈바닉 쌍의 전기화학적 특성
오근택,김명화,최병갑,김경남 大韓齒科器材學會 2003 대한치과재료학회지 Vol.30 No.1
For the aesthetic and functional restoration of edentulous patients, recently dental implants have been used widely. Dental implants and restorative alloys are required with the high corrosion resistance. Suprastructure and implant with different compositions, which are in electrical contact, may develop galvanic or coupled corrosion problems. Besides galvanic corrosion, crevice and pitting corrosion may occur in the marginal gap or the gap between dental implant assemblies. In this study, Ti implants, gold, silver-palladium, cobalt-chromium and nickel-chromium suprastructures were used to investigate their galvanic and crevice corrosion of suprastructure/Ti implant couples. Potentiodynamic and potentiostaic testing were performed in artificial saliva at 37℃. Potentiodynamic testing was carried out at the potential scan rate of 1 ㎷/sec and in the range of -600∼1600 ㎷(SCE). Potentiostatic testing such as open circuit potential and current densities at -250, 0 and 250 ㎷(SCE) was performed for 5000 seconds in artificial saliva. After electrochemical testing, the surface and cross-sectional morphologies of the samples were observed using optical microscopy. Potentiodynamic test results indicated that suprastructure/Tim implant couples exhibited the passive current density range of 0.5∼12 ㎂/㎠, Ti abutment/Tim implant and gold/Tim implant couples exhibited relatively low passive current density, Co-Cr/Tim implant couples the highest. Co-Cr and Ni-Cr/Tim implant couples showed the breakdown potentials of 700 and 570 ㎷(SCE), respectively. Open circuit potentials of silver, Ti abutment, gold, Ni-Cr and Co-Cr/Ti implant couples were -93.2±93.9, -123.7±58.8, -140.0±80.6, -223.5±35.1, and -312.7±29.8, respectively and stable according to immersion time. The couples exhibited cathodic current densities at -250 ㎷(SCE), especially, gold and silver alloys showed the high cathodic current densities of ±3.18 and ±6.63 ㎂/㎠, respectively. At 250 ㎷(SCE), Ti abutment/Ti implant couples exhibited the lowest current density of 9.48×10^-2 ㎂/㎠, and gold, Ni-Cr, Co-Cr and silver/Ti implant couples exhibited 0.313, 1.27, 5.60 and 8.06 ㎂/㎠, respectively. The couples exhibited relatively low current densities at 0 ㎷(SCE). The photographs after electrochemical testing showed crevice or pitting corrosion in the marginal gap and suprastructure surface. Although Co-Cr/Ti implant couples among the tested samples had the possibility of the galvanic corrosion, its degree was not significant.
지구성 운동이 자연발생 고혈압 흰쥐의 혈압에 미치는 영향
이규승,전병화,김일곤,전종귀 忠南大學校體育科學硏究所 1996 體育科學硏究誌 Vol.14 No.1
The purpose of this study is to investigate the effects of indurance exercise on BP of SHR Experimental animals were SHR(180) and SD(90) and they were divided into three groups ; a experimental group1( practice group), a experiment group2(non practice group), and a comparative group (normal group). The experimental group 1 was practicing on a treadmill at 15m/min exercise intensity for 30 minutes a day four times per week for eight weeks. While raising experimental animals, We measured BP for each group once a week, and took the weight of the heart after killing a rat. and then we examined the concentration of ?? and ??, compared, and analyzed them. we have reached the following results. 1. As time passed, BP in the experimental group 1 was almost equal to BP eight weeks ago. BP in the experimental group 2 continued to rise and then showed typical hypertension. 2. The three groups were inclined to increase the weight of their hearts as time passed. However, the experimental group 2 presented the weight of hearts increasing compared with the experimental group1 after eight weeks. 3. In the experimental group 1, and experimental group 2 groups, ?? concentration was but ?? concentration increased as time passed. However, the experimental group1 showed fewer changes than the experimental group 2. 4. The weight of all three groups were inclined to increase as time passed, but it didn't present any noteworthy differences. According to the analysed result of the above experiment, endurannsce exercise becomes an important factor in preventing the raising of BP of SHR, and the hypertrophy of hearts. Key Words : Spontaneously Hypertension Rats, Blood Pressure, Endurance Ecercise
이원철,최병철,오민화,박정일,김현욱,구정완 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.3
Objectives: In order to establish prevalence and characteristics of tinnitus and hearing thresholes according to tinnitus, this study was carried out. Methods: Nine hundred and thirty two subjects, undergone human dock or general health check-up and been in college, were surveyed to the questionnaire on the general characteristics, past medical histories, life styles, subjective symptoms about hearing, taking ototoxic drugs and were conducted on the hearing thresholds by pure tone audiometry. Results: Of the total population, 98 reported tinnitus, giving an overall prevalence of 10.5%, prevalence of tinnitus in the subjects with the factors influencing hearing thresholds were 17.4%, prevalence without the factors influencing hearing thresholds were 7.5%. Frequency of tinnitus of the total population was the highest in 'once per several months' (39.6%) and followed by 'once per several days'(29.7%), 'all day long' (16.5%) and 'several times per day' (14.3%). Complaint site of tinnitus was 41.8% in left ear or right ear, 39.6% in both ear and 18.7% in head. The 13.6% of the total subjects complained sleep disturbance. Hearing thresholds in the subjects without the factors influencing hearing thresholds tended to increase or decrease in 20 and 30 years old according to tinnitus, but those with tinnitus tended to increase more than those without tinnitus in 40 and 50 years old. Conclusions: Results also provide evidence that reports of tinnitus at the time of annual audiometric testing may be useful in identifying workers at greater risk for developing significant shifts in hearing thresholds. Awareness of the possible occurrence of tinnitus may encourage workers to cooperate more actively in a company hearing conservation programme.
Tissue Engineered Mini-Cornea Model for Eye Irritation Test
Kim Seon-Hwa,Jo Sung-Han,Kim Byeong Kook,Park Sang-Hyug 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.2
BACKGROUND: Eye irritation tests with animals have been conducted for a long time. However, the subjective decision to irritation, the anatomic/physiologic difference between species and humans, and ethical issues are crucial problems. Various research groups have paid attention to alternative testing methods. In these senses, we fabricated in vitro minicornea models with immortalized human corneal epithelial cells (iHCECs) and keratocytes (iHCKs) and used them for irritation tests. This study hypothesized that our mini-cornea model could present different viability tendencies according to test chemicals with different irritancy levels. METHODS: Cells used in this study were characterized with cornea-specific markers by immunocytochemistry and western blot. To make a three-dimensional hemisphere construct like cornea stroma, we cultured iHCKs under modified culture conditions verified by matrix formation and total collagen content. iHCECs were seeded on the construct and cultured at an air–liquid interface. The model was treated with 2-phenoxyethanol, triton X-100, sodium lauryl sulfate, and benzalkonium chloride. RESULTS: iHCECs and iHCKs presented their specific cell markers. In modifying the culture condition, the group treating ascorbic acid (200 lg/ml) presented an intact cellular matrix and included the highest collagen content; thus, we used this condition to fabricate the mini-cornea model. The model shows hemisphere shape and homogenous cell distributions in histological analysis. We observed different sensitivity tendencies by types of chemicals, and the model’s viability significantly decreased when the chemical concentration increased. CONCLUSION: In this study, we performed and observed irritation tests using a tissue-engineered mini-cornea model and considered to apply as an alternative approach for animal tests.