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Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau
Joo, Yuyoung,Schumacher, Benjamin,Landrieu, Isabelle,Bartel, Maria,Smet-Nocca, Caroline,Jang, Ahram,Choi, Hee Soon,Jeon, Noo Li,Chang, Keun-A,Kim, Hye-Sun,Ottmann, Christian,Suh, Yoo-Hun The Federation of American Societies for Experimen 2015 The FASEB Journal Vol.29 No.10
<P>14-3-3 proteins act as adapters that exert their function by interacting with their various protein partners. 14-3-3 proteins have been implicated in a variety of human diseases including neurodegenerative diseases. 14-3-3 proteins have recently been reported to be abundant in the neurofibrillary tangles (NFTs) observed inside the neurons of brains affected by Alzheimer’s disease (AD). These NFTs are mainly constituted of phosphorylated Tau protein, a microtubule-associated protein known to bind 14-3-3. Despite this indication of 14-3-3 protein involvement in the AD pathogenesis, the role of 14-3-3 in the Tauopathy remains to be clarified. In the present study, we shed light on the role of 14-3-3 proteins in the molecular pathways leading to Tauopathies. Overexpression of the 14-3-3σ isoform resulted in a disruption of the tubulin cytoskeleton and prevented neuritic outgrowth in neurons. NMR studies validated the phosphorylated residues pSer214 and pSer324 in Tau as the 2 primary sites for 14-3-3 binding, with the crystal structure of 14-3-3σ in complex with Tau-pSer214 and Tau-pSer324 revealing the molecular details of the interaction. These data suggest a rationale for a possible pharmacologic intervention of the Tau/14-3-3 interaction.—Joo, Y., Schumacher, B., Landrieu, I., Bartel, M., Smet-Nocca, C., Jang, A., Choi, H. S., Jeon, N. L., Chang, K.-A., Kim, H.-S., Ottmann, C., Suh, Y.-H. Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau.</P>
Rotaru, Horatiu,Schumacher, Ralf,Kim, Seong-Gon,Dinu, Cristian Korean Association of Maxillofacial Plastic and Re 2015 Maxillofacial Plastic Reconstructive Surgery Vol.37 No.-
The restoration of extensive zygomatic complex defects is a surgical challenge owing to the difficulty of accurately restoring the normal anatomy, symmetry, proper facial projection and facial width. In the present study, an extensive post-traumatic zygomatic bone defect was reconstructed using a custom-made implant that was made with a selective laser melting (SLM) technique. The computer-designed implant had the proper geometry and fit perfectly into the defect without requiring any intraoperative adjustments. A one-year follow-up revealed a stable outcome with no complications.
Chun, B.S.,Kim, K.H.,Leibing, N.,Serrano-Guisan, S.,Schumacher, H.W.,Abid, M.,Chu, I.C.,Mryasov, O.N.,Kim, D.K.,Wu, H.C.,Hwang, C.,Kim, Y.K. Elsevier Science 2012 ACTA MATERIALIA Vol.60 No.19
We report the correlation between the crystalline structure, electronic structure and magnetic properties of Co<SUB>2</SUB>FeAl films as a function of growing temperature both experimentally and theoretically. The Co<SUB>2</SUB>FeAl film grown at room temperature is initially in the partially disordered B2 state, but then it gains a much higher ordered structure with increasing growing temperature due to its transition from short-range to long-range crystallographic order by surface diffusion. Electron energy loss spectroscopy measurements reveals that the increase in the I(L3)/I(L2) ratio of Co can be attributed to the enhanced ferromagnetic exchange interaction between neighboring Co atoms and the fact that the Co contribution is more dominant than the Fe contribution. As the growing temperature increases, many more unoccupied 3d states in Co are observed, hence the Gilbert damping constant increases due to a strong spin-orbit interaction. We also present the results of highly accurate quasiparticle self-consistent GW calculations and confirm that Co<SUB>2</SUB>FeAl in an ideal L2<SUB>1</SUB> structure is indeed a half-metal with a well-defined band gap in the minority spin channel.
Primate Model for the Evaluation of Vaginal Contraceptives
Zoneveld, L.J.D.,Bhattacharyya, A.K.,Kim, D-S,Schumacher, G.F.B.,Beluhan, Z. The Korean Society for Reproductive Medicine 1979 Clinical and Experimental Reproductive Medicine Vol.6 No.1
A good animal model that simulates the human subject has not been available for the evaluation of the in vivo effectiveness of vaginal contraceptives. After careful consideration, The stumptailed macaque (Macaca arctoides) was studied for its applicability since it has a reproductive tract similar to that of the woman, is easy to handle, does not require tranquilization or anesthesia when the contraceptive is deposited, and breeds and conceives readily under caged conditions. The reported observations show the usefulness of this animal. Both postcoital sperm motility studies and breeding experiments were performed with the use of Delfen vaginal cream and K-Y jelly. K-Y jelly had no effect on the motility of vaginal spermatozoa or on the conception rate of the primates. Although Delfen vaginal cream consistently immobilized all spermatozoa in the postcoital test, half of the animals became pregnant within an average of 3.7 breeding cycles. These results illustrate the discrepancy between spermicidal tests and fertility measurements, and it is recommended that primate-breeding experiments be performed before a spermicide is evaluated in women as a contraceptive. (AM J. OBSTET. GYNECOL, 129:368, 1977.)