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Nitroblue tetrazolium test를 이용한 소아백혈구의 임상실험
김순겸 고려대학교 의과대학 1980 고려대 의대 잡지 Vol.17 No.2
Nitroblus tetrazolium dye reduction test has been widely used cytochemically which can be reduced to water insoluble formazan by neutrophils during phagocytosis. The slightly modified cytochemical NBT test to Gifford and Malawista was performed in 140 cases with healthy normal children and various infectious diseases to determine whether this NBT test would be of diagnostic value in patients having infectious diseases. The followings were obtained as results. 1) The mean ±SD of NBT positive neutrophils was 31.5±11.7% in healthy control group and no differences were observed between NBT test without latex particles and the test with latex particls. 2) In newborn infants the percentage of NBT positive neutrophils was initially increased on the first day of life, decreasing gradually day by after birth. 3) The percentage of NBT positive neutrophils was highly increased in bacterial infections, however in viral infections and tuberculosis the results of the test were in normal range. 4) Bacterial endotoxin stimulated NBT reduction by actin in first incubation and stercid did not depress the formazan cell count in vitro.
Kim, Jee Hung,Park, Hyung Soon,Heo, Su Jin,Kim, Sang Kyum,Han, Jung Woo,Shin, Kyoo-Ho,Kim, Seung Hyun,Hur, Hyuk,Kim, Kyung Sik,Choi, Young Deuk,Kim, Sunghoon,Lee, Young Han,Suh, Jin-Suck,Ahn, Joong-Ba S. Karger AG 2019 Oncology Vol.96 No.2
<P><B><I>Background:</I></B> We retrospectively investigated the treatment outcomes of second-line treatment with pazopanib or gemcitabine/docetaxel in patients with advanced soft tissue sarcoma (STS). <B><I>Methods:</I></B> Ninety-one patients who were treated with pazopanib or gemcitabine/docetaxel for advanced STS between 1995 and 2015 were analyzed. <B><I>Results:</I></B> Forty-six and 45 patients received pazopanib and gemcitabine/docetaxel, respectively. The median progression-free survival for the group treated with pazopanib was 4.5 months compared with 3.0 months for the gemcitabine/docetaxel group (<I>p</I> = 0.593). The median overall survival for the group treated with pazopanib was 12.6 months compared with 14.2 months for the gemcitabine/docetaxel group (<I>p</I> = 0.362). The overall response rates (ORRs) were 6.5 and 26.7% in the pazopanib and gemcitabine/docetaxel groups, respectively. The following parameters had ORRs favoring gemcitabine/docetaxel: age ≥50 years (31.6 vs. 2.9%, <I>p</I> = 0.006), histologic grade 1–2 (40.9 vs. 0%, <I>p</I> = 0.001), and poor first-line treatment response (23.3 vs. 3.0%, <I>p</I> = 0.022). Gemcitabine/docetaxel was associated with better ORRs for the following histologic subtypes: leiomyosarcoma (<I>p</I> = 0.624), malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma (<I>p</I> = 0.055), and angiosarcoma (<I>p</I> = 0.182). However, the ORR of synovial sarcoma favored pazopanib (<I>p</I> = 0.99). <B><I>Conclusions:</I></B> The efficacies of pazopanib and gemcitabine/docetaxel as second-line treatments after doxorubicin or ifosfamide failure differed among clinical and histologic subgroups and appeared to facilitate a more personalized treatment approach for advanced STS.</P>
Unrecorded prokaryotic species belonging to the class Actinobacteria in Korea
Kim, Mi-Sun,Jeong, Seong-Hwa,Kang, Joo-Won,Kim, Seung-Bum,Cho, Jang-Cheon,Cha, Chang-Jun,Im, Wan-Taek,Bae, Jin-Woo,Lee, Soon-Dong,Kim, Won-Yong,Kim, Myung-Kyum,Seong, Chi-Nam The National Institute of Biological Resources 2019 Journal of species research Vol.8 No.1
For the collection of indigenous prokaryotic species in Korea, 35 strains within the class Actinobacteria were isolated from various environmental samples (animals and clinical specimens) in 2017. Each strain showed high 16S rRNA gene sequence similarity (>98.8%) and formed a robust clade with recognized actinobacterial species. The isolates were assigned to 35 species, 22 genera, 15 families, and 8 orders of the class Actinobacteria. There are no official descriptions of these 35 bacterial species in Korea. Morphological properties, basic biochemical characteristics, isolation source, and strain IDs are included in the species descriptions.
Kim, Dong-Uk,Seong, Chi-Nam,Jahng, Kwangyeop,Lee, Soon Dong,Cha, Chang-Jun,Joh, Kiseong,Jeon, Che Ok,Kim, Seung-Bum,Kim, Myung Kyum The National Institute of Biological Resources 2018 Journal of species research Vol.7 No.2
In 2016, as a subset study to discover indigenous prokaryotic species in Korea, a total of 15 bacterial strains were isolated and assigned to the class Betaproteobacteria. From the high 16S rRNA gene sequence similarity (>98.8%) and formation of a robust phylogenetic clade with the closest species, it was determined that each strain belonged to each independent and predefined bacterial species. There is no official report that these 15 species have been described in Korea; therefore, 1 strain of the Aquitalea, 5 strains of the Paraburkholderia, 2 strains of the Comamonas, 1 strain of the Cupriavidus, 1 strain of the Diaphorobacter, 2 strains of the Hydrogenophaga, 1 strain of the Iodobacter, 1 strain of the Massilia and 1 strain of the Rhodoferax within the Betaproteobacteria are described for unreported bacterial species in Korea. Gram reaction, colony and cell morphology, basic biochemical characteristics, and isolation sources are also described in the species description section.
e-서비스품질요인이 고객만족과 관계유지의도에 미치는 영향
김형순(Kim, Hyoung-Soon),김원겸(Kim, Won-Kyum),범경기(Fan, Qing ji),석서(Shi, Shu) 한국상품학회 2009 商品學硏究 Vol.27 No.2
본 연구의 주된 목적은 웹 사이트 서비스품질요인과 고객만족 및 관계유지의도간의 관계를 규명하고자 하는 것이다. 이를 위해 웹 사이트 서비스의 신뢰성, 편리성, 콘텐츠, 오락성, 커뮤니케이션, 디자인 등 웹 사이트 서비스 평가차원을 독립변수로 선정하였다. 고객이 웹 사이트에 대한 고객의 만족을 매개변수로 설정하고, 종속변수인 소비자의 관계유지의도간의 인과관계를 나타내는 연구모형과 가설을 설정하였다. 평가 모형의 활용도 제고를 위하여 웹 사이트 유형별로 e-서비스품질요인들이 고객만족에 미치는 영향의 효과차이를 분석하였다. 본 연구의 실증분석 결과는 웹 사이트 서비스품질요인을 밝혀냈고, 고객이 웹 사이트에 대해 만족할수록 앞으로 웹 사이트와 지속적인 관계를 유지할 가능성이 높은 것으로 분석되었다. 마지막으로 본 연구에서 웹 사이트 유형에 따라 서비스품질요인이 고객만족에 미치는 영향의 효과차이가 있는 것을 밝혀냈다. 이러한 연구결과에 의하면 실무적으로는 웹 사이트 운영기업들이 웹 사이트를 운영할 수 있는 새로운 방법을 제공해 줄 수 있을 것이다. The purpose of this study is to investigate the impacts of e-service quality factors on customer satisfaction and relationship intention by Web site types. Difference and moderating effect resulting from the type of web site users about an association with reaction of satisfaction and those component concepts are also one of the aims in the study. As the results, the study found that factors of web site service quality variables has a positive impact on customer satisfaction. And customer satisfaction also has a positive impact on relationship intention. Furthermore, through the comparative analysis, we found that the service quality differed on the effects of customer satisfaction by web site types. According to those results, marketing managers should develop different service strategies based on different web site types.