베체트병 환자에서 Azathioprine으로 유발된 급성 췌장염 1례

김기향,권민정,김동기,김애란,김윤정,박지훈,이영태,박보민,김동욱 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Although many drug are thought capable of initiating acute pancreatitis, following azathioprine administration represents the 5% incidence by far the highest recorded incidence to date. We report a 35-year-old male who developed acute pancreatitis in the course of treatment with azathioprine for Behcet's disease. He was admitted due to abdominal pain, diarrhea, and fever for 10 days. Serum amylase and lipase levels were 510U/L and 3702U/L respectively. The abdominal CT scan revealed diffuse enlargement of the pancreas. There was no history of alcohol use or gall bladder disease. We considered drugs, especially azathioprine, as the cause of acute pancreatitis. We diagnosed it as acute pancreatitis. The patient was treated conservatively with hydration and analgesics. The symptom subsided within four days. Five days later, azathioprine was resumed. And the patient complained of abdominal pain. The elevated levels of serum amylase and lipase confirmed the recurrence of pancreatitis. His symptom subsided when azathioprine intake the stopped, and the serum amylase and lipase levels returned to normal level within five days.

관상동맥질환을 동반한 모야모야병 1례

김동기,이영태,김기향,김성만,김대경,김두일,김동수 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Moyamoya disease is an occlusive intracranial arteriopathy with an abnormal cerebral vascular collateral networks. Although this disease is known to be associated with stenosis of extracranial arteries, such as the renal artery, a case associated with stenosis of the coronary artery is extremely rare. We report a case of coronary artery occlusive disease affected by Moyamoya disease. The patient was a 38-year-old female experiencing intermittent headache and exer tional chest pain. Cerebral MRI showed complete obstruction of both internal carotid arteries and abnormal cerebrovascular systems which confirmed Moyamoya disease. Coronary angiography showed a significant stenosis of left anterior descending coronary artery ostium with TIMI grade I collateral blood flow from the normal right coronary artery. After coronary artery stenting and medical treatment for headache, her subjective symptoms were relieved. In Moyamoya patient, an evaluation of the extracranial (especially coronary artery) vascular system should be considered if there are some evidences of coronary artery disease.

中國中古前期時代의 數學史槪觀

金東琪 명지대학교 1983 明大論文集 Vol.14 No.-

상악 제1소구치의 교두각에 따른 전부도재관의 응력분포에 관한 연구

김원규,신동국,송기범,동진근 원광대학교 치의학연구소 2003 圓光齒醫學 Vol.12 No.3

The purpose of this study was to know stress distribution of ceramic crown according to the cusp angle. For the study, it was manufactured a three dimensional finite element model simplified maxillary first premolar, and then analyzed stress distribution when cusp angle was each 80°, 90°, l00°, 110° and 120°. The results obtained were as follows; 1. The von Mises stress showed that stress decreases as cusp angle increases in the central groove of the occlusal surface. 2. It showed that maximum principal stress was centered at the region of the central groove of the occlusal surface and a region which the force was inflicted. And also it appeared high on the lingual and buccal side of finish line. 3. The X axis of normal stress was focused in the central groove of the occlusal surface. The Y axis of normal stress appeared high in the central groove of the occlusal surface, b u d and lingual side. 4. The stress near the finish line showed a low value compared with stress in the region of the central groove of the occlusal surface. 5. It showed that the most dangerous angle for tooth fracture was on 80° of the cusp angle and low on 120° of its.

有限半群의 Construction 理論에 對하여

金東璂 명지대학교 1979 明大論文集 Vol.12 No.-

CAE를 이용한 플라스틱 사출금형 제품 개발

김기환,권창오,송동주 嶺南大學校 工業技術硏究所 2002 工業技術硏究所論文集 Vol.30 No.2

Optimal design for the injection molding process of a hand brake cover was investigated by using CAE. The viscoelastic flow through a hand brake cover shape mold were calculated and compared with the experimental data. Numerical analysis reasonably predicted the general performance, i.e, hold pressure, cooling time and hold pressure time. In order to determine optimal process parameters, Numerical analysis and experiments have been performed for various process conditions. In this study, we increased the productivity by 160% by optimal process conditions.

치아회분과 석고혼합제재 매식후 Digital Subtraction Radiography에 의한 골량 변화의 평가

김재덕,최의환,김광원,조영곤,김동기 大韓口腔顎顔面 放射線學會 1999 Imaging Science in Dentistry Vol.29 No.2

Purpose : To assess the methods for the clinical evaluation of the longitudinal bone changes after implantation of tooth ash-plaster mixture into the defect area of human jaws. Materials and methods : Tooth ash-plaster mixtures were implanted into the defects of 8 human jaws. 48 intraoral radiograms taken with copper step wedge as reference at soon, 1st, 2nd, 4th, and 6th week after implantation on mixture were used. X-ray raking was standardized by using Rinn XCP device customized directly to the individual dentition with resin bite block. The images inputted by Quick scanner were digitized and analyzed by NIH image program. Cu-equivalent values were measured at the implanted sites from the periodic digital images. Analysis was performed by the bidirectional subtraction with color enhancement and the surface plot of resliced contiguous image. The obtained results by the two methods were compared with Cu-equivalent value changes. Results : The average determination coefficient of Cu-equivalent equations was 0.9988 and the coefficient of variation of measured Cu values ranged from 0.08∼0.10. The coefficient of variation of Cu-equivalent values measured at the areas of the mixture and the bone by the conversion equation ranged from 0.06∼0.09. The analyzed results by the bidirectional subtraction with color enhancement were coincident with the changes of Cu-equivalent values. The surface plot of the resliced contiguous image showed the three dimensional view of the longtudinal bone changes on one image and also coincident with Cu-equivalent value changes after implantation. Conclusion : The bidirectional subtraction with color enhancement and the surface plot of the resliced contiguous image was very effective and reasonable to analyze clinically and qualitatively the longitudinal bone change. These methods are expected to be applicable to the non-destructive test in other fields.(J Korean Oral Maxillofac Radiol 1999;29:423-434)

일부 지역사회에서 구강건강관리인력의 금연지도활동에 관한 조사연구

김동기,김진선,성진효 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.4

Purposes: The purposes of this descriptive correlational study were to assess knowledge and attitude related to smoking, smoking cessation counselling activity, and to identify predictors of smoking cessation counselling activity among oral health care team(OHCT) in a community. Method: All of oral health care personnels employed by university dental hospital, dental hospital, dental clinic and dental clinic of health center in a community were surveyed using a structured questionnaire. Of the oral health personnel surveyed, 760(38.5%) returned completed questionnaires. Results: OHCT had a relatively positive attitude toward the their roles and responsibilities about smoking cessation counselling activity. However, smoking cessation counselling activity was not a routine part of dental practice. Moreover, the level of smoking cessation counselling activity was significantly different by working place. OHCT who working at the university dental hospital, dental hospital and dental clinic of health center were more actively participate in smoking cessation counselling activity than OHCT who working at the dental clinic. Smoking cessation counselling activity was correlated with knowledge of smoking, attitudes to smoking related issues, and self-efficacy of smoking cessation counselling activity. In the final stepwise multiple regression, smoking cessation activity was predicted by OHCT's working place, attitudes to related to smoking issues, and self-efficacy of counselling knowledge and skills. Condusion: OHCT need to participate routinely and actively in smoking cessation counselling activity. For OHCT to effectively counsel and intervene patients regarding smoking cessation, it is essential to integrate smoking cessation intervention education into dental school curricula and to offer continuing education smoking cessation intervention to practicing OHCT.

방선균 WCM-9가 생산하는 Polyene 항진균성 항생물질(AF1)의 생물학적 성상

신운섭,정선호,이동희,이경호,김수기,박주영,고춘명 대한의진균학회 1996 대한의진균학회지 Vol.1 No.1

Background: Pathogenic fungi infect humans, especially immunocompromised patients, with superficial or deeply invasive pattern. In the past 20 years, fungal infections have been increased dramatically resulted by increment of organ transplantation, cancer, AIDS patients, or use of broad-spectrum antibacterial agents. Fungal infections are now important causes of morbidity and mortality of hospitalized patients. but there is no effective antifungal antibiotics as well as antibacterial antibiotics Objective: Effective new antifungal antibiotics are needed for the treatment of mycosis. So in an effort to develop effective antifungal antibiotics, we screened over 600 isolates of Streptomyces spp. from soil. Methods: Antifungal producing strain was selected using disk diffusion method, An antifungal substance (AF1) was purified with ethyl acetate extraction, silica gel column chromatography and reverse phase HPLC. MICs of AF1 were detected by agar dilition method. Results: The compound showed UV maxima of 307, 321, 340, 359 nm indicating methylpentaene. Minimum inhibitory concentrations of the AF1 were 3.7 ㎍/ml against mold, and 3.7 - 7.4 ㎍/ml against Candida species. AF1 was also active against Cryptococcus neoformans, with MIC of 0.9 ㎍/ml. The concentration of AF1 for K^+ ion release from human red blood cell and hemolysis were 5 ㎍/ml. Conclusion: The antibiotic purified from culture broth of Streptomyces sp. WCM-9 was a polyene antifungal antibiotic which have broad spectrum antifungal activity.

난소의 평활근종 - 2예 보고 -

기정혜,김태승,신동환 대한병리학회 1999 Journal of Pathology and Translational Medicine Vol.33 No.7