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PBD공법이 적용된 대심도 연약지반에 대한 압밀분석해에 관한 연구
최기철 ( Choi¸ Ki-chul ),오원근 ( Oh¸ Won-keun ),천병식 ( Chun¸ Byung-sik ) 한국구조물진단유지관리공학회 2007 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.11 No.1
It is very important to determine the consolidation rate of ground, depending on the progress of time in applying vertical drain method, so that various consolidation analysis solutions are proposed for forecasting of the consolidation rate. The consolidation rate measured in the actual field, however, has a considerable difference from the value which was obtained by the interpretation of vertical drain consolidation. This study was assessed the applicability and validity of each consolidation analysis solution by comparing and analyzing the degree of consolidation actually measured in the field and the degree of consolidation based on the theoretical equation for the analysis of the consolidation of Hansbo, Onoue, Zeng&Xie used as the consolidation analysis solution before the start of construction, on the basis of the site measurement data and ground survey data as to the deep soft ground in Busan area which applies PBD method.
Robust speaker recognition against background noise in an enhanced multi-condition domain
Kichul Kim,Moo Young Kim IEEE 2010 IEEE transactions on consumer electronics Vol.56 No.3
<P>In the midst of background noise environments, the performance of speaker recognition (SR) systems is considerably degraded. To estimate the model mismatch between training and evaluation data, we also propose an intra Kullback-Leibler distance (intra-KLD) measure. Based on the intra-KLD, the performance of SR systems using speech enhancement (SE) and multi-condition (MC) training can be predicted with reduced computational complexity. Since SE cannot fully remove real-world noise without modifying the clean speech signal, the SR model trained only with a clean speech signal cannot fully represent the evaluation data that include various noisy signals preprocessed by SE. To compensate for this problem, we apply SE as a preprocessing block not only for the evaluation stage, but for the training stage. Moreover, we propose to combine SE and MC training (SE-MC) where various sets of features are extracted in an SE domain and a model for each speaker is trained based on the mixture of SE-domain features. Under various background noise environments, SE, MC, and SE-MC produced SR error rates of 43.51%, 25.00%, and 20.29%, respectively.</P>
Roles of Sex Hormones and Gender in the Gut Microbiota
( Kichul Yoon ),( Nayoung Kim ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2021 Journal of Neurogastroenterology and Motility (JNM Vol.27 No.3
The distribution of gut microbiota varies according to age (childhood, puberty, pregnancy, menopause, and old age) and sex. Gut microbiota are known to contribute to gastrointestinal (GI) diseases such as irritable bowel syndrome, inflammatory bowel disease, and colon cancer; however, the exact etiology remains elusive. Recently, sex and gender differences in GI diseases and their relation to gut microbiota has been suggested. Furthermore, the metabolism of estrogen and androgen was reported to be related to the gut microbiome. As gut microbiome is involved in the excretion and circulation process of sex hormones, the concept of “microgenderome” indicating the role of sex hormone on the gut microbiota has been suggested. However, further research is needed for this concept to be universally accepted. In this review, we summarize sex- and gender-differences in gut microbiota and the interplay of microbiota and GI diseases, focusing on sex hormones. We also describe the metabolic role of the microbiota in this regard. Finally, current subjects, such as medication including probiotics, are briefly discussed. (J Neurogastroenterol Motil 2021;27:314-325)
Dynamic Changes in Helicobacter pylori Status Following Gastric Cancer Surgery
( Kichul Yoon ),( Nayoung Kim ),( Jaeyeon Kim ),( Jung Won Lee ),( Hye Seung Lee ),( Jong-chan Lee ),( Hyuk Yoon ),( Cheol Min Shin ),( Young Soo Park ),( Sang-hoon Ahn ),( Do Joong Park ),( Hyung Ho 대한소화기학회 2017 Gut and Liver Vol.11 No.2
Background/Aims: Helicobacter pylori eradication is recom-mended in patients with early gastric cancer. However, the possibility of spontaneous regression raises a question for clinicians about the need for “retesting” postoperative H. py-lori status. Methods: Patients who underwent curative gas-trectomy at Seoul National University Bundang Hospital and had a positive H. pylori status without eradication therapy at the time of gastric cancer diagnosis were prospectively enrolled in this study. H. pylori status and atrophic gastritis (AG) and intestinal metaplasia (IM) histologic status were as-sessed pre- and postoperatively. Results: One hundred forty patients (mean age, 59.0 years; 60.7% male) underwent subtotal gastrectomy with B-I (65.0%), B-II (27.1%), Roux-en-Y (4.3%), jejunal interposition (0.7%), or proximal gastrectomy (4.3%). Preoperative presence of AG (62.9%) and IM (72.9%) was confirmed. The mean period between surgery and the last endoscopic follow-up was 38.0±25.6 months. Of the 140 patients, 80 (57.1%) were found to be persistently posi-tive for H. pylori, and 60 (42.9%) showed spontaneous nega-tive conversion at least once during follow-up. Of these 60 patients, eight (13.3%) showed more complex postoperative dynamic changes between negative and positive results. The spontaneous negative conversion group showed a trend of having more postoperative IM compared to the persistent H. pylori group. Conclusions: A high percentage of spontaneous regression and complex dynamic changes in H. pylori status were observed after partial gastrectomy, especially in individ-uals with postoperative histological IM. It is better to consider postoperative eradication therapy after retesting for H. pylori. (Gut Liver 2017;11:209-215)
Using reverse docking to identify potential targets for ginsenosides
Kichul Park,Art E. Cho 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.4
Background: Ginsenosides are the main ingredients of ginseng, which, in traditional Eastern medicine, has been claimed to have therapeutic values for many diseases. In order to verify the effects of ginseng that have been empirically observed, we utilized the reverse docking method to screen for target proteins that are linked to specific diseases. Methods: We constructed a target protein database including 1,078 proteins associated with various kinds of diseases, based on the Potential Drug Target Database, with an added list of kinase proteins. We screened 26 kinds of ginsenosides of this target protein database using docking. Results: We found four potential target proteins for ginsenosides, based on docking scores. Implications of these “hit” targets are discussed. From this screening, we also found four targets linked to possible side effects and toxicities, based on docking scores. Conclusion: Our method and results can be helpful for finding new targets and developing new drugs from natural products.
( Kichul Shin ),( Sung Soo Kim ),( Sang-heon Lee ),( Seung-jae Hong ),( Sung Jae Choi ),( Jung-yoon Choe ),( Seung-geun Lee ),( Hoon-suk Cha ),( Eun Young Lee ),( Sung-hwan Park ),( Jin-wuk Hur ),( Su 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.1
Background/Aims: The objective of this study was to compare changes in the simplified disease activity index (SDAI) between biologic (b) and conventional (c) disease-modifying antirheumatic drugs (DMARD) users with seropositive rheumatoid arthritis (RA) in daily clinical practice. Methods: This was a nationwide multicenter observational study. Patients who had three or more active joint counts and abnormal inf lammatory marker in blood test were enrolled. The selection of DMARDs was determined by the attending rheumatologist. Clinical parameters, laboratory findings, and Health Assessment Questionnaire (HAQ) scores were obtained at baseline and at 6 and 12 months. Serial SDAI changes and clinical remission rate at 6 and 12 months were assessed. Results: A total of 850 patients participated in this study. The mean baseline SDAI score in bDMARD group was higher than that in cDMARD group (32.08 ± 12.98 vs 25.69 ± 10.97, p < 0.0001). Mean change of SDAI at 12 months was -19.0 in the bDMARD group and -12.6 in the cDMARD group (p < 0.0001). Clinical remission rates at 12 months in bDMARD and cDMARD groups were 15.4% and 14.6%, respectively. Patient global assessment and HAQ at 12 months were also significantly improved in both groups. Multivariate logistic regression showed that baseline HAQ score was the most notable factor associated with remission. Conclusions: There was a significant reduction in SDAI within 12 months after receiving DMARDs in Korean seropositive RA patients irrespective of bDMARD or cDMARD use in real-world practice. Clinical remission was achieved in those with lower baseline HAQ scores.