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( Hyang Jee ),( Su Hyung Lee ),( Jun Won Park ),( Bo Ram Lee ),( Ki Taek Nam ),( Dae Yong Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2013 BMB Reports Vol.46 No.1
Gap junctions and their structural proteins, connexins (Cxs), have been implicated in carcinogenesis. To explore the involvement of Cx32 in gastric carcinogenesis, immunochemical analysis of Cx32 and proliferation marker Ki67 using tissue-microarrayed human gastric cancer and normal tissues was performed. In addition, after Cx32 overexpression in the human gastric cancer cell line AGS, cell proliferation, cell cycle analyses, and p21^Cip1 and p27^Kip1 expression levels were examined by bromodeoxyuridine assay, flow cytometry, real-time RT-PCR, and western blotting. Immunohistochemical study noted a strong inverse correlation between Cx32 and Ki67 expression pattern as well as their location. In vitro, overexpression of Cx32 in AGS cells inhibited cell proliferation significantly. G1 arrest, up-regulation of cell cycle-regulatory proteins p21^Cip1 and p27^Kip1 was also found at both mRNA and protein levels. Taken together, Cx32 plays some roles in gastric cancer development by inhibiting gastric cancer cell proliferation through cell cycle arrest and cell cycle regulatory proteins. [BMB Reports 2013; 46(1): 25-30]
이기택 서울대학교 사회과학연구소 1984 社會科學과政策硏究 Vol.6 No.1
외교사난 국제정치사에서 네이션 스테이트(nation state)형성 또는 민족국가 형성이라고 하는 것을 근대사에서 살피면, 100년전 독일이 통일할 때, 또 이탈리아가 흩어진 자기네 민족을 결합, 통합하여 근대적인 통일국가를 형성하는 것이나, 또 섬나라로 형성되어 있었기 때문에 오랫동안 오토만(Ottoman)제국 하에서 민족이 흩어져 있었던 그리이스가 센트 페테스부르크(Saint Petersburg)나 런던(London)이나 파리(Paris)로 흩어졌던 민족들을 문화적인 전통을 가지고서 결합시켜 들어간 경우들이 있읍니다.
PVC 열분해에 따른 분자량 변화 및 열안정성에 관한 연구
맹기석,황택성 忠南大學校 産業技術硏究所 1990 산업기술연구논문집 Vol.5 No.1
To investigate the influence of the microstructure of PVC on the it's thermal degradation mechanism, the thermal degradation was done at 190℃ in nitrogen atmosphere furnance. And the evolved HCI content, microstructure of PVC, molecular weight, content of tertiary chlorine number of internal double bonds were measured by PH meter, FT-IR, C-NMR, UV-visible spectroscopy and GPC, phenolysis, and bromination reaction, respectively. The experimental results show that the most important defect site of the thermal degradation of PVC is the tertiary chlorine.
이기섭,임계택 全南大學校 農業科學技術硏究所 1997 農業科學技術硏究 Vol.32 No.-
S에 대한 생체의 반응을 유도단백질로 표현하여 생리적인 급여 수준을 결정할 목적으로 mouse를 model로 실험한 결과는 다음과 같다. Na₂S·9H₂O를 1mM, 2mM, 3mM로 농도로 쥐에게 급여한 후 3h, 6h, 12h, 24h, 48h 간격으로 근육, 비장, 간, 뇌를 채취하여 유도단백질의 생성을 측정하였을때 근육은 1mM의 12h에서 약 27KDa를, 1mM의 12h, 24h, 48h과 2mM의 3h, 6h에서 약 15KDa의 유도단백질을 생성 하였다. 비장은 1mM의 6h와 3mM의 12h, 24h에서 약 50KDa의 유도단백질을 생성 하였으며 간에서는 3mM에서 6h, 12h, 24h에 약 18KDa의 유도단백질을 생성 하였으나 뇌의 경우에는 유도단백질을 관찰 하지 못하였다. 따라서 S와 Se는 근육에서 유사한 유도단백질을 보였으며 S에 있어서 근육과 비장에서 비교적 민감하게 반응 하였고 뇌의 경우에는 반응이 없음을 알 수 있었다. We measured the amount of the induction proteins to see the physiological level of S(sulfur). Two induction proteins in the muscle were detected by sulfur treatment. One of them is 27KDa at the concentration of 1mM/12hr, the other is 15KDa at 2mM/3hr. In the spleen, we observed just one induction protein, 50KDa, at 1 mM /6hr and 3mM/12hr respectively. 18KDa induction protein was expressed at 3mM/6hr in liver. In the brain, we didn't find any inducton protein . Generally, the induction proteins by S treatment were expressed early at high concentration, while the expression time of protein was slowly at low concentration, comparison with the high concentrations. The tendencies of the expression of induction protein by S treatment were similar to the case of Se. 6)
partial pulpotomy를 이용한 미성숙 영구치의 치수 치료: 증례 보고
장기택,노승철,한세현,김정욱,김용수 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.4
치수치료의 주요한 목적은 구강조직의 본래의 건강을 유지하는 것이며, 치수치료 시 가장 중요하고 어려운 점은 치수조직의 건강상태 또는 염증의 정도를 결정함으로써 최선의 치료방법을 결정하는 것이다. 미성숙 영구치는 풍부한 혈류 공급으로 다양한 손상에 성공적으로 반응하게끔 치수의 능력을 향상시킴으로써 많은 치수치료 술식을 위한 좋은 조건을 가지고 있다. 기저재(base) 또는 이장재(liner), 간접 치수복조술, 직접 치수복조술, 그리고 치경부 치수절단술을 포함한 여러 종류의 보존적인 치수치료가 미성숙 영구치를 위해 추천되어 왔다. 근래에는 외상으로 인하여 치수노출된 영구절치를 치료하는데 있어 주로 제시된 부분 치수절단술(partial pulpotomy)이 우식으로 인해 치수노출된 영구대구치를 치료하는 또다른 술식으로 제안되고 있다. 부분 치수절단술 후 치아가 다음의 criteria를 만족시킬 때 치유가 되었다고 결론지었다. 1. 임상적 무증상 2. dentin bridge 형성의 방사선학적 증거 3. 방사선상에 치수내 또는 치근단 병소가 없다는 증거 4. 지속적인 치근 발육과 미성숙 치아의 치근첨 형성 5. 성숙된 치아에서 정상적인 상아질의 축적 6. 전기치수검사에서 양성 반응 이에 저자는 미성숙 영구치에서 우식 또는 외상으로 인한 치수노출시 부분 치수절단술을 행하여 양호한 결과를 얻었기에 이를 보고하는 바이다. The primary objective of pulp treatment is to maintain the integrity and health of the oral tissues. The most important and difficult aspect of pulp therapy is determining the health of the pulp, or its stage of inflammation, so that a decision can be made regarding the best form of treatment. Immature permanent teeth are good candidates for many pulp healing procedures, due to their rich blood supply, which is believed to enhance the pulp's ability to react successfully to various insults. Healing was considered to have taken place when the tooth fulfilled the following criteria: 1. Abscence of clinical symtoms 2. Radiographic evidence of dentin bridge formation 3. No intrapulpal or periapical pathosis was evident radiographically 4. Continued root development and closure of the apex in immature teeth 5. Normal dentin apposition in mature teeth 6. Positive response to electrical pulp test This presents a report of cases in which immature permanent teeth, pulp-exposed by caries or trauma, was treated successfully by partial pulpotomy
5세 된 유전성 구상 적혈구증 환아에서 폐쇄성 황달을 동반한 다발성 담석증 1례
민택기,이인규,박경배,박준수 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
Hereditary spherocytosis is a common cause of hemolysis and hemolytic anemia. Some children remain asymptomatic into adulthood but others may have severe anemia with pallor, jaundice and fatigue. After infancy, the spleen is usually enlarged, and pigmentary gallstones may form as early as age 4~5 year. But it increases abruptly after age 10 year. At least 50% of unsplenectomized patients ultimately form gallstones, although for the most part they remain asymptomatic. We report herewith a case of multiple gallstone with obstructive jaundice in 5 years old patient with hereditary spherocytosis.
한랭환경하에서 면양의 Glucose 및 Insulin 분비의 Adrenalin 작동성 분비조절에 관한 연구
남기택 안성산업대학교 2006 論文集 Vol.38 No.-
In the present work, using sheep, we studied in detail the effects of α- and β-adrenergic receptor activation on the secretory response of both glucose and insulin by various doses of adrenergic blockers to obtain further information about the adrenergic modulation of insulin secretion in ruminant animals in cold environment. The plasma concentrations of glucose and insulin were determined at 15min intervals during before (2hour) and after 8(hour) intravenous infusion of adrenergic antagonist. The effects of intravenous infusion of adrenergic antagonist, Phenoxybenzamine(α-antagonist, 50nmol/kg/min), Propranolol(β-antagonist, 1 00nmol/kg/min), and Phenoxybenzamine + Propranolol, on the secretion insulin, were studied in six cross-bred castrated adult male sheep. The effects of β-receptor antagonist infusion (propranolol) was not clear, but the plasma insulin concentration was increased significantly by α-receptor antagonist infusion (phenoxybenzamine) in cold exposure. In the α- and β-receptor antagonist coinfusion, plasma insulin concentration was decreased significantly compared with saline infusion, but there was no difference in comparison with β-receptor antagonist infusion. Therefore it has been thought plasma insulin concentration was controlled by β-receptor in cold environment. Plasma glucose concentration was increased drastically by β-receptor antagonist infusion, however, there was no effect of α-receptor antagonist infusion. In both the α- and β-receptor antagonist coinfusion, plasma glucose concentration was increased. This result blood glucose was controlled through both α- and β-receptor under cold exposure. Furthermore, the action mechanism of α-receptor is prior to that of β-receptor.
한국 재래酒에 관한 연구 : Ⅳ報약탁주에서 분리한 효모에 관하여 Ⅳ. Isolation of yeasts from Tack Ju and Yack Ju
鄭基澤 慶北大學校 1975 論文集 Vol.20 No.-
1. 5 strains T-T-4 T-T-2 T-T-1 T-T-3, T-K-2 produced Capacity of alcohol more than 5.78% 2. 5 strains of yeast T-T-2 T-T-4 T-K-2 T-T-18 T-T-1 were the most Wailable in View of fermentative power by Capacity of CO_2 3. 6 strains T-T-2, T-K-2, T-T-4, T-S-2 T-I-3 T-I-1 are available not only taste and flavour but productive power of alcohol in sweet potato starch. 4. The Cells form of industrialized 6 strains, are long oval and round, and most of them are similar to the other yeast in size. 5. In giant Colony the Color was cream color and creambuff. and T-K-2 was formed by 15×12㎜ on diameter and by 3.5㎜ on high. 6. Optimum temperature of all strains is 25˚∼30℃ but T-K-4 is 28∼30℃ 7. Optimum PH is 3.4∼4.6 8. T-S-2 was died off at 65℃, but the strains died 60℃