정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

제조업 근로자의 수면실태에 관한 조사

노정균,류기하,이영수,조영채 大韓産業醫學會 1994 대한직업환경의학회지 Vol.6 No.2

산업체 근로자의 수면실태를 조사하고자 1993년 3월에 한 고무제품 제조업 근로자 479명을 대상으로 수면양상에 대한 설문조사를 실시한 결과는 다음과 같다. 1. 전체 조사대상자의 수면장애 유병율은 32.8%였으며, 수면장애의 유형별로는 취면곤란 11.9%, 수면유지곤란6.1%, 조조각성이 6.9%였다. 2. 연령군별 수면유지곤란은 20대가 가장 낮았고 30대가 가장 높았으며, 취침전 진정제 또는 알코올을 이용한 군의 수면장애가 비사용군에 비해 현저히 높게 나타났다. 3. 직업이나 가정에 대해 만족하는 군일수록 수면장애가 불만족군에 비해 낮았으며, 낮잠을 자는 군, 신체적 통증이 없는 군일수록 적게 나타났다. 4. 수면장애에 대한 회귀분석결과 통계적 유의성을 보인 변수는 낮잠여부, 신체적 통증여부 및 근무기간이었다. This study was conducted to investigate sleep qualitys of manufacturing workers. The data were collected from the 479 manufacturing factory workers who were most 3 shift workers. The results obtained were as follows. The prevalence rate of sleep disorder was 32.8%, rate of difficulty in intiating sleep was 11.9%, that of difficulty in maintaining sleep was 6.1%, and that of early morning awakening was 6.9%. Disorders of difficulty in maintaining sleep was low in the age group of twenties and high in thirties. The group of sedative or alcohol use before sleep induction showed high prevalence rate of sleep disorder. The group of satisfying for job or family had the lower rate of sleep disorder than the unsatisfying group. The rate of sleep disorder were low in the group of day sleeping, no physical pain. The variables such as day sleep, physical pain and job tenure showed statistical significance in the logistic regression of sleep disorder.

컬링 경기의 팀 수준간 작전 비교

조기정,백종철 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

This study set out to compare and analyze the strategy used by excellent male curling teams and non-excellent ones in an attempt to see if there were any differences between them based on the idea that strategy affect the results of games. For that purpose, total ten curling male teams that competed in the 2003 National Winter Athletic Games were chosen. Four of them were defined excellent while the rest six non-excellent. Among the total 1,385 strategy used by the 40 players of the ten teams, 1,124 that were identified as successful were selected. A 6㎜ Camcorder was used to tape the games, which were played using a VTR. The game data was put down on the recording document by the investigator in order to increase the validity. Based on the data recorded on the document, the frequencies were presented in percentage and x² tested according to the research purposes. Those research methods and processes led to the following results: First, there were significant differences between the excellent and non-excellent teams in strategy. Among the subcategories of the strategy, there were significant differences between the two groups in the draw strategy. Second, there were found significant differences in the strategy by ends during the early ends including End 1, 2, and 3 out of the ten ends between the two groups. Third, the two group of teams showed significant differences in the skip strategy among the strategy by positions.

유도 허벅다리 걸기 동작시 주동근의 동원양상 분석

조기정,한동성 한국학교체육학회 2002 한국학교 체육학회지 Vol.12 No.1

The purpose of this study was to verify what major muscles are during Judo uchimata, and analyze major muscle type on recruitment during repeated uchimata. 16 university students(male) were participated in the exercise test. The subject were divided into two groups; expert(N=8) and non-expert(N=8). Electromyogram test was analyzed muscle type on recruitment during repeated uchimata by surface electrode. Major muscle was measured by Integrated EMC in pre-test while seoi-otoshi 3 times. The results of this study as follows: 1. In expert goop on Judo uchimata showed that major muscle of upper limb was measured Left Brachi oradialis, Left Trapezeius, Right Brachi oradialis, Left Deltoid, and major muscle of lower limb was Left Rectusfemoris, Left Castrocnemius. 2. Non-expert group on Judo Uchimata showed that major muscle of upper limb was measured Left Brachi oradialis, Left Trapezeius, Left Biceps brachii , Left Deltoid, and major muscle of lower limb was Left Rectusfemoris, Left Biceps femoris.

냉찜질 및 온찜질이 위절제술 환자의 복부통증완화에 미치는 영향

김민정,도복늠,성기월 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.1

목적 : 수술환자의 통증조절은 환자의 안위간호에 핵심이다. 위절제술환자에게 계획된 사전정보제공, 냉찜질, 온찜질 등의 종합적인 접근방법을 모두 적용함으로써 단일 방법의 간호중재보다 효과적인 통증조절이 가능한지를 파악하고자 하였다. 대상 및 방법 : 대구시내 일 대학병원에 입원하여 1994년 12월 10일부터 4월 40일까지 위절제술을 받은 환자 40명을 대상으로 계획된 사전정보제공, 냉·온찜질을 제공받은 실험군과 단편적인 수술정보제공만 받은 대조군 20명으로 나누어 통증점수, 불편감점수, 활력증후 등의 차이를 비교하였다. 결과 : 계획된 정보제공, 냉·온찜질을 모두 제공받은 실험군은 대조군보다 통증점수, 불패감점수가 모두 유의하게 낮았으나 활력증후의 차이는 없었고 사전정보제공과 냉찜질 1회 시행직후는 시행전보다 통증점수, 불쾌감점수가 유의하게 낮아졌다. 결론 : 수술에 대한 단편적인 정보제공을 위주로 하고 있는 간호중재는 환자의 통증관리에 효과적이지 못하며 보다 종합적인 계획적 간호중재가 통증관리를 효율적으로 할 수 있음이 입증되었고 특히 계획된 수술정보제공과 수술후 6시간후부터 할 수 있는 최초의 냉찜질이 통증관리에 매우 효과적이라고 생각된다. The purpose of this study was to observe the pain relief effect of planned information, cold and hot application on the postoperative pain after gastrectomy. Fourty patients at Kyungpook National University Hospital who underwent gastrectomy and permitted this study were chosen and observed from February 10 to April 14, 1994. Twenty patients in the experimental group received the planned information on the previous day of surgery and cold and hot application, cold bags were applicated for twenty minutes on the operational site from 6 hours after gastrectomy to postperative 24 hours at every 6 hours by 4 times, and hot bags were applicated for 20 minutes on operational site from 30 hours after gastrectomy to postoperative 48 hours at every 6 hours by 4 times. The other twenty patients in the control group didn't sake the planned information, cold and hot application. Pain of experimental and control group was checked with graphic rating scale(GRS), blood pressure, body temperature, pulse, and amples of analgesics. (Nubain) The results of this study were summerized as follows. · The experimental group revealed significantly lower pain score and unpleasantness score in GRS than those of control group. · No significant difference were found between the experimental and control group in vital sign. · No significant difference were found between the experimental and control group in amples of Nubains. · The experimental group who received the planned information and 1st cold application reveald signifi cantly lower pain score and unpleasant score than those at the pretest.

상업스포츠 시설의 서비스 품질평가에 대한 소고

조기정,정영남 한국스포츠산업경영학회 1998 한국스포츠산업경영학회지 Vol.3 No.1

국민들의 스포츠활동의 욕구를 수용하고 있는 상업스포츠 시설은 양적인 증가를 보이고 있음에도 불구하고 이용자들의 만족도는 낮게 나타나고 있다. 상업스포츠 시설에 대한 의존도가 높아지고 있는 현시점에서 체계적이고 설득력이 높은 상업스포츠 시설의 서비스 품질 평가 모형 개발을 통하여 서비스에 대한 실증적 평가를 할 수 있는 근거를 제시해 주는 것은 매우 중요하다. 따라서 본고에서는 상업스포츠 시설의 특성을 파악해 보고 이를 토대로 하여 Parasuraman, Zelthaml, & Berry(1985)의 SERVQUAL(service quality) 모델에서 사용한 10가지 측정 항목, 즉, 신뢰성(reliability), 반응성(responsiveness), 능력(competence), 접근성(accessiveness), 예절(courtesy), 의사소통(communication), 신용성(credibility), 안정성(security), 이해성(understanding), 유형성(tanglbles)을 중심으로 상업스포츠 시설에서의 서비스 품질 평가문항을 제시하였다. 향후 상업스포츠 시설 이용 고객의 만족 방안을 모색하는데 기초 자료로 제공 되었으면 한다. This study consists of empirical investigations on the relationship of customer satisfaction & service quality in using commercial sport facilities. (1) commercial sport facilities as a service industry and customer satisfaction. (2) the relationship of customer satisfaction & service quality in using commercial sport facilities, and then browsing in the data on ten measurements used in Parasuraman, Zeithaml, & Berry's Servqual models as service marketing studies. (3) theoretical survey on service quality evaluation in using commercial sport facilities. Afterwards, this study supplies basic data for prospective researchers on service quality evaluation in using commercial sport facilities. In the end, this kind of study will improve customer satisfaction scale, and revitalize 'sport for all' movements. The main subjects in commercial sport services are customers, and then paticipation in the service field in a necessity. Customer types are individualized, and then depend on personal characteristics. Commercial sport facilities are individual on certain group's properties. Their first aim is to make money, using their properties in the name of sport facility. Their service traits are intangibility, inseparability, variability, perishability, and subjectivity in addition. Service quality evaluation, or supply of high-quality services in an affective strategy for service goods positioning on the market. Reliability, responsiveness, ability, proximity, etiquette, communication, credibility, safety, understandability, and types are ten measurements to evaluate service quality. Utilizing these elements in developing service quality evaluation item, the evaluation item model according to each dimension & definition plays a key role in evaluating commercial sport quality.

담배팽화율에 대한 잎담배의 이화학적 특성과 공정조건의 역할

김기환,한정성,김병구 충북대학교 엽연초연구소 1988 煙草硏究 Vol.13 No.-

The purpose of this research was to examine the factors, that is, chemical constituents, casing blending ratio, determination methods of filling value, grade, moisture, expansion time and tobacco variety, influencing the expansion rate of shredded tobacco. The important results obtained were as follows ; 1.Multiple regression formula about the relation of the chemical constituents to the expansion rate of shredded tobacco was statistically calculated with many experimental data attained on typical varieties. The preliminary relationship for estimating expansion rate(ER) was as follows : ER=94.2827-3.3572 (% sug) + 10.0940(% fib)-1.4316(% ash) - 1.4316(% ash)-17.2319 (fineness index) The relationship accounted for estimating approximately 95% of the observed variance of expansion rate. 2.The influence of casing blend ratio and determination methods of filling value upon expansion rate did not appear to be significant contributors in the evaluation. 3.ER was decreased toward the center position in a stalk. 4.The condition of the highest ER was 14-15% moisture contents of shred del tobacco and 90 minute of expansion time. 5.The influence of two varieties of NC82 and BY-4 on ER did not appear to be significant contributors in the evaluations.

자외선 및 Li^+이온에 의하여 여기된 단결정 KCㅣ의 열자극 발광

柳命浩,李丁柱,鄭基守,崔洪守 慶尙大學校 기초과학연구소 1985 基礎科學硏究所報 Vol.1 No.-

Thermoluminescence(TL) of KCI single crystal and Li^+ ion implanted KCI have been investigated below room temperature. The TL curves for KCI single crystal irradiated with UV at 77K to 300K. The thermal activation energy obtained from the initial rise method are 0.11eV and 0.19eV at 125K and 167K respectively, and the values of escape frequency S are 1.6×10^9 sec^-1 for 125K peak and 3.14×10^9 sec^-1 for 167K peak. The TL glow curves for KCI single crystal increased UV dosage showed that the 125K peak overlapped partially with the lower part of 167K peak and the 167K peak increased. As the low energy Li^+ ion were implanted in KCI single crystal at 77K, the 167K peak disappeared and 125K peak increased. The value of δ/ω was 0.54 for 125K peak which means that the TL curve is due to the second order kinetics mechanism. The thermal activation energy obtained from the peak shape method was 0.10eV for Li^+ ion implanted KCI at 125K peak.

장기간 수지침 및 뜸요법 처치후 혈중 지질 농도 변화

김효재,정한영,조기정 한국학교체육학회 2001 한국학교 체육학회지 Vol.11 No.2

이 연구는 수지요법이 건강관련 요인에 미치는 영향을 구명하기 위하여 서울시에 거주하는 40세에서 45세 사이의 어떠한 질병치료도 받고 있지 않는 건강한 성인중 뜸요법집단 (N=5명), 뜸과 수지침 자극집단 (N=5명)으로 총 10명을 연구의 대상으로 선정하였다. 실험은 3개월간 걸쳐서 매주 3회씩 실시하였으며 채혈은 전완정맥에서 실시하였으며, 채혈시기는 실험전, 실험 1개월, 3개월 후에 채혈하여 분석하였다. 이 연구의 주요 결과는 뜸요법집단과 뜸, 침자극 집단간의 ALT농도는 유의한 차가 없는 것으로 나타났지만 기술통계 측면에서 살펴볼 때 두 집단간의 자극전, 후의 ALT농도는 group I은 12.08 ± 3.39U/ I에서 15.80 ± 4.92U/ I로 증가의 경향을 보인 반면, group Ⅱ는 뜸침자극 전 (24.20 ± 9.99U/ I)에 비해, 처치 후 (20.4 ± 8.91U/ I)로 감소하는 것으로 나타났다. 그리고, 3개월간의 자극처치 후 AST, HDL, LDL, TC, Total Cholesterol의 농도에서는 감소하는 경향으로 나타났다. The purpose of the present study was to investigate the realationship of palm acupuncture and heating stress on blood lipid profiles in healthy mid-aged adults. Ten subjects were participated in the study, and compared two regimens of palm heating stress group (N=5) and concurrent trial of palm acupuncture and heating stress group (N=5). The trials were lasted for three months and drown blood before and after one and three months. The majoring finding was that no difference in ALT was found between the groups, but the trendly of increased in both groups after three month application of palm acupuncture and heating stress. The trend of decrease in AST, HDL, LDL, TC, TC after three months application of palm acupuncture and heating stress.

Aerobic Biodegradability of Polyester/Polylactic Acid Composites for Automotive NVH Parts

Jeoung, Sun Kyoung,Ha, Jin Uk,Ko, Youn Ki,Kim, Bo-Ram,Yoo, Seung Eul,Lee, Ki Dong,Lee, Su Nam,Lee, Pyoung-Chan Korean Society for Precision Engineering 2014 International Journal of Precision Engineering and Vol.15 No.8

The biodegradability of the environmental dash isolation pad was determined under aerobic conditions (ISO-14855-1). The environmental dash isolation pad was fabricated with polyester fiber and low-melting PLA fiber (LM-PLA), instead of low-melting polyester fiber. The results showed a biodegradation of 27% under aerobic conditions within a period of 45 days of composting. The commercial dash isolation pad using LM-PET (polyethylene terephthalate) fiber did not biodegrade under aerobic condition. The decrement of tensile strength and weight loss of PET/30% LM-PLA composite after 40 days were 50% and 24%, respectively, since the LM-PLA was degraded due to the progression of biodegradation. The change of molecular weight of LM-PLA fiber was examined by Gel Permeation Chromatography (GPC). The degradation of the polymer chains was caused by aerobic bacteria and its molecular weight was gradually reduced. The environmental dash isolation pads were left with 18 months under atmospheres, however, the change of tensile strength were lowing 19.8%, while the commercial dash isolation pad resulted in 19.6%. It showed a reduction of 50% in its tensile strength under aerobic conditions, no deformation or cracks were observed after the durability test.