간내 담석과 동반된 간내 담도암에서의 p53과 Ki-ras의 발현

김명환,이성구,서동완,이승규,남승우,박능화,민영일,김연석,심기남,공경엽 대한소화기학회 1997 대한소화기학회지 Vol.30 No.5

Background/Aims: Hepatolithiasis or primary intrahepatic stones may be accompanied later by intrahepatic cholangiocarcinoma. This cancerous lesion is frequently associated with atypical hyperplastic epithelium that was suspected of being precancerous. To investigate the Ki-ras or p53 mutation may play a role in carcinogenesis, and to determine whether atypical hyperplastic epithelium may be precancerous, this study was performed in intrahepatic cholangiocarcinomas associated with hepatolithiasis. Methods: We examined 12 patients with intrahepatic cholangiocarcinomas associated with hepatolithiasis. Ki-ras point mutations were assessed by direct DNA sequencing. Expressions of p53 protein were immunohistochemically assessed. The overexpression of p53 and point mutation of Ki-ras were examined in normal, hyperplastic, atypical hyperplastic, and can- cerous tissues separately. Results: The expressions of p53 protein were detected in 4 (33%) of 12 cholangiocarcinomas and Ki-ras point mutations at codon 12 were found in 2 (17%) of 12 cholangiocarcinomas. In those two carcinoma cases which contained the mutant sequence of Ki-ras, the same point mutation from wild type GGT (glycine) to GAT (aspartic acid) was. found in the associated atypical hyperplastic epithelium. However, none of the normal and hyperplastic epithelium harbored Ki-ras or p53 mutations. Conclusions: The overexpression of p53 may play a part in the carcinogenesis of some intrahepatic cholangiocarcinomas associated with hepatolithiasis, whereas the role of Ki-ras mutations in those cases is dubious. However, Ki-ras point mutation at codon 12 may be responsible for either cancer or atypical hyperplastic epithelium associated with hepatolithiasis in certain cases, suggesting atypical hyperplastic epithelium may give rise to carcinoma.

Phonology-Morphology Interaction in Lexical Phonology

Kim, Ki Hwa 대한언어학회 1995 언어학 Vol.3 No.-

Kim, Ki-Hwa(1995).Phonology-Morphology Interaction in Lexical Phonology. Linguistics 3. In this paper a theory of phonology-morphology interaction in Lexical Phonology is proposed. This theory distinguishes two types of phonology in relation to phonology-morphology interaction: cyclic phonology and noncyclic phonology. It is argued that clear distinction between cyclic and noncyclic phonological rules exists and that the domain of noncyclic phonology, different from that of cyclic phonology, is not confined to the lexicon. The validity of the arguments is examined through the analyses of Korean.

A Project Work on English Pronunciation

Kim, Ki Hwa 대한언어학회 1999 언어학 Vol.7 No.3

Kim, Ki-Hwa. 1999. A Project Work on English Pronunciation. Linguistics 7-3, 321-339. The purpose of this paper is to present a teaching model for English pronunciation. This model is designed to develop the student's English pronunciation skill with an emphasis on the communicative interaction. The first part of this paper examines major affecting factors on the acquisition of English pronunciation, where the importance of the teacher's role is emphasized, and then proceeds to discuss the conditions of good class management The second part of this paper discusses why an integrated approach is preferred to a linear approach and suggests a project work on English pronunciation which can be characterized as 'heuristic, student-centered, communication-centered'. (Sohae College)

Consonant Cluster Simplification in Korean English

Kim, Ki Hwa 대한언어학회 2000 언어학 Vol.8 No.1

Kim, Ki-Hwa. 2000. Consonant Cluster Simplification in Korean English. Linguistics 8-1, 275-295. The purpose of this paper is to examine within the OT framework whether it is possible to predict the CCS of Korean English. The analysis in rule-and-derivation phonology shows that the CCS of Korean English is characterized by extra-vowel insertion regardless of its syllabic constituency, which leads to the assumption that the CCS is the result of filtering English in terms of Korean phonology and of the consonant cluster being simplified. Such assumption enables prediction on the CCS of Korean English within the OT framework, as follows. The CCS, the Korean version of English, is an error pattern caused by assuming different constraint ranking from that of English, and also the result of a transfer of Korean phonology by assuming the Korean language specific constraints. (Sohae College)

아산시 신정호소의 수질오염 현황 및 부영양화 저감 방안

박종안,이종화,장봉기 순천향대학교 기초과학연구소 1998 순천향자연과학연구 논문집 Vol.4 No.1

This study was conducted to estimate the amount of water pollution load, water quantity and quality of inflow stream, status of water pollution and reduction of eutrophication in the Sinjung lake in Asan city. Inflow of branch to Sinjung lake have two streams, one is Cho-sa stream which are Ki-san bridge and Cho-sa bridge and the other is Hwang-san stream. Number of sampling points for water quality are 23 in the Sinjung lake and it's sediment of bottom from March to July, 1997. Water quality had been tested pH, dissolved oxygen(DO), chemical oxygen demand(COD), suspended solid(SS), total nitrogen(T-N), total phosphorus(T-P), E.coli group, and spring out test for sediment are total nitrogen, total phosphorus and heavy metals(Fe, Pb, Cd). The results were as follows; Amounts of pollution load were highest at Cho-sa stream. The ratio of livestock wastewater was occupied with the above 90% of total water pollution load. Mean daily inflow of Cho-sa stream and Hwang-san stream were 34,092㎥ and 25,524㎥, respectively. In mean level of inflow water quality, COD, SS, T-N, T-P and E. coli group were 16.96㎎/ℓ, 50.3㎎/ℓ, 5.85㎎/ℓ, 0.51㎎/ℓ and 4,096/100㎖, respectively. Water quality of inflow was worst at the point of Ki-san bridge in Cho-sa stream. Mean level of DO, COD, SS, T-N, T-P and E. coli group were 6.43㎎/ℓ, 17.11㎎/ℓ, 194.0㎎/ℓ, 5.96㎎/ℓ, 0.56㎎/ℓ and 2,191/100㎖, respectively at Sinjung lake. These are higher than class V by environmental water quality standards for lake. Spring out level of T-N, T-P, Fe and Pb in sediment of Sinjung lake were 326.6ppm, 17.9ppm, 624.2ppm and 2.65ppm, respectively.

Cell proliferation and neuroblast differentiation in the rat dentate gyrus after intrathecal treatment with adipose-derived mesenchymal stem cells.

Choi, Jung Hoon,Chung, Jin Young,Yoo, Dae Young,Hwang, In Koo,Yoo, Ki-Yeon,Lee, Choong Hyun,Yan, Bing Chun,Ahn, Jin Ok,Youn, Hwa Young,Won, Moo-Ho Kluwer Academic/Plenum Publishers 2011 Cellular and molecular neurobiology Vol.31 No.8

<P>Mesenchymal stem cells (MSC) have emerged as a new therapeutic tool for a number of clinical applications, because they have multipotency and paracrine effects via various factors. In the present study, we investigated the effects of adipose-derived MSC (Ad-MSC) transplantation via intrathecal injection through the cisterna magna on cell proliferation and differentiation of endogenous stem cells in the hippocampal dentate gyrus (DG) using Ki-67 (a marker for proliferating cells), and doublecortin (DCX, a marker for neuroblasts). The transplanted Ad-MSC were detected in the meninges, not in the hippocampal parenchyma. However, the number of Ki-67-immunoreactive cells was significantly increased by 83% in the DG 2 days after single Ad-MSC injection, and by 67% at 23 days after repeated Ad-MSC treatment compared with that in the vehicle-treated group after Ad-MSC transplantation. On the other hand, the number of DCX-immunoreactive cells in the DG was not changed at 2 days after single Ad-MSC injection; however, it was significantly increased by 62% 9 days after single Ad-MSC injection. At 23 days after repeated Ad-MSC application, the number of DCX-immunoreactive cells was much more increased (223% of the vehicle-treated group). At this time point, DCX protein levels were also significantly increased compared with those in the vehicle-treated group. These results suggest that the intrathecal injection of Ad-MSC could enhance endogenous cell proliferation, and the repeated Ad-MSC injection could be more efficient for an enhancement of endogenous cell proliferation and differentiation in the brain.</P>

섬유강화형 포스트를 이용한 치관-치근 파절의 치료: 증례 보고

임화신,라지영,이광희,안소연,김윤희,금기석,이상봉 大韓小兒齒科學會 2012 大韓小兒齒科學會誌 Vol.39 No.1

The crown-root fracture is defined as a fracture of tooth that contains enamel, dentin and cementum with or without pulp exposure. Generally the fracture lines place obliquely from labial surface, between incisal edge of the crown and marginal gingiva, to palatal surface subgingivally. If the fracture line is located supragingivally, the removal of tooth fragment and supragingival restoration can be performed. In subgingival fracture line, the surgical exposure, orthodontic eruption or surgical eruption can be considered. If the fracture line is too deep to restorate, extraction or decoronation can be selected. In children and adolescents, the extraction should be the last option. Another option to select before extraction is the restoration using fiber-reinforced post and the reattachment of tooth fragment. The fiber-rainforced post enhances the retention and the durability of tooth fragment. The reattachment of crown fragment using resin adhesive system is considered minimal invasive treatment biologically. This case reports the treatment of crown-root fracture using the reattachment of crown fragment and the insertion of fiber-reinforced post. 치관-치근 파절은 법랑질, 상아질, 백악질이 모두 포함된 치아의 파절로, 파절선이 대부분 절단연이나 순측의 변연부 치은 에서 구개측 치은열구 하방으로 사선으로 진행된다. 파절선의 위치가 치은 연상이라면 파절편의 제거 및 치은연상 수복을 시 행하고, 치은 연하라면 파절면의 외과적 노출술, 교정적 정출술, 외과적 정출술을 이용한 치아의 수복이 이루어진다. 그 외에 섬유 강화형 포스트를 삽입하여 치관 수복물의 유지력을 높이고, 레진 접착 시스템을 사용하여 치관 파절편을 재부착함으로 써 생물학적으로 최소한으로 침습적인 치료를 하는 방법도 있다. 만약 파절의 정도가 치은 연하로 깊은 경우 발치나 치관절제 술을 이용한 치근의 유지 등을 고려할 수 있다. 본 증례는 치관-치근파절로 내원한 12세 환아로 섬유강화형 포스트를 사용하여 치관 파절편 재부착을 시행하였으며 양호 한 경과를 보여 이를 보고하는 바이다.

전신성 홍반성 낭창이 속발된 헐괄 면역아구성 임프선종 1예

양기화,김병기,심상인,김원일,김선무 大韓血液學會 1984 大韓血液學會誌 Vol.19 No.2

골전이를 보인 혈관외피세포성 수막종

양기화,김병기,김선무 대한병리학회 1991 Journal of Pathology and Translational Medicine Vol.25 No.1

Hippocampal CA 2-3 부위의 Ubiquitin 양성 Neuritic Thread와 대뇌피질 Lewy Body와의 관계

양기화,양기승,강충구,성주호 대한병리학회 1995 Journal of Pathology and Translational Medicine Vol.29 No.5