http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Molecular diagnosis of spinal muscular atrophy
Ki-Sun Lee,Hee-Yu Hwang,Key-Hyoung Lee,Moon-Sung Park,Si-Houn Hahn,Chang-Ho Hong 대한의학유전학회 1997 대한의학유전학회지 Vol.1 No.1
Spinal muscular atrophy (SMA) is the second most common fatal disease of childhood with autosomal dominant mode of inheritance, and in its less severe form the third most common neuromuscular disease of childhood after Duchenne muscular dystrophy. The genetic defect was found to be on the long arm of chromosome 5 (5q11.2-q13.3) where many genes and microsatellite markers were missing. One of the most important genes is the Survival Motor Neuron (SMN) gene which is homozygously missing in 90% of SMA patients. Another important gene, the Neuronal Apoptosis Inhibitory Protein (NAIP) gene was found to be defective in 67% of SMA type Ⅰ patients. Studies so far suggest SMA occurs when the genes on the long arm of chromosome 5 are mutated or deleted. Recently our hospital encountered 2 SMA patients of type Ⅰ and Ⅱ respectively. These patients both had homozygously defective SMN genes but intact NAIP genes. We are reporting these cases with bibliographic review and discussion. Korean SMA patients presumably have defects in SMN genes similar to those found in Caucasian patients, although the siginificance of NAIP genes remains to be established. SMN gene defects can be easily diagnosed using PCR and restriction enzymes, and this method could be applied towards convenient prenatal diagnosis and towards screening for family members at risk.
양성 부인과질환 환자에서 다양한 자궁적출술 방법에 따른 임상경과의 비교
김현영,조현희,이윤진,권지영,김석원,팽기영,김장흡,김진홍 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.4
목적 : 소복부절개를 통한 자궁적출술의 방법이 기존에 사용되어왔던 각종 자궁적출술의 방법에 비해 어떠한 장점이 있는지를 알아보고자 한다. 연구 방법 : 양성의 부인과 질환으로 자궁적출술을 받은 환자 300명중 40명은 소복부반월형횡절개로 자궁적출술을 시행하고, 186명은 복부반월형횡절개를 통한 고전적 자궁적출술을, 28명은 복강경하 질식자궁적출술을, 46명은 질식자궁적출술을 시행한 후 각군의 특징과 수술후 회복정도를 비교하였다. 결과 : 소복부절개를 이용한 수술군은 수술군의 선택에 있어서는 기존의 고전적방법과 마찬가지로 질환군이나 과거수술력 등에 따른 한계가 없었으며, 수술후 임상경과는 복강경하 질식자궁적출술과 같은 빠른 회복의 장점을 가졌다. 결론 : 소복부절개를 통한 자궁적출술은 기존의 여러 자궁적출술의 방법에 따른 장점을 갖는 수술방법이다. Objective : To evaluate the clinical effectiveness of minilaparotomy total hysterectomy compared with other methods of hysterectomy ever used. Methods : Data of 300 women who had been done hysterectomy due to benign gynecologic disease were used for this thesis. Minilaparotomy hysterectomy was done for 40 women, classical transabdominal hysterectomy for 186 women, laparoscopic assisted vaginal total hysterectomy for 28 women and vaginal total hysterectomy for 46 women. Women's clinical data and clinical outcome were compared using Excel and SPSS. Results : Minilaparotomy hysterectomy has no limitation in choosing patient and adnexal surgery like classical transabdominal hysterectomy, and postoperative clinical course is so rapid similar with laparosocopic assisted vaginal total hysterectomy. Conclusion : Minilaparotomy hysterecomy is good choice for treatment of benign gynecologic disease.
Molecular diagnosis of spinal muscular atrophy
Lee, Ki-Sun,Hwang, Hee-Yu,Lee, Key-Hyoung,Park, Moon-Sung,Hahn, Si-Houn,Hong, Chang-Ho Korean Society of Medical Genetics 1997 대한의학유전학회지 Vol.1 No.1
Spinal muscular atrophy (SMA) is the second most common fatal disease of childhood with autosomal dominant mode of inheritance, and in its less severe form the third most common neuromuscular disease of childhood after Duchenne muscular dystrophy. The genetic defect was found to be on the long arm of chromosome 5 (5q11.2-q13.3) where many genes and microsatellite markers were missing. One of the most important genes is the Survival Motor Neuron (SMN) gene which is homozygously missing in 90% of SMA patients. Another important gene, the Neuronal Apoptosis Inhibitory Protein (NAIP) gene was found to be defective in 67% of SMA type I patients. Studies so far suggest SMA occurs when the genes on the long arm of chromosome 5 are mutated or deleted. Recently our hospital encountered 2 SMA patients of type I and II respectively. These patients both had homozygously defective SMN genes but intact NAIP genes. We are reporting these cases with bibliographic review and discussion. Korean SMA patients presumably have defects in SMN genes similar to those found in European patients, although the significance of NAIP genes remains to be established. SMN gene defects can be easily diagnosed using PCR and restriction enzymes, and this method could be applied towards convenient prenatal diagnosis and towards screening for family members at risk.
위선암 환자의 위암조직과 위액의 RNase Isozyme, RNase Inhibitor 및 단백의 상호관계에 관한 연구
김기형,이준규,이상훈,고재경 한양대학교 의과대학 1996 한양의대 학술지 Vol.16 No.1
Ribonuclease (RNase) known to be associated with carcinogenesis processes was determined in its activity in stomach cancer tissue and gastric juice of patients with stomach cnacer. Rnases, Rnase inhibitoras and proteins were isolated from the cancer tissue were studied. The results were compared with those obtaind from gastric juice and stomach tissue of normal control in order to find out whether cancer specific RNases were present and were released from the cancer tissue into the gastric juice. Rnases wer present and were released from the cancer tissue into the gastric juice. Rhase activity was significantly decreased and RNase inhibitor activity was unchanged in the stomach cancer tissue, while RNase and Rnase inhibitor activities were markedly increased in gastric juice of patients with stomach cancer. This indicates that Rnase activities in the gastric juice could be used as biochemical and clinical markers for the stomach cancer. DEAE-cellulose oclumn chromatography revealed that proteins and RNases in the stomach cancer tissue were separated into 7 protein peaks and 6 isozymes each, of which one Rnase isozyme appeared to be specific to the cancer. Proteins and RNases in the gastric juice of the patients with stomach cancer were separated into 8 protein peaksand 4 isozymes each, of which 2 proteins and 4 isoyzmes were speicfic to the cancer. Substrated specificity, ratio of Rnase inhibitor/Rnase and ratio of RNA/poly C for RNase activity of RNase isozymes isolated from the gastric juice of patients with stomach cancer were observed to be similar to those of RNase isozymes isolated from the stomach cancer tissue, indicating that the Rnase isozymes in the gastric juice were released from the cancer tissue.
Acute Renal Proximal Tubular Dysfunction in Two Dogs Associated with Grapes Ingestion
Ji-Houn Kang,Dongwoo Chang,Byeongwoo Ahn,Ki-Jeong Na,Mhan-Pyo Yang 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.4
Acute renal failure caused by renal proximal tubular dysfunction was diagnosed in two dogs who had ingested grapes. In both cases serum biochemistry revealed severe azotemia, hyperphosphatemia, and hyponatremia. Normoglycemic glycosuria was observed, and the percentage of amino acids that were reabsorbed was reduced. Histopathological examination of the kidneys demonstrated diffuse tubular epithelial degeneration and necrosis manifested by nuclear pyknosis, and cytoplasmic vacuolation. The damage to the proximal tubules was more severe than to the distal or collecting tubules. These findings indicate that grapes ingestion in dogs may induce severe proximal tubular dysfunction, which in turn progresses to renal failure.
Carbamazepine에 의한 독성 표피 괴사융해증 1례
박경신,김창기,기선완,배종훈 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.5
저자들은 Carbamazepine을 임상에서 사용하면서 가장 심각하게 문제가 되는 독성 표피 괴사융해증 1례를 경험하였기에 문헌 고찰과 함께 보고 하였다. 정신과 영역에서 Carbamazepine의 사용이 증대함에 따라 많은 부작용이 보고 될 것이다. Carbamazepine 치료 중에 기본적인 혈액 검사, 전해질 검사, 간 기능 검사, 심전도, 뇌파 검사, 적절한 혈증 농도 검사와 세심한 임상적 주의가 부작용을 최소화하고 치료 효과를 크게 할 것이고 독성 표피 괴사융해증이 의심될 경우에는 혈액 전문의와 전문의에게 자문 의뢰하는 것이 필요할 것이다. The authors reported one case of toxic epidermal necrolysis that occurred in the carbamazepine treatment in a 47-year old male patient with aggressive organic mental disorder. This case developed toxic epidermal necrolysis while taking carbamazepine with a dose of 600mg/day. Toxic epidermal necrolysis did not improve after discontiuation of carbamazepine. We reviewed incidence and the natural history of toxic epidermal necrolysis.
Evaluation of Hypertriglyceridemia as a Mediator Between Endocrine Diseases and Pancreatitis in Dogs
Kim, Hakhyun,Kang, Ji-Houn,Heo, Tae-Young,Kang, Byeong-Teck,Kim, Gonhyung,Chang, Dongwoo,Na, Ki-Jeong,Yang, Mhan-Pyo American Animal Hospital Association 2019 The Journal of the American Animal Hospital Associ Vol.55 No.2